The role of transcription factors p53 and MEF in a mouse model of chronic kidney disease (CKD)
Project/Area Number |
26460098
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pharmacology in pharmacy
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Research Institution | Kumamoto University |
Principal Investigator |
Suico Mary Ann 熊本大学, 大学院生命科学研究部(薬), 助教 (20363525)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 分子生物学 / 慢性腎臓病 / p53 / MEF / ミトコンドリア / 物理刺激 |
Outline of Final Research Achievements |
Alport syndrome (AS) is a progressive hereditary kidney disease caused by mutation in collagen Type 4A3, A4 or A5, which are some of the components of glomerular basement membrane. Effective treatment for AS has not been established, and development of novel therapy is required. Here, we treated AS mice with MitoQ, which is an anti-oxidant that normalizes mitochondrial dysfunction by protecting against oxidative stress, and determined whether the mitochondrial dysfunction in AS is due to oxidative stress. Treatment of 6-week-old AS mice for 2 months ameliorates AS phenotypes such as renal fibrosis and kidney injury and inflammatory cytokines expression. Further investigations will reveal the causative molecules and signaling pathways that mediate mitochondrial dysfunction in Alport mice.
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Report
(4 results)
Research Products
(43 results)
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[Journal Article] Activation of heat shock response to treat obese subjects with type 2 diabetes: a prospective, frequency-escalating, randomized, open-label, triple-arm trial.2016
Author(s)
Kondo T, Goto R, Ono K, Kitano S, Suico MA, Sato M, Igata M, Kawashima J, Motoshima H, Matsumura T, Kai H, Araki E.
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Journal Title
Sci Rep.
Volume: 19
Issue: 1
Pages: 35690-35690
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] The effect of mild electrical stimulation with heat shock on diabetic KKAy mice.2015
Author(s)
Kai Y, Tsurekawa Y, Fukuda R, Omachi K, Piruzyan M, Okamoto Y, Motomura K, Suico MA, Shuto T, Kondo T, Araki E, Kai H.
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Journal Title
Integr Mol Med.
Volume: 3
Issue: 1
Pages: 473-477
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Endoplasmic Reticulum (ER) Stress Induces Sirtuin 1 (SIRT1) Expression via the PI3K-Akt-GSK3β Signaling Pathway and Promotes Hepatocellular Injury.2015
Author(s)
Koga T, Suico MA, Shimasaki S, Watanabe E, Kai Y, Koyama K, Omachi K, Morino-Koga S, Sato T, Shuto T, Mori K, Hino S, Nakao M, Kai H.
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Journal Title
J Biol Chem.
Volume: 290
Issue: 51
Pages: 30366-30374
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] COMMD1/Murr1 reinforces HIV-1 latent infection through IκB-α stabilization.2015
Author(s)
Taura M, Kudo E, Kariya R, Goto H, Matsuda K, Hattori S, Vaeteewoottacharn K, McDonald F, Suico MA, Shuto T, Kai H, Okada S.
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Journal Title
Journal of Virology
Volume: 89(5)
Issue: 5
Pages: 2643-58
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Mild electrical stimulation with heat shock reduces visceral adiposity and improves metabolic abnormalities in subjects with metabolic syndrome or type 2 diabetes: Randomized crossover trials.2014
Author(s)
Kondo T, Ono K, Kitano S, Matsuyama R, Goto R, Suico MA, Kawasaki S, Igata M, Kawashima J, Motoshima H, Matsumura T, Kai H, Araki E
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Journal Title
EBioMedicine
Volume: 1
Issue: 1
Pages: 80-89
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] SIRT1 IS UP-REGULATED BY ER STRESS VIA THE PI3K-AKT-GSK3βPATHWAY AND MEDIATES ER STRESS-INDUCED HEPATOCELLULAR INJURY2016
Author(s)
Tomoaki Koga, Mary Ann Suico, Shogo Shimasaki, Eriko Watanabe, Yukari Kai, Kosuke Koyama, Kohei Omachi, Saori Morino-Koga, Takashi Sato, Tsuyoshi Shuto, Kazutoshi Mori, Shinjiro Hino, Mitsuyoshi Nakao, Hirofumi Kai
Organizer
第89回日本薬理学会年会
Place of Presentation
パシフィコ横浜(神奈川)
Year and Date
2016-03-09
Related Report
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[Presentation] Podocyte p53 limits the severity of experimental Alport syndrome2015
Author(s)
Mary Ann Suico, Ryosuke Fukuda, Yukari Kai, Kohei Omachi, Keishi Motomura, Tomoaki Koga, Kosuke Koyama, Tsubasa Yokota, Manabu Taura, Tsuyoshi Shuto, Hirofumi Kai
Organizer
第68回日本薬理学会西南部会
Place of Presentation
海峡メッセ下関(山口)
Year and Date
2015-11-21
Related Report
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[Presentation] Podocyte p53 limits the severity of experimental Alport syndrome2015
Author(s)
M.A. Suico, R. Fukuda, Y. Kai, K. Omachi, K. Motomura, T. Koga, K. Koyama, T. Yokota, M. Taura, T. Shuto, H. Kai
Organizer
International Symposium on Chronic Inflammatory Diseases, Kumamoto (ISCIDK2015)
Place of Presentation
熊本大学薬学部(熊本)
Year and Date
2015-10-16
Related Report
Int'l Joint Research / Invited
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[Presentation] Clarify the intracellular stress response in early-stage Alport Syndrome (AS) and establish an evaluation system for intracellular regulation of COL4A5, the causal protein for AS2015
Author(s)
K. Omachi, M. Kamura, K. Teramoto, T. Yokota, K. Motomura, R. Fukuda, M. Suico, T. Shuto, H. Kai
Organizer
International Symposium on Chronic Inflammatory Diseases, Kumamoto (ISCIDK2015)
Place of Presentation
熊本大学薬学部(熊本)
Year and Date
2015-10-16
Related Report
Int'l Joint Research
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[Presentation] Glomerular proteome analysis reveals progressive mitochondrial dysfunction in Alport syndrome mouse model2015
Author(s)
M. Kamura, K. Omachi, K. Teramoto, T. Yokota, K. Motomura, S. Kotani, M. Suico, T. Shuto, S. Misumi, H. Kai
Organizer
International Symposium on Chronic Inflammatory Diseases, Kumamoto (ISCIDK2015)
Place of Presentation
熊本大学薬学部(熊本)
Year and Date
2015-10-16
Related Report
Int'l Joint Research
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[Presentation] Podocyte-specific p53 Deletion Promotes Alport Syndrome Progression by Enhancement of Podocyte Proliferation and Migration2014
Author(s)
R. Fukuda, Y. Kai, K. Omachi, K. Motomura, T. Koga, K. Koyama, M. A. Suico, T. Shuto, H. Kai
Organizer
Pharmacology 2014
Place of Presentation
Queen Elizabeth II Conference Centre, London, UK
Year and Date
2014-12-16 – 2014-12-18
Related Report
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