Development of hippocampal neurogenesis-promoting drugs as a target for the treatment and prevention of psychiatric disorders
| Project/Area Number |
26460102
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Tohoku Medical and Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
小野木 弘志 東北福祉大学, 健康科学部, 講師 (50610200)
根本 亙 東北医科薬科大学, 薬学部, 助手 (80635136)
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| Co-Investigator(Renkei-kenkyūsha) |
TAN-NO Koichi 東北医科薬科大学, 薬学部, 教授 (20207260)
OBARA Yutarou 山形大学, 医学部, 准教授 (40400270)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 神経新生 / 認知症 / うつ病 / 脳由来神経栄養因子 / 動物モデル / うつ / 記憶障害 / 嗅球摘出動物 / 海馬歯状回 / スカブロニン / 嗅球摘出 |
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| Outline of Final Research Achievements |
The aim of this study was to explore the effects and underlying mechanisms of a newly synthesized scabronine G - methylester (SG-ME) on memory impairment in olfactory bulbectomized (OBX) mice, experimental animal models of depression and dementia. We observed that the memory impairment in OBX mice was improved at 24 hours after an intracerebroventricular (i.c.v.) injection of SG-ME. The present study has shown that SG-ME has anti-dementia effect, and the SG-ME activity to improve impaired memory is accompanied by enhancement of hippocampal cell proliferation mediated via activation of brain-derived neurotrophic factor - extracellular signal-regulated kinase - cAMP-response element binding protein (BDNF-ERK-CREB) signal pathway on neuronal cells. These results indicate that SG-ME may become a potential leading compound for drug development for Alzheimer's disease.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] BE360, a new selective estrogen receptor modulator, produces antidepressant and antidementia effects through the enhancement of hippocampal cell proliferation in olfactory bulbectomized mice.2016
Author(s)
Osamu Nakagawasai, Wataru Nemoto, Hiroshi Onogi, Takahiro Moriya, Jia-Rong Lin, Takayo Odaira, Fukie Yaoita, Takumi Ogawa, Kiminori Ohta, Yasuyuki Endo, Koichi Tan-No
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Journal Title
Behav Brain Res
Volume: 297
Pages: 315-322
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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