| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Endothelial dysfunction is a hallmark of the pathophysiology of diabetes and hypertension. Although there is a possibility to associate between endothelial dysfunction and chronic inflammation in these diseases, detailed mechanisms in difference among arteries, their disease stages, and sexes remain unclear. Major findings obtained in this study are as follows: increased 5-HT-induced contractions are seen in carotid arteries from type 2 diabetic GK rats, SHR and high insulin-treated arteries (vs. their corresponding controls) and such increased contractions were resulted in activated various kinase pathways; sex difference of 5-HT-induced carotid arterial contraction is seen in STZ-induced diabetic rats; time-course difference of vascular responses to ACh, Up4A, and PE in renal arteries from type 2 diabetic OLETF rats and associated with increased COX activities; and EDH-mediated relaxation is impaired in superior mesenteric arteries from female OLETF rats.
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