| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
The present study investigated a possible involvement of group IVA phospholipase A2 (PLA2), an inflammatory enzyme, in the development of non-alcoholic steatohepatitis (NASH). The results showed that the development of NASH was suppressed in PLA2-knockout mice but not monocyte- or endothelial cell-specific conditional PLA2 knockout mice. A specific inhibitor of PLA2 ameliorated liver fibrosis in NASH model mice. The present results suggest that the development and progression of NASH is mediated by PLA2 probably in hepatocytes and/or hepatic stellate cells.
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