Involvement of group IVA phospholipase A2 in the development and progression of non-alcoholic steatohepatitis
| Project/Area Number |
26460110
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
Akiba Satoshi 京都薬科大学, 薬学部, 教授 (70231826)
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| Co-Investigator(Renkei-kenkyūsha) |
ISHIHARA Keiichi 京都薬科大学, 薬学部, 講師 (80340446)
KAWASHITA Eri 京都薬科大学, 薬学部, 助教 (80509266)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 非アルコール性脂肪肝炎 / ホスホリパーゼA2 / マクロファージ / 炎症 / 肝線維化 / 炎症反応 |
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| Outline of Final Research Achievements |
The present study investigated a possible involvement of group IVA phospholipase A2 (PLA2), an inflammatory enzyme, in the development of non-alcoholic steatohepatitis (NASH). The results showed that the development of NASH was suppressed in PLA2-knockout mice but not monocyte- or endothelial cell-specific conditional PLA2 knockout mice. A specific inhibitor of PLA2 ameliorated liver fibrosis in NASH model mice. The present results suggest that the development and progression of NASH is mediated by PLA2 probably in hepatocytes and/or hepatic stellate cells.
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Report
(4 results)
Research Products
(16 results)
