Physiological roles of endogenous hydrogen sulfide

• Project/Area Number: 26460115
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pharmacology in pharmacy
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: Kimura Hideo 国立研究開発法人国立精神・神経医療研究センター, 神経研究所, その他 (30321889)
• Co-Investigator(Renkei-kenkyūsha): HANAOKA Kenjiro 東京大学, 大学院薬学系研究科, 准教授 (70451854)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 硫化水素 / ポリサルファイド / シグナル分子 / TRPA1チャネル / ３MST / 阻害剤 / 酵素阻害剤 / 蛍光プローブ / 一酸化窒素 / TRPチャネル / D-システイン / 細胞保護

Outline of Final Research Achievements

Hydrogen sulfide is produced by enzymes and functions as a signaling molecule. Polysulfides, which have a higher number of sulfur atoms than hydrogen sulfide, were found to be produced by 3MST and transmit signals.Polysulfides activate TRPA1 channels, which are involved in the transmission of pain, by sulfurating two cysteine residues at the amino terminus of the channels. In the present study, we identified the producing pathways of polysulfides　and　the　mechanism　for　the　activation　of　TRPA1　channels.　We　also　developped specific inhibitors of 3MST and a polysulfide specific fluorescence probe.

Research Products

• [Int'l Joint Research] LSU Health Science Center(米国)
• [Int'l Joint Research] LSU Health Science Center(米国)
• [Int'l Joint Research] LSU Health Science Center(米国)
• [Journal Article] Alternative pathway of H2S and polysilfides production form reaction intermediate of 3-mercaptopyruvate sulfurtransferase (2018)
  • Author(s): Nagahara N, Koike S, Nirasawa T ,Kimura H, Ogasawara Y
  • Journal Title: Biochem Biophys Res Commun Volume: 496 Issue: 2 Pages: 648-653
  • DOI: 10.1016/j.bbrc.2018.01.056
  • Peer Reviewed / Open Access
• [Journal Article] Discovery and Mechanistic Characterization of Selective Inhibitors of H2S-producing Enzyme: 3-Mercaptopyruvate Sulfurtransferase (3MST) Targeting Active-site Cysteine Persulfide (2017)
  • Author(s): K. Hanaoka, K. Sasakura, Y. Suwanai, S. Toma-Fukai, K. Shimamoto, Y. Takano, N. Shibuya, T. Terai, T. Komatsu, T. Ueno, Y. Ogasawara, Y. Tsuchiya, Y. Watanabe, H. Kimura, C. Wang, M. Uchiyama, H. Kojima, T. Okabe, Y. Urano, T. Shimizu, T. Nagano
  • Journal Title: Sci. Rep. Volume: 7 Issue: 1 Pages: 40227-40227
  • DOI: 10.1038/srep40227
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Development of a Reversible Fluorescent Probe for Reactive Sulfur Species, Sulfane Sulfur, and its Biological Application (2017)
  • Author(s): Takano Y, Hanaoka K, Shimamoto K, Miyamoto R, Komatsu T, Ueno T, Terai T, Kimura H, Nagano T, Urano Y
  • Journal Title: Chem Commun Volume: 53 Issue: 6 Pages: 1064-1067
  • DOI: 10.1039/c6cc08372b
  • Peer Reviewed / Open Access
• [Journal Article] 3-Mercaptopyruvate sulfurtransferase produces potential redox regularots cysteine- and glutathione-persulfide (Cys-SSH and GSSH) together with signaling molecules H2S2, H2S3 and H2S. (2017)
  • Author(s): Kimura, Y., Koike, S., Shibuya, N., Lefer, D., Ogasawara, Y., Kimura, H.
  • Journal Title: Sci. Rep. Volume: 7 Issue: 1 Pages: 10459-10459
  • DOI: 10.1038/s41598-017-11004-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Analysis of endogenous H2S and H2Sn in mouse brain by high-performance liquid chromatography with fluorescence and tandem mass spectrometric detection. (2017)
  • Author(s): Koike, S., Kawamura, K., Kimura, Y., Shibuya, N., Kimura, H., Ogasawara, Y.
  • Journal Title: Free Rad. Biol. Med. Volume: 113 Pages: 355-362
  • DOI: 10.1016/j.freeradbiomed.2017.10.346
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Hydrogen sulfide and polysalfide signaling (2017)
  • Author(s): Kimura Hideo
  • Journal Title: Antioxid. Redox Signal. Volume: 27 Issue: 10 Pages: 619-621
  • DOI: 10.1089/ars.2017.7076
  • Peer Reviewed
• [Journal Article] Polysulfides (H2Sn) produced from the interaction of hydrogen sulfide (H2S) and nitric oxide(NO) activate TRPA1 channels (2016)
  • Author(s): R Miyamoto, S Koike, Y Takano, N Shibuya, Y Kimura, K Hanaoka, Y Urano, Y Ogasawara,H Kimura
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 45995-45995
  • DOI: 10.1038/srep45995
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Hydrogen polysulfide (H2Sn) signaling along with hydrogen sulfide (H2S) and nitric oxide (NO). (2016)
  • Author(s): Kimura, H.
  • Journal Title: J. Neural Transm Volume: 123 Issue: 11 Pages: 1235-1245
  • DOI: 10.1007/s00702-016-1600-z
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 硫化水素とポリサルファイドの生理機能 (2016)
  • Author(s): 木村英雄
  • Journal Title: 日薬理誌 Volume: 147 Pages: 23-29
  • NAID: 130005118581
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Polysulfide promotes neuroblastoma cell differentiation by accelerating calcium influx (2015)
  • Author(s): 103. Koike, S., Shibuya, N., Kimura, H., Ishii, K., Ogasawara, Y.
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 459 Issue: 3 Pages: 488-492
  • DOI: 10.1016/j.bbrc.2015.02.133
  • Peer Reviewed
• [Journal Article] Polysulfide evokes acute pain through the activation of nociceptive TRPA1 in mouse sensory neurons. (2015)
  • Author(s): Hatakeyama Y, Takahashi K, Tominaga M, Kimura H, Ohta T.
  • Journal Title: Molecular Pain Volume: 11 Pages: 24-24
  • DOI: 10.1186/s12990-015-0023-4
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Identification of H2S3 and H2S produced by 3-mercaptopyruvate sulfurtransferase in the brain. (2015)
  • Author(s): Yuka Kimura, Yukiko Toyofuku, Shin Koike, Norihiro Shibuya, Noriyuki Nagahara, David Lefer, Yuki Ogasawara, Hideo Kimura.
  • Journal Title: Scientific Reports Volume: 5 Issue: 1 Pages: 14774-14774
  • DOI: 10.1038/srep14774
  • Peer Reviewed / Open Access
• [Journal Article] Signaling of hydrogen sulfide and polysulfides. (2015)
  • Author(s): Kimura, H.
  • Journal Title: Antioxid. Redox Signal. Volume: 22 Pages: 347-349
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Signaling molecules:Hydrogen sulfide and polylsulfide (2015)
  • Author(s): Hideo Kimura
  • Journal Title: Antioxidants & Redox Signaling Volume: 22 Issue: 5 Pages: 362-376
  • DOI: 10.1089/ars.2014.5869
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] H2S2014 in Kyoto: The 3rd International Conference on H2S in Biology and Medicine. (2015)
  • Author(s): Kimura, H.
  • Journal Title: Nitric Oxide Volume: 46 Pages: 1-6
  • DOI: 10.1016/j.niox.2014.10.001
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Hydrogen sulfide and polysulfides as signaling molecules (2015)
  • Author(s): Kimura, H.
  • Journal Title: Proceedings of the Japan Academy, Series B Volume: 91 Issue: 4 Pages: 131-159
  • DOI: 10.2183/pjab.91.131
  • NAID: 130005061418
  • ISSN: 0386-2208, 1349-2896
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Signaling of hydrogen sulfide and polysulfides (2015)
  • Author(s): Kimura, H.
  • Journal Title: Antioxid. Redox Signal. Volume: 22 Pages: 347-349
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The physiological role of hydrogen sulfide and beyond (2014)
  • Author(s): Kimura, H
  • Journal Title: Nitric Oxide Volume: (in press) Pages: 4-10
  • DOI: 10.1016/j.niox.2014.01.002
  • Peer Reviewed
• [Journal Article] Production and physiological effects of hydrogen sulfide (2014)
  • Author(s): Kimura, H.
  • Journal Title: Antioxid. Redox Signal Volume: 20 Issue: 5 Pages: 783-793
  • DOI: 10.1089/ars.2013.5309
  • Peer Reviewed
• [Journal Article] Hydrogen sulfide and polysulfides as biological mediators (2014)
  • Author(s): Kimura, H.
  • Journal Title: molecules Volume: 19 Issue: 10 Pages: 16146-16157
  • DOI: 10.3390/molecules191016146
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Mechanisms of polysulfide production: enzymatic biosynthesis and chemical interaction between hydrogen sulfide and nitric oxide. (2017)
  • Author(s): Yuka Kimura
  • Organizer: ConBio2017
• [Presentation] 生理活性物質硫化水とポリサルファイドの産生機構 (2017)
  • Author(s): 渋谷典弘
  • Organizer: ConBio2017
• [Presentation] Signaling molecules:H2S and H2Sn (2017)
  • Author(s): Hideo Kimura
  • Organizer: ConBio2017
• [Presentation] シグナル分子：硫化水素（H2S）とポリサルファイド（H2Sn） (2017)
  • Author(s): 木村英雄
  • Organizer: 第90回日本薬理学会年会 教育セミナー
  • Place of Presentation: 長崎ブリックホール 長崎
  • Invited
• [Presentation] ポリサルファイドH2S3とH2Sは脳内で３－メルカプトピルビン酸硫黄転移酵素により産生される (2017)
  • Author(s): 木村由佳、豊福優希子、小池伸、渋谷典広、永原則之、David Lefer、小笠原裕樹、木村英雄
  • Organizer: 第90回日本薬理学会年会
  • Place of Presentation: 長崎ブリックホール 長崎
• [Presentation] マウスにおける生理活性物質H2Sの産生経路 (2016)
  • Author(s): 渋谷典広、小池伸、田中真紀子、湯浅磨里、木村由佳、小笠原裕樹、福井清、永原則之、木村英雄
  • Organizer: ８９回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2016-03-11
• [Presentation] 新規シグナル分子H2S3とその生合成酵素３－メルカプトピルビン酸イオウ転移酵素の同定 (2016)
  • Author(s): 木村由佳、豊福優希子、小池伸、渋谷典広、永原則之、David Lefer、小笠原裕樹、木村英雄
  • Organizer: ８９回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2016-03-11
• [Presentation] 硫化水素とポリサルファイドの生理機能 (2016)
  • Author(s): 木村英雄
  • Organizer: 第８９回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2016-03-09
• [Presentation] The signaling molecules: hydrogen sulfide (H2S) and hydrogen polysulfides (H2Sn) (2016)
  • Author(s): Kimura, H.
  • Organizer: A Symposium on Pharmacology of Gaseous Mediators. Pharmacological Society of Singapore and Department of Pharmacology Yong Loo Lin School of Medicine, National University of Health System, Singapore.
  • Place of Presentation: Singapore University, Singapore
  • Int'l Joint Research / Invited
• [Presentation] Signaling molecules: hydrogen sulfide and polysulfides (2016)
  • Author(s): Kimura, H.
  • Organizer: Annual Meeting of the Society for Free Radical Research Europe.
  • Place of Presentation: Danubius Thermal Hotel Helia, Budapest, Hungary
  • Int'l Joint Research / Invited
• [Presentation] Production and Functions of Hydrogen Sulfide and Hydrogen Polysulfides (2016)
  • Author(s): Kimura, H.
  • Organizer: 4th International Conference on Hydrogen Sulfide in Biology and Medicine.
  • Place of Presentation: Centro Conferenze Universita di Napoli Federico II, Naples, Italy
  • Int'l Joint Research / Invited
• [Presentation] Hydrogen sulfide (H2S) and hydrogen polysulfides (H2Sn) as signaling molecules (2016)
  • Author(s): Kimura, H.
  • Organizer: 9th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide.
  • Place of Presentation: Sendai International Center, Sendai
  • Int'l Joint Research / Invited
• [Presentation] ガスによる脳疾患の治療の可能性 (2016)
  • Author(s): 木村英雄
  • Organizer: 第20回日本医療ガス学会学術大会・総会 教育講演
  • Place of Presentation: 秋田にぎわい交流館AU、秋田
  • Invited
• [Presentation] 硫化水素（H2S）とポリサルファイド（H2Sn）によるシグナル伝達。 (2016)
  • Author(s): 木村英雄、木村由佳、小池 伸、豊福優希子、渋谷典広、小笠原裕樹、永原則之
  • Organizer: 第89回日本生化学会大会
  • Place of Presentation: 仙台国際センター、仙台
• [Presentation] D-システインからの硫化水素産生 (2016)
  • Author(s): 渋谷典広、小池伸、田中真紀子、湯浅（石上）磨里、木村由佳、小笠原裕樹、福井清、永原則之、木村英雄
  • Organizer: 第89回日本生化学会大会
  • Place of Presentation: 仙台国際センター、仙台
• [Presentation] Physiological roles of hydrogen sulfide (H2S) and hydrogen polysulfide (H2Sn). (2016)
  • Author(s): 11)Hideo Kimura, Yuka Kimura, Yukiko Toyofuku, Norihiro Shibuya, Shin Koike, Yuki Ogasawara, Noriyuki Nagahara, David Lefer, Yoshinori Mikami, Jun-ichiro Oka.
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜、横浜
• [Presentation] Identification of H2S3 as a novel signaling molecule in the brain, and its biosynthesis by 3-mercaptopyruvate sulfurtransferase. (2016)
  • Author(s): uka Kimura, Yukiko Toyofuku, Shin Koike, Norihiro Shibuya, Noriyuki Nagahara, David Lefer, Yuki Ogasawara, Hideo Kimura
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜、横浜
• [Presentation] Another pathway to produce H2S. (2016)
  • Author(s): 13)Norihiro Shibuya, Shin Koike, Makiko Tanaka, Mari Yuasa, Yuka Kimura, Yuki Ogasawara, Kiyoshi Fukui, Noriyuki Nagahara, Hideo Kimura.
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜、横浜
• [Presentation] 生理活性物質硫化水素の産生経路（口頭発表） (2015)
  • Author(s): 渋谷典広、小池伸、田中真紀子、湯浅磨里、木村由佳、小笠原裕樹、福井清、永原則之、木村英雄
  • Organizer: BMB2015
  • Place of Presentation: 神戸国際会議場、神戸
  • Year and Date: 2015-12-04
• [Presentation] 生理活性物質硫化水素の産生経路（ポスター発表） (2015)
  • Author(s): 渋谷典広、小池伸、田中真紀子、湯浅磨里、木村由佳、小笠原裕樹、福井清、永原則之、木村英雄
  • Organizer: BMB2015
  • Place of Presentation: 神戸国際会議場、神戸
  • Year and Date: 2015-12-04
• [Presentation] 結合型イオウの一種であるポリサルファイドは神経細胞を酸化ストレスから保護し、神経突起の伸張を促進する。 (2015)
  • Author(s): 小池伸、渋谷典広、木村英雄、鈴木俊宏、小笠原裕樹
  • Organizer: BMB2015
  • Place of Presentation: 神戸国際会議場、神戸
  • Year and Date: 2015-12-03
• [Presentation] シグナル分子としての硫化水素（H2S）とポリサルファイド（H2Sn） (2015)
  • Author(s): 木村英雄
  • Organizer: BMB2015
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2015-12-01
• [Presentation] 脳のTRPA1チャネルを活性化するシグナル分子としてのポリサルファイドとその生合成。 (2015)
  • Author(s): 木村由佳、三上義礼、大隅貴美子、津金麻実子、岡淳一郎、豊福優希子、小池伸、渋谷典広、永原則之、小笠原裕樹、木村英雄
  • Organizer: BMB2015
  • Place of Presentation: 神戸国際会議場、神戸
  • Year and Date: 2015-12-01
• [Presentation] The physiological roles of hydrogen sulfide and polysulfides. (2015)
  • Author(s): Kimura, H.
  • Organizer: 14th International Congress on Amino Acids, Peptides and Proteins.
  • Place of Presentation: Juridicum Hall, Vienna, Austria
  • Year and Date: 2015-08-07
  • Int'l Joint Research / Invited
• [Presentation] Hydrogen sulfide and polysulfides as signaling molecules. (2015)
  • Author(s): Kimura, H., Kimura, Y., Shibuya, N., Toyofuku, Y., Oka, J-I., Ogasawara, Y., Koike, S., Tsugane, M.
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸国際会議場、神戸
  • Year and Date: 2015-07-28
• [Presentation] Polysulfides derived from H2S are possible signaling molecules that activate TRPA1 channels in rat brain. (2015)
  • Author(s): Kimura, Y., Mikami, Y., Osumi, K., Tsugane, M., Oka, J-I., Kimura, H.
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸国際会議場、神戸
  • Year and Date: 2015-07-28
• [Presentation] A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells. (2015)
  • Author(s): Shibuya, N., Koike, S., Tanaka, M., Ishigami-Yuasa, M., Kimura, Y., Ogasawara, Y., Fukui, K., Nagahara, N., Kimura, H.
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸国際会議場、神戸
  • Year and Date: 2015-07-28
• [Presentation] シグナル分子としての硫化水素とポリサルファイド (2015)
  • Author(s): 木村英雄
  • Organizer: 第１５回日本NO学会学術集会
  • Place of Presentation: 千里ライフサイエンスセンター、大阪
  • Year and Date: 2015-06-09
  • Invited
• [Presentation] Hydrogen sulfide and polysulfides as signaling molecules. (2015)
  • Author(s): Kimura, H.
  • Organizer: 3rd European Conference on the Biology of Hydrogen Sulfide (H2S2015)
  • Place of Presentation: Athens Palace, Athens, Greece
  • Year and Date: 2015-05-04
  • Int'l Joint Research / Invited
• [Presentation] Physiological roles of hydrogen sulfide and polysulfides (2015)
  • Author(s): Kimura, H.
  • Organizer: 第８８回日本薬理学会年会
  • Place of Presentation: Nagoya International Conference Ceter, Nagoya
  • Year and Date: 2015-03-19
  • Invited
• [Presentation] 活性型の硫化水素であるポリサルファイドは、ラット脳でTRPA1チャンネルを活性化する (2015)
  • Author(s): 木村由佳、三上義礼、大隅貴美子、津金麻実子、岡淳一郎、木村英雄
  • Organizer: 第８８回日本薬理学会年会
  • Place of Presentation: 名古屋国際会議場、愛知県、名古屋
  • Year and Date: 2015-03-19
• [Presentation] D-システインからの生理活性物質硫水素の生産 (2015)
  • Author(s): 渋谷 典広, 小池 伸, 湯浅（石上） 磨里, 田中 真紀子, 木村 由佳, 小笠原 裕樹,福井 清, 木村 英雄
  • Organizer: 第８８回日本薬理学会年会
  • Place of Presentation: 名古屋国際会議場、愛知県、名古屋
  • Year and Date: 2015-03-19
• [Presentation] 硫化水素産生酵素cystathionine γ-lyase (CSE)の阻害剤探索 (2014)
  • Author(s): 島本一史, 花岡健二郎, 土屋幸弘, 渡邊泰男, 渋谷典広, 木村英雄, 岡部隆義, 長野哲雄, 浦野泰照
  • Organizer: 第32回メディシナルケミストリーシンポジウム
  • Place of Presentation: 神戸国際会議場、兵庫県、神戸
  • Year and Date: 2014-11-26
• [Presentation] Physiological roles of hydrogen sulfide and polysulfides. (2014)
  • Author(s): Hideo Kimura, Norihiro Shibuya, Yoshinori Mikami, Yuka Kimura, Yuki Ogaawara, Noriyuki Nagahara, Jun-ichiro Oka, Shin Koike,
  • Organizer: 第８７回日本生化学会大会
  • Place of Presentation: Kyoto International Conference Center, Kyoto, Japan
  • Year and Date: 2014-10-18
• [Presentation] D-システインからの生理活性物質硫化水素の生産 (2014)
  • Author(s): 渋谷典広、小池伸、田中真紀子、湯浅（石上）磨里、木村由佳、小笠原裕樹、福井清、永原則之、木村英雄
  • Organizer: 第８７回日本生化学会大会
  • Place of Presentation: Kyoto International Conference Center, 京都
  • Year and Date: 2014-10-18
• [Presentation] Polysulfides derived from H2S are possible signaling molecules that activate TRPA1 channels in rat brain (2014)
  • Author(s): Yuka Kimura, Yoshinori Mikami, Kimiko Osumi, Mamiko Tsugane, Jun-ichiro Oka
  • Organizer: 第８７回日本生化学会大会
  • Place of Presentation: Kyoto International Conference Center, Kyoto, Japan
  • Year and Date: 2014-10-16
• [Presentation] Physiological roles of hydrogen sulfide and polysulfides (2014)
  • Author(s): Kimura, H.
  • Organizer: International Symposium. Gasotransmitters: Physiology and pathophysiology
  • Place of Presentation: Kazan University Medical School Lecture Hall, Kazan, Russia
  • Year and Date: 2014-09-23
  • Invited
• [Presentation] 硫化水素の合成調節と視神経における役割 (2014)
  • Author(s): 木村英雄、三上義礼、渋谷典広、木村由佳、小笠原裕樹、永原則之、山田雅弘
  • Organizer: 第３７回日本神経科学大会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2014-09-11
• [Presentation] 生理活性物質硫化水素の新規生産経路 (2014)
  • Author(s): 渋谷典広、小池伸、田中真紀子、湯浅（石上）磨里、木村由佳、小笠原裕樹、福井清、永原則之、木村英雄
  • Organizer: 第３７回日本神経科学大会
  • Place of Presentation: パシフィコ横浜、神奈川県、横浜
  • Year and Date: 2014-09-11
• [Presentation] The pharmacology of H2S (2014)
  • Author(s): Kimura, H.
  • Organizer: 17th World Congress of Basic and Clinical Pharmacology (WCP2014)
  • Place of Presentation: International Convention Center, Cape Town, South Africa
  • Year and Date: 2014-07-17
  • Invited
• [Presentation] 生理活性物質としての硫化水素（H2S）とポリサルファイド(H2Sn) (2014)
  • Author(s): 木村英雄
  • Organizer: 第１８回アミノ酸セミナー：基礎と臨床を結ぶ会
  • Place of Presentation: 東京国際フォーラム、東京都、東京
  • Year and Date: 2014-07-04
  • Invited
• [Presentation] Physiological roles of hydrogen sulfide and polysulfides (2014)
  • Author(s): Kimura, H.
  • Organizer: Nitric Oxide-Nitrite/Nitrate Conference
  • Place of Presentation: Renaissance Cleveland Hotel, Cleveland, OH, USA
  • Year and Date: 2014-06-16
  • Invited
• [Presentation] 硫化水素産生酵素cystathionine γ-lyase (CSE)の阻害剤探索 (2014)
  • Author(s): 島本一史, 花岡健二郎, 土屋幸弘, 渡邊泰男, 渋谷典広, 木村英雄, 岡部隆義, 長野哲雄, 浦野泰照
  • Organizer: 日本ケミカルバイオロジー学会第9回年会
  • Place of Presentation: 大阪大学会館、大阪府、大阪
  • Year and Date: 2014-06-11
• [Presentation] Nociceptive action of hydrogen sulfide throught the activation of transient receptor potential ankyrin 1 (TRPA1) (2014)
  • Author(s): Ogawa, H., Hatakeyama, Y., Takahoashi, K., Tominaga, M., Kimura, H., Ohta, T.
  • Organizer: Third International Conference on Hydrogen Sulfide in Biology and Medicine
  • Place of Presentation: Shiran Kaikan, Kyoto, Japan
  • Year and Date: 2014-06-06
  • Invited
• [Presentation] Bound sulfur esxerts protective effect against cytotoxicity in neuronal cells. (2014)
  • Author(s): Ogasawara, Y., Koike, S., Shibuya, N., Ishii, K., Kimura, H.
  • Organizer: Third International Conference on Hydrogen Sulfide in Biology and Medicine
  • Place of Presentation: Shiran Kaikan, Kyoto, Japan
  • Year and Date: 2014-06-06
  • Invited
• [Presentation] H2S and beyond (2014)
  • Author(s): Kimura, H.
  • Organizer: Third International Conference on Hydrogen Sulfide in Biology and Medicine
  • Place of Presentation: Shiran Kaikan, Kyoto, Japan
  • Year and Date: 2014-06-04
  • Invited
• [Presentation] A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells. (2014)
  • Author(s): Shibuya, N., Koike, S., Tnaka, M., Ishigami-Yuasa, M., Kimura, Y., Ogasawara, Y., Fukui, K., Nagahara, N., Kimura, H.
  • Organizer: Third International Conference on Hydrogen Sulfide in Biology and Medicine
  • Place of Presentation: Shiran Kaikan, Kyoto, Japan
  • Year and Date: 2014-06-04
• [Presentation] Polysulfides are possible H2S-derived signaling molecules in rat brain (2014)
  • Author(s): Kimura, Y., Mikami, Y., Osumi, K., Tsugane, M., Oka, J-I., Kimura, H.
  • Organizer: Third International Conference on Hydrogen Sulfide in Biology and Medicine
  • Place of Presentation: Shiran Kaikan, Kyoto, Japan
  • Year and Date: 2014-06-04
• [Presentation] Polysulfide exerts protective effect against cytotoxicity throught Nrf2 signaling in neuronal cells. (2014)
  • Author(s): Koike, S., Ogasawara, Y., Shibuya, N., Ishii, K., Kimura, H.
  • Organizer: Third International Conference on Hydrogen Sulfide in Biology and Medicine
  • Place of Presentation: Shiran Kaikan, Kyoto, Japan
  • Year and Date: 2014-06-04
• [Presentation] Inhibitor screening for 3-mercaptopyruvate sulfurtransferase (3MST) and cystathionine gamma lyase (CSE) (2014)
  • Author(s): Shimamoto, K., Hanaoka, K., Sasakura, K., Tsuchiya, Y., Watanabe, Y., Kimura, H., Okabe, T., Nagano, T., Urano, Y.
  • Organizer: Third International Conference on Hydrogen Sulfide in Biology and Medicine
  • Place of Presentation: Shiran Kaikan, Kyoto, Japan
  • Year and Date: 2014-06-04
• [Presentation] システインから生合成される硫化水素（H2S）とその代謝産物ポリサルファイドの機能 (2014)
  • Author(s): 木村英雄
  • Organizer: 第６８回日本栄養・食糧学会大会
  • Place of Presentation: 酪農学園大学、北海道、札幌
  • Year and Date: 2014-05-31
  • Invited
• [Presentation] Physiological role of hydrogen sulfide and polysulfides (2014)
  • Author(s): Kimura, H.
  • Organizer: International Symposium on: Hydrogen Sulfide and Nitric Oxide in Health and Disease
  • Place of Presentation: Universita degli Studi Federico II, Naples, Italy
  • Year and Date: 2014-05-16
  • Invited
• [Presentation] Hydrogen sulfide: overview of its production and function (2014)
  • Author(s): Kimura, H.
  • Organizer: Experimental Biology (EB) 2014
  • Place of Presentation: Convention Center, San Diego, CA, USA
  • Year and Date: 2014-04-30
  • Invited
• [Book] Chemistry, Biochemistry and pharmacology of Hydrogen Sulfide. (2015)
  • Author(s): Kimura, H.
  • Total Pages: 395
  • Publisher: Springer
• [Remarks] 日本医療研究開発機構 成果情報 木村英雄博士がトムソン・ロイター第4回リサーチフロントアワードを受賞
  • URL: https://www.amed.go.jp/news/seika/jyusho/20160725.html
• [Remarks] 日本医療研究開発機構 プレスリリース 酸化還元制御因子生合成経路の解明ー疾患治療応用に期待ー
  • URL: https://www.amed.go.jp/news/release_20170905-03.html
• [Remarks] 日本医療研究開発機構 事業の成果 受賞記事一覧
  • URL: https://www.amed.go.jp/seika/jusyo_list.html
• [Remarks] 日本医療研究開発機構 成果情報 2016(平成２８）年 成果情報一覧
  • URL: https://www.amed.go.jp/news/seika/2016_index.html
• [Remarks] 国立精神・神経医療研究センター シグナル分子H2SとNOの相乗効果がH2Sn生成によることを解明
  • URL: https://www.ncnp.go.jp/press/release.html?no=342
• [Remarks] シグナル分子硫化水素と一酸化窒素の相乗効果がポリサルファイド生成によることを解明
  • URL: http://www.ncnp.go.jp/press/release.html?no=342
• [Remarks] NCNP 神経研究所 木村英雄 部長 第４回リサーチフロントアワード（トムソン・ロイター）を受賞
  • URL: http://www.ncnp.go.jp/news.html?no=111
• [Remarks] 木村英雄博士がトムソン・ロイター第４回リサーチフロントアワードを受賞
  • URL: http://www.amed.go.jp/news/other/20160725.html
• [Remarks] 国立精神・神経医療研究センター 神経研究所 神経薬理研究部
  • URL: http://www.ncnp.go.jp/nin/guide/r_dna/index.html
• [Patent(Industrial Property Rights)] Dーシステインを有効成分として含有する硫化水素産生誘導剤 (2014)
  • Inventor(s): 木村英雄、渋谷典広
  • Industrial Property Rights Holder: 木村英雄、渋谷典広
  • Industrial Property Rights Type: 特許
  • Filing Date: 2014-04-01
  • Overseas