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Physiological roles of endogenous hydrogen sulfide

Research Project

Project/Area Number 26460115
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pharmacology in pharmacy
Research InstitutionNational Center of Neurology and Psychiatry

Principal Investigator

Kimura Hideo  国立研究開発法人国立精神・神経医療研究センター, 神経研究所, その他 (30321889)

Co-Investigator(Renkei-kenkyūsha) HANAOKA Kenjiro  東京大学, 大学院薬学系研究科, 准教授 (70451854)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords硫化水素 / ポリサルファイド / シグナル分子 / TRPA1チャネル / 3MST / 阻害剤 / 酵素阻害剤 / 蛍光プローブ / 一酸化窒素 / TRPチャネル / D-システイン / 細胞保護
Outline of Final Research Achievements

Hydrogen sulfide is produced by enzymes and functions as a signaling molecule. Polysulfides, which have a higher number of sulfur atoms than hydrogen sulfide, were found to be produced by 3MST and transmit signals.Polysulfides activate TRPA1 channels, which are involved in the transmission of pain, by sulfurating two cysteine residues at the amino terminus of the channels. In the present study, we identified the producing pathways of polysulfides and the mechanism for the activation of TRPA1 channels. We also developped specific inhibitors of 3MST and a polysulfide specific fluorescence probe.

Report

(6 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Products Report
  • Research Products

    (87 results)

All 2018 2017 2016 2015 2014 Other

All Int'l Joint Research (3 results) Journal Article (20 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 20 results,  Open Access: 10 results,  Acknowledgement Compliant: 11 results) Presentation (53 results) (of which Int'l Joint Research: 6 results,  Invited: 20 results) Book (1 results) Remarks (9 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Int'l Joint Research] LSU Health Science Center(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] LSU Health Science Center(米国)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] LSU Health Science Center(米国)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Alternative pathway of H2S and polysilfides production form reaction intermediate of 3-mercaptopyruvate sulfurtransferase2018

    • Author(s)
      Nagahara N, Koike S, Nirasawa T ,Kimura H, Ogasawara Y
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 496 Issue: 2 Pages: 648-653

    • DOI

      10.1016/j.bbrc.2018.01.056

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Discovery and Mechanistic Characterization of Selective Inhibitors of H2S-producing Enzyme: 3-Mercaptopyruvate Sulfurtransferase (3MST) Targeting Active-site Cysteine Persulfide2017

    • Author(s)
      K. Hanaoka, K. Sasakura, Y. Suwanai, S. Toma-Fukai, K. Shimamoto, Y. Takano, N. Shibuya, T. Terai, T. Komatsu, T. Ueno, Y. Ogasawara, Y. Tsuchiya, Y. Watanabe, H. Kimura, C. Wang, M. Uchiyama, H. Kojima, T. Okabe, Y. Urano, T. Shimizu, T. Nagano
    • Journal Title

      Sci. Rep.

      Volume: 7 Issue: 1 Pages: 40227-40227

    • DOI

      10.1038/srep40227

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Development of a Reversible Fluorescent Probe for Reactive Sulfur Species, Sulfane Sulfur, and its Biological Application2017

    • Author(s)
      Takano Y, Hanaoka K, Shimamoto K, Miyamoto R, Komatsu T, Ueno T, Terai T, Kimura H, Nagano T, Urano Y
    • Journal Title

      Chem Commun

      Volume: 53 Issue: 6 Pages: 1064-1067

    • DOI

      10.1039/c6cc08372b

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 3-Mercaptopyruvate sulfurtransferase produces potential redox regularots cysteine- and glutathione-persulfide (Cys-SSH and GSSH) together with signaling molecules H2S2, H2S3 and H2S.2017

    • Author(s)
      Kimura, Y., Koike, S., Shibuya, N., Lefer, D., Ogasawara, Y., Kimura, H.
    • Journal Title

      Sci. Rep.

      Volume: 7 Issue: 1 Pages: 10459-10459

    • DOI

      10.1038/s41598-017-11004-7

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Analysis of endogenous H2S and H2Sn in mouse brain by high-performance liquid chromatography with fluorescence and tandem mass spectrometric detection.2017

    • Author(s)
      Koike, S., Kawamura, K., Kimura, Y., Shibuya, N., Kimura, H., Ogasawara, Y.
    • Journal Title

      Free Rad. Biol. Med.

      Volume: 113 Pages: 355-362

    • DOI

      10.1016/j.freeradbiomed.2017.10.346

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hydrogen sulfide and polysalfide signaling2017

    • Author(s)
      Kimura Hideo
    • Journal Title

      Antioxid. Redox Signal.

      Volume: 27 Issue: 10 Pages: 619-621

    • DOI

      10.1089/ars.2017.7076

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polysulfides (H2Sn) produced from the interaction of hydrogen sulfide (H2S) and nitric oxide(NO) activate TRPA1 channels2016

    • Author(s)
      R Miyamoto, S Koike, Y Takano, N Shibuya, Y Kimura, K Hanaoka, Y Urano, Y Ogasawara,H Kimura
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 45995-45995

    • DOI

      10.1038/srep45995

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Hydrogen polysulfide (H2Sn) signaling along with hydrogen sulfide (H2S) and nitric oxide (NO).2016

    • Author(s)
      Kimura, H.
    • Journal Title

      J. Neural Transm

      Volume: 123 Issue: 11 Pages: 1235-1245

    • DOI

      10.1007/s00702-016-1600-z

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 硫化水素とポリサルファイドの生理機能2016

    • Author(s)
      木村英雄
    • Journal Title

      日薬理誌

      Volume: 147 Pages: 23-29

    • NAID

      130005118581

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Polysulfide promotes neuroblastoma cell differentiation by accelerating calcium influx2015

    • Author(s)
      103. Koike, S., Shibuya, N., Kimura, H., Ishii, K., Ogasawara, Y.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 459 Issue: 3 Pages: 488-492

    • DOI

      10.1016/j.bbrc.2015.02.133

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Polysulfide evokes acute pain through the activation of nociceptive TRPA1 in mouse sensory neurons.2015

    • Author(s)
      Hatakeyama Y, Takahashi K, Tominaga M, Kimura H, Ohta T.
    • Journal Title

      Molecular Pain

      Volume: 11 Pages: 24-24

    • DOI

      10.1186/s12990-015-0023-4

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification of H2S3 and H2S produced by 3-mercaptopyruvate sulfurtransferase in the brain.2015

    • Author(s)
      Yuka Kimura, Yukiko Toyofuku, Shin Koike, Norihiro Shibuya, Noriyuki Nagahara, David Lefer, Yuki Ogasawara, Hideo Kimura.
    • Journal Title

      Scientific Reports

      Volume: 5 Issue: 1 Pages: 14774-14774

    • DOI

      10.1038/srep14774

    • Related Report
      2015 Research-status Report Products Report
    • Peer Reviewed / Open Access
  • [Journal Article] Signaling of hydrogen sulfide and polysulfides.2015

    • Author(s)
      Kimura, H.
    • Journal Title

      Antioxid. Redox Signal.

      Volume: 22 Pages: 347-349

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Signaling molecules:Hydrogen sulfide and polylsulfide2015

    • Author(s)
      Hideo Kimura
    • Journal Title

      Antioxidants & Redox Signaling

      Volume: 22 Issue: 5 Pages: 362-376

    • DOI

      10.1089/ars.2014.5869

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] H2S2014 in Kyoto: The 3rd International Conference on H2S in Biology and Medicine.2015

    • Author(s)
      Kimura, H.
    • Journal Title

      Nitric Oxide

      Volume: 46 Pages: 1-6

    • DOI

      10.1016/j.niox.2014.10.001

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Hydrogen sulfide and polysulfides as signaling molecules2015

    • Author(s)
      Kimura, H.
    • Journal Title

      Proceedings of the Japan Academy, Series B

      Volume: 91 Issue: 4 Pages: 131-159

    • DOI

      10.2183/pjab.91.131

    • NAID

      130005061418

    • ISSN
      0386-2208, 1349-2896
    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Signaling of hydrogen sulfide and polysulfides2015

    • Author(s)
      Kimura, H.
    • Journal Title

      Antioxid. Redox Signal.

      Volume: 22 Pages: 347-349

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The physiological role of hydrogen sulfide and beyond2014

    • Author(s)
      Kimura, H
    • Journal Title

      Nitric Oxide

      Volume: (in press) Pages: 4-10

    • DOI

      10.1016/j.niox.2014.01.002

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Production and physiological effects of hydrogen sulfide2014

    • Author(s)
      Kimura, H.
    • Journal Title

      Antioxid. Redox Signal

      Volume: 20 Issue: 5 Pages: 783-793

    • DOI

      10.1089/ars.2013.5309

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hydrogen sulfide and polysulfides as biological mediators2014

    • Author(s)
      Kimura, H.
    • Journal Title

      molecules

      Volume: 19 Issue: 10 Pages: 16146-16157

    • DOI

      10.3390/molecules191016146

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Mechanisms of polysulfide production: enzymatic biosynthesis and chemical interaction between hydrogen sulfide and nitric oxide.2017

    • Author(s)
      Yuka Kimura
    • Organizer
      ConBio2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] 生理活性物質硫化水とポリサルファイドの産生機構2017

    • Author(s)
      渋谷典弘
    • Organizer
      ConBio2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] Signaling molecules:H2S and H2Sn2017

    • Author(s)
      Hideo Kimura
    • Organizer
      ConBio2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] シグナル分子:硫化水素(H2S)とポリサルファイド(H2Sn)2017

    • Author(s)
      木村英雄
    • Organizer
      第90回日本薬理学会年会 教育セミナー
    • Place of Presentation
      長崎ブリックホール 長崎
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] ポリサルファイドH2S3とH2Sは脳内で3-メルカプトピルビン酸硫黄転移酵素により産生される2017

    • Author(s)
      木村由佳、豊福優希子、小池伸、渋谷典広、永原則之、David Lefer、小笠原裕樹、木村英雄
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎ブリックホール 長崎
    • Related Report
      2016 Research-status Report
  • [Presentation] マウスにおける生理活性物質H2Sの産生経路2016

    • Author(s)
      渋谷典広、小池伸、田中真紀子、湯浅磨里、木村由佳、小笠原裕樹、福井清、永原則之、木村英雄
    • Organizer
      89回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Year and Date
      2016-03-11
    • Related Report
      2015 Research-status Report
  • [Presentation] 新規シグナル分子H2S3とその生合成酵素3-メルカプトピルビン酸イオウ転移酵素の同定2016

    • Author(s)
      木村由佳、豊福優希子、小池伸、渋谷典広、永原則之、David Lefer、小笠原裕樹、木村英雄
    • Organizer
      89回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Year and Date
      2016-03-11
    • Related Report
      2015 Research-status Report
  • [Presentation] 硫化水素とポリサルファイドの生理機能2016

    • Author(s)
      木村英雄
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Year and Date
      2016-03-09
    • Related Report
      2015 Research-status Report
  • [Presentation] The signaling molecules: hydrogen sulfide (H2S) and hydrogen polysulfides (H2Sn)2016

    • Author(s)
      Kimura, H.
    • Organizer
      A Symposium on Pharmacology of Gaseous Mediators. Pharmacological Society of Singapore and Department of Pharmacology Yong Loo Lin School of Medicine, National University of Health System, Singapore.
    • Place of Presentation
      Singapore University, Singapore
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Signaling molecules: hydrogen sulfide and polysulfides2016

    • Author(s)
      Kimura, H.
    • Organizer
      Annual Meeting of the Society for Free Radical Research Europe.
    • Place of Presentation
      Danubius Thermal Hotel Helia, Budapest, Hungary
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Production and Functions of Hydrogen Sulfide and Hydrogen Polysulfides2016

    • Author(s)
      Kimura, H.
    • Organizer
      4th International Conference on Hydrogen Sulfide in Biology and Medicine.
    • Place of Presentation
      Centro Conferenze Universita di Napoli Federico II, Naples, Italy
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Hydrogen sulfide (H2S) and hydrogen polysulfides (H2Sn) as signaling molecules2016

    • Author(s)
      Kimura, H.
    • Organizer
      9th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide.
    • Place of Presentation
      Sendai International Center, Sendai
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] ガスによる脳疾患の治療の可能性2016

    • Author(s)
      木村英雄
    • Organizer
      第20回日本医療ガス学会学術大会・総会 教育講演
    • Place of Presentation
      秋田にぎわい交流館AU、秋田
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 硫化水素(H2S)とポリサルファイド(H2Sn)によるシグナル伝達。2016

    • Author(s)
      木村英雄、木村由佳、小池 伸、豊福優希子、渋谷典広、小笠原裕樹、永原則之
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター、仙台
    • Related Report
      2016 Research-status Report
  • [Presentation] D-システインからの硫化水素産生2016

    • Author(s)
      渋谷典広、小池伸、田中真紀子、湯浅(石上)磨里、木村由佳、小笠原裕樹、福井清、永原則之、木村英雄
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター、仙台
    • Related Report
      2016 Research-status Report
  • [Presentation] Physiological roles of hydrogen sulfide (H2S) and hydrogen polysulfide (H2Sn).2016

    • Author(s)
      11)Hideo Kimura, Yuka Kimura, Yukiko Toyofuku, Norihiro Shibuya, Shin Koike, Yuki Ogasawara, Noriyuki Nagahara, David Lefer, Yoshinori Mikami, Jun-ichiro Oka.
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Related Report
      2016 Research-status Report
  • [Presentation] Identification of H2S3 as a novel signaling molecule in the brain, and its biosynthesis by 3-mercaptopyruvate sulfurtransferase.2016

    • Author(s)
      uka Kimura, Yukiko Toyofuku, Shin Koike, Norihiro Shibuya, Noriyuki Nagahara, David Lefer, Yuki Ogasawara, Hideo Kimura
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Related Report
      2016 Research-status Report
  • [Presentation] Another pathway to produce H2S.2016

    • Author(s)
      13)Norihiro Shibuya, Shin Koike, Makiko Tanaka, Mari Yuasa, Yuka Kimura, Yuki Ogasawara, Kiyoshi Fukui, Noriyuki Nagahara, Hideo Kimura.
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Related Report
      2016 Research-status Report
  • [Presentation] 生理活性物質硫化水素の産生経路(口頭発表)2015

    • Author(s)
      渋谷典広、小池伸、田中真紀子、湯浅磨里、木村由佳、小笠原裕樹、福井清、永原則之、木村英雄
    • Organizer
      BMB2015
    • Place of Presentation
      神戸国際会議場、神戸
    • Year and Date
      2015-12-04
    • Related Report
      2015 Research-status Report
  • [Presentation] 生理活性物質硫化水素の産生経路(ポスター発表)2015

    • Author(s)
      渋谷典広、小池伸、田中真紀子、湯浅磨里、木村由佳、小笠原裕樹、福井清、永原則之、木村英雄
    • Organizer
      BMB2015
    • Place of Presentation
      神戸国際会議場、神戸
    • Year and Date
      2015-12-04
    • Related Report
      2015 Research-status Report
  • [Presentation] 結合型イオウの一種であるポリサルファイドは神経細胞を酸化ストレスから保護し、神経突起の伸張を促進する。2015

    • Author(s)
      小池伸、渋谷典広、木村英雄、鈴木俊宏、小笠原裕樹
    • Organizer
      BMB2015
    • Place of Presentation
      神戸国際会議場、神戸
    • Year and Date
      2015-12-03
    • Related Report
      2015 Research-status Report
  • [Presentation] シグナル分子としての硫化水素(H2S)とポリサルファイド(H2Sn)2015

    • Author(s)
      木村英雄
    • Organizer
      BMB2015
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
  • [Presentation] 脳のTRPA1チャネルを活性化するシグナル分子としてのポリサルファイドとその生合成。2015

    • Author(s)
      木村由佳、三上義礼、大隅貴美子、津金麻実子、岡淳一郎、豊福優希子、小池伸、渋谷典広、永原則之、小笠原裕樹、木村英雄
    • Organizer
      BMB2015
    • Place of Presentation
      神戸国際会議場、神戸
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
  • [Presentation] The physiological roles of hydrogen sulfide and polysulfides.2015

    • Author(s)
      Kimura, H.
    • Organizer
      14th International Congress on Amino Acids, Peptides and Proteins.
    • Place of Presentation
      Juridicum Hall, Vienna, Austria
    • Year and Date
      2015-08-07
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Hydrogen sulfide and polysulfides as signaling molecules.2015

    • Author(s)
      Kimura, H., Kimura, Y., Shibuya, N., Toyofuku, Y., Oka, J-I., Ogasawara, Y., Koike, S., Tsugane, M.
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際会議場、神戸
    • Year and Date
      2015-07-28
    • Related Report
      2015 Research-status Report
  • [Presentation] Polysulfides derived from H2S are possible signaling molecules that activate TRPA1 channels in rat brain.2015

    • Author(s)
      Kimura, Y., Mikami, Y., Osumi, K., Tsugane, M., Oka, J-I., Kimura, H.
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際会議場、神戸
    • Year and Date
      2015-07-28
    • Related Report
      2015 Research-status Report
  • [Presentation] A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells.2015

    • Author(s)
      Shibuya, N., Koike, S., Tanaka, M., Ishigami-Yuasa, M., Kimura, Y., Ogasawara, Y., Fukui, K., Nagahara, N., Kimura, H.
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際会議場、神戸
    • Year and Date
      2015-07-28
    • Related Report
      2015 Research-status Report
  • [Presentation] シグナル分子としての硫化水素とポリサルファイド2015

    • Author(s)
      木村英雄
    • Organizer
      第15回日本NO学会学術集会
    • Place of Presentation
      千里ライフサイエンスセンター、大阪
    • Year and Date
      2015-06-09
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Hydrogen sulfide and polysulfides as signaling molecules.2015

    • Author(s)
      Kimura, H.
    • Organizer
      3rd European Conference on the Biology of Hydrogen Sulfide (H2S2015)
    • Place of Presentation
      Athens Palace, Athens, Greece
    • Year and Date
      2015-05-04
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Physiological roles of hydrogen sulfide and polysulfides2015

    • Author(s)
      Kimura, H.
    • Organizer
      第88回日本薬理学会年会
    • Place of Presentation
      Nagoya International Conference Ceter, Nagoya
    • Year and Date
      2015-03-19
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 活性型の硫化水素であるポリサルファイドは、ラット脳でTRPA1チャンネルを活性化する2015

    • Author(s)
      木村由佳、三上義礼、大隅貴美子、津金麻実子、岡淳一郎、木村英雄
    • Organizer
      第88回日本薬理学会年会
    • Place of Presentation
      名古屋国際会議場、愛知県、名古屋
    • Year and Date
      2015-03-19
    • Related Report
      2014 Research-status Report
  • [Presentation] D-システインからの生理活性物質硫水素の生産2015

    • Author(s)
      渋谷 典広, 小池 伸, 湯浅(石上) 磨里, 田中 真紀子, 木村 由佳, 小笠原 裕樹,福井 清, 木村 英雄
    • Organizer
      第88回日本薬理学会年会
    • Place of Presentation
      名古屋国際会議場、愛知県、名古屋
    • Year and Date
      2015-03-19
    • Related Report
      2014 Research-status Report
  • [Presentation] 硫化水素産生酵素cystathionine γ-lyase (CSE)の阻害剤探索2014

    • Author(s)
      島本一史, 花岡健二郎, 土屋幸弘, 渡邊泰男, 渋谷典広, 木村英雄, 岡部隆義, 長野哲雄, 浦野泰照
    • Organizer
      第32回メディシナルケミストリーシンポジウム
    • Place of Presentation
      神戸国際会議場、兵庫県、神戸
    • Year and Date
      2014-11-26
    • Related Report
      2014 Research-status Report
  • [Presentation] Physiological roles of hydrogen sulfide and polysulfides.2014

    • Author(s)
      Hideo Kimura, Norihiro Shibuya, Yoshinori Mikami, Yuka Kimura, Yuki Ogaawara, Noriyuki Nagahara, Jun-ichiro Oka, Shin Koike,
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      Kyoto International Conference Center, Kyoto, Japan
    • Year and Date
      2014-10-18
    • Related Report
      2014 Research-status Report
  • [Presentation] D-システインからの生理活性物質硫化水素の生産2014

    • Author(s)
      渋谷典広、小池伸、田中真紀子、湯浅(石上)磨里、木村由佳、小笠原裕樹、福井清、永原則之、木村英雄
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      Kyoto International Conference Center, 京都
    • Year and Date
      2014-10-18
    • Related Report
      2014 Research-status Report
  • [Presentation] Polysulfides derived from H2S are possible signaling molecules that activate TRPA1 channels in rat brain2014

    • Author(s)
      Yuka Kimura, Yoshinori Mikami, Kimiko Osumi, Mamiko Tsugane, Jun-ichiro Oka
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      Kyoto International Conference Center, Kyoto, Japan
    • Year and Date
      2014-10-16
    • Related Report
      2014 Research-status Report
  • [Presentation] Physiological roles of hydrogen sulfide and polysulfides2014

    • Author(s)
      Kimura, H.
    • Organizer
      International Symposium. Gasotransmitters: Physiology and pathophysiology
    • Place of Presentation
      Kazan University Medical School Lecture Hall, Kazan, Russia
    • Year and Date
      2014-09-23
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 硫化水素の合成調節と視神経における役割2014

    • Author(s)
      木村英雄、三上義礼、渋谷典広、木村由佳、小笠原裕樹、永原則之、山田雅弘
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Year and Date
      2014-09-11
    • Related Report
      2014 Research-status Report
  • [Presentation] 生理活性物質硫化水素の新規生産経路2014

    • Author(s)
      渋谷典広、小池伸、田中真紀子、湯浅(石上)磨里、木村由佳、小笠原裕樹、福井清、永原則之、木村英雄
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜、神奈川県、横浜
    • Year and Date
      2014-09-11
    • Related Report
      2014 Research-status Report
  • [Presentation] The pharmacology of H2S2014

    • Author(s)
      Kimura, H.
    • Organizer
      17th World Congress of Basic and Clinical Pharmacology (WCP2014)
    • Place of Presentation
      International Convention Center, Cape Town, South Africa
    • Year and Date
      2014-07-17
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 生理活性物質としての硫化水素(H2S)とポリサルファイド(H2Sn)2014

    • Author(s)
      木村英雄
    • Organizer
      第18回アミノ酸セミナー:基礎と臨床を結ぶ会
    • Place of Presentation
      東京国際フォーラム、東京都、東京
    • Year and Date
      2014-07-04
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Physiological roles of hydrogen sulfide and polysulfides2014

    • Author(s)
      Kimura, H.
    • Organizer
      Nitric Oxide-Nitrite/Nitrate Conference
    • Place of Presentation
      Renaissance Cleveland Hotel, Cleveland, OH, USA
    • Year and Date
      2014-06-16
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 硫化水素産生酵素cystathionine γ-lyase (CSE)の阻害剤探索2014

    • Author(s)
      島本一史, 花岡健二郎, 土屋幸弘, 渡邊泰男, 渋谷典広, 木村英雄, 岡部隆義, 長野哲雄, 浦野泰照
    • Organizer
      日本ケミカルバイオロジー学会第9回年会
    • Place of Presentation
      大阪大学会館、大阪府、大阪
    • Year and Date
      2014-06-11
    • Related Report
      2014 Research-status Report
  • [Presentation] Nociceptive action of hydrogen sulfide throught the activation of transient receptor potential ankyrin 1 (TRPA1)2014

    • Author(s)
      Ogawa, H., Hatakeyama, Y., Takahoashi, K., Tominaga, M., Kimura, H., Ohta, T.
    • Organizer
      Third International Conference on Hydrogen Sulfide in Biology and Medicine
    • Place of Presentation
      Shiran Kaikan, Kyoto, Japan
    • Year and Date
      2014-06-06
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Bound sulfur esxerts protective effect against cytotoxicity in neuronal cells.2014

    • Author(s)
      Ogasawara, Y., Koike, S., Shibuya, N., Ishii, K., Kimura, H.
    • Organizer
      Third International Conference on Hydrogen Sulfide in Biology and Medicine
    • Place of Presentation
      Shiran Kaikan, Kyoto, Japan
    • Year and Date
      2014-06-06
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] H2S and beyond2014

    • Author(s)
      Kimura, H.
    • Organizer
      Third International Conference on Hydrogen Sulfide in Biology and Medicine
    • Place of Presentation
      Shiran Kaikan, Kyoto, Japan
    • Year and Date
      2014-06-04
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells.2014

    • Author(s)
      Shibuya, N., Koike, S., Tnaka, M., Ishigami-Yuasa, M., Kimura, Y., Ogasawara, Y., Fukui, K., Nagahara, N., Kimura, H.
    • Organizer
      Third International Conference on Hydrogen Sulfide in Biology and Medicine
    • Place of Presentation
      Shiran Kaikan, Kyoto, Japan
    • Year and Date
      2014-06-04
    • Related Report
      2014 Research-status Report
  • [Presentation] Polysulfides are possible H2S-derived signaling molecules in rat brain2014

    • Author(s)
      Kimura, Y., Mikami, Y., Osumi, K., Tsugane, M., Oka, J-I., Kimura, H.
    • Organizer
      Third International Conference on Hydrogen Sulfide in Biology and Medicine
    • Place of Presentation
      Shiran Kaikan, Kyoto, Japan
    • Year and Date
      2014-06-04
    • Related Report
      2014 Research-status Report
  • [Presentation] Polysulfide exerts protective effect against cytotoxicity throught Nrf2 signaling in neuronal cells.2014

    • Author(s)
      Koike, S., Ogasawara, Y., Shibuya, N., Ishii, K., Kimura, H.
    • Organizer
      Third International Conference on Hydrogen Sulfide in Biology and Medicine
    • Place of Presentation
      Shiran Kaikan, Kyoto, Japan
    • Year and Date
      2014-06-04
    • Related Report
      2014 Research-status Report
  • [Presentation] Inhibitor screening for 3-mercaptopyruvate sulfurtransferase (3MST) and cystathionine gamma lyase (CSE)2014

    • Author(s)
      Shimamoto, K., Hanaoka, K., Sasakura, K., Tsuchiya, Y., Watanabe, Y., Kimura, H., Okabe, T., Nagano, T., Urano, Y.
    • Organizer
      Third International Conference on Hydrogen Sulfide in Biology and Medicine
    • Place of Presentation
      Shiran Kaikan, Kyoto, Japan
    • Year and Date
      2014-06-04
    • Related Report
      2014 Research-status Report
  • [Presentation] システインから生合成される硫化水素(H2S)とその代謝産物ポリサルファイドの機能2014

    • Author(s)
      木村英雄
    • Organizer
      第68回日本栄養・食糧学会大会
    • Place of Presentation
      酪農学園大学、北海道、札幌
    • Year and Date
      2014-05-31
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Physiological role of hydrogen sulfide and polysulfides2014

    • Author(s)
      Kimura, H.
    • Organizer
      International Symposium on: Hydrogen Sulfide and Nitric Oxide in Health and Disease
    • Place of Presentation
      Universita degli Studi Federico II, Naples, Italy
    • Year and Date
      2014-05-16
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Hydrogen sulfide: overview of its production and function2014

    • Author(s)
      Kimura, H.
    • Organizer
      Experimental Biology (EB) 2014
    • Place of Presentation
      Convention Center, San Diego, CA, USA
    • Year and Date
      2014-04-30
    • Related Report
      2014 Research-status Report
    • Invited
  • [Book] Chemistry, Biochemistry and pharmacology of Hydrogen Sulfide.2015

    • Author(s)
      Kimura, H.
    • Total Pages
      395
    • Publisher
      Springer
    • Related Report
      2015 Research-status Report
  • [Remarks] 日本医療研究開発機構 成果情報 木村英雄博士がトムソン・ロイター第4回リサーチフロントアワードを受賞

    • URL

      https://www.amed.go.jp/news/seika/jyusho/20160725.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] 日本医療研究開発機構 プレスリリース 酸化還元制御因子生合成経路の解明ー疾患治療応用に期待ー

    • URL

      https://www.amed.go.jp/news/release_20170905-03.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] 日本医療研究開発機構 事業の成果 受賞記事一覧

    • URL

      https://www.amed.go.jp/seika/jusyo_list.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] 日本医療研究開発機構 成果情報 2016(平成28)年 成果情報一覧

    • URL

      https://www.amed.go.jp/news/seika/2016_index.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] 国立精神・神経医療研究センター シグナル分子H2SとNOの相乗効果がH2Sn生成によることを解明

    • URL

      https://www.ncnp.go.jp/press/release.html?no=342

    • Related Report
      2017 Annual Research Report
  • [Remarks] シグナル分子硫化水素と一酸化窒素の相乗効果がポリサルファイド生成によることを解明

    • URL

      http://www.ncnp.go.jp/press/release.html?no=342

    • Related Report
      2016 Research-status Report
  • [Remarks] NCNP 神経研究所 木村英雄 部長 第4回リサーチフロントアワード(トムソン・ロイター)を受賞

    • URL

      http://www.ncnp.go.jp/news.html?no=111

    • Related Report
      2016 Research-status Report
  • [Remarks] 木村英雄博士がトムソン・ロイター第4回リサーチフロントアワードを受賞

    • URL

      http://www.amed.go.jp/news/other/20160725.html

    • Related Report
      2016 Research-status Report
  • [Remarks] 国立精神・神経医療研究センター 神経研究所 神経薬理研究部

    • URL

      http://www.ncnp.go.jp/nin/guide/r_dna/index.html

    • Related Report
      2014 Research-status Report
  • [Patent(Industrial Property Rights)] Dーシステインを有効成分として含有する硫化水素産生誘導剤2014

    • Inventor(s)
      木村英雄、渋谷典広
    • Industrial Property Rights Holder
      木村英雄、渋谷典広
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-04-01
    • Related Report
      2014 Research-status Report
    • Overseas

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Published: 2014-04-04   Modified: 2022-06-07  

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