| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Outline of Final Research Achievements |
Hydrogen sulfide is produced by enzymes and functions as a signaling molecule. Polysulfides, which have a higher number of sulfur atoms than hydrogen sulfide, were found to be produced by 3MST and transmit signals.Polysulfides activate TRPA1 channels, which are involved in the transmission of pain, by sulfurating two cysteine residues at the amino terminus of the channels. In the present study, we identified the producing pathways of polysulfides and the mechanism for the activation of TRPA1 channels. We also developped specific inhibitors of 3MST and a polysulfide specific fluorescence probe.
|
