Establishment of the disinfection technique applying photo-irradiation of polyphenols combined with polyphenol-induced wound healing effect based on structure-activity relationship analysis
| Project/Area Number |
26460116
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Natural medicines
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ポリフェノール / 光照射殺菌 / 創傷治癒 / logP / ぶどう種子エキス / 酸化ストレス / 細胞保護効果 / フェノール酸 / フラボノイド / 光酸化 / 抗菌活性 / 線維芽細胞 / 増殖促進 |
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| Outline of Final Research Achievements |
Short-term treatment with some polyphenols accelerated proliferation of fibroblasts. In addition, grape seed extract with a high content of catechin monomers and oligomers showed cytoprotective effect on fibroblasts exposed to various oxidative stressors. As octanol-water partition coefficient logP was thought to be a good indicator to predict such activity through affinity to cells, but no clear relationship between logP values and such biological activity was found. Of the polyphenols tested, some also showed bactericidal effect upon photoirradiation due to hydroxyl radicals generated possibly via photooxidation of their phenolic moieties. From these, it would be expected that some polyphenols could be agents possessing both disinfection and wound healing potentials.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Bactericidal Action of Photo-Irradiated Aqueous Extracts from the Residue of Crushed Grapes from Winemaking2016
Author(s)
Tsukada, M., Sheng, H., Tada, M., Mokudai, T., Oizumi, S., Kamachi, T. & Niwano, Y.
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Journal Title
Biocontrol Science
Volume: 21
Issue: 2
Pages: 113-121
DOI
NAID
ISSN
1342-4815, 1884-0205
Related Report
Peer Reviewed / Open Access
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[Journal Article] Cytoprotective effects of grape seed extract on human gingival fibroblasts in relation to its antioxidant potential2015
Author(s)
Katsuda, Y., Niwano, Y., Nakashima, T., Nakamura, K., Oizumi, S., Kanno, T., Kanetaka, H., Egusa, H.
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Journal Title
PLoS One
Volume: 10
Issue: 8
Pages: 01347040134722-01347040134722
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Acceleration of proliferative response of mouse fibroblasts by short-time pretreatment with polyphenols.2014
Author(s)
Tsuruya, M., Niwano, Y., Nakamura, K., Kanno, T., Nakashima, T., Egusa, H., Sasaki, K.
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Journal Title
Applied Biochemistry and Biotechnology.
Volume: 174(6)
Issue: 6
Pages: 2223-2235
DOI
Related Report
Peer Reviewed
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