| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Short-term treatment with some polyphenols accelerated proliferation of fibroblasts. In addition, grape seed extract with a high content of catechin monomers and oligomers showed cytoprotective effect on fibroblasts exposed to various oxidative stressors. As octanol-water partition coefficient logP was thought to be a good indicator to predict such activity through affinity to cells, but no clear relationship between logP values and such biological activity was found. Of the polyphenols tested, some also showed bactericidal effect upon photoirradiation due to hydroxyl radicals generated possibly via photooxidation of their phenolic moieties. From these, it would be expected that some polyphenols could be agents possessing both disinfection and wound healing potentials.
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