| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
|---|
| Outline of Final Research Achievements |
In this application research, in order to develop the tubulin polymerization and the depolymerization inhibitory substance of the marine invertebrate as a seed compound of a new antineoplastic drug and to separate an active ingredient, the sea invertebrate animal was collected, each animal was processed, and the rough extract was obtained. Furthermore, the extract which has a possibility of having investigated the action on PC12 cell and having affected the tubulin function under nerve growth factor existence about the obtained sample as the first activity testing was found out. The active ingredient was searched about the sponges, sea cucumbers, and sea glass, that was accepted to be that activity will be shown. A ceramide, cerebrosides, and asebotin derivatives have been separated. Synthesis of several sorts of analog objects, required in order to evaluate structure activity relationship, was also started.
|
