| Project/Area Number |
26460125
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Natural medicines
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| Research Institution | Nagasaki University |
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Principal Investigator |
TANAKA Takashi 長崎大学, 医歯薬学総合研究科(薬学系), 教授 (90171769)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUO Yosuke 長崎大学, 医歯薬学総合研究科(薬学系), 助教 (10432981)
SAITO Yoshinori 長崎大学, 医歯薬学総合研究科(薬学系), 准教授 (30441588)
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| Research Collaborator |
KOJIMA Daisetu
WAKAMATSU Hatsumi
ERA Manami
TSUJITA Takaaki
SHII Takuya
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | エラジタンニン / 生合成 / 酸化還元不均化 / キノン / 紅茶 / ポリフェノール / タンニン / カテキン / ツバキ / 植物ポリフェノール / 酸化還元 / 代謝 / Carpinus / Quercus / Camellia |
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| Outline of Final Research Achievements |
Ellagitannins have hexahydroxydiphenoyl (HHDP) esters, and biogenesis of which was thought to be simple oxidative couplings between two galloyl esters. However, the HHDP esters in the leaves of Carpinus sp. were generated reductively from dehydrohexahydroxydiphenoyl (DHHDP) esters. Similar reductive metabolism were also observed in the leaves of Sapium sp. and Punica sp. Purified DHHDP esters isolated Carpinus sp. and Sapium sp. were spontaneously decomposed to give HHDP esters in aqueous solution. The reaction is non-enzymatic and probably proceed by the reduction-oxidation dismutation mechanism. The results may propose a new biosynthetic mechanisms of ellagitannins.
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