| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
Our findings suggest that allyl isothiocyanate, a pungent ingredient of wasabi, induced gastric low-grade inflammation with no mucosal damage is independent on TRPA1 channels in rat stomachs, but is dependent on capsaicin-sensitive sensory neurons and endogenous prostaglandin. In contrast, endogenous nitric oxide facilitates to suppress gastric low-grade inflammation in response to AITC. These factors are thought to lead to low grade inflammation in gastric mucosa, resulting in the impaired motility in rodents.
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