Allyl isothiocyanate, a pungent ingredient of wasabi, induces gastric low-grade inflammation in rodents to lead to the impaired gastric motility for the development of functional dyspepsia
| Project/Area Number |
26460127
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Natural medicines
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| Research Institution | Josai International University |
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Principal Investigator |
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| Research Collaborator |
UCHIDA Masayuki
NAMIKI Takahiro
SHIMADA Hirobumi
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | ストレス / 胃腸機能障害 / 炎症 / 実験動物 / トウガラシ / ワサビ / アリルイソチオシアネート / 国際情報交換 / 機能性ディスペプシア / 微小炎症 / マウス / ラット / ワサビ受容体TRPA1 / 胃運動 / カプサイシン / 胃粘膜微小炎症 / バニロイド受容体TRPV1 |
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| Outline of Final Research Achievements |
Our findings suggest that allyl isothiocyanate, a pungent ingredient of wasabi, induced gastric low-grade inflammation with no mucosal damage is independent on TRPA1 channels in rat stomachs, but is dependent on capsaicin-sensitive sensory neurons and endogenous prostaglandin. In contrast, endogenous nitric oxide facilitates to suppress gastric low-grade inflammation in response to AITC. These factors are thought to lead to low grade inflammation in gastric mucosa, resulting in the impaired motility in rodents.
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Report
(4 results)
Research Products
(40 results)
