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Mechanism of anti-inflammatory activity of flavonoid mixture

Research Project

Project/Area Number 26460130
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Natural medicines
Research InstitutionKeio University

Principal Investigator

KIUCHI FUMIYUKI  慶應義塾大学, 薬学部(芝共立), 教授 (60161402)

Research Collaborator SHIMIZU Tomofumi  
YUJI Narukawa  
HADA Noriyasu  
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsオウゴン / 抗炎症作用 / プロスタグランジン / フラボノイド / 混合物 / 相乗作用 / COX-2 / 遺伝子発現 / baicalein / wogonin / oroxylin A / iNOS / oroxylin-A
Outline of Final Research Achievements

Three flavonoids contained in Scutellaria Root show synergistic effect on production of prostaglandin (PG) E2, a mediator of inflammation, in lipopolysaccharide-stimulated cells. In this study, the mechanism of this synergistic effect was investigated. Although the structures of the flavonoids are similar, they inhibited different processes leading to the production of PGE2: i. e. translocation of NF-κB to nucleus, NF-κB dependent transcription, and COX-2 enzyme activity. As the mixture of the flavonoids did not show synergistic effect on each step, the synergistic effect of the mixture is due to multi-step effects by different compounds in the LPS-initiated signal transduction processes. A crude drug contains many constituents. Although the amount of each constituent is not so large, the result obtained in this project indicates that synergistic effect of many constituents to different targets lead to the effectiveness of the crude drug.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (4 results)

All 2016 2015 2014

All Presentation (4 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results)

  • [Presentation] Inhibition of prostaglandin E2 production by a combination of flavonoids from Scutellaria baicalensis2016

    • Author(s)
      Tomofumi Shimizu, Nobuhiko Shibuya, Takuya Fujii, Megumi Tago, Yuji Narukawa, Hiroomi Tamura, Fumiyuki Kiuchi
    • Organizer
      9th Joint Natural Products Conference 2016
    • Place of Presentation
      Copenhagen, Denmark
    • Year and Date
      2016-07-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A study for scientific bases of effectiveness of a Kampo formula2016

    • Author(s)
      Fumiyuki Kiuchi
    • Organizer
      The 6th International Conference on Natural Products for Health and Beauty
    • Place of Presentation
      KHON KAEN, THAILAND
    • Year and Date
      2016-01-21
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] オウゴンのフラボノイドによる抗炎症作用メカニズムの解析22015

    • Author(s)
      清水智史,渋谷信彦,玉木翠,多胡めぐみ,成川佑次,羽田紀康,田村悦臣,木内文之
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      デザインクリエイティブデンター神戸(神戸)
    • Year and Date
      2015-03-25 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] オウゴンのフラボノイドによる抗炎症作用メカニズムの解析2014

    • Author(s)
      清水智史,渋谷信彦,玉木翠,多胡めぐみ,成川佑次,羽田紀康,田村悦臣,木内文之
    • Organizer
      第20回天然薬物の開発と応用シンポジウム
    • Place of Presentation
      東京大学(東京)
    • Year and Date
      2014-11-05 – 2014-11-06
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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