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Search of the seeds of an antineoplastic drug and development of a lead compound which marine organism origin fungi produce

Research Project

Project/Area Number 26460136
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Natural medicines
Research InstitutionOsaka University of Pharmaceutical Sciences

Principal Investigator

Yamada Takeshi  大阪薬科大学, 薬学部, 准教授(移行) (20278592)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords海洋生物 / 真菌 / 細胞毒性物質 / 抗腫瘍性物質 / 海洋天然物 / tandyukisins / pseurotins / altercrasin A / 海洋菌類
Outline of Final Research Achievements

We examined the metabolites produced the fungi separated from the various marine organization. A new compounds exhibiting potent cytotoxicity was isolated from an algae and a sea anemone, respectively, and we established the structures of new compounds. On the other hand, our continual examination about the cytotoxic substance production fungus led to find many new substances. In this study, we reaped rich harvest including the discovery of novel metabolites exhibiting significant biological activity, and the acquirement of the useful information for the stereochemistry.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (13 results)

All 2016 2015 2014

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 5 results,  Acknowledgement Compliant: 4 results) Presentation (8 results)

  • [Journal Article] Assignment of the CD Cotton Effect to the Chiral Center in Pseurotins, and the Stereochemical Revision of Pseurotin A22016

    • Author(s)
      Takeshi Yamada, Mina Ohshima, Kaori Yuasa, Takashi Kikuchi, Reiko Tanaka
    • Journal Title

      Marine Drugs

      Volume: 14 Issue: 4 Pages: 74-80

    • DOI

      10.3390/md14040074

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Tandyukisins E and F, novel cytotoxic decalin derivatives isolated from a marine sponge-derived fungus2016

    • Author(s)
      Mayo Suzue, Takashi Kikuchi, Reiko Tanaka, Takeshi Yamada
    • Journal Title

      Tetrahedron Letters

      Volume: 57 Issue: 46 Pages: 5070-5073

    • DOI

      10.1016/j.tetlet.2016.10.004

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Altercrasin A, a novel decalin derivative with spirotetramic acid, produced by a sea urchin-derived Alternaria sp.2015

    • Author(s)
      Takeshi Yamada, Takashi Kikuchi, Reiko Tanaka
    • Journal Title

      Tetrahedron Letter

      Volume: 56 Issue: 10 Pages: 1229-1232

    • DOI

      10.1016/j.tetlet.2015.01.066

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Determination of the chemical Structures of tandyukisins B–D, isolated from a marine sponge-derived fungus2015

    • Author(s)
      Takeshi Yamada, Yoshihide Umebayashi, Maiko Kawashima, Yuma Sugiura, Takashi Kikuchi, Reiko Tanaka
    • Journal Title

      Marine Drugs

      Volume: 13 Issue: 5 Pages: 3231-3240

    • DOI

      10.3390/md13053231

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Tandyukisin, a novel ketoaldehyde decalin derivative, produced by a marine sponge-derived Trichoderma harzianum2014

    • Author(s)
      Takeshi Yamada, Yuki Mizutani, Yoshihide Umebayashi, Naoko Inno, Maiko Kawashima, Takashi Kikuchi, Reiko Tanaka
    • Journal Title

      Tetrahedton Lett

      Volume: 55 Issue: 3 Pages: 662-664

    • DOI

      10.1016/j.tetlet.2013.11.107

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 海水魚由来真菌の産生するspiro-heterocyclic g-lactam -Pseurotin A の立体異性体の絶対構造-2016

    • Author(s)
      湯浅香織、篠原莉奈、山田剛司、菊地 崇、田中麗子
    • Organizer
      第66回日本薬学会近畿支部総会・大会
    • Place of Presentation
      大阪薬科大学
    • Year and Date
      2016-10-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] クロイソカイメン由来真菌の産生する新規ジテルペンの化学構造2016

    • Author(s)
      鈴江真世、新井貴順、山田剛司、菊地 崇、田中麗子
    • Organizer
      第66回日本薬学会近畿支部総会・大会
    • Place of Presentation
      大阪薬科大学
    • Year and Date
      2016-10-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] ワカメ表皮から分離した真菌の産生する新規細胞毒性物質2016

    • Author(s)
      広瀬恵美、松田美和、山田剛司、菊地 崇、田中麗子
    • Organizer
      第66回日本薬学会近畿支部総会・大会
    • Place of Presentation
      大阪薬科大学
    • Year and Date
      2016-10-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] イソギンチャク由来真菌の産生するポリフェノール2016

    • Author(s)
      徳水彩乃、工藤真希、山田剛司、菊地 崇、田中麗子
    • Organizer
      第66回日本薬学会近畿支部総会・大会
    • Place of Presentation
      大阪薬科大学
    • Year and Date
      2016-10-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] ムラサキウニ由来真菌の産生する新規decalin 誘導体2016

    • Author(s)
      田中亜純、久住祐介、山田剛司、菊地 崇、田中麗子
    • Organizer
      第66回日本薬学会近畿支部総会・大会
    • Place of Presentation
      大阪薬科大学
    • Year and Date
      2016-10-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] カイメン由来真菌の産生する新規細胞毒性物質の絶対構造2016

    • Author(s)
      山田 剛司,鈴江 真世,杉浦 右真,菊地 崇,田中 麗子
    • Organizer
      日本薬学会 第136年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-27
    • Related Report
      2015 Research-status Report
  • [Presentation] ムラサキウニ由来真菌の新規代謝産物altercrasin類の構造2016

    • Author(s)
      田中 亜純,西井 拓巳,菊地 崇,田中 麗子,山田 剛司
    • Organizer
      日本薬学会 第136年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-27
    • Related Report
      2015 Research-status Report
  • [Presentation] カイメン由来真菌の産生する新規代謝物の絶対構造(2)2015

    • Author(s)
      山田 剛司,河島 舞子,杉浦 右真,菊地 崇,田中 麗子
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-25 – 2015-03-28
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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