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Development and application of assay systems for searching antipruritic drug.

Research Project

Project/Area Number 26460138
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Natural medicines
Research InstitutionMukogawa Women's University

Principal Investigator

Oku Hisae  武庫川女子大学, 薬学部, 准教授 (90281518)

Co-Investigator(Kenkyū-buntansha) 石黒 京子  武庫川女子大学, 薬学部, 教授 (70151363)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords抗かゆみ物質 / 天然資源 / アッセイ法 / 淤血 / ストレス / 抗かゆみ / 病態モデル / マウス
Outline of Final Research Achievements

By the disease with serious itches such as atopic dermatitis, stress and blood stasis are a trigger to turn the worse and intractable. Therefore, we demonstrated the relationship blood stasis, stress and worse of itch by making full use of the blood stasis model mice which developed originally. Furthermore, we identified the proteins which may be new treatment target factor for a patient with the itch sensitive skin (itchy skin), and found the seeds plant for searching antipruritic compounds.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (10 results)

All 2016 2015 2014 Other

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (6 results) (of which Int'l Joint Research: 1 results) Remarks (2 results)

  • [Journal Article] Development of an assay method to search for compounds inhibiting stress-enhanced allergy2016

    • Author(s)
      Oku Hisae, a Kanaya Ryokoa, Ishiguro Kyoko
    • Journal Title

      Biol. Pharm. Bull.

      Volume: 39 Pages: 874-878

    • NAID

      130005149274

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Development of an assay method to search for compounds inhib iting stress-enhanced allergy2014

    • Author(s)
      Ishiguro, K., Okumura, M., Miyawaki, M., Oku, H
    • Journal Title

      Planta Medica

      Volume: 80 Pages: 2020-2020

    • NAID

      130005149274

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] Development of an assay method to search for compounds inhibiting stress-enhanced allergy2015

    • Author(s)
      Ishiguro Kyoko, Okumura Midori, Miyawaki Megumi, Oku Hisae.
    • Organizer
      THE INTERNATIONAL CHEMICAL CONGRESS OF PACIFIC BASIN SOCIETIES 2015
    • Place of Presentation
      Hawaii Convention Center (Honolulu, Hawaii)
    • Year and Date
      2015-12-15
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 「女性薬命の母ホワイト」の精神神経症状に対する効果2015

    • Author(s)
      張涛、荒井哲也、山崎寛生、奥尚枝、石黒京子
    • Organizer
      日本生薬学会第62回年会
    • Place of Presentation
      長良川国際会議場(岐阜県, 岐阜市)
    • Year and Date
      2015-09-11
    • Related Report
      2015 Research-status Report
  • [Presentation] キンシバイ( Impatiens balsami na) 花弁の抗アレルギー予防効果2015

    • Author(s)
      廣住育美、安藤舞、吉竹彩、奥尚枝、石黒京子
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸学院大学・兵庫医療大学 (兵庫県神戸市)
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] ストレス性アレルギーを抑制する 物質の探索を目的としたアッセイ 法の開発と応用2014

    • Author(s)
      奥尚枝, 奥村翠, 宮脇恵, 石黒京子
    • Organizer
      第20回天然薬物の開 発と応用シンポジウム
    • Place of Presentation
      東京大学(東京都文京区)
    • Year and Date
      2014-11-05 – 2014-11-06
    • Related Report
      2014 Research-status Report
  • [Presentation] Antipruritic compounds from th e colored buds of Hibiscus syr iacus L.2014

    • Author(s)
      Oku H., Kuwahara E., Ueko M. and Ishiguro K.
    • Organizer
      International Confere nce on Food for Healt h in Niigata 2014
    • Place of Presentation
      朱鷺メッセ新潟コンベンションセンター(新潟県新潟市)
    • Year and Date
      2014-10-30 – 2014-10-31
    • Related Report
      2014 Research-status Report
  • [Presentation] Development of an assay method to search for compounds inhib iting stress-enhanced allergy2014

    • Author(s)
      Ishiguro, K., Okumura, M., Miyawaki, M., Oku, H
    • Organizer
      62nd International Co ngress and Annual Mee ting of the Society f or Medicinal Plant an d Natural Product Res earch-GA2014
    • Place of Presentation
      Minho大学(ボルトガル、ギマランイシュ)
    • Year and Date
      2014-08-31 – 2014-09-04
    • Related Report
      2014 Research-status Report
  • [Remarks] 武庫川女子大学生薬学研究室ホームページ

    • URL

      http://ph.mukogawa-u.ac.jp/~shouyaku/sheng_yao_xue_yan_jiu_shi/homu.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 武庫川女子大学薬学部生薬学研究室ホームページ

    • URL

      http://ph.mukogawa-u.ac.jp/~shouyaku/sheng_yao_xue_yan_jiu_shi/homu.html

    • Related Report
      2015 Research-status Report 2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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