Biosynthetic studies on actinomycete metabolites for development of novel diabetes drugs
Project/Area Number |
26460140
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Natural medicines
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Research Institution | University of Toyama |
Principal Investigator |
Ito Takuya 富山大学, 和漢医薬学総合研究所, 准教授 (90517484)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 放線菌 / 糖尿病 / 生合成 / アミノサイクリトール |
Outline of Final Research Achievements |
Trestatin and amylostatin are aminocyclitols, which have alpha-glycosidase inhibitory activities. In order to develop new diabetes drugs, biosynthetic studies on trestatin and amylostatin, were carried out. Draft sequence analysis of trestatin and amylostatin producing strains indicated gene clusters involved in biosynthesis of these compounds. Furthermore, biosynthetic pathways of these compounds were predicted on the basis of the amino acid sequence data. In addition, we prepared genetic-disruption mutants of several functional proteins for creating new analogs of these antibiotics.
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Report
(4 results)
Research Products
(50 results)
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[Journal Article] Isopimarane diterpenoids from Kaempferia pulchra rhizomes collected in Myanmar and their Vpr inhibitory activity2016
Author(s)
N. N. Win, T. Ito, T. Matsui, S. Aimaiti, T. Kodama, H. Ngwe, Y. Okamoto, M. Tanaka, Y. Asakawa, I. Abe, H. Morita
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Journal Title
Bioorg. Med. Chem. Lett.
Volume: 26
Issue: 7
Pages: 1789-1793
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] A new isoflavanol from the fruits of Kotschya strigosa (Fabaceae)2016
Author(s)
Awouafack, M. D., Tchuenguem, R. T., Ito, T., Dzoyem, J. P., Tane, P., Morita, H.
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Journal Title
Helv. Chim. Acta.
Volume: 99
Issue: 4
Pages: 321-324
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] A new alkenylmethylresorcinol from the fruits of Ardisia kivuensis2016
Author(s)
Nguekeu, Y. M. M., Ndontsa, B. L. Mbouangouere, R., Awouafack, M. D. Ito, T., Tane, P., Morita, H.
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Journal Title
Nat. Prod. Comm.
Volume: 11
Pages: 661-662
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Two novel diphenolic metabolites from the inedible mushroom Thelephora palmate2016
Author(s)
Nishio, A., Mikami, H., Imagawa, H., Hashimoto, T., Tanaka, M., Ito, T., Iguchi, M., Iseki, K., Noji, M., Umeyama, A.
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Journal Title
Nat. Prod. Comm.
Volume: 11
Pages: 1147-1149
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Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] New acylphloroglucinol derivatives from the leaves of Baeckea frutescens.2016
Author(s)
Nisa, K., Ito, T., Subehan, Matsui, T., Kodama, T., Morita, H.
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Journal Title
Phytochemistry Letters
Volume: 15
Pages: 42-45
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Picrajavanicins H-M, new quassinoids from Picrasma javanica collected in Myanmar and their antiproliferative activities.2016
Author(s)
Win, N. N., Ito, T., Ismail, Kodama, T., Win, Y. Y., Tanaka, M., Okamoto, Y., Imagawa, H., Ngwe, H., Asakawa, Y., Abe, I., Morita, H.
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Journal Title
Tetrahedron
Volume: 72
Issue: 5
Pages: 746-752
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Terpenoids, Flavonoids and Acetogenins from some Malagasy plants.2016
Author(s)
Nagashima, F., Tabuchi, Y., Ito, T., Harinantenaina, L., Asakawa, Y.
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Journal Title
Natural Product Communication
Volume: 11
Pages: 153-157
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] New cytotoxic acylphloroglucinols, baeckenone D-F, from the leaves of Indonesian Baeckea frutescens.2016
Author(s)
Nisa, K., Ito, T., Kodama, T., Tanaka, M., Okamoto, Y., Asakawa, Y., Imagawa, H., Morita, H.
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Journal Title
Fitoterapia
Volume: 109
Pages: 236-240
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] A new cycloartane-type triterpene and a new eicosanoic acid ester from fruits of Paullinia pinnata L.2016
Author(s)
Awouafack, M. D., Ito, T., Tane, P., Kodama, T., Tanaka, M., Asakawa, Y., Morita, H.
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Journal Title
Phytochemistry Letters
Volume: 15
Pages: 220-224
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Kaempulchraols A-H, Diterpenoids from the Rhizomes of Kaempferia pulchra Collected in Myanmar.2015
Author(s)
Win, N. N., Ito, T., Aimaiti, S., Imagawa, H., Ngwe, H., Abe, I., Morita, H.
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Journal Title
Journal of Natural Products
Volume: 78
Issue: 5
Pages: 1113-1118
DOI
NAID
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Kaempulchraols I-O: New isopimarane diterpenoids from Kaempferia pulchra rhizomes collected in Myanmar and their antiproliferative activity.2015
Author(s)
Win, N. N., Ito, T., Aimaiti, S., Kodama, T., Imagawa, H., Ngwe, H., Asakawa, Y., Abe, I., Morita, H.
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Journal Title
Tetrahedron
Volume: 71
Issue: 29
Pages: 4707-4703
DOI
NAID
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] A new polyoxygenated cyclohexene and a new megastigmane glycoside from Uvaria grandiflora. Bioorg.2015
Author(s)
Duc, H. V., Kodama, T., Hien, L. T. B. P., Kiem, V., Thao, D. T., Tai, B. H., Anh, L. T., Win, N. N., Imagawa, H., Ito, T., Morita, H., Hoai, T. N.
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Journal Title
Bioorganic Medicinal Chemistry Letters
Volume: 25
Issue: 16
Pages: 3245-3250
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Kaempulchraols P-T, Diterpenoids from Kaempferia pulchra Rhizomes Collected in Myanmar.2015
Author(s)
Win, N. N., Ito, T., Aimaiti, S., Kodama, T., Tanaka, M., Ngwe, H., Asakawa, Y., Abe, I., Morita, H.
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Journal Title
Journal of Natural Products
Volume: 78
Issue: 9
Pages: 2306-2309
DOI
NAID
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Picrajavanicins A-G: Quassinoids from Picrasma javanica Collected in Myanmar.2015
Author(s)
Win, N. N., Ito, T., Ismail, Kodama, T., Win, Y. Y., Tanaka, M., Ngwe, H., Asakawa, Y., Abe, I., Morita, H.
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Journal Title
Journal of Natural Products
Volume: 78
Issue: 12
Pages: 3024-3030
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Calyculin biogenesis from a pyrophosphate protoxin produced by a sponge symbiont2014
Author(s)
Wakimoto, T., Egami, Y., Nakashima, Y., Wakimoto,Y., Mori, T., Awakawa,T., Ito, T., Kenmoku, H., Asakawa, Y., Piel, J., Abe, I.
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Journal Title
Nature Chem. Biol.
Volume: 10
Issue: 8
Pages: 648-655
DOI
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Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] A methyltransferase initiates terpene cyclization in teleocidin B biosynthesis2014
Author(s)
Awakawa, T., Zhang, L., Wakimoto, T., Hoshino, S., Mori, T., Ito, T., Ishikawa, J., Tanner, M. E., Abe, I.
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Journal Title
J. Am. Chem. Soc.
Volume: 136
Issue: 28
Pages: 9910-9913
DOI
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Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Opaliferin, a new polyketide from cultures of entomopathogenic fungus Cordyceps sp. NBRC 106954.2014
Author(s)
Grudniewska A, Hayashi S, Shimizu M, Kato M, Suenaga M, Imagawa H, Ito T, Asakawa Y, Ban S, Kumada T, Hashimoto T, Umeyama A.
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Journal Title
Organic Letter
Volume: 16
Issue: 18
Pages: 4695-4697
DOI
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Peer Reviewed / Open Access
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[Journal Article] Isolation and Total Syntheses of Cytotoxic Cryptolactones A1, A2, B1, and B2: α,β-Unsaturated δ-Lactones from a Cryptomyzus sp. Aphid.2014
Author(s)
M. Horikawa, M. Inai, Y. Oguri, E. Kuroda, M. Tanaka, S. Suzuki, T. Ito, S. Takahashi, H. Kaku, and T. Tsunoda
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Journal Title
J. Nat. Prod.
Volume: 77
Issue: 11
Pages: 2459-2464
DOI
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Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Two novel aromatic glucosides, marylaurencinosides D and E, from the fresh flowers of Cymbidium Great Flower 'Marylaurencin2014
Author(s)
Yoshikawa, K., Okahuji, M., Iseki, K., Ito, T., Asakawa, Y., Kawano, S., Hashimoto, T.
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Journal Title
J. Nat. Med.
Volume: 68
Issue: 2
Pages: 455-458
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Quassinoids: Viral protein R inhibitors from Picrasma javanica bark collected in Myanmar2017
Author(s)
Win, N. N., Ito, T., Kodama, T., Win, Y. Y., Hgwe, H., Morita, H.
Organizer
日本薬学会 第137回年会
Place of Presentation
仙台
Year and Date
2017-03-24
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[Presentation] Precursor-directed biosynthesis of unnatural novel alkaloids by using a plant type III polyketide synthase obtained from Evodia rutaecarpa.2015
Author(s)
Ito, T., Kodama, T., Noguchi, H, Abe, I., Morita, H.
Organizer
PacifiChem 2015
Place of Presentation
Honolulu, Hawaii
Year and Date
2015-12-15
Related Report
Int'l Joint Research
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