| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Because advanced glycation end products (AGEs) are reported that involved in the pathogenesis and progression of lifestyle-related diseases and aging diseases, treatment with AGEs inhibitors is believed to be a potential strategy for the prevention of these diseases. Accordingly, we have been searched for natural products that inhibits the formation of AGEs. In our previous study, MeOH extract of Epimedii Herba (EH) was found to inhibit the formation of AGEs during incubation of collagen-derived gelatin with ribose.
Epimedokoreanin B (EKB) which was typical prenylflavonoid from EH was found having most strong inhibitory activity among the tested samples. This result was able to demonstrate the potential of anti-glycation effect in EH in addition to the traditional tonic effect. Furthermore the development of foodstuff including EKB is expected as a supplement, tea or cosmetics with anti-glycation action.
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