| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
This research aimed at regulating subcellular localization of proteins through their catalytic chemical modifications in living cells as a new method for functional regulations of the proteins. I succeeded in developing a novel catalyst system to enable protein-selective acylation, and I found that a protein modified by the catalyst system (fatty acylation) localized in liposomes. I, furthermore, succeeded in protein-selective acylation in living cells using the catalyst system. Although I, unfortunately, have not achieved subcellular localization control in living cells, I believe that this research achievement paved a way for a new method of regulating protein functions through a novel mechanism.
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