| Project/Area Number |
26460146
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
KABASHIMA Tsutomu 長崎大学, 医歯薬学総合研究科(薬学系), 准教授 (20274673)
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| Co-Investigator(Renkei-kenkyūsha) |
KAI Masaaki 長崎大学, 医歯薬学総合研究科(薬学系), 教授 (00160953)
SHIBATA Takayuki 長崎大学, 医歯薬学総合研究科(薬学系), 助教 (10448491)
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| Research Collaborator |
SHIMAMURA Ryosuke
OOSHIMA Sumika
ADACHI Anna
JINNOUCHI Nobutoshi
TANOUE Naomi
KAWASHIMA Kaori
SOMIYA Miwako
YIN Sheng
Ejupi Valon
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | エイズ / HIV / アプタマー / siRNA / プロテアーゼ / CD4 / 変異 / 薬剤耐性 |
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| Outline of Final Research Achievements |
Novel nucleic acid molecule that combined DNA aptamer and siRNA (DNA aptamer-siRNA: DAS) was developed. DNA aptamer of DAS recognizes the CD4, which is essential for HIV infection, and siRNA of DAS represses the expression of HIV protease. Anti-HIV effects of DAS were examined. DAS was selectively taken into CD4+ T cell, and reduced the expression of HIV protease. Furthermore, DAS was relatively stable in serum. These results indicated that the possibility as the anti-HIV drug of DAS.
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