Development of inhibitors based on the molecular structure and mechanism of substrate hydrolysis by metallo-beta-lactamases
Project/Area Number |
26460147
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Drug development chemistry
|
Research Institution | Kinjo Gakuin University (2015-2016) Kumamoto University (2014) |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
藤田 美歌子 熊本大学, 薬学部附属創薬研究センター, 准教授 (00322256)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 感染症 / ラクタマーゼ / 抗生物質 / X線結晶構造解析 / 阻害剤 / ラクタム剤 / X線結晶構造解析 |
Outline of Final Research Achievements |
The emergence and rapid spread of carbapenem-resistant pathogens producing metallo-beta-lactamases such as IMP-1 and NDM-1 are of great concern in the clinical setting worldwide. There are no clinically available inhibitors for metallo-beta-lactamases at present. In order to develop the inhibitors for metallo-beta-lactamases, we synthesized seven novel compounds based on the X-crystal structure of metallo-beta-lactamase (IMP-1).
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Report
(4 results)
Research Products
(1 results)