| Project/Area Number |
26460151
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Tohoku Medical and Pharmaceutical University |
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Principal Investigator |
ENDO Yasuyuki 東北医科薬科大学, 薬学部, 教授 (80126002)
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| Co-Investigator(Kenkyū-buntansha) |
猪股 浩平 東北医科薬科大学, 薬学部, 准教授 (60221785)
太田 公規 東北医科薬科大学, 薬学部, 講師 (90347906)
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| Co-Investigator(Renkei-kenkyūsha) |
TAN-NO Koichi 東北医科薬科大学, 薬学部, 教授 (20207260)
NAKAGAWASAI Osamu 東北医科薬科大学, 薬学部, 准教授 (50296018)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 医薬分子設計 / 核内受容体 / エストロゲン受容体 / アンドロゲン受容体 / アゴニスト / アンタゴニスト / レチノイドX受容体 / i医薬分子設計 |
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| Outline of Final Research Achievements |
In this project, we focused design and synthesis of new estrogen receptor ligands and androgen receptor ligands utilizing a new hydrophobic structure such as boron cluster, carboranes. We have developed lead compounds for anti-osteoporosis drugs and anti-prostate cancer drugs which are effective for resistant cancer cells against conventional anticancer drugs. On the other hand, he present study has demonstrated that a new carborane compound BE360 has antidepressant and antidementia effects related by hippocampal cell proliferation. These results indicate that BE360 may have a valuable therapeutic potential against depression and neurodegenerative diseases such as AD.
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