Design and synthesis of boron-containing drugs and application to dual resonance MRI and neutron capture therapy

• Project/Area Number: 26460156
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Drug development chemistry
• Research Institution: Tokyo University of Science
• Principal Investigator: Aoki Shin 東京理科大学, 薬学部生命創薬科学科, 教授 (00222472)
• Co-Investigator(Kenkyū-buntansha): 安部 良 東京理科大学, 研究推進機構生命医科学研究所, 教授 (20159453) ; 西道 隆臣 国立研究開発法人理化学研究所, 脳科学総合研究センター, チームリーダー (80205690) ; 小野 公二 京都大学, 原子炉実験所, 寄附研究部門教員 (90122407)
• Co-Investigator(Renkei-kenkyūsha): HISAMATSU YOSUKE 東京理科大学, 薬学部, 助教 (80587270)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2014: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
• Keywords: ホウ素中性子捕捉療法 / 天然物 / グルコサミン / ホウ素クラスター / 銅 / ホウ素 / キャリア / グルコース / 中性子捕捉療法 / NMR / MRI

Outline of Final Research Achievements

Objective of this work is to deliver boron-containing compounds to tumor sites and to detect (visualize) the accumulation of boron in tumor size (in vivo imaging of boron compounds) for boron neutron capture therapy (BNCT). In this work, we have succeeded in the synthesis of sulfoquinovosylacyl-1,3-propanediol (SQAP) having a hydrophobic boron-containing alkyl group containing boron cluster for BNCT and iodo groups for computed tomography (CT). However, tumor accumulation of those SQAP derivatives were low and their toxicity to mouse was detected. Next, design and synthesis of sugar derivatives to target glucose transporters that are overexpressed on cancer cells were conducted. These D-glucosamine analogs are less toxic and some compounds exhibit fairly good T/B (tumor/blood) ratios. It was found that o-carborane undergoes decomposition in the presence of copper(II) ion in aqueous solution at neutral pH to generate 10 B(OH)3, which was applied to 11B MRI probe of Cu2+.

Research Products

• [Journal Article] Cationic Amphiphilic Tris-Cyclometalated Iridium(III) Complexes Induce Cancer Cell Death via Interaction with Ca2+-Calmodulin Complex. (2017)
  • Author(s): Hisamatsu Y, Suzuki N, Masum AA, Shibuya A, Abe R, Sato A, Tanuma SI, Aoki S.
  • Journal Title: Bioconjug Chem Volume: 28(2) Issue: 2 Pages: 507-523
  • DOI: 10.1021/acs.bioconjchem.6b00627
  • Peer Reviewed
• [Journal Article] Efficient Synthesis of Tris-Heteroleptic Iridium(III) Complexes Based on the Zn2+-Promoted Degradation of Tris-Cyclometalated Iridium (III) Complexes and Their Photophysical Properties (2017)
  • Author(s): Yuichi Tamura, Yosuke Hisamatsu, Sarvendra Kumar, Taiki Itoh, Kyouhei Sato, Reiko Kuroda, Shin Aoki
  • Journal Title: Inorganic Chemistry Volume: 56 Issue: 2 Pages: 812-833
  • DOI: 10.1021/acs.inorgchem.6b02270
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Design and Synthesis of Tris-Heteroleptic Cyclometalated Iridium(III) Complexes Consisting of Three Different Nonsymmetric Ligands Based on Ligand-Selective Electrophilic Reactions via Interligand HOMO Hopping Phenomena (2017)
  • Author(s): Yosuke Hisamatsu, Sarvendra Kumar, Shin Aoki
  • Journal Title: Inorganic Chemistry Volume: 56 Issue: 2 Pages: 886-899
  • DOI: 10.1021/acs.inorgchem.6b02519
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Concise and Versatile Synthesis of Sulfoquinovosyl Acyl Glycerol Derivatives for Biological Applications (2017)
  • Author(s): Tomohiro Tanaka, Yasuhiro Sawamoto, and Shin Aoki
  • Journal Title: Chemical and Pharmaceutical Bulletin Volume: 65
  • NAID: 130005686027
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Design and Synthesis of Heteroleptic Cyclometalated Iridium(III) Complexes Containing Quinoline-Type Ligands that Exhibit Dual Phosphorescence (2016)
  • Author(s): Sarvendra Kumar, Yosuke Hisamatsu, Yusuke Tamaki, Osamu Ishitani, and Shin Aoki
  • Journal Title: Inorganic Chemistry Volume: 55 Issue: 8 Pages: 3829-3843
  • DOI: 10.1021/acs.inorgchem.5b02872
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 11B NMR Probes of Copper(II): Finding and Implications of the Cu2+-Promoted Decomposition of ortho-Carborane Deriviatives. (2016)
  • Author(s): Tomohiro Tanaka, Yukiko Nishiura, Rikita Araki, Takaomi Saido, Ryo Abe and Shin Aoki,
  • Journal Title: European Journal of Inorganic Chemistry, Volume: 2016 Issue: 12 Pages: 1819-1834
  • DOI: 10.1002/ejic.201600117
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Supramolecular Complexes Formed by the Self-assembly of Hydrophobic Bis(Zn²⁺-cyclen) Complexes, Copper, and Di- or Triimide Units for the Hydrolysis of Phosphate Mono- and Diesters in Two-Phase Solvent Systems (Cyclen=1,4,7,10-Tetraazacyclododecane) (2016)
  • Author(s): Yosuke Hisamatsu, Yuya Miyazawa, Takeru Yoneda, Miki Miyauchi, Mohd Zulkefeli, and Shin Aoki
  • Journal Title: Chemical and Pharmaceutical Bulletin Volume: 64 Issue: 5 Pages: 451-464
  • DOI: 10.1248/cpb.c15-01014
  • NAID: 130005148749
  • ISSN: 0009-2363, 1347-5223
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Comparison of Random forest anpd SVM for Raw Data in Drug Discovery:Prediction of Radiation Protection and Toxicity Case Study (2016)
  • Author(s): Atsushi Matsumoto, Shin Aoki, Hayato Ohwada
  • Journal Title: International Journal of Machine Learning and Computing Volume: 6 Issue: 2 Pages: 145-148
  • DOI: 10.18178/ijmlc.2016.6.2.589
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 11B NMR/MRI Sensing of Copper(II) Ions In Vitro by the Decomposition of a Hybrid Compound of a nido-o-Carborane and a Metal Chelator (2016)
  • Author(s): omohiro Tanaka, Rikita Araki, Takaomi Saido, Ryo Abe, and Shin Aoki
  • Journal Title: European Journal of Inorganic Chemistry Volume: - Issue: 20 Pages: 3330-3337
  • DOI: 10.1002/ejic.201600346
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 8-quinolinol誘導体の化学反応とバイオケミカルツール・酵素阻害剤への応用 (2016)
  • Author(s): 青木伸、有安真也、花屋賢悟、久松洋介、須貝威
  • Journal Title: 8-quinolinol誘導体の化学反応とバイオケミカルツール・酵素阻害剤への応用 Volume: 74 Pages: 482-493
  • NAID: 130005159416
  • Peer Reviewed
• [Journal Article] Development of a Novel Sulfonate Ester-based Prodrug Strategy (2016)
  • Author(s): Kengo Hanaya, Shohei Yoshioka, Shinya Ariyasu, Shin Aoki, Mitsuru Shoji, Takeshi Sugai
  • Journal Title: Bioorganic and Medicinal Chemistry Letters Volume: 26 Issue: 2 Pages: 545-560
  • DOI: 10.1016/j.bmcl.2015.11.074
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 8-quinolinol誘導体の化学反応とバイオケミカルツール・酵素阻害剤への応用 (2016)
  • Author(s): 青木伸、有安真也、花屋賢悟、久松洋介、須貝威
  • Journal Title: 有機合成化学協会誌 Volume: 74
  • NAID: 130005159416
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Design and Synthesis of Amphiphilic and Luminescent Tris-Cyclometalated Iridium(III) Complexes Containing Cationic Peptides as Inducers and Detectors of Cell Death via a Calcium-Dependent Pathway (2015)
  • Author(s): Yosuke Hisamatsu, Ai Shibuya, Nozomi Suzuki, Toshinori Suzuki, Ryo Abe, and Shin Aoki,
  • Journal Title: Bioconjugate Chemistry Volume: 26 Issue: 5 Pages: 857-879
  • DOI: 10.1021/acs.bioconjchem.5b00095
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] “Photochemical Properties of Red-Emitting Tris(cyclometalated) Iridium(III) Complexes Having Basic and Nitro Groups and Application to pH Sensing and Photoinduced Cell Death (2015)
  • Author(s): Aya Kando, Yosuke Hisamatsu, Hiroki Ohwada, Shinsuke Moromizato, Taiki Itoh, Masahiro Kohno, and Shin Aoki,
  • Journal Title: Inorganic Chemistry Volume: 54 Issue: 11 Pages: 5342-5357
  • DOI: 10.1021/acs.inorgchem.5b00369
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Enrichment of circulating tumor cells in tumor-bearing mouse blood by a deterministic lateral displacement microfluidic device. (2015)
  • Author(s): Okano H, Konishi T, Suzuki T, Suzuki T, Ariyasu S, Aoki S, Abe R, Hayase M.
  • Journal Title: Biomed. Microdevices Volume: 17 Issue: 3 Pages: 9964-9964
  • DOI: 10.1007/s10544-015-9964-7
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Docking Score Calculation Using Machine Learning with an Enhanced Inhibitor Database (2015)
  • Author(s): Masato Okada, Tadasuke Ito, Hayato Ohwada and Shin Aoki
  • Journal Title: Journal of Medical Imaging and Health Informatics Volume: 5 Issue: 5 Pages: 1104-1107
  • DOI: 10.1166/jmihi.2015.1503
  • Peer Reviewed
• [Journal Article] Combining Two Machine Learning Methods for Predicting Protein-Ligand Docking Using Structure and Physiochemical Properties (2015)
  • Author(s): Tadasuke Ito, Hayato Ohwada, Shin Aoki
  • Journal Title: Proceedings of the 7th International Conference on Bioinformatics and Computational Biology Volume: 3 Pages: 19-24
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Synthesis of Disaccharide Nucleosides by Direct O-Glycosylation of Natural Nucleosides with Thioglycoside Donors (2015)
  • Author(s): Shin Aoki, Taketo Fukumoto, Taiki Itoh, Masayuki Kurihara, Shigeto Saito, and Shinya Komabiki
  • Journal Title: Chemistry-Asian Journal Volume: 10 Issue: 3 Pages: 740-751
  • DOI: 10.1002/asia.201403319
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Design, Synthesis, and Photochemical Reactivation of Caged Prodrugs of 8-Hydroxyquinoline-base Enzyme Inhibitors (2014)
  • Author(s): Shinya Ariyasu, Yuki Mizuseda, Kengo Hanaya, Miho Suetsugu, and Shin Aoki
  • Journal Title: Chemical and Pharmaceutical Bulletin Volume: 67 Pages: 642-648
  • NAID: 130004053800
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Supramolecular Phosphatases Formed by the Self-Assembly of Bis(Zn2+-cyclen) Complex, Copper(II), and Barbital Derivatives in Water (Cyclen = 1,4,7,10-Tetraazacyclododecane) (2014)
  • Author(s): Mohd Zulkefeli, Yosuke Hisamatsu, Asami Suzuki, Yuya Miyazawa, Motoo Shiro, and Shin Aoki,
  • Journal Title: Chemistry, An Asian Journal Volume: 9 Issue: 10 Pages: 2831-2841
  • DOI: 10.1002/asia.201402513
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Design and synthesis of 8-hydroxyquinoline-based radioprotective agents. (2014)
  • Author(s): S. Ariyasu, A. Sawa, A. Morita, K. Hanaya, M. Hoshi, I. Takahashi, B. Wang, and S. Aoki.
  • Journal Title: Bioorg. Med. Chem. Volume: 22 Issue: 15 Pages: 3891-3905
  • DOI: 10.1016/j.bmc.2014.06.017
  • Peer Reviewed
• [Journal Article] AS-2, A Novel Inhibitor of p53-Dependent Apoptosis, Prevents Apoptotic Mitochondrial Dysfunction in A Transcription-Independent Manner and Protects Mice from a Lethal Dose of Ionizing Radiation (2014)
  • Author(s): Akinori Morita, Shinya Ariyasu, Bing Wang, Tetsuo Asanuma, Takayoshi Onoda, Akiko Sawa, Kaoru Tanaka, Ippei Takahashi, Shotaro Togami, Mitsuru Nenoi, Toshiya Inaba, and Shin Aoki
  • Journal Title: Biochemical and Biophysical Research Communication Volume: 450 Pages: 1498-1504
  • Acknowledgement Compliant
• [Presentation] 位置選択的O-グリコシル化反応によるDisaccharide Ribonucleosideの合成 (2017)
  • Author(s): 染谷英寿、青木伸
  • Organizer: 日本薬学会第138年会
  • Place of Presentation: 東北大学川北キャンパス（宮城県・仙台市）
  • Year and Date: 2017-03-25
• [Presentation] ルイス酸によるシクロメタレート型イリジウム錯体の分解反応とトリスヘテロレプティック型イリジウム錯体の合成への応用 (2017)
  • Author(s): 田村裕一、久松洋介、Sarvendra Kumar、伊藤太基、佐藤享平、黒田玲子、青木伸
  • Organizer: 日本薬学会第138年会
  • Place of Presentation: 東北大学川北キャンパス（宮城県・仙台市）
  • Year and Date: 2017-03-25
• [Presentation] 両親媒性二核亜鉛錯体・銅・バルビタール誘導体の自己集積型超分子の設計・合成と二層系におけるホスファターゼ活性評価 (2017)
  • Author(s): 今福 浩輝、Akib Bin Rahman、宮内 美樹、久松 洋介、青木 伸
  • Organizer: 日本薬学会第138年会
  • Place of Presentation: 東北大学川北キャンパス（宮城県・仙台市）
  • Year and Date: 2017-03-25
• [Presentation] Development of Convenient and Efficient Methods for Detection, Isolation, and Growth of Anomalous Cells in Blood (2017)
  • Author(s): Shin Aoki, Babita Shashni, Hidehiko Matsuura, Kenta Nomura, Takuto Maeda, Shota Shiina, Kazunori Akimoto, Hiroshi Takemura, Atsuo Yasumori, Naoyuki Aikawa, Tomohiro Ohsaki, and Norihiko Itoh
  • Organizer: 2017 International Biomedical Interface Sympsosium (IBMI2017)
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2017-03-04
  • Int'l Joint Research / Invited
• [Presentation] Evaluation of 5-Chloro-8-quinolinol that Acts as Radioprotective Agonist (2017)
  • Author(s): Shohei Ujita, Akinori Morita, Shin Aoki, Yurie Nishi, Tatsuro Teraoka, Megumi Sasatani, Bing Wang, Ippei Takahashi, Kaoru Tanaka, Tomoaki Yamakawa, Mitsuru Nenoi, Kenji Kamiya, Toshiya Iniba
  • Organizer: The 1st International Symposium of the Triangle Project with Hiroshima University, Nagasaki University and Fukushima Medical University
  • Place of Presentation: 広島大学霞キャンパス（広島県・広島市）
  • Year and Date: 2017-02-21
  • Int'l Joint Research
• [Presentation] 金属イオンによる含ホウ素化合物の分解反応の発見と金属イオン検出用11B NMR/MRIプローブへの応用 (2017)
  • Author(s): 青木伸、田中智博、西浦由紀子、田村佳、安部良、荒木力太、西道隆臣
  • Organizer: 第11回ホウ素・ホウ素化化合物シンポジウム（JSBB11）
  • Place of Presentation: 東京理大葛飾キャンパス（東京都・葛飾区）
  • Invited
• [Presentation] Findings of Selective Reactions and Assembly of Metal Complexes and Their Application to Biological and Material Sciences (2017)
  • Author(s): Shin Aoki
  • Organizer: Joint Seminar of Academia Sinica and the Institute of Chemistry
  • Place of Presentation: Taipei, Taiwan
  • Int'l Joint Research / Invited
• [Presentation] Mechanistic Study of Cancer Cell Induced by Cationic Amphilphilic Tris-cyclometalated Iridium(III) Complex and Its Interaction with Target Protein (2016)
  • Author(s): Yosuke Hisamatsu, Nozoumi Suzuki, Abdullah-Al Masum, Ai Shibuya, Shin Aoki
  • Organizer: 8th Asian Biological Inorganic Chemistry Conference (AsBIC8)
  • Place of Presentation: Aukland, New Zealand
  • Year and Date: 2016-12-05
  • Int'l Joint Research
• [Presentation] 毒性低減を目指した8-quinolinol防護線防護剤の設計・合成と活性評価 (2016)
  • Author(s): 西 友里恵、寺岡 達朗、氏田 将平、山川 知晃、森田 明典、松本 淳志、大和田 勇人、王 冰、青木 伸
  • Organizer: 第33回メディシナルケミストリーシンポジウム
  • Place of Presentation: つくば国際会議場（茨城県・つくば市）
  • Year and Date: 2016-11-30
• [Presentation] 生体内金属イオンと C3 対称性錯体を形成する新規トリスビピリジンリガンド分子の設計・合成と錯体形成能の評価 (2016)
  • Author(s): 朱 俊傑、久松 洋介、青木 伸
  • Organizer: 第33回メディシナルケミストリーシンポジウム
  • Place of Presentation: つくば国際会議場（茨城県・つくば市）
  • Year and Date: 2016-11-30
• [Presentation] Development of Convenient and Efficient Methods for Detection and Capture of Circulating Tumor Cells in Blood (2016)
  • Author(s): Shin Aoki, Babita Shashni, Hidehiko Matsuura, Kenta Nomura, Takuto Maeda, Shota Shiina, Kazunori Akimoto, Hiroshi Takemura, Atsuo Yasumori, Naoyuki Aikawa, Tomohiro Ohsaki, and Norihiko Itoh
  • Organizer: The 3rd International Conference on Biomaterial Science in Tokyo (ICBS016)
  • Place of Presentation: 東京大学本郷キャンパス（東京都・文京区）
  • Year and Date: 2016-11-28
  • Int'l Joint Research
• [Presentation] カルボラン分解反応を利用した銅(II)イオン検出のための11B NMR/MRIプローブの設計と合成 (2016)
  • Author(s): 田中 智博、西浦 由紀子、荒木 力太、西道 隆臣、安部 良、青木 伸
  • Organizer: 第42回反応と合成の進歩シンポジウム
  • Place of Presentation: 清水文化会館マリナート（静岡県・静岡市）
  • Year and Date: 2016-11-07
• [Presentation] ８-キノリノールスルホン酸エステルの光分解反応を利用した光応答性細胞分離磁気ビーズの開発 (2016)
  • Author(s): 松本 和恵、Babita Shashni、竹田 礼紗、向井 祐人、青木 伸
  • Organizer: 第42回反応と合成の進歩シンポジウム
  • Place of Presentation: 清水文化会館マリナート（静岡県・静岡市）
  • Year and Date: 2016-11-07
• [Presentation] p53を標的とする放射線防護剤5-chloro-8-quinolinolの作用機構解析 (2016)
  • Author(s): 氏田奨平、森田 明典、青木伸、西友里恵、王冰、笹谷めぐみ、田中薫、山川知晃、根井充、神谷研二、稲葉俊哉
  • Organizer: 日本放射線影響学会第59回大会
  • Place of Presentation: JMSアステールプラザ（広島県・広島市）
  • Year and Date: 2016-10-26
• [Presentation] Novel Synthetic Approaches to Cyclometalated Iridium(III) Complexes Having Three Different Ligands (2016)
  • Author(s): 久松 洋介・田村 祐一・Sarvendra Kumar・伊藤 太基・佐藤 享平・黒田 玲子・畑中 美穂・青木 伸
  • Organizer: 錯体化学会第66回討論会
  • Place of Presentation: 福岡大学（福岡県・福岡市）
  • Year and Date: 2016-09-10
• [Presentation] ルイス酸によるトリスシクロメタレート型イリジウム錯体の分解反応と３つの異なる配位子を有するイリジウム錯体の設計・合成への応用 (2016)
  • Author(s): 田村 祐一・久松 洋介・Sarvendra Kumar・伊藤 太基・佐藤 享平・黒田 玲子・畑中 美穂・青木 伸
  • Organizer: 錯体化学会第66回討論会
  • Place of Presentation: 福岡大学（福岡県・福岡市）
  • Year and Date: 2016-09-10
• [Presentation] ソーダ石灰ガラスビーズを用いた血中がん細胞分離用ガラスフィルタの作製 (2016)
  • Author(s): 松浦英彦、岩崎謙一郎、野村健太、竹村裕、Babita Shashni、青木 伸、安盛敦雄
  • Organizer: 日本セラミックス協会・第29回秋季シンポジウム
  • Place of Presentation: 広島大学東広島キャンパス（広島県・東広島市）
  • Year and Date: 2016-09-07
• [Presentation] カチオン性両親媒性イリジウム(III)錯体の細胞死誘導とフォトアフィニティーラベリングを用いた分子機構の解析 (2016)
  • Author(s): 久松 洋介・鈴木 希美・渋谷 愛・Abdullah-Al Masum・佐藤 聡・田沼 靖一・青木 伸
  • Organizer: 第10回バイオ関連化学シンポジウム
  • Place of Presentation: 金沢市
  • Year and Date: 2016-09-07
• [Presentation] Development of Convenient Methods in Detection and Separation of Circulating Tumor Cells (CTCs) and CTC Clusters (2016)
  • Author(s): Babita Shashni, Hidehiko Matsuura, Kenta Nomura, Takuto Maeda, Kazunori Akimoto, Masanori Hayase, Hiroshi Takemura, Atsuo Yasumori, Naoyuki Aikawa, Shin Aoki
  • Organizer: 第10回バイオ関連化学シンポジウム
  • Place of Presentation: 石川県立音楽堂（石川県・金沢市）
  • Year and Date: 2016-09-07
• [Presentation] キラル亜鉛錯体によって触媒される不斉アルドール反応と錯体構造および遷移状態 (2016)
  • Author(s): 青木 伸、安田真人、菊地千陽、畑中美穂、北川裕一、長谷川靖哉、久松洋介
  • Organizer: 第26回金属の関与する生体関連反応シンポジウム
  • Place of Presentation: 北海道大学（北海道・札幌市）
  • Year and Date: 2016-06-17
• [Presentation] 細胞死誘導の時間スケールが異なるペプチドを導入した発光性イリジウム錯体の設計・合成と作用メカニズム解析 (2016)
  • Author(s): 久松洋介、鈴木希美、Abdullah-Al Masum、渋谷愛、鈴木利宙、安部良、青木伸
  • Organizer: 日本ケミカルバイオロジー学会第11回年会
  • Place of Presentation: 京都テルサ（京都府・京都市）
  • Year and Date: 2016-06-15
• [Presentation] 三つの異なる配位子で構成される新規シクロメタレート型イリジウム錯体の設計・合成と発光特性評価 (2016)
  • Author(s): 久松洋介、田村裕一、Sarvendra Kumar、青木伸
  • Organizer: 第109回有機合成化学シンポジウム
  • Place of Presentation: 東京工業大学大岡山キャンパス（東京都・目黒区）
  • Year and Date: 2016-06-08
• [Presentation] 二相系中でリン酸加水分解活性を有する疎水性超分子ホスファターゼの設計・合成と反応速度論解析 (2016)
  • Author(s): 久松洋介、宮内美樹、宮澤有哉、米田翔、Mohd Zulkefeli、青木伸
  • Organizer: 第14回ホスト―ゲスト・超分子化学シンポジウム
  • Place of Presentation: 高知城ホール（高知県・高知市）
  • Year and Date: 2016-06-04
• [Presentation] DLD法による血液細胞の自動分類計測法 (2016)
  • Author(s): 前田 啄斗、早瀬仁則、青木伸、相川直幸
  • Organizer: 電子通信情報学会信号処理研究会(PRMU IE MI SIP)
  • Place of Presentation: 名古屋大学（愛知県・名古屋市)
  • Year and Date: 2016-05-19
• [Presentation] Design, Synthesis, and Reactivity of Supramolecular Complexes Formed by Self-Assembly of Dinuclear Zinc complexes, Functionalized Di- or Triimide Building Blocks and Copper(II) (2016)
  • Author(s): Yosuke Hisamatsu, Yuya Miyazawa, Miki Miyauchi, Shin Aoki
  • Organizer: The 25th French-Japanese Symposium on Medicinal and Fine Chemistry (FJU-2016)
  • Place of Presentation: 京王プラザホテル多摩（東京都・多摩市）
  • Year and Date: 2016-05-15
  • Int'l Joint Research
• [Presentation] 光反応性ジアジリンを有するカチオン性両親媒性トリスシクロメタレート型イリジウム錯体の設計・合成 (2016)
  • Author(s): 久松洋介、鈴木希美、渋谷愛、鈴木利宙、安部良、青木伸
  • Organizer: 日本薬学会第137年会
  • Place of Presentation: 横浜市、パシフィコ横浜
  • Year and Date: 2016-03-27
• [Presentation] 11B NMR/MRIによる銅イオン検出のためのキレーター導入型o-carboraneプローブの設計、合成及び反応性評価 (2016)
  • Author(s): 田中智博、荒木力太、西道隆臣、安部良、青木伸
  • Organizer: 日本薬学会第137年会
  • Place of Presentation: 横浜市、パシフィコ横浜
  • Year and Date: 2016-03-27
• [Presentation] Design and Synthesis of Artificial TRAIL Mimics Based on C3-symmetric and Luminescent Iridium Complexes that are Able to Stain and Induce Cell Death of Cancer Cells (2016)
  • Author(s): Abdullah-Al Masum, Yosuke Hisamasu, Nozomi Suzuki,, Shin Aoki
  • Organizer: 日本薬学会第137年会
  • Place of Presentation: 横浜市、パシフィコ横浜
  • Year and Date: 2016-03-27
• [Presentation] 生体内金属イオンと C3 対称性錯体を形成する新規リガンド分子の設計・合成と錯体形成能の評価 (2016)
  • Author(s): 朱俊傑、久松洋介、青木伸
  • Organizer: 日本薬学会第137年会
  • Place of Presentation: 横浜市、パシフィコ横浜
  • Year and Date: 2016-03-27
• [Presentation] Drug Development for Radiation Therapy of Cancer (2016)
  • Author(s): Shin Aoki
  • Organizer: 2016 International Biomedical Interface Symposium (2016IBMI)
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2016-03-04
  • Int'l Joint Research / Invited
• [Presentation] Development of Biological Tools Based on Finding of the Decomposition Reactions, Decomposition Reaction is not Useless” (2016)
  • Author(s): Shin Aoki
  • Organizer: 4th International Postgraduate Conference on Pharmaceutical Sciences 2016 (iPoPS2016)
  • Place of Presentation: Noda (東京理科大学）, Chiba
  • Year and Date: 2016-02-27
  • Int'l Joint Research / Invited
• [Presentation] Design and synthesis of C3-symmetric and luminescent tris-cyclometalated iridium(III) complexes having biologically active peptides (2016)
  • Author(s): Yosuke Hisamatsu, Ai Shibuya, Nozomi Suzuki, Hiroshi Tanaka, Abdullah-Al Masum, and Shin Aoki
  • Organizer: 4th International Postgraduate Conference on Pharmaceutical Sciences 2016 (iPoPS2016)
  • Place of Presentation: Noda (東京理科大学）, Chiba
  • Year and Date: 2016-02-27
  • Int'l Joint Research / Invited
• [Presentation] Finding of deboronation reaction of ortho-carborane derivatives catalyzed by metal ions and its application to 11B NMR probes (2016)
  • Author(s): Tomohiro Tanaka, Yukiko Nishiura, Rikita Araki, Takaomi Saido, Ryo Abe, and Shin Aoki
  • Organizer: 4th International Postgraduate Conference on Pharmaceutical Sciences 2016 (iPoPS2016)
  • Place of Presentation: Noda (東京理科大学）, Chiba
  • Year and Date: 2016-02-27
  • Int'l Joint Research / Invited
• [Presentation] Synthesis of disaccharide nucleosides by the chemical O-glycosylation of natural nucleosides with thioglycoside donors (2016)
  • Author(s): Taiki Itoh , Taketo Fukumoto, Masayuki Kurihara, Shigeto Saito, Shinya Komabiki, and Shin Aoki
  • Organizer: 4th International Postgraduate Conference on Pharmaceutical Sciences 2016 (iPoPS2016)
  • Place of Presentation: Noda (東京理科大学）, Chiba
  • Year and Date: 2016-02-27
  • Int'l Joint Research
• [Presentation] Design and synthesis of heteroleptic cyclometalated iridium(III) complexes that exhibit unusual dual color phosphorescence (2016)
  • Author(s): Sarvendra Kumar, Yosuke Hisamatsu , Shin Aoki
  • Organizer: 4th International Postgraduate Conference on Pharmaceutical Sciences 2016 (iPoPS2016)
  • Place of Presentation: Noda (東京理科大学）, Chiba
  • Year and Date: 2016-02-27
  • Int'l Joint Research / Invited
• [Presentation] Development of photoreactive silicon wafer and magnetic beads for isolating target cells based on photolysis of 8-quinolynyl sulfonate based linkers (2016)
  • Author(s): Kazue Matsumoto, Reisa Takeda, Shinya Ariyasu, Yuto Mukai, and Shin Aoki
  • Organizer: 4th International Postgraduate Conference on Pharmaceutical Sciences 2016 (iPoPS2016)
  • Place of Presentation: Noda (東京理科大学）, Chiba
  • Year and Date: 2016-02-27
  • Int'l Joint Research
• [Presentation] Design and synthesis of quinolone-based radioprotecting agents (2016)
  • Author(s): Design and synthesis of quinolone-based radioprotecting agents
  • Organizer: 4th International Postgraduate Conference on Pharmaceutical Sciences 2016 (iPoPS2016)
  • Place of Presentation: Noda (東京理科大学）, Chiba
  • Year and Date: 2016-02-27
  • Int'l Joint Research
• [Presentation] Design and synthesis of thioglycoside donors having electron-donating groups for the efficient glycosylations (2016)
  • Author(s): Sidehisa Someya, Taiki Itoh, Shin Aoki
  • Organizer: 4th International Postgraduate Conference on Pharmaceutical Sciences 2016 (iPoPS2016)
  • Place of Presentation: Noda (東京理科大学）, Chiba
  • Year and Date: 2016-02-27
  • Int'l Joint Research
• [Presentation] Marker Free Approach for the Detection of Circulating Tumor Cell (CTC) Clusters (2016)
  • Author(s): Babita Shashni, Reisa Takeda, Kazue Matsumoto, Tomohiro Ohsaki, Norihiko Itoh, Hidehiko Matsuura, Kenta Nomura, Takuto Maeda, Kazunori Akimoto, Hiroshi Takemura, Atsuo Yasumori, Naoyuki Aikawa, Shin Aoki
  • Organizer: 4th International Postgraduate Conference on Pharmaceutical Sciences 2016 (iPoPS2016)
  • Place of Presentation: Noda (東京理科大学）, Chiba
  • Year and Date: 2016-02-27
  • Int'l Joint Research
• [Presentation] Design and Synthesis of Cyclometalated Iridium(III) Complexes Containing Cationic Peptides as Mid-Size and Luminescent Drugs that Induce and Detect Cell Death of Cancer Cells (2016)
  • Author(s): Shin Aoki, Yosuke Hisamatsu, Nozomi Suzuki, Abdullah-Al Masum, Yuichi Tamura, Sarvendra Kumar
  • Organizer: The 8th Takeda Science Foundation Symposium on PharmaSciences
  • Place of Presentation: 吹田市、武田薬品工業研修所
  • Year and Date: 2016-01-21
  • Int'l Joint Research
• [Presentation] キラル亜鉛錯体による触媒的不斉アルドール反応における亜鉛の配位構造と反応遷移状態の解析 (2016)
  • Author(s): 青木 伸、安田真人、菊地千陽、畑中美穂、北川裕一、長谷川靖哉、久松洋介
  • Organizer: 第71回有機合成化学協会関東支部シンポジウム（東京農工大シンポジウム）
  • Place of Presentation: 東京農工大小金井キャンパス（東京都・小金井市）
• [Presentation] 細胞死誘導能を有するカチオン性両親媒性イリジウム(III)錯体の標的分子の探索と相互作用評価 (2016)
  • Author(s): 久松洋介・鈴木希美、渋谷愛、Abdullah-Al Masum、佐藤聡、田沼靖一、青木伸
  • Organizer: 第60回日本薬学会関東支部大会
  • Place of Presentation: 東京大学本郷キャンパス(東京都・文京区）
• [Presentation] Development of Convenient Methods in Detection and Separation of Circulating Tumor Cells (CTCs) and CTC Clusters (2016)
  • Author(s): Babita Shashni, Hidehiko Matsuura, Kenta Nomura, Takuto Maeda, Kazunori Akimoto, Masanori Hayase, Hiroshi Takemura, Atsuo Yasumori, Naoyuki Aikawa, Shin Aoki
  • Organizer: 第60回日本薬学会関東支部大会
  • Place of Presentation: 東京大学本郷キャンパス(東京都・文京区）
• [Presentation] Design and Synthesis of Artificial TRAIL Mimics Based on C3-symmetric and Luminescent Iridium Complexes that are Able to Stain and Induce Cell Death of Cancer Cells (2016)
  • Author(s): Abdullah-Al Masum, Yosuke Hisamasu, Nozomi Suzuki,, Shin Aoki
  • Organizer: 第60回日本薬学会関東支部大会
  • Place of Presentation: 東京大学本郷キャンパス(東京都・文京区）
• [Presentation] がんの早期発見と再発リスク低減のための理科大異分野連携研究の挑戦 (2016)
  • Author(s): 青木伸
  • Organizer: TUSフォーラム2016
  • Place of Presentation: ホテルメトロポリタンエドモント（東京都・千代田区）
  • Invited
• [Presentation] Design and Synthesis of Luminescent Cyclometalated Iridium(III) Complexes for Material and Biomedical Science (2015)
  • Author(s): Shin Aoki
  • Organizer: 2015 International Chemical Congress of Pacific Basin Societies (PACICHEM2015)
  • Place of Presentation: Honolulu, Hawaii, USA
  • Year and Date: 2015-12-15
  • Int'l Joint Research / Invited
• [Presentation] Design and synthesis of C3-symmetric and luminescent tris-cyclometalated iridium(III) complexes having biologically active peptides (2015)
  • Author(s): Yosuke Hisamatsu, Ai Shibuya, Nozomi Suzuki, Hiroshi Tanaka, Masum, Abdullarh-Al, Shin Aoki
  • Organizer: 2015 International Chemical Congress of Pacific Basin Societies (PACICHEM2015)
  • Place of Presentation: Honolulu, Hawaii, USA
  • Year and Date: 2015-12-15
  • Int'l Joint Research
• [Presentation] Design, synthesis, and reactivity of supramolecular complexes formed by self-assembly of multinuclear zinc complexes, functionalized organic building blocks, and metals (2015)
  • Author(s): Yosuke Hisamatsu, Miki Miyauchi , Kakeru Yoneda, Yuya Miyazawa, Shin Aoki
  • Organizer: 2015 International Chemical Congress of Pacific Basin Societies (PACICHEM2015)
  • Place of Presentation: Honolulu, Hawaii, USA
  • Year and Date: 2015-12-15
  • Int'l Joint Research
• [Presentation] Finding of deboronation reaction of ortho-carborane derivatives catalyzed by metal ions and its application to 11B NMR probes (2015)
  • Author(s): Tomohiro Tanaka, Yukiko Nishiura, Rikita Araki, Takaomi Saido, Ryo Abe, Shin Aoki
  • Organizer: 2015 International Chemical Congress of Pacific Basin Societies (PACICHEM2015)
  • Place of Presentation: Honolulu, Hawaii, USA
  • Year and Date: 2015-12-15
  • Int'l Joint Research
• [Presentation] Design and synthesis of heteroleptic cyclometalated iridium(III) complexes that exhibit unusual dual color phosphorescence (2015)
  • Author(s): Sarvendra Kumar, Yosuke Hisamatsu , Shin Aoki
  • Organizer: 2015 International Chemical Congress of Pacific Basin Societies (PACICHEM2015)
  • Place of Presentation: Honolulu, Hawaii, USA
  • Year and Date: 2015-12-15
  • Int'l Joint Research
• [Presentation] Design and synthesis of artificial TRAIL mimics based on C3-symmetric and luminescent iridium complexes (2015)
  • Author(s): Abdullah-Al Masum, Hiroshi Tanaka , Nozomi Suzuki , Yosuke Hisamatsu , Shin Aoki
  • Organizer: 2015 International Chemical Congress of Pacific Basin Societies (PACICHEM2015)
  • Place of Presentation: Honolulu, Hawaii, USA
  • Year and Date: 2015-12-15
  • Int'l Joint Research
• [Presentation] Synthesis of disaccharide nucleosides by the chemical O-glycosylation of natural nucleosides with thioglycoside donors (2015)
  • Author(s): Taiki Itoh, Taketo Fukumoto, Masayuki Kurihara, Shigeto Saito, Shinya Komabiki, Shin Aok
  • Organizer: 2015 International Chemical Congress of Pacific Basin Societies (PACICHEM2015)
  • Place of Presentation: Honolulu, Hawaii, USA
  • Year and Date: 2015-12-15
  • Int'l Joint Research
• [Presentation] Induction, detection, and mechanistic study of cell death induced by luminescent tris-cyclometalated iridium(III) complex-peptide hybrid (2015)
  • Author(s): Nozomi Suzuki, Yosuke Hisamatsu, Ai Shibuya, Hiroshi Tanaka, Abdullah-Al Masum, Shin Aoki
  • Organizer: 2015 International Chemical Congress of Pacific Basin Societies (PACICHEM2015)
  • Place of Presentation: Honolulu, Hawaii, USA
  • Year and Date: 2015-12-15
  • Int'l Joint Research
• [Presentation] Improved synthesis and mechanistic study of a radiosensitizer, sulfoquinovosylacylglycerol (SQAG) derivative (2015)
  • Author(s): Yasuhiro Sawamoto, Tomohiro Tanaka,, Masakazu Umezawa, Yosuke Hisamatsu, Ikumi Tamai, Kengo Sakaguchi, Shin Aoki
  • Organizer: 2015 International Chemical Congress of Pacific Basin Societies (PACICHEM2015)
  • Place of Presentation: Honolulu, Hawaii, USA
  • Year and Date: 2015-12-15
  • Int'l Joint Research
• [Presentation] Design and synthesis of light and redox reaction-driven molecular shuttles (2015)
  • Author(s): Motoko Karasaki, Asato Ota, Tomohiro Tanaka, Shin Aoki
  • Organizer: 015 International Chemical Congress of Pacific Basin Societies (PACICHEM2015)
  • Place of Presentation: Honolulu, Hawaii, USA
  • Year and Date: 2015-12-15
  • Int'l Joint Research
• [Presentation] 位置選択的な置換反応を用いた青～赤色発光性および生物活性シクロメタレート型イリジウム(III)錯体の設計と合成 (2015)
  • Author(s): 青木伸、久松洋介、渋谷愛、神戸彩、鈴木希美、Abdullah-Al Masum、Sarvendra Kumar
  • Organizer: 第41回反応と合成の進歩シンポジウム
  • Place of Presentation: 東大阪市、近畿大学
  • Year and Date: 2015-10-26
• [Presentation] Design, Synthesis and Photophysical Properties of Cyclometalated Iridium(III) Complexes of Quinoline Derivatives (2015)
  • Author(s): Sarvendra Kumar, Yosuke Hisamats, Shin Aoki
  • Organizer: 錯体化学会第65回討論会
  • Place of Presentation: 奈良市、奈良女子大学
  • Year and Date: 2015-09-21
• [Presentation] 疎水性二核亜鉛錯体と有機アニオンと銅イオンによる自己集積体の構築とエステル・アミドの加水分解活性 (2015)
  • Author(s): 久松洋介・米田翔 ・宮内美樹・宮澤有哉・青木伸
  • Organizer: 第57回日本薬学会関東支部大会
  • Place of Presentation: 千葉、日本大学
  • Year and Date: 2015-09-12
• [Presentation] o-carborane分解反応に基づく銅イオン検出のための11B NMR/MRIプローブの設計、合成と反応性評価 (2015)
  • Author(s): 田中智博、西浦由希子、田村佳、荒木力太、西道隆臣、安部良、青木伸
  • Organizer: 第57回日本薬学会関東支部大会
  • Place of Presentation: 千葉、日本大学
  • Year and Date: 2015-09-12
• [Presentation] カチオン性ペプチドを導入したイリジウム(III)錯体の設計・合成とその細胞死誘導メカニズムの検討 (2015)
  • Author(s): 鈴木希美、久松洋介、渋谷愛、鈴木利宙、安部良、青木伸
  • Organizer: 第57回日本薬学会関東支部大会
  • Place of Presentation: 千葉、日本大学
  • Year and Date: 2015-09-12
• [Presentation] がん放射線治療の副作用低減を目的とするp53標的放射線防護剤の開発 (2015)
  • Author(s): 青木伸、森田明典、王冰、有安真也、西友里恵、寺岡達朗、氏田将平、福井大智、田中薫、田中智博
  • Organizer: 第9回バイオ関連化学シンポジウム
  • Place of Presentation: 熊本、熊本大学
  • Year and Date: 2015-09-10
• [Presentation] In Silico Screening of Zinc(II) Enzyme Inhibitors by ILP (2015)
  • Author(s): Tadasuke Itoh, Masato Okada, Shotaro Togami, Shinya Ariyasu, Shin Aoki, and Hayato Ohwada
  • Organizer: 25th International Conference on Inductive Logic Programming (ILP2015
  • Place of Presentation: Kyoto, 京都国際会議場, Japan
  • Year and Date: 2015-08-20
  • Int'l Joint Research
• [Presentation] Design and Synthesis of Chiral Zn2+ Complexes Inspired by Natural Aldolases for Catalytic Asymmetric Aldol Reactions (2015)
  • Author(s): Shin Aoki, Susumu Itoh, Masato Yasuda, Shotaro Sonoike, Takuyam Tokunaga
  • Organizer: 4th International Symposium on Energy Challenges and Mechanics-working on small scales- (ECM4)
  • Place of Presentation: Aberdeen, Scotland
  • Year and Date: 2015-08-11
  • Int'l Joint Research / Invited
• [Presentation] カチオン性両親媒性トリスシクロメタレート型イリジウム(III)錯体により誘導される細胞死とそのメカニズムの解析 (2015)
  • Author(s): 久松洋介、渋谷愛、鈴木希美、鈴木利宙、安部良、青木伸
  • Organizer: 日本ケミカルバイオロジー学会第10回年会
  • Place of Presentation: 仙台、東北大学
  • Year and Date: 2015-06-10
• [Presentation] o-carborane分解反応に基づく金属イオン検出のための11B NMR/MRIプローブの設計、合成と反応性評価 (2015)
  • Author(s): 田中智博、西浦由希子、、荒木力太、西道隆臣、安部良、青木伸
  • Organizer: 日本ケミカルバイオロジー学会第10回年会
  • Place of Presentation: 仙台、東北大学
  • Year and Date: 2015-06-10
• [Presentation] 修飾した二核亜鉛錯体と有機ビルディングブロックの組み合わせにより構築される自己集積体のホスファターゼ活性評価 (2015)
  • Author(s): 久松洋介、宮内美樹、米田翔、宮澤有哉、青木伸
  • Organizer: 第13回ホストゲスト化学シンポジウム
  • Place of Presentation: 仙台、東北大学
  • Year and Date: 2015-06-06
• [Presentation] シクロデキストリンとZn(Ⅱ)-サイクレン錯体から構成される水溶性ロタキサンの設計と合成 (2015)
  • Author(s): 唐崎幹子、大田麻人、田中智博、青木伸
  • Organizer: 第13回ホストゲスト化学シンポジウム
  • Place of Presentation: 仙台、東北大学
  • Year and Date: 2015-06-06
• [Presentation] 銅イオンによるo-carborane分解反応の発見とそれを応用した11B NMRプローブの設計と合成 (2015)
  • Author(s): 田中智博、西浦由希子、荒木力太、西道隆臣、安部良、青木伸
  • Organizer: 第25回金属の関与する生体関連反応シンポジウム
  • Place of Presentation: 長崎、長崎大学
  • Year and Date: 2015-05-30
• [Presentation] 亜鉛酵素・タンパクを標的とする新薬剤の開発 (2015)
  • Author(s): 青木伸
  • Organizer: 日本薬学会第135年会
  • Place of Presentation: 神戸国際会議場（神戸市）
  • Year and Date: 2015-03-26 – 2015-03-28
  • Invited
• [Presentation] Design and Synthesis of 8-Hydroxyquinoline Derivatives for the Diagnosis and Treatment of Cancer (2014)
  • Author(s): Shin Aoki
  • Organizer: 4th World Conference on Cancer Science and Therapy (WCCST2014)
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-10-20 – 2014-10-22
  • Invited
• [Presentation] 疾病の診断と治療のための有機・無機システムの設計と構築－東京理科大学における異分野連携－ (2014)
  • Author(s): 青木 伸
  • Organizer: 第56回日本薬学会関東支部大会
  • Place of Presentation: 昭和薬大（町田市）
  • Year and Date: 2014-10-04
  • Invited
• [Presentation] o-carboraneを有する金属検出用11B NMRプローブの設計・合成と機能評価 (2014)
  • Author(s): 西浦由紀子、田中智博、久松洋介、青木伸
  • Organizer: 第56回日本薬学会関東支部大会
  • Place of Presentation: 昭和薬大（町田市）
  • Year and Date: 2014-10-04
• [Presentation] ぺプチドを導入したトリスシクロメタレート型イリジウム(III)錯体の設計・合成と生物活性評価 (2014)
  • Author(s): 久松 洋介、鈴木 希美、渋谷 愛、田中 裕志、犬飼 岳史、鈴木 利宙、安部 良、青木 伸
  • Organizer: 第8回バイオ関連化学シンポジウム
  • Place of Presentation: 岡山大学津島キャンパス
  • Year and Date: 2014-09-11 – 2014-09-13
• [Presentation] Chemistry and Biomedical Applicatoins of Hydroxyquinoline Derivatives (2014)
  • Author(s): Shin Aoki
  • Organizer: 3rd International Postgraduate Conference on Pharmaceutical Sciences 2014 (iPoPS2014)
  • Place of Presentation: Puncak Alam campus of Universiti Teknologi MARA, Malaysia
  • Year and Date: 2014-08-11 – 2014-08-12
  • Invited
• [Presentation] Design and, Synthesis of o-Carborane Derivatives as 11B NMR Probes of d-Block Metal Ions (2014)
  • Author(s): Yukiko Nishiura, Tomohiro Tanaka, Yosuke Hisamatsu, and Shin Aoki
  • Organizer: 3rd International Postgraduate Conference on Pharmaceutical Sciences 2014 (iPoPS2014)
  • Place of Presentation: Puncak Alam campus of Universiti Teknologi MARA, Malaysia
  • Year and Date: 2014-08-11 – 2014-08-12
• [Presentation] Design and Synthesis of Cyclometalated Iridium Complexes as Photochemical and Biomedical Tools (2014)
  • Author(s): Shin Aoki, Yosuke Hisamatsu, Akihiro Nakagawa, Ai Shibuya, Aya Kando, Hiroshi Tanaka, Nozomi Suzuki
  • Organizer: 26th International Conference on Organometallic Chemistry (ICOMC2014)
  • Place of Presentation: ロイトンホテル札幌（札幌）
  • Year and Date: 2014-07-13 – 2014-07-18
• [Presentation] Design and Synthesis of Red-Color Emitting Cyclometalated Iridium(III) Complexes and Their Biological Applications as pH Probes and Singlet Oxygen Sensitizers (2014)
  • Author(s): Aya Kando, Akihiro Nakagawa, Yosuke Hisamatsu, and Shin Aoki
  • Organizer: 26th International Conference on Organometallic Chemistry (ICOMC2014)
  • Place of Presentation: ロイトンホテル札幌（札幌）
  • Year and Date: 2014-07-13 – 2014-07-18
• [Presentation] Design, Synthesis and Evaluation of 11B NMR Probes of d-Block Metal Ions. (2014)
  • Author(s): Yukiko Nishiura, Yosuke Hisamatsu, Tomohiro Tanaka, Toshihiro Suzuki, Ryo Abe, and Shin Aoki
  • Organizer: 26th International Conference on Organometallic Chemistry (ICOMC2014)
  • Place of Presentation: ロイトンホテル札幌（札幌）
  • Year and Date: 2014-07-13 – 2014-07-18
• [Presentation] シクロメタレート型イリジウム錯体―ペプチドハイブリッドによるがん細胞のイメージングと細胞死誘導 (2014)
  • Author(s): 久松 洋介、渋谷 愛、鈴木 希美、青木 伸
  • Organizer: 第9回日本ケミカルバイオロジー学会
  • Place of Presentation: 大阪大学豊中キャンパス（豊中市）
  • Year and Date: 2014-06-11 – 2014-06-13
• [Presentation] 長鎖アルキル基を導入した複核亜鉛錯体の自己集積による疎水性超分子ホスファターゼの構築とリン酸加水分解活性 (2014)
  • Author(s): 青木 伸、宮澤 有哉、久松 洋介、鈴木 麻美、米田 翔、田中 亮
  • Organizer: 第12回ホストゲスト化学シンポジウム
  • Place of Presentation: 東工大大岡山キャンパス（東京）
  • Year and Date: 2014-05-31 – 2014-06-01
• [Presentation] ヌクレオシドのO-グリコシル化反応によるdisaccharide nucleosideの合成 (2014)
  • Author(s): 福本 健人、伊藤 太基、栗原 正幸、青木 伸
  • Organizer: 第67回有機合成化学協会関東支部シンポジウム
  • Place of Presentation: 慶應義塾大学理工学部矢上キャンパス（横浜市）
  • Year and Date: 2014-05-17
• [Book] フロンティア生物無機化学”(錯体化学会フロンティア選書) (2016)
  • Author(s): 伊東忍、青野重利、林高史、増田秀樹、廣田俊、藤井浩、小寺政人、城宣嗣、樋口芳樹、高妻孝光、杉本秀樹、小倉尚志、民秋均、大久保敬、正岡重行、小江誠司、久枝良雄、青木伸、菊地和也、上野隆史
  • Total Pages: 535
  • Publisher: 三共出版
• [Book] Macrocyclic and Supramolecular Chemistry: How Izatt-Christensen Award Winners Shaped the Field (2016)
  • Author(s): Eiichi Kimura, Tohru Koike, and Shin Aoki
  • Total Pages: 470
  • Publisher: John Wiley & Sons
• [Book] Robert R. Crichton “生物無機化学”（邦訳） (2016)
  • Author(s): 塩谷光彦監訳
  • Total Pages: 354
  • Publisher: 東京化学同人
• [Book] スタンダード薬学シリーズII 3“化学系薬学 II. 生体分子・医薬品の化学による理解” (2016)
  • Author(s): 日本薬学会編
  • Total Pages: 346
  • Publisher: 東京化学同人
• [Book] Synergy in Supramolecular Chemistry (2015)
  • Author(s): Shin Aoki, Mohd Zulkefeli, Yosuke Hisamatsu, and Masanori Kitamura
  • Total Pages: 339
  • Publisher: CRC
• [Book] マクマリー生物有機化学 基礎化学編 第4版（原書第7版） (2015)
  • Author(s): 菅原二三男監訳
  • Total Pages: 382
  • Publisher: 丸善
• [Remarks] 東京理科大学薬学部青木研究室ホームページ
  • URL: http://www.rs.noda.tus.ac.jp/~aokilab/
• [Patent(Industrial Property Rights)] 細胞分離方法及び細胞分離装置 (2016)
  • Inventor(s): 青木 伸、安盛敦雄
  • Industrial Property Rights Holder: 青木 伸、安盛敦雄
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2016-165889
  • Filing Date: 2016-08-26
• [Patent(Industrial Property Rights)] イリジウム錯体化合物及びイリジウム錯体化合物の製造方 (2015)
  • Inventor(s): 青木伸、サーベンドラ クマール、久松洋介、田村裕一
  • Industrial Property Rights Holder: 青木伸、サーベンドラ クマール、久松洋介、田村裕一
  • Industrial Property Rights Type: 特許
  • Filing Date: 2015-12-18
• [Patent(Industrial Property Rights)] チオアルドヘキソース誘導体及びその製造方法 (2015)
  • Inventor(s): 青木伸、田中智博、久松洋介、澤本泰宏、坂口謙吾、菅原二三男
  • Industrial Property Rights Holder: 青木伸、田中智博、久松洋介、澤本泰宏、坂口謙吾、菅原二三男
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2015-027694
  • Filing Date: 2015-02-16