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Design and synthesis of boron-containing drugs and application to dual resonance MRI and neutron capture therapy

Research Project

Project/Area Number 26460156
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Drug development chemistry
Research InstitutionTokyo University of Science

Principal Investigator

Aoki Shin  東京理科大学, 薬学部生命創薬科学科, 教授 (00222472)

Co-Investigator(Kenkyū-buntansha) 安部 良  東京理科大学, 研究推進機構生命医科学研究所, 教授 (20159453)
西道 隆臣  国立研究開発法人理化学研究所, 脳科学総合研究センター, チームリーダー (80205690)
小野 公二  京都大学, 原子炉実験所, 寄附研究部門教員 (90122407)
Co-Investigator(Renkei-kenkyūsha) HISAMATSU YOSUKE  東京理科大学, 薬学部, 助教 (80587270)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywordsホウ素中性子捕捉療法 / 天然物 / グルコサミン / ホウ素クラスター / 銅 / ホウ素 / キャリア / グルコース / 中性子捕捉療法 / NMR / MRI
Outline of Final Research Achievements

Objective of this work is to deliver boron-containing compounds to tumor sites and to detect (visualize) the accumulation of boron in tumor size (in vivo imaging of boron compounds) for boron neutron capture therapy (BNCT). In this work, we have succeeded in the synthesis of sulfoquinovosylacyl-1,3-propanediol (SQAP) having a hydrophobic boron-containing alkyl group containing boron cluster for BNCT and iodo groups for computed tomography (CT). However, tumor accumulation of those SQAP derivatives were low and their toxicity to mouse was detected. Next, design and synthesis of sugar derivatives to target glucose transporters that are overexpressed on cancer cells were conducted. These D-glucosamine analogs are less toxic and some compounds exhibit fairly good T/B (tumor/blood) ratios. It was found that o-carborane undergoes decomposition in the presence of copper(II) ion in aqueous solution at neutral pH to generate 10 B(OH)3, which was applied to 11B MRI probe of Cu2+.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (113 results)

All 2017 2016 2015 2014 Other

All Journal Article (22 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 21 results,  Acknowledgement Compliant: 17 results) Presentation (81 results) (of which Int'l Joint Research: 29 results,  Invited: 15 results) Book (6 results) Remarks (1 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] Cationic Amphiphilic Tris-Cyclometalated Iridium(III) Complexes Induce Cancer Cell Death via Interaction with Ca2+-Calmodulin Complex.2017

    • Author(s)
      Hisamatsu Y, Suzuki N, Masum AA, Shibuya A, Abe R, Sato A, Tanuma SI, Aoki S.
    • Journal Title

      Bioconjug Chem

      Volume: 28(2) Issue: 2 Pages: 507-523

    • DOI

      10.1021/acs.bioconjchem.6b00627

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficient Synthesis of Tris-Heteroleptic Iridium(III) Complexes Based on the Zn2+-Promoted Degradation of Tris-Cyclometalated Iridium (III) Complexes and Their Photophysical Properties2017

    • Author(s)
      Yuichi Tamura, Yosuke Hisamatsu, Sarvendra Kumar, Taiki Itoh, Kyouhei Sato, Reiko Kuroda, Shin Aoki
    • Journal Title

      Inorganic Chemistry

      Volume: 56 Issue: 2 Pages: 812-833

    • DOI

      10.1021/acs.inorgchem.6b02270

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Design and Synthesis of Tris-Heteroleptic Cyclometalated Iridium(III) Complexes Consisting of Three Different Nonsymmetric Ligands Based on Ligand-Selective Electrophilic Reactions via Interligand HOMO Hopping Phenomena2017

    • Author(s)
      Yosuke Hisamatsu, Sarvendra Kumar, Shin Aoki
    • Journal Title

      Inorganic Chemistry

      Volume: 56 Issue: 2 Pages: 886-899

    • DOI

      10.1021/acs.inorgchem.6b02519

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Concise and Versatile Synthesis of Sulfoquinovosyl Acyl Glycerol Derivatives for Biological Applications2017

    • Author(s)
      Tomohiro Tanaka, Yasuhiro Sawamoto, and Shin Aoki
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 65

    • NAID

      130005686027

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Design and Synthesis of Heteroleptic Cyclometalated Iridium(III) Complexes Containing Quinoline-Type Ligands that Exhibit Dual Phosphorescence2016

    • Author(s)
      Sarvendra Kumar, Yosuke Hisamatsu, Yusuke Tamaki, Osamu Ishitani, and Shin Aoki
    • Journal Title

      Inorganic Chemistry

      Volume: 55 Issue: 8 Pages: 3829-3843

    • DOI

      10.1021/acs.inorgchem.5b02872

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 11B NMR Probes of Copper(II): Finding and Implications of the Cu2+-Promoted Decomposition of ortho-Carborane Deriviatives.2016

    • Author(s)
      Tomohiro Tanaka, Yukiko Nishiura, Rikita Araki, Takaomi Saido, Ryo Abe and Shin Aoki,
    • Journal Title

      European Journal of Inorganic Chemistry,

      Volume: 2016 Issue: 12 Pages: 1819-1834

    • DOI

      10.1002/ejic.201600117

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Supramolecular Complexes Formed by the Self-assembly of Hydrophobic Bis(Zn<sup>2+</sup>-cyclen) Complexes, Copper, and Di- or Triimide Units for the Hydrolysis of Phosphate Mono- and Diesters in Two-Phase Solvent Systems (Cyclen=1,4,7,10-Tetraazacyclododecane)2016

    • Author(s)
      Yosuke Hisamatsu, Yuya Miyazawa, Takeru Yoneda, Miki Miyauchi, Mohd Zulkefeli, and Shin Aoki
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 64 Issue: 5 Pages: 451-464

    • DOI

      10.1248/cpb.c15-01014

    • NAID

      130005148749

    • ISSN
      0009-2363, 1347-5223
    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Comparison of Random forest anpd SVM for Raw Data in Drug Discovery:Prediction of Radiation Protection and Toxicity Case Study2016

    • Author(s)
      Atsushi Matsumoto, Shin Aoki, Hayato Ohwada
    • Journal Title

      International Journal of Machine Learning and Computing

      Volume: 6 Issue: 2 Pages: 145-148

    • DOI

      10.18178/ijmlc.2016.6.2.589

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 11B NMR/MRI Sensing of Copper(II) Ions In Vitro by the Decomposition of a Hybrid Compound of a nido-o-Carborane and a Metal Chelator2016

    • Author(s)
      omohiro Tanaka, Rikita Araki, Takaomi Saido, Ryo Abe, and Shin Aoki
    • Journal Title

      European Journal of Inorganic Chemistry

      Volume: - Issue: 20 Pages: 3330-3337

    • DOI

      10.1002/ejic.201600346

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 8-quinolinol誘導体の化学反応とバイオケミカルツール・酵素阻害剤への応用2016

    • Author(s)
      青木伸、有安真也、花屋賢悟、久松洋介、須貝威
    • Journal Title

      8-quinolinol誘導体の化学反応とバイオケミカルツール・酵素阻害剤への応用

      Volume: 74 Pages: 482-493

    • NAID

      130005159416

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of a Novel Sulfonate Ester-based Prodrug Strategy2016

    • Author(s)
      Kengo Hanaya, Shohei Yoshioka, Shinya Ariyasu, Shin Aoki, Mitsuru Shoji, Takeshi Sugai
    • Journal Title

      Bioorganic and Medicinal Chemistry Letters

      Volume: 26 Issue: 2 Pages: 545-560

    • DOI

      10.1016/j.bmcl.2015.11.074

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 8-quinolinol誘導体の化学反応とバイオケミカルツール・酵素阻害剤への応用2016

    • Author(s)
      青木伸、有安真也、花屋賢悟、久松洋介、須貝威
    • Journal Title

      有機合成化学協会誌

      Volume: 74

    • NAID

      130005159416

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Design and Synthesis of Amphiphilic and Luminescent Tris-Cyclometalated Iridium(III) Complexes Containing Cationic Peptides as Inducers and Detectors of Cell Death via a Calcium-Dependent Pathway2015

    • Author(s)
      Yosuke Hisamatsu, Ai Shibuya, Nozomi Suzuki, Toshinori Suzuki, Ryo Abe, and Shin Aoki,
    • Journal Title

      Bioconjugate Chemistry

      Volume: 26 Issue: 5 Pages: 857-879

    • DOI

      10.1021/acs.bioconjchem.5b00095

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] “Photochemical Properties of Red-Emitting Tris(cyclometalated) Iridium(III) Complexes Having Basic and Nitro Groups and Application to pH Sensing and Photoinduced Cell Death2015

    • Author(s)
      Aya Kando, Yosuke Hisamatsu, Hiroki Ohwada, Shinsuke Moromizato, Taiki Itoh, Masahiro Kohno, and Shin Aoki,
    • Journal Title

      Inorganic Chemistry

      Volume: 54 Issue: 11 Pages: 5342-5357

    • DOI

      10.1021/acs.inorgchem.5b00369

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Enrichment of circulating tumor cells in tumor-bearing mouse blood by a deterministic lateral displacement microfluidic device.2015

    • Author(s)
      Okano H, Konishi T, Suzuki T, Suzuki T, Ariyasu S, Aoki S, Abe R, Hayase M.
    • Journal Title

      Biomed. Microdevices

      Volume: 17 Issue: 3 Pages: 9964-9964

    • DOI

      10.1007/s10544-015-9964-7

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Docking Score Calculation Using Machine Learning with an Enhanced Inhibitor Database2015

    • Author(s)
      Masato Okada, Tadasuke Ito, Hayato Ohwada and Shin Aoki
    • Journal Title

      Journal of Medical Imaging and Health Informatics

      Volume: 5 Issue: 5 Pages: 1104-1107

    • DOI

      10.1166/jmihi.2015.1503

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Combining Two Machine Learning Methods for Predicting Protein-Ligand Docking Using Structure and Physiochemical Properties2015

    • Author(s)
      Tadasuke Ito, Hayato Ohwada, Shin Aoki
    • Journal Title

      Proceedings of the 7th International Conference on Bioinformatics and Computational Biology

      Volume: 3 Pages: 19-24

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Synthesis of Disaccharide Nucleosides by Direct O-Glycosylation of Natural Nucleosides with Thioglycoside Donors2015

    • Author(s)
      Shin Aoki, Taketo Fukumoto, Taiki Itoh, Masayuki Kurihara, Shigeto Saito, and Shinya Komabiki
    • Journal Title

      Chemistry-Asian Journal

      Volume: 10 Issue: 3 Pages: 740-751

    • DOI

      10.1002/asia.201403319

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Design, Synthesis, and Photochemical Reactivation of Caged Prodrugs of 8-Hydroxyquinoline-base Enzyme Inhibitors2014

    • Author(s)
      Shinya Ariyasu, Yuki Mizuseda, Kengo Hanaya, Miho Suetsugu, and Shin Aoki
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 67 Pages: 642-648

    • NAID

      130004053800

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Supramolecular Phosphatases Formed by the Self-Assembly of Bis(Zn2+-cyclen) Complex, Copper(II), and Barbital Derivatives in Water (Cyclen = 1,4,7,10-Tetraazacyclododecane)2014

    • Author(s)
      Mohd Zulkefeli, Yosuke Hisamatsu, Asami Suzuki, Yuya Miyazawa, Motoo Shiro, and Shin Aoki,
    • Journal Title

      Chemistry, An Asian Journal

      Volume: 9 Issue: 10 Pages: 2831-2841

    • DOI

      10.1002/asia.201402513

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Design and synthesis of 8-hydroxyquinoline-based radioprotective agents.2014

    • Author(s)
      S. Ariyasu, A. Sawa, A. Morita, K. Hanaya, M. Hoshi, I. Takahashi, B. Wang, and S. Aoki.
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 22 Issue: 15 Pages: 3891-3905

    • DOI

      10.1016/j.bmc.2014.06.017

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] AS-2, A Novel Inhibitor of p53-Dependent Apoptosis, Prevents Apoptotic Mitochondrial Dysfunction in A Transcription-Independent Manner and Protects Mice from a Lethal Dose of Ionizing Radiation2014

    • Author(s)
      Akinori Morita, Shinya Ariyasu, Bing Wang, Tetsuo Asanuma, Takayoshi Onoda, Akiko Sawa, Kaoru Tanaka, Ippei Takahashi, Shotaro Togami, Mitsuru Nenoi, Toshiya Inaba, and Shin Aoki
    • Journal Title

      Biochemical and Biophysical Research Communication

      Volume: 450 Pages: 1498-1504

    • Related Report
      2014 Research-status Report
    • Acknowledgement Compliant
  • [Presentation] 位置選択的O-グリコシル化反応によるDisaccharide Ribonucleosideの合成2017

    • Author(s)
      染谷英寿、青木伸
    • Organizer
      日本薬学会第138年会
    • Place of Presentation
      東北大学川北キャンパス(宮城県・仙台市)
    • Year and Date
      2017-03-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] ルイス酸によるシクロメタレート型イリジウム錯体の分解反応とトリスヘテロレプティック型イリジウム錯体の合成への応用2017

    • Author(s)
      田村裕一、久松洋介、Sarvendra Kumar、伊藤太基、佐藤享平、黒田玲子、青木伸
    • Organizer
      日本薬学会第138年会
    • Place of Presentation
      東北大学川北キャンパス(宮城県・仙台市)
    • Year and Date
      2017-03-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] 両親媒性二核亜鉛錯体・銅・バルビタール誘導体の自己集積型超分子の設計・合成と二層系におけるホスファターゼ活性評価2017

    • Author(s)
      今福 浩輝、Akib Bin Rahman、宮内 美樹、久松 洋介、青木 伸
    • Organizer
      日本薬学会第138年会
    • Place of Presentation
      東北大学川北キャンパス(宮城県・仙台市)
    • Year and Date
      2017-03-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] Development of Convenient and Efficient Methods for Detection, Isolation, and Growth of Anomalous Cells in Blood2017

    • Author(s)
      Shin Aoki, Babita Shashni, Hidehiko Matsuura, Kenta Nomura, Takuto Maeda, Shota Shiina, Kazunori Akimoto, Hiroshi Takemura, Atsuo Yasumori, Naoyuki Aikawa, Tomohiro Ohsaki, and Norihiko Itoh
    • Organizer
      2017 International Biomedical Interface Sympsosium (IBMI2017)
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2017-03-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Evaluation of 5-Chloro-8-quinolinol that Acts as Radioprotective Agonist2017

    • Author(s)
      Shohei Ujita, Akinori Morita, Shin Aoki, Yurie Nishi, Tatsuro Teraoka, Megumi Sasatani, Bing Wang, Ippei Takahashi, Kaoru Tanaka, Tomoaki Yamakawa, Mitsuru Nenoi, Kenji Kamiya, Toshiya Iniba
    • Organizer
      The 1st International Symposium of the Triangle Project with Hiroshima University, Nagasaki University and Fukushima Medical University
    • Place of Presentation
      広島大学霞キャンパス(広島県・広島市)
    • Year and Date
      2017-02-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 金属イオンによる含ホウ素化合物の分解反応の発見と金属イオン検出用11B NMR/MRIプローブへの応用2017

    • Author(s)
      青木伸、田中智博、西浦由紀子、田村佳、安部良、荒木力太、西道隆臣
    • Organizer
      第11回ホウ素・ホウ素化化合物シンポジウム(JSBB11)
    • Place of Presentation
      東京理大葛飾キャンパス(東京都・葛飾区)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Findings of Selective Reactions and Assembly of Metal Complexes and Their Application to Biological and Material Sciences2017

    • Author(s)
      Shin Aoki
    • Organizer
      Joint Seminar of Academia Sinica and the Institute of Chemistry
    • Place of Presentation
      Taipei, Taiwan
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Mechanistic Study of Cancer Cell Induced by Cationic Amphilphilic Tris-cyclometalated Iridium(III) Complex and Its Interaction with Target Protein2016

    • Author(s)
      Yosuke Hisamatsu, Nozoumi Suzuki, Abdullah-Al Masum, Ai Shibuya, Shin Aoki
    • Organizer
      8th Asian Biological Inorganic Chemistry Conference (AsBIC8)
    • Place of Presentation
      Aukland, New Zealand
    • Year and Date
      2016-12-05
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 毒性低減を目指した8-quinolinol防護線防護剤の設計・合成と活性評価2016

    • Author(s)
      西 友里恵、寺岡 達朗、氏田 将平、山川 知晃、森田 明典、松本 淳志、大和田 勇人、王 冰、青木 伸
    • Organizer
      第33回メディシナルケミストリーシンポジウム
    • Place of Presentation
      つくば国際会議場(茨城県・つくば市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 生体内金属イオンと C3 対称性錯体を形成する新規トリスビピリジンリガンド分子の設計・合成と錯体形成能の評価2016

    • Author(s)
      朱 俊傑、久松 洋介、青木 伸
    • Organizer
      第33回メディシナルケミストリーシンポジウム
    • Place of Presentation
      つくば国際会議場(茨城県・つくば市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] Development of Convenient and Efficient Methods for Detection and Capture of Circulating Tumor Cells in Blood2016

    • Author(s)
      Shin Aoki, Babita Shashni, Hidehiko Matsuura, Kenta Nomura, Takuto Maeda, Shota Shiina, Kazunori Akimoto, Hiroshi Takemura, Atsuo Yasumori, Naoyuki Aikawa, Tomohiro Ohsaki, and Norihiko Itoh
    • Organizer
      The 3rd International Conference on Biomaterial Science in Tokyo (ICBS016)
    • Place of Presentation
      東京大学本郷キャンパス(東京都・文京区)
    • Year and Date
      2016-11-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] カルボラン分解反応を利用した銅(II)イオン検出のための11B NMR/MRIプローブの設計と合成2016

    • Author(s)
      田中 智博、西浦 由紀子、荒木 力太、西道 隆臣、安部 良、青木 伸
    • Organizer
      第42回反応と合成の進歩シンポジウム
    • Place of Presentation
      清水文化会館マリナート(静岡県・静岡市)
    • Year and Date
      2016-11-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] 8-キノリノールスルホン酸エステルの光分解反応を利用した光応答性細胞分離磁気ビーズの開発2016

    • Author(s)
      松本 和恵、Babita Shashni、竹田 礼紗、向井 祐人、青木 伸
    • Organizer
      第42回反応と合成の進歩シンポジウム
    • Place of Presentation
      清水文化会館マリナート(静岡県・静岡市)
    • Year and Date
      2016-11-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] p53を標的とする放射線防護剤5-chloro-8-quinolinolの作用機構解析2016

    • Author(s)
      氏田奨平、森田 明典、青木伸、西友里恵、王冰、笹谷めぐみ、田中薫、山川知晃、根井充、神谷研二、稲葉俊哉
    • Organizer
      日本放射線影響学会第59回大会
    • Place of Presentation
      JMSアステールプラザ(広島県・広島市)
    • Year and Date
      2016-10-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] Novel Synthetic Approaches to Cyclometalated Iridium(III) Complexes Having Three Different Ligands2016

    • Author(s)
      久松 洋介・田村 祐一・Sarvendra Kumar・伊藤 太基・佐藤 享平・黒田 玲子・畑中 美穂・青木 伸
    • Organizer
      錯体化学会第66回討論会
    • Place of Presentation
      福岡大学(福岡県・福岡市)
    • Year and Date
      2016-09-10
    • Related Report
      2016 Annual Research Report
  • [Presentation] ルイス酸によるトリスシクロメタレート型イリジウム錯体の分解反応と3つの異なる配位子を有するイリジウム錯体の設計・合成への応用2016

    • Author(s)
      田村 祐一・久松 洋介・Sarvendra Kumar・伊藤 太基・佐藤 享平・黒田 玲子・畑中 美穂・青木 伸
    • Organizer
      錯体化学会第66回討論会
    • Place of Presentation
      福岡大学(福岡県・福岡市)
    • Year and Date
      2016-09-10
    • Related Report
      2016 Annual Research Report
  • [Presentation] ソーダ石灰ガラスビーズを用いた血中がん細胞分離用ガラスフィルタの作製2016

    • Author(s)
      松浦英彦、岩崎謙一郎、野村健太、竹村裕、Babita Shashni、青木 伸、安盛敦雄
    • Organizer
      日本セラミックス協会・第29回秋季シンポジウム
    • Place of Presentation
      広島大学東広島キャンパス(広島県・東広島市)
    • Year and Date
      2016-09-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] カチオン性両親媒性イリジウム(III)錯体の細胞死誘導とフォトアフィニティーラベリングを用いた分子機構の解析2016

    • Author(s)
      久松 洋介・鈴木 希美・渋谷 愛・Abdullah-Al Masum・佐藤 聡・田沼 靖一・青木 伸
    • Organizer
      第10回バイオ関連化学シンポジウム
    • Place of Presentation
      金沢市
    • Year and Date
      2016-09-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] Development of Convenient Methods in Detection and Separation of Circulating Tumor Cells (CTCs) and CTC Clusters2016

    • Author(s)
      Babita Shashni, Hidehiko Matsuura, Kenta Nomura, Takuto Maeda, Kazunori Akimoto, Masanori Hayase, Hiroshi Takemura, Atsuo Yasumori, Naoyuki Aikawa, Shin Aoki
    • Organizer
      第10回バイオ関連化学シンポジウム
    • Place of Presentation
      石川県立音楽堂(石川県・金沢市)
    • Year and Date
      2016-09-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] キラル亜鉛錯体によって触媒される不斉アルドール反応と錯体構造および遷移状態2016

    • Author(s)
      青木 伸、安田真人、菊地千陽、畑中美穂、北川裕一、長谷川靖哉、久松洋介
    • Organizer
      第26回金属の関与する生体関連反応シンポジウム
    • Place of Presentation
      北海道大学(北海道・札幌市)
    • Year and Date
      2016-06-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] 細胞死誘導の時間スケールが異なるペプチドを導入した発光性イリジウム錯体の設計・合成と作用メカニズム解析2016

    • Author(s)
      久松洋介、鈴木希美、Abdullah-Al Masum、渋谷愛、鈴木利宙、安部良、青木伸
    • Organizer
      日本ケミカルバイオロジー学会第11回年会
    • Place of Presentation
      京都テルサ(京都府・京都市)
    • Year and Date
      2016-06-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] 三つの異なる配位子で構成される新規シクロメタレート型イリジウム錯体の設計・合成と発光特性評価2016

    • Author(s)
      久松洋介、田村裕一、Sarvendra Kumar、青木伸
    • Organizer
      第109回有機合成化学シンポジウム
    • Place of Presentation
      東京工業大学大岡山キャンパス(東京都・目黒区)
    • Year and Date
      2016-06-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] 二相系中でリン酸加水分解活性を有する疎水性超分子ホスファターゼの設計・合成と反応速度論解析2016

    • Author(s)
      久松洋介、宮内美樹、宮澤有哉、米田翔、Mohd Zulkefeli、青木伸
    • Organizer
      第14回ホスト―ゲスト・超分子化学シンポジウム
    • Place of Presentation
      高知城ホール(高知県・高知市)
    • Year and Date
      2016-06-04
    • Related Report
      2016 Annual Research Report
  • [Presentation] DLD法による血液細胞の自動分類計測法2016

    • Author(s)
      前田 啄斗、早瀬仁則、青木伸、相川直幸
    • Organizer
      電子通信情報学会信号処理研究会(PRMU IE MI SIP)
    • Place of Presentation
      名古屋大学(愛知県・名古屋市)
    • Year and Date
      2016-05-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] Design, Synthesis, and Reactivity of Supramolecular Complexes Formed by Self-Assembly of Dinuclear Zinc complexes, Functionalized Di- or Triimide Building Blocks and Copper(II)2016

    • Author(s)
      Yosuke Hisamatsu, Yuya Miyazawa, Miki Miyauchi, Shin Aoki
    • Organizer
      The 25th French-Japanese Symposium on Medicinal and Fine Chemistry (FJU-2016)
    • Place of Presentation
      京王プラザホテル多摩(東京都・多摩市)
    • Year and Date
      2016-05-15
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 光反応性ジアジリンを有するカチオン性両親媒性トリスシクロメタレート型イリジウム錯体の設計・合成2016

    • Author(s)
      久松洋介、鈴木希美、渋谷愛、鈴木利宙、安部良、青木伸
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      横浜市、パシフィコ横浜
    • Year and Date
      2016-03-27
    • Related Report
      2015 Research-status Report
  • [Presentation] 11B NMR/MRIによる銅イオン検出のためのキレーター導入型o-carboraneプローブの設計、合成及び反応性評価2016

    • Author(s)
      田中智博、荒木力太、西道隆臣、安部良、青木伸
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      横浜市、パシフィコ横浜
    • Year and Date
      2016-03-27
    • Related Report
      2015 Research-status Report
  • [Presentation] Design and Synthesis of Artificial TRAIL Mimics Based on C3-symmetric and Luminescent Iridium Complexes that are Able to Stain and Induce Cell Death of Cancer Cells2016

    • Author(s)
      Abdullah-Al Masum, Yosuke Hisamasu, Nozomi Suzuki,, Shin Aoki
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      横浜市、パシフィコ横浜
    • Year and Date
      2016-03-27
    • Related Report
      2015 Research-status Report
  • [Presentation] 生体内金属イオンと C3 対称性錯体を形成する新規リガンド分子の設計・合成と錯体形成能の評価2016

    • Author(s)
      朱俊傑、久松洋介、青木伸
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      横浜市、パシフィコ横浜
    • Year and Date
      2016-03-27
    • Related Report
      2015 Research-status Report
  • [Presentation] Drug Development for Radiation Therapy of Cancer2016

    • Author(s)
      Shin Aoki
    • Organizer
      2016 International Biomedical Interface Symposium (2016IBMI)
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2016-03-04
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of Biological Tools Based on Finding of the Decomposition Reactions, Decomposition Reaction is not Useless”2016

    • Author(s)
      Shin Aoki
    • Organizer
      4th International Postgraduate Conference on Pharmaceutical Sciences 2016 (iPoPS2016)
    • Place of Presentation
      Noda (東京理科大学), Chiba
    • Year and Date
      2016-02-27
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Design and synthesis of C3-symmetric and luminescent tris-cyclometalated iridium(III) complexes having biologically active peptides2016

    • Author(s)
      Yosuke Hisamatsu, Ai Shibuya, Nozomi Suzuki, Hiroshi Tanaka, Abdullah-Al Masum, and Shin Aoki
    • Organizer
      4th International Postgraduate Conference on Pharmaceutical Sciences 2016 (iPoPS2016)
    • Place of Presentation
      Noda (東京理科大学), Chiba
    • Year and Date
      2016-02-27
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Finding of deboronation reaction of ortho-carborane derivatives catalyzed by metal ions and its application to 11B NMR probes2016

    • Author(s)
      Tomohiro Tanaka, Yukiko Nishiura, Rikita Araki, Takaomi Saido, Ryo Abe, and Shin Aoki
    • Organizer
      4th International Postgraduate Conference on Pharmaceutical Sciences 2016 (iPoPS2016)
    • Place of Presentation
      Noda (東京理科大学), Chiba
    • Year and Date
      2016-02-27
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Synthesis of disaccharide nucleosides by the chemical O-glycosylation of natural nucleosides with thioglycoside donors2016

    • Author(s)
      Taiki Itoh , Taketo Fukumoto, Masayuki Kurihara, Shigeto Saito, Shinya Komabiki, and Shin Aoki
    • Organizer
      4th International Postgraduate Conference on Pharmaceutical Sciences 2016 (iPoPS2016)
    • Place of Presentation
      Noda (東京理科大学), Chiba
    • Year and Date
      2016-02-27
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Design and synthesis of heteroleptic cyclometalated iridium(III) complexes that exhibit unusual dual color phosphorescence2016

    • Author(s)
      Sarvendra Kumar, Yosuke Hisamatsu , Shin Aoki
    • Organizer
      4th International Postgraduate Conference on Pharmaceutical Sciences 2016 (iPoPS2016)
    • Place of Presentation
      Noda (東京理科大学), Chiba
    • Year and Date
      2016-02-27
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of photoreactive silicon wafer and magnetic beads for isolating target cells based on photolysis of 8-quinolynyl sulfonate based linkers2016

    • Author(s)
      Kazue Matsumoto, Reisa Takeda, Shinya Ariyasu, Yuto Mukai, and Shin Aoki
    • Organizer
      4th International Postgraduate Conference on Pharmaceutical Sciences 2016 (iPoPS2016)
    • Place of Presentation
      Noda (東京理科大学), Chiba
    • Year and Date
      2016-02-27
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Design and synthesis of quinolone-based radioprotecting agents2016

    • Author(s)
      Design and synthesis of quinolone-based radioprotecting agents
    • Organizer
      4th International Postgraduate Conference on Pharmaceutical Sciences 2016 (iPoPS2016)
    • Place of Presentation
      Noda (東京理科大学), Chiba
    • Year and Date
      2016-02-27
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Design and synthesis of thioglycoside donors having electron-donating groups for the efficient glycosylations2016

    • Author(s)
      Sidehisa Someya, Taiki Itoh, Shin Aoki
    • Organizer
      4th International Postgraduate Conference on Pharmaceutical Sciences 2016 (iPoPS2016)
    • Place of Presentation
      Noda (東京理科大学), Chiba
    • Year and Date
      2016-02-27
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Marker Free Approach for the Detection of Circulating Tumor Cell (CTC) Clusters2016

    • Author(s)
      Babita Shashni, Reisa Takeda, Kazue Matsumoto, Tomohiro Ohsaki, Norihiko Itoh, Hidehiko Matsuura, Kenta Nomura, Takuto Maeda, Kazunori Akimoto, Hiroshi Takemura, Atsuo Yasumori, Naoyuki Aikawa, Shin Aoki
    • Organizer
      4th International Postgraduate Conference on Pharmaceutical Sciences 2016 (iPoPS2016)
    • Place of Presentation
      Noda (東京理科大学), Chiba
    • Year and Date
      2016-02-27
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Design and Synthesis of Cyclometalated Iridium(III) Complexes Containing Cationic Peptides as Mid-Size and Luminescent Drugs that Induce and Detect Cell Death of Cancer Cells2016

    • Author(s)
      Shin Aoki, Yosuke Hisamatsu, Nozomi Suzuki, Abdullah-Al Masum, Yuichi Tamura, Sarvendra Kumar
    • Organizer
      The 8th Takeda Science Foundation Symposium on PharmaSciences
    • Place of Presentation
      吹田市、武田薬品工業研修所
    • Year and Date
      2016-01-21
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] キラル亜鉛錯体による触媒的不斉アルドール反応における亜鉛の配位構造と反応遷移状態の解析2016

    • Author(s)
      青木 伸、安田真人、菊地千陽、畑中美穂、北川裕一、長谷川靖哉、久松洋介
    • Organizer
      第71回有機合成化学協会関東支部シンポジウム(東京農工大シンポジウム)
    • Place of Presentation
      東京農工大小金井キャンパス(東京都・小金井市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 細胞死誘導能を有するカチオン性両親媒性イリジウム(III)錯体の標的分子の探索と相互作用評価2016

    • Author(s)
      久松洋介・鈴木希美、渋谷愛、Abdullah-Al Masum、佐藤聡、田沼靖一、青木伸
    • Organizer
      第60回日本薬学会関東支部大会
    • Place of Presentation
      東京大学本郷キャンパス(東京都・文京区)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Development of Convenient Methods in Detection and Separation of Circulating Tumor Cells (CTCs) and CTC Clusters2016

    • Author(s)
      Babita Shashni, Hidehiko Matsuura, Kenta Nomura, Takuto Maeda, Kazunori Akimoto, Masanori Hayase, Hiroshi Takemura, Atsuo Yasumori, Naoyuki Aikawa, Shin Aoki
    • Organizer
      第60回日本薬学会関東支部大会
    • Place of Presentation
      東京大学本郷キャンパス(東京都・文京区)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Design and Synthesis of Artificial TRAIL Mimics Based on C3-symmetric and Luminescent Iridium Complexes that are Able to Stain and Induce Cell Death of Cancer Cells2016

    • Author(s)
      Abdullah-Al Masum, Yosuke Hisamasu, Nozomi Suzuki,, Shin Aoki
    • Organizer
      第60回日本薬学会関東支部大会
    • Place of Presentation
      東京大学本郷キャンパス(東京都・文京区)
    • Related Report
      2016 Annual Research Report
  • [Presentation] がんの早期発見と再発リスク低減のための理科大異分野連携研究の挑戦2016

    • Author(s)
      青木伸
    • Organizer
      TUSフォーラム2016
    • Place of Presentation
      ホテルメトロポリタンエドモント(東京都・千代田区)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Design and Synthesis of Luminescent Cyclometalated Iridium(III) Complexes for Material and Biomedical Science2015

    • Author(s)
      Shin Aoki
    • Organizer
      2015 International Chemical Congress of Pacific Basin Societies (PACICHEM2015)
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2015-12-15
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Design and synthesis of C3-symmetric and luminescent tris-cyclometalated iridium(III) complexes having biologically active peptides2015

    • Author(s)
      Yosuke Hisamatsu, Ai Shibuya, Nozomi Suzuki, Hiroshi Tanaka, Masum, Abdullarh-Al, Shin Aoki
    • Organizer
      2015 International Chemical Congress of Pacific Basin Societies (PACICHEM2015)
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2015-12-15
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Design, synthesis, and reactivity of supramolecular complexes formed by self-assembly of multinuclear zinc complexes, functionalized organic building blocks, and metals2015

    • Author(s)
      Yosuke Hisamatsu, Miki Miyauchi , Kakeru Yoneda, Yuya Miyazawa, Shin Aoki
    • Organizer
      2015 International Chemical Congress of Pacific Basin Societies (PACICHEM2015)
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2015-12-15
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Finding of deboronation reaction of ortho-carborane derivatives catalyzed by metal ions and its application to 11B NMR probes2015

    • Author(s)
      Tomohiro Tanaka, Yukiko Nishiura, Rikita Araki, Takaomi Saido, Ryo Abe, Shin Aoki
    • Organizer
      2015 International Chemical Congress of Pacific Basin Societies (PACICHEM2015)
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2015-12-15
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Design and synthesis of heteroleptic cyclometalated iridium(III) complexes that exhibit unusual dual color phosphorescence2015

    • Author(s)
      Sarvendra Kumar, Yosuke Hisamatsu , Shin Aoki
    • Organizer
      2015 International Chemical Congress of Pacific Basin Societies (PACICHEM2015)
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2015-12-15
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Design and synthesis of artificial TRAIL mimics based on C3-symmetric and luminescent iridium complexes2015

    • Author(s)
      Abdullah-Al Masum, Hiroshi Tanaka , Nozomi Suzuki , Yosuke Hisamatsu , Shin Aoki
    • Organizer
      2015 International Chemical Congress of Pacific Basin Societies (PACICHEM2015)
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2015-12-15
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Synthesis of disaccharide nucleosides by the chemical O-glycosylation of natural nucleosides with thioglycoside donors2015

    • Author(s)
      Taiki Itoh, Taketo Fukumoto, Masayuki Kurihara, Shigeto Saito, Shinya Komabiki, Shin Aok
    • Organizer
      2015 International Chemical Congress of Pacific Basin Societies (PACICHEM2015)
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2015-12-15
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Induction, detection, and mechanistic study of cell death induced by luminescent tris-cyclometalated iridium(III) complex-peptide hybrid2015

    • Author(s)
      Nozomi Suzuki, Yosuke Hisamatsu, Ai Shibuya, Hiroshi Tanaka, Abdullah-Al Masum, Shin Aoki
    • Organizer
      2015 International Chemical Congress of Pacific Basin Societies (PACICHEM2015)
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2015-12-15
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Improved synthesis and mechanistic study of a radiosensitizer, sulfoquinovosylacylglycerol (SQAG) derivative2015

    • Author(s)
      Yasuhiro Sawamoto, Tomohiro Tanaka,, Masakazu Umezawa, Yosuke Hisamatsu, Ikumi Tamai, Kengo Sakaguchi, Shin Aoki
    • Organizer
      2015 International Chemical Congress of Pacific Basin Societies (PACICHEM2015)
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2015-12-15
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Design and synthesis of light and redox reaction-driven molecular shuttles2015

    • Author(s)
      Motoko Karasaki, Asato Ota, Tomohiro Tanaka, Shin Aoki
    • Organizer
      015 International Chemical Congress of Pacific Basin Societies (PACICHEM2015)
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2015-12-15
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 位置選択的な置換反応を用いた青~赤色発光性および生物活性シクロメタレート型イリジウム(III)錯体の設計と合成2015

    • Author(s)
      青木伸、久松洋介、渋谷愛、神戸彩、鈴木希美、Abdullah-Al Masum、Sarvendra Kumar
    • Organizer
      第41回反応と合成の進歩シンポジウム
    • Place of Presentation
      東大阪市、近畿大学
    • Year and Date
      2015-10-26
    • Related Report
      2015 Research-status Report
  • [Presentation] Design, Synthesis and Photophysical Properties of Cyclometalated Iridium(III) Complexes of Quinoline Derivatives2015

    • Author(s)
      Sarvendra Kumar, Yosuke Hisamats, Shin Aoki
    • Organizer
      錯体化学会第65回討論会
    • Place of Presentation
      奈良市、奈良女子大学
    • Year and Date
      2015-09-21
    • Related Report
      2015 Research-status Report
  • [Presentation] 疎水性二核亜鉛錯体と有機アニオンと銅イオンによる自己集積体の構築とエステル・アミドの加水分解活性2015

    • Author(s)
      久松洋介・米田翔 ・宮内美樹・宮澤有哉・青木伸
    • Organizer
      第57回日本薬学会関東支部大会
    • Place of Presentation
      千葉、日本大学
    • Year and Date
      2015-09-12
    • Related Report
      2015 Research-status Report
  • [Presentation] o-carborane分解反応に基づく銅イオン検出のための11B NMR/MRIプローブの設計、合成と反応性評価2015

    • Author(s)
      田中智博、西浦由希子、田村佳、荒木力太、西道隆臣、安部良、青木伸
    • Organizer
      第57回日本薬学会関東支部大会
    • Place of Presentation
      千葉、日本大学
    • Year and Date
      2015-09-12
    • Related Report
      2015 Research-status Report
  • [Presentation] カチオン性ペプチドを導入したイリジウム(III)錯体の設計・合成とその細胞死誘導メカニズムの検討2015

    • Author(s)
      鈴木希美、久松洋介、渋谷愛、鈴木利宙、安部良、青木伸
    • Organizer
      第57回日本薬学会関東支部大会
    • Place of Presentation
      千葉、日本大学
    • Year and Date
      2015-09-12
    • Related Report
      2015 Research-status Report
  • [Presentation] がん放射線治療の副作用低減を目的とするp53標的放射線防護剤の開発2015

    • Author(s)
      青木伸、森田明典、王冰、有安真也、西友里恵、寺岡達朗、氏田将平、福井大智、田中薫、田中智博
    • Organizer
      第9回バイオ関連化学シンポジウム
    • Place of Presentation
      熊本、熊本大学
    • Year and Date
      2015-09-10
    • Related Report
      2015 Research-status Report
  • [Presentation] In Silico Screening of Zinc(II) Enzyme Inhibitors by ILP2015

    • Author(s)
      Tadasuke Itoh, Masato Okada, Shotaro Togami, Shinya Ariyasu, Shin Aoki, and Hayato Ohwada
    • Organizer
      25th International Conference on Inductive Logic Programming (ILP2015
    • Place of Presentation
      Kyoto, 京都国際会議場, Japan
    • Year and Date
      2015-08-20
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Design and Synthesis of Chiral Zn2+ Complexes Inspired by Natural Aldolases for Catalytic Asymmetric Aldol Reactions2015

    • Author(s)
      Shin Aoki, Susumu Itoh, Masato Yasuda, Shotaro Sonoike, Takuyam Tokunaga
    • Organizer
      4th International Symposium on Energy Challenges and Mechanics-working on small scales- (ECM4)
    • Place of Presentation
      Aberdeen, Scotland
    • Year and Date
      2015-08-11
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] カチオン性両親媒性トリスシクロメタレート型イリジウム(III)錯体により誘導される細胞死とそのメカニズムの解析2015

    • Author(s)
      久松洋介、渋谷愛、鈴木希美、鈴木利宙、安部良、青木伸
    • Organizer
      日本ケミカルバイオロジー学会第10回年会
    • Place of Presentation
      仙台、東北大学
    • Year and Date
      2015-06-10
    • Related Report
      2015 Research-status Report
  • [Presentation] o-carborane分解反応に基づく金属イオン検出のための11B NMR/MRIプローブの設計、合成と反応性評価2015

    • Author(s)
      田中智博、西浦由希子、、荒木力太、西道隆臣、安部良、青木伸
    • Organizer
      日本ケミカルバイオロジー学会第10回年会
    • Place of Presentation
      仙台、東北大学
    • Year and Date
      2015-06-10
    • Related Report
      2015 Research-status Report
  • [Presentation] 修飾した二核亜鉛錯体と有機ビルディングブロックの組み合わせにより構築される自己集積体のホスファターゼ活性評価2015

    • Author(s)
      久松洋介、宮内美樹、米田翔、宮澤有哉、青木伸
    • Organizer
      第13回ホストゲスト化学シンポジウム
    • Place of Presentation
      仙台、東北大学
    • Year and Date
      2015-06-06
    • Related Report
      2015 Research-status Report
  • [Presentation] シクロデキストリンとZn(Ⅱ)-サイクレン錯体から構成される水溶性ロタキサンの設計と合成2015

    • Author(s)
      唐崎幹子、大田麻人、田中智博、青木伸
    • Organizer
      第13回ホストゲスト化学シンポジウム
    • Place of Presentation
      仙台、東北大学
    • Year and Date
      2015-06-06
    • Related Report
      2015 Research-status Report
  • [Presentation] 銅イオンによるo-carborane分解反応の発見とそれを応用した11B NMRプローブの設計と合成2015

    • Author(s)
      田中智博、西浦由希子、荒木力太、西道隆臣、安部良、青木伸
    • Organizer
      第25回金属の関与する生体関連反応シンポジウム
    • Place of Presentation
      長崎、長崎大学
    • Year and Date
      2015-05-30
    • Related Report
      2015 Research-status Report
  • [Presentation] 亜鉛酵素・タンパクを標的とする新薬剤の開発2015

    • Author(s)
      青木伸
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Design and Synthesis of 8-Hydroxyquinoline Derivatives for the Diagnosis and Treatment of Cancer2014

    • Author(s)
      Shin Aoki
    • Organizer
      4th World Conference on Cancer Science and Therapy (WCCST2014)
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2014-10-20 – 2014-10-22
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 疾病の診断と治療のための有機・無機システムの設計と構築-東京理科大学における異分野連携-2014

    • Author(s)
      青木 伸
    • Organizer
      第56回日本薬学会関東支部大会
    • Place of Presentation
      昭和薬大(町田市)
    • Year and Date
      2014-10-04
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] o-carboraneを有する金属検出用11B NMRプローブの設計・合成と機能評価2014

    • Author(s)
      西浦由紀子、田中智博、久松洋介、青木伸
    • Organizer
      第56回日本薬学会関東支部大会
    • Place of Presentation
      昭和薬大(町田市)
    • Year and Date
      2014-10-04
    • Related Report
      2014 Research-status Report
  • [Presentation] ぺプチドを導入したトリスシクロメタレート型イリジウム(III)錯体の設計・合成と生物活性評価2014

    • Author(s)
      久松 洋介、鈴木 希美、渋谷 愛、田中 裕志、犬飼 岳史、鈴木 利宙、安部 良、青木 伸
    • Organizer
      第8回バイオ関連化学シンポジウム
    • Place of Presentation
      岡山大学津島キャンパス
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Research-status Report
  • [Presentation] Chemistry and Biomedical Applicatoins of Hydroxyquinoline Derivatives2014

    • Author(s)
      Shin Aoki
    • Organizer
      3rd International Postgraduate Conference on Pharmaceutical Sciences 2014 (iPoPS2014)
    • Place of Presentation
      Puncak Alam campus of Universiti Teknologi MARA, Malaysia
    • Year and Date
      2014-08-11 – 2014-08-12
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Design and, Synthesis of o-Carborane Derivatives as 11B NMR Probes of d-Block Metal Ions2014

    • Author(s)
      Yukiko Nishiura, Tomohiro Tanaka, Yosuke Hisamatsu, and Shin Aoki
    • Organizer
      3rd International Postgraduate Conference on Pharmaceutical Sciences 2014 (iPoPS2014)
    • Place of Presentation
      Puncak Alam campus of Universiti Teknologi MARA, Malaysia
    • Year and Date
      2014-08-11 – 2014-08-12
    • Related Report
      2014 Research-status Report
  • [Presentation] Design and Synthesis of Cyclometalated Iridium Complexes as Photochemical and Biomedical Tools2014

    • Author(s)
      Shin Aoki, Yosuke Hisamatsu, Akihiro Nakagawa, Ai Shibuya, Aya Kando, Hiroshi Tanaka, Nozomi Suzuki
    • Organizer
      26th International Conference on Organometallic Chemistry (ICOMC2014)
    • Place of Presentation
      ロイトンホテル札幌(札幌)
    • Year and Date
      2014-07-13 – 2014-07-18
    • Related Report
      2014 Research-status Report
  • [Presentation] Design and Synthesis of Red-Color Emitting Cyclometalated Iridium(III) Complexes and Their Biological Applications as pH Probes and Singlet Oxygen Sensitizers2014

    • Author(s)
      Aya Kando, Akihiro Nakagawa, Yosuke Hisamatsu, and Shin Aoki
    • Organizer
      26th International Conference on Organometallic Chemistry (ICOMC2014)
    • Place of Presentation
      ロイトンホテル札幌(札幌)
    • Year and Date
      2014-07-13 – 2014-07-18
    • Related Report
      2014 Research-status Report
  • [Presentation] Design, Synthesis and Evaluation of 11B NMR Probes of d-Block Metal Ions.2014

    • Author(s)
      Yukiko Nishiura, Yosuke Hisamatsu, Tomohiro Tanaka, Toshihiro Suzuki, Ryo Abe, and Shin Aoki
    • Organizer
      26th International Conference on Organometallic Chemistry (ICOMC2014)
    • Place of Presentation
      ロイトンホテル札幌(札幌)
    • Year and Date
      2014-07-13 – 2014-07-18
    • Related Report
      2014 Research-status Report
  • [Presentation] シクロメタレート型イリジウム錯体―ペプチドハイブリッドによるがん細胞のイメージングと細胞死誘導2014

    • Author(s)
      久松 洋介、渋谷 愛、鈴木 希美、青木 伸
    • Organizer
      第9回日本ケミカルバイオロジー学会
    • Place of Presentation
      大阪大学豊中キャンパス(豊中市)
    • Year and Date
      2014-06-11 – 2014-06-13
    • Related Report
      2014 Research-status Report
  • [Presentation] 長鎖アルキル基を導入した複核亜鉛錯体の自己集積による疎水性超分子ホスファターゼの構築とリン酸加水分解活性2014

    • Author(s)
      青木 伸、宮澤 有哉、久松 洋介、鈴木 麻美、米田 翔、田中 亮
    • Organizer
      第12回ホストゲスト化学シンポジウム
    • Place of Presentation
      東工大大岡山キャンパス(東京)
    • Year and Date
      2014-05-31 – 2014-06-01
    • Related Report
      2014 Research-status Report
  • [Presentation] ヌクレオシドのO-グリコシル化反応によるdisaccharide nucleosideの合成2014

    • Author(s)
      福本 健人、伊藤 太基、栗原 正幸、青木 伸
    • Organizer
      第67回有機合成化学協会関東支部シンポジウム
    • Place of Presentation
      慶應義塾大学理工学部矢上キャンパス(横浜市)
    • Year and Date
      2014-05-17
    • Related Report
      2014 Research-status Report
  • [Book] フロンティア生物無機化学”(錯体化学会フロンティア選書)2016

    • Author(s)
      伊東忍、青野重利、林高史、増田秀樹、廣田俊、藤井浩、小寺政人、城宣嗣、樋口芳樹、高妻孝光、杉本秀樹、小倉尚志、民秋均、大久保敬、正岡重行、小江誠司、久枝良雄、青木伸、菊地和也、上野隆史
    • Total Pages
      535
    • Publisher
      三共出版
    • Related Report
      2016 Annual Research Report
  • [Book] Macrocyclic and Supramolecular Chemistry: How Izatt-Christensen Award Winners Shaped the Field2016

    • Author(s)
      Eiichi Kimura, Tohru Koike, and Shin Aoki
    • Total Pages
      470
    • Publisher
      John Wiley & Sons
    • Related Report
      2015 Research-status Report
  • [Book] Robert R. Crichton “生物無機化学”(邦訳)2016

    • Author(s)
      塩谷光彦監訳
    • Total Pages
      354
    • Publisher
      東京化学同人
    • Related Report
      2015 Research-status Report
  • [Book] スタンダード薬学シリーズII 3“化学系薬学 II. 生体分子・医薬品の化学による理解”2016

    • Author(s)
      日本薬学会編
    • Total Pages
      346
    • Publisher
      東京化学同人
    • Related Report
      2015 Research-status Report
  • [Book] Synergy in Supramolecular Chemistry2015

    • Author(s)
      Shin Aoki, Mohd Zulkefeli, Yosuke Hisamatsu, and Masanori Kitamura
    • Total Pages
      339
    • Publisher
      CRC
    • Related Report
      2014 Research-status Report
  • [Book] マクマリー生物有機化学 基礎化学編 第4版(原書第7版)2015

    • Author(s)
      菅原二三男監訳
    • Total Pages
      382
    • Publisher
      丸善
    • Related Report
      2014 Research-status Report
  • [Remarks] 東京理科大学薬学部青木研究室ホームページ

    • URL

      http://www.rs.noda.tus.ac.jp/~aokilab/

    • Related Report
      2015 Research-status Report
  • [Patent(Industrial Property Rights)] 細胞分離方法及び細胞分離装置2016

    • Inventor(s)
      青木 伸、安盛敦雄
    • Industrial Property Rights Holder
      青木 伸、安盛敦雄
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-165889
    • Filing Date
      2016-08-26
    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] イリジウム錯体化合物及びイリジウム錯体化合物の製造方2015

    • Inventor(s)
      青木伸、サーベンドラ クマール、久松洋介、田村裕一
    • Industrial Property Rights Holder
      青木伸、サーベンドラ クマール、久松洋介、田村裕一
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-12-18
    • Related Report
      2015 Research-status Report
  • [Patent(Industrial Property Rights)] チオアルドヘキソース誘導体及びその製造方法2015

    • Inventor(s)
      青木伸、田中智博、久松洋介、澤本泰宏、坂口謙吾、菅原二三男
    • Industrial Property Rights Holder
      青木伸、田中智博、久松洋介、澤本泰宏、坂口謙吾、菅原二三男
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-027694
    • Filing Date
      2015-02-16
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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