Antivirus drug development based on inhibition of N-glycan processing process
| Project/Area Number |
26460157
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Nihon University |
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Principal Investigator |
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| Research Collaborator |
ARAI Shiori
UEMA Shun
ONDA Momoko
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 抗ウイルス / 糖鎖 / グルコシダーゼ / 阻害剤 / スクリーニング / 抗ウイルス薬 / 蛍光基質 |
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| Outline of Final Research Achievements |
An endoplasmic reticulum glucosidase II in host cells is a key target for the development of anti-virus agents aimed at the measure of virus outbreak. A disturbance of maturation of N-linked glycosylation of virus envelope proteins inhibited of the α-glucosidases have an influence on particle assembly and infectivity of the virus. Here we report on the identification of novel inhibitors of glucosidase II through a discovery of inhibitor screening from compound library and its biological evaluations, and anti-virus activity.
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Report
(4 results)
Research Products
(10 results)
