| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Outline of Final Research Achievements |
The increase of dementia patients is a big issue for Japan as it faces a rapidly against society. To conquer Alzheimer's disease, this reaearch aimed the development of inhibitors of amyloid beta aggregation and BACE1. We designed and synthesized a series of small-sized BACE1 inhibitors with a thiadiazole moiety. These compounds with improved membrane permeability appear to have promise as drug candidates. And we synthesized aggregation inhibitors. These aggregation inhibitors could recognized a specific Abeta conformer, and are expected to use a research tool for pathogenic mechanism analysis.
|
