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Development of stabilized helical peptides as POI degradation inducers

Research Project

Project/Area Number 26460169
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Drug development chemistry
Research InstitutionNational Institute of Health Sciences

Principal Investigator

DEMIZU YOSUKE  国立医薬品食品衛生研究所, 有機化学部, 部長 (90389180)

Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsアミノ酸 / ペプチド / PPI阻害剤 / 標的タンパク質分解誘導剤 / 細胞膜透過性ペプチド / ヘリカル構造 / ユビキチン-プロテアソームシステム / Hisタグタンパク質 / 膜透過ペプチド / タンパク質分解誘導剤 / プロテインノックダウン / 癌 / 二次構造制御
Outline of Final Research Achievements

Peptide drugs having the advantages of small-molecule medicines and antibodies are attracting attention as new drug discovery seeds. In this study, I developed stabilized helical peptides as POI degradation inducers. Within the period, I succeeded in developing helical peptide-based transcriptional inhibitors and degradation inducers targeting nuclear receptors. I have also developed cell penetrating peptides for efficient delivery of these molecules into cells.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (180 results)

All 2018 2017 2016 2015 2014

All Journal Article (55 results) (of which Int'l Joint Research: 11 results,  Peer Reviewed: 54 results,  Acknowledgement Compliant: 24 results,  Open Access: 6 results) Presentation (122 results) (of which Int'l Joint Research: 9 results,  Invited: 4 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 1 results)

  • [Journal Article] Rational design and synthesis of post-functionalizable peptide foldamers as helical templates2017

    • Author(s)
      T. Misawa,* Y. Kanda, Y. Demizu*
    • Journal Title

      Bioconj. Chem.

      Volume: 28 Issue: 12 Pages: 3029-3035

    • DOI

      10.1021/acs.bioconjchem.7b00621

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Right-handed and left-handed helical structures with fourteen (R)-chiral centers2017

    • Author(s)
      R. Eto, M. Oba, A. Ueda, T. Uku, M. Doi, Y. Demizu, M. Kurihara, M. Tanaka*
    • Journal Title

      Chem. Eur. J.

      Volume: 23 Issue: 72 Pages: 18120-18124

    • DOI

      10.1002/chem.201705306

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preorganized cyclic alpha,alpha-disubstituted alpha-amino acids bearing functionalized side chains that act as peptide-helix inducers2017

    • Author(s)
      H. Kobayashi, T. Misawa, K. Matsuno, Y. Demizu*
    • Journal Title

      J. Org. Chem.

      Volume: 82 Issue: 19 Pages: 10722-10726

    • DOI

      10.1021/acs.joc.7b01946

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of a peptide-based inducer of protein degradation targeting NOTCH12017

    • Author(s)
      Ohoka N, Misawa T, Kurihara M, Demizu Y, Naito M.
    • Journal Title

      Bioorg Med Chem Lett.

      Volume: 27 Issue: 22 Pages: 4985-4988

    • DOI

      10.1016/j.bmcl.2017.10.011

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simple and efficient knockdown of His-tagged proteins by ternary molecules consist of His-tag ligand, ubiquitin ligase ligand and cell penetrating peptide2017

    • Author(s)
      T. Hattori, K. Okitsu, N. Yamazaki, N. Ohoka, N. Shibata, T. Misawa, M. Kurihara, Y. Demizu,* M. Naito*
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 27 Issue: 18 Pages: 4478-4481

    • DOI

      10.1016/j.bmcl.2017.08.001

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of helix-stabilized antimicrobial peptides composed of lysine and hydrophobic alpha,alpha-disubstituted alpha-amino acid residues2017

    • Author(s)
      T. Misawa, M. Imamura, Y. Ozawa, K. Haishima, M. Kurihara, Y. Kikuchi,* Y. Demizu*
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 27 Issue: 17 Pages: 3950-3953

    • DOI

      10.1016/j.bmcl.2017.07.074

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PNA monomers fully compatible with standard Fmoc-based solid-phase synthesis of pseudocomplementary PNA2017

    • Author(s)
      Toru Sugiyama, Genki Hasegawa, Chie Niikura, Keiko Kuwata, Yasutada Imamura, Yosuke Demizu, Masaaki Kurihara, and Atsushi Kittaka
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 27 Issue: 15 Pages: 3337

    • DOI

      10.1016/j.bmcl.2017.06.015

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Low pH-responsive change in side chain structure of an amino acid from cyclic acetal to acyclic diol leads to conformational change in a peptide from a helical to random structure2017

    • Author(s)
      K. Furukawa, M. Oba,* K. Toyama, G. O. Opiyo, Y. Demizu, M. Kurihara, M. Doi, M. Tanaka*
    • Journal Title

      Org. Biomol. Chem.

      Volume: 15 Issue: 30 Pages: 6302-6305

    • DOI

      10.1039/c7ob01374d

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Helical L-Leu-based peptides having chiral five-membered carbocyclic ring amino acids with an ethylene acetal moiety2017

    • Author(s)
      Y. Koba, A. Ueda, M. Oba, M. Doi, Y. Demizu, M. Kurihara, M. Tanaka*
    • Journal Title

      ChemistrySelect

      Volume: 2 Issue: 26 Pages: 8108-8114

    • DOI

      10.1002/slct.201700832

    • NAID

      120006988059

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of an ON/OFF switchable fluorescent probe targeting His tag fused proteins in living cells2017

    • Author(s)
      Okitsu K, Misawa T, Shoda T, Kurihara M, Demizu Y.
    • Journal Title

      Bioorg Med Chem Lett.

      Volume: 27 Issue: 15 Pages: 3417-3422

    • DOI

      10.1016/j.bmcl.2017.05.087

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficient synthesis of a multi-substituted diphenylmethane skeleton as a steroid mimetic2017

    • Author(s)
      takashi misawa, katsuya tanaka, yosuke demizu, masaaki kurihara
    • Journal Title

      bioorganic medicinal chemistry letter

      Volume: 印刷中 Issue: 11 Pages: 2590-2593

    • DOI

      10.1016/j.bmcl.2017.03.066

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Tamoxifen and fulvestrant hybrid showed potency as a selective estrogen receptor down-regulator2017

    • Author(s)
      Takuji Shoda, Masashi Kato, Takuma Fujisato, Yosuke Demizu, Hideshi Inoue, Mikihiko Naito, Masaaki Kurihara
    • Journal Title

      Med. Chem.

      Volume: 13 Issue: 3 Pages: 206-213

    • DOI

      10.2174/1573406412666160805101408

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Development of helix-stabilized cell-penetrating peptides containing cationic α,α-disubstituted amino acids as helical promoters.2017

    • Author(s)
      Yamashita H, Misawa T, Oba M, Tanaka M, Naito M, Kurihara M, Demizu Y.
    • Journal Title

      Bioorg Med Chem.

      Volume: 25(6) Issue: 6 Pages: 1846-1851

    • DOI

      10.1016/j.bmc.2017.01.044

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Targeted Degradation of Proteins Localized in Subcellular Compartments by Hybrid Small Molecules.2017

    • Author(s)
      Okuhira, K., Shoda, T., Omura, R., Ohoka, N., Hattori, T., Shibata, N., Demizu, Y., Sugihara, R., Ichino, A., Kawahara, H., Itoh, Y., Ishikawa, M., Hashimoto, Y., Kurihara, M., Itoh, S., Saito, H. & Naito, M.
    • Journal Title

      Mol pharmacol

      Volume: 91 Issue: 3 Pages: 159-166

    • DOI

      10.1124/mol.116.105569

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Design and synthesis of novel selective estrogen receptor degradation inducers based on diphenylheptane skeleton2017

    • Author(s)
      T. Misawa, T. Fujisato, Y. Kanda, N. Ohoka, T. Shoda, M. Yorioka, M. Makishima, Y. Sekino, M. Naito, Y. Demizu, Masaaki Kurihara
    • Journal Title

      MedChemComm

      Volume: 8 Issue: 1 Pages: 239-246

    • DOI

      10.1039/c6md00553e

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Influence of L-Leu to D-Leu replacement on the helical secondary structures of L-Leu-Aib-based dodecapeptides2016

    • Author(s)
      Y. Demizu,* K. Okitsu, M. Doi, T. Misawa, M. Oba, M. Tanaka, M. Kurihara*
    • Journal Title

      ChemistrySelect

      Volume: 1 Issue: 18 Pages: 5805-5811

    • DOI

      10.1002/slct.201601493

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Development of BCR-ABL degradation inducers via the conjugation of an imatinib derivative and a cIAP1 ligand.2016

    • Author(s)
      Demizu, Y., Shibata, N., Hattori, T., Ohoka, N., Motoi, H., Misawa, T., Shoda, T., Naito, M. & Kurihara, M.
    • Journal Title

      Bioorg Med Chem Lett

      Volume: 26 Issue: 20 Pages: 4865-4869

    • DOI

      10.1016/j.bmcl.2016.09.041

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Helical structures of homo-chiral isotope-labeled alpha-aminoisobutyric acid peptides2016

    • Author(s)
      A. Ueda, M. Oba, Y. Izumi, Y. Sueyoshi, M. Doi, Y. Demizu, M. Kurihara, M. Tanaka*
    • Journal Title

      Tetrahedron

      Volume: 39 Issue: 39 Pages: 5864-5871

    • DOI

      10.1016/j.tet.2016.08.011

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development of a Cell-penetrating Peptide that Exhibits Responsive Changes in its Secondary Structure in the Cellular Environment2016

    • Author(s)
      H. Yamashita, T. Kato, M. Oba, T. Misawa, T. Hattori, N. Ohoka, M. Tanaka, M. Naito, M. Kurihara, Y. Demizu
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 33003-33003

    • DOI

      10.1038/srep33003

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The side-chain hydroxy groups of a cyclic alpha,alpha-disubstituted alpha-amino acid promote oligopeptide helix packing in the crystalline state2016

    • Author(s)
      Y. Demizu,* M. Doi, H. Yamashita, T. Misawa, M. Oba, M. Kurihara, H. Suemune, M. Tanaka
    • Journal Title

      Biopolymers (Pept. Sci.)

      Volume: 106 Issue: 5 Pages: 757-768

    • DOI

      10.1002/bip.22881

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Identification of embryonic precursor cells that differentiate into thymic epithelial cells expressing autoimmune regulator.2016

    • Author(s)
      Akiyama N, Takizawa N, Miyauchi M, Yanai H, Tateishi R, Shinzawa M, Yoshinaga R, Kurihara M, Demizu Y, Yasuda H, Yagi S, Wu G, Matsumoto M, Sakamoto R, Yoshida N, Penninger JM, Kobayashi Y, Inoue J, Akiyama T.
    • Journal Title

      The Journal of Experimental Medicine

      Volume: 213 Issue: 8 Pages: 1441-1458

    • DOI

      10.1084/jem.20151780

    • NAID

      120006532434

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Synthesis of chiral five-membered carbocyclic ring amino acids with an acetal moiety and helical conformations of its homo-chiral homopeptide2016

    • Author(s)
      Y. Koba, Y. Hirata, A. Ueda, M. Oba, M. Doi, Y. Demizu, M. Kurihara, M. Tanaka
    • Journal Title

      Biopolymers (Pept.Sci.)

      Volume: 印刷中 Issue: 4 Pages: 555-562

    • DOI

      10.1002/bip.22769

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Peptide Nucleic Acid with a Lysine Side Chain at the β-Position: Synthesis and Application for DNA Cleavage2016

    • Author(s)
      Toru Sugiyama, Keiko Kuwata, Yasutada Imamura, Yosuke Demizu, Masaaki Kurihara, Masashi Takano, and Atsushi Kittaka
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 64 Issue: 7 Pages: 817-823

    • DOI

      10.1248/cpb.c16-00191

    • NAID

      130005160035

    • ISSN
      0009-2363, 1347-5223
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Synthesis and evaluation of raloxifene derivatives as a selective estrogen receptor down-regulator2016

    • Author(s)
      Takuji Shoda, Masashi Kato, Takuma Fujisato, Takashi Misawa, Yosuke Demizu, Hideshi Inoue, Mikihiko Naito, Masaaki Kurihara
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 24 Issue: 13 Pages: 2914-2919

    • DOI

      10.1016/j.bmc.2016.04.068

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] alpha-Helical structures of oligopeptides with alternating L-Leu-Aib segment2016

    • Author(s)
      Y. Demizu,* K. Okitsu, H. Yamashita, M. Doi, T. Misawa, M. Oba, M. Tanaka, M. Kurihara*
    • Journal Title

      Eur. J. Org. Chem.

      Volume: XX Issue: 16 Pages: 2815-2820

    • DOI

      10.1002/ejoc.201600327

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Plasmid DNA delivery by arginine-rich cell-penetrating peptides containing unnatural amino acids2016

    • Author(s)
      T. Kato, H. Yamashita, T. Misawa, K. Nishida, M. Kurihara, M. Tanaka, Y. Demizu, M. Oba
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 24 Issue: 12 Pages: 2681-2687

    • DOI

      10.1016/j.bmc.2016.04.031

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Development of a peptide-based inducer of nuclear receptors degradation.2016

    • Author(s)
      Demizu Y, Ohoka N, Nagakubo T, Yamashita H, Misawa T, Okuhira K, Naito M, Kurihara M.
    • Journal Title

      Bioorg Med Chem Lett.

      Volume: 26 Issue: 11 Pages: 2655-2658

    • DOI

      10.1016/j.bmcl.2016.04.013

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Handedness preferences of heterochiral helical peptides containing homochiral peptide segments2016

    • Author(s)
      Y. Demizu,* H. Yamashita, T. Misawa, M. Doi, M. Oba, M. Tanaka, M. Kurihara*
    • Journal Title

      Eur. J. Org. Chem.

      Volume: 4 Issue: 4 Pages: 840-846

    • DOI

      10.1002/ejoc.201501146

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A Helix-Stabilized Cell-Penetrating Peptide As An Intracellular-Delivery Tool2016

    • Author(s)
      Hiroko Yamashita, Makoto Oba, Takashi Misawa, Masakazu Tanaka, Takayuki Hattori, Mikihiko Naito, Masaaki Kurihara, Yosuke Demizu
    • Journal Title

      Chembiochem

      Volume: 17 Issue: 2 Pages: 137-140

    • DOI

      10.1002/cbic.201500468

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Induction of proteasomal degradation of ERα and subsequent cell death in breast cancer cells2016

    • Author(s)
      K. Okuhira, Y. Demizu, T. Hattori, N. Ohoka, N. Shibata, T. Nishimaki-Mogami, H. Okuda, M. Kurihara, M. Naito*
    • Journal Title

      Methods Mol. Biol.

      Volume: 1366 Pages: 549-560

    • DOI

      10.1007/978-1-4939-3127-9_42

    • ISBN
      9781493931262, 9781493931279
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effects of alkyl side chains and terminal hydrophilicity on vitamin D receptor (VDR) agonistic activity based on the diphenylpentane skeleton2015

    • Author(s)
      Takashi Misawa, Momoko Yorioka, Yosuke Demizu, Tomomi Noguchi-Yachide, Nobumichi Ohoka, Megumi Kurashima-Kinoshita, Hitomi Motoyoshi, Hisao Nojiri, Atsushi Kittaka, Makoto Makishima, Mikihiko Naito, Masaaki Kurihara
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 25 Issue: 22 Pages: 5362-5366

    • DOI

      10.1016/j.bmcl.2015.09.030

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Topological study of the structures of heterochiral peptides with equal amounts of L-Leu and D-Leu2015

    • Author(s)
      Y. Demizu,* H. Yamashita, M. Doi, T. Misawa, M. Oba, M. Tanaka, M. Kurihara*
    • Journal Title

      J. Org. Chem.

      Volume: 80 Issue: 17 Pages: 8597-8603

    • DOI

      10.1021/acs.joc.5b01541

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] A synthetic cannabinoid FDU-NNEI, two 2H-indazole isomers of synthetic cannabinoids AB-CHMINACA and NNEI indazole analog (MN-18), a phenethylamine derivative N-OH-EDMA, and a cathinone derivative dimethoxy-α-PHP, newly identified in illegal products2015

    • Author(s)
      N. Uchiyama,* Y. Shimokawa, R. Kikura-Hanajiri, Y. Demizu, Y. Goda, T. Hakamatsuka
    • Journal Title

      Forensic Toxicol.

      Volume: 33 Issue: 2 Pages: 244-259

    • DOI

      10.1007/s11419-015-0268-7

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Synthesis and Evaluation of Novel Carbocyclic Oxetanocin A (COA-Cl) Derivatives as Potential Tube Formation Agents2015

    • Author(s)
      N. Sakakibara,* J. Igarashi, M. Takata, Y. Demizu, T. Misawa, M. Kurihara, R. Konishi, Y. Kato, T. Maruyama, I. Tsukamoto
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 63 Issue: 9 Pages: 701-709

    • DOI

      10.1248/cpb.c15-00386

    • NAID

      130005096030

    • ISSN
      0009-2363, 1347-5223
    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Design, synthesis, and anti-HIV-1 activity of 1-substituted 3-(3,5-dimethylbenzyl)triazine derivatives2015

    • Author(s)
      N. Sakakibara,* G. Balboni, C. Congiu, V. Onnis, Y. Demizu, T. Misawa, M. Kurihara, Y. Kato, T. Maruyama, M. Toyama, M. Okamoto, M. Baba
    • Journal Title

      Antiviral Chem. Chemother.

      Volume: 24 Issue: 2 Pages: 62-71

    • DOI

      10.1177/2040206615612208

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Plasmid DNA delivery using fluorescein-labeled arginine-rich peptides2015

    • Author(s)
      M. Oba,* Y. Demizu, H. Yamashita, M. Kurihara, M. Tanaka
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 23 Issue: 15 Pages: 4911-4918

    • DOI

      10.1016/j.bmc.2015.05.025

    • NAID

      120006986986

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Structural development of stabilized helical peptides as inhibitors of estrogen receptor (ER)-mediated transcription2015

    • Author(s)
      Y. Demizu*, T. Misawa, T. Nagakubo, Y. Kanda, K. Okuhira, Y. Sekino, M. Naito, M. Kurihara*
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 23 Issue: 15 Pages: 4132-4138

    • DOI

      10.1016/j.bmc.2015.06.067

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Synthesis and resolution of substituted [5]carbohelicenes2015

    • Author(s)
      K. Usui,* K. Yamamoto, T. Shimizu, M. Biao, M. Okazumi, Y. Demizu, M. Kurihara, H. Suemune*
    • Journal Title

      J. Org. Chem.

      Volume: 80 Issue: 12 Pages: 6502-6508

    • DOI

      10.1021/acs.joc.5b00759

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Synthesis and evaluation of tamoxifen derivatives with a long alkyl side chain as selective estrogen receptor down-regulators2015

    • Author(s)
      T. Shoda,* M. Kato, T. Fujisato, K. Okuhira, Y. Demizu, H. Inoue, M. Naito, M. Kurihara*
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 23 Issue: 13 Pages: 3091-3096

    • DOI

      10.1016/j.bmc.2015.05.002

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] A preorganized β-amino acid bearing a guanidinium side chain and its use in cell-penetrating peptides2015

    • Author(s)
      Y. Demizu,* M. Oba, K. Okitsu, H. Yamashita, T. Misawa, M. Doi, M. Tanaka, M. Kurihara, S. H. Gellman
    • Journal Title

      Org. Biomol. Chem.

      Volume: 13 Issue: 20 Pages: 5617-5620

    • DOI

      10.1039/c5ob00389j

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Peptide foldamers composed of six-membered ring α,α-disubstituted α-amino acid with two changeable chiral acetal moieties2015

    • Author(s)
      K. Tanda, R. Eto, K. Kato, M. Oba, A. Ueda, H. Suemune, M. Doi, Y. Demizu, M. Kurihara, M. Tanaka*
    • Journal Title

      Tetrahedron

      Volume: 71 Issue: 23 Pages: 3909-3914

    • DOI

      10.1016/j.tet.2015.04.031

    • NAID

      120006987063

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Amino equatorial effect of a six-membered ring amino acid on its peptide 310- and a-helices2015

    • Author(s)
      Takayuki Hirata, Atsushi Ueda, Makoto Oba, Mitsunobu Doi, Yosuke Demizu, Masaaki Kurihara, Masanobu Nagano, Hiroshi Suemune, Masakazu Tanaka
    • Journal Title

      Tetrahedron

      Volume: 71 Issue: 16 Pages: 2409-2420

    • DOI

      10.1016/j.tet.2015.02.075

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Synthesis of a bis-cationic α,α-disubstituted amino acid (9-amino-bispidine-9-carboxylic acid) and its effects on the conformational properties of peptides2015

    • Author(s)
      H. Yamashita, Y. Demizu,* T. Misawa, T. Shoda, M. Kurihara*
    • Journal Title

      Tetrahedron

      Volume: 71 Issue: 15 Pages: 2241-2245

    • DOI

      10.1016/j.tet.2015.02.076

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Structural development of stapled short helical peptides as vitamin D receptor (VDR)-coactivator interaction inhibitors.2015

    • Author(s)
      T. Misawa, Y. Demizu, M. Kawamura, N. Yamagata, M. Kurihara.
    • Journal Title

      Bioorganic medicinal chemistry

      Volume: 23 Issue: 5 Pages: 1055-1061

    • DOI

      10.1016/j.bmc.2015.01.007

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of D-Leu Residues on the Helical Secondary Structures of L-Leu-Based Nonapeptides2015

    • Author(s)
      Y. Demizu,* H. Yamashita, T. Misawa, M. Doi, M. Tanaka, M. Kurihara*
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 63 Issue: 3 Pages: 218-224

    • DOI

      10.1248/cpb.c14-00760

    • NAID

      130004803775

    • ISSN
      0009-2363, 1347-5223
    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Design, synthesis and anti-HIV-1 activity of 1-aromatic methyl-substituted 3-(3,5-dimethylbenzyl)uracil and N-3,5-dimethylbenzyl-substituted urea derivatives2015

    • Author(s)
      N. Sakakibara,* M. Baba, M. Okamoto, M. Toyama, Y. Demizu, T. Misawa, M. Kurihara, K. Irie, Y. Kato, T. Maruyama
    • Journal Title

      Antiviral Chem. Chemother.

      Volume: 24 Issue: 1 Pages: 3-18

    • DOI

      10.1177/2040206614566584

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] 短鎖ペプチドのヘリカル構造制御と機能化2015

    • Author(s)
      出水庸介*,三澤隆史,栗原正明*
    • Journal Title

      有機合成化学協会誌

      Volume: 72 Pages: 1336-1359

    • NAID

      130004749130

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Development of cell-penetrating R7 fragment-conjugated helical peptides as inhibitors of estrogen receptor-mediated transcription.2014

    • Author(s)
      2.Nagakubo, T., Demizu, Y., Kanda, Y., Misawa, T., Shoda, T., Okuhira, K., Sekino., Y., Naito, M. and Kurihara, M
    • Journal Title

      Bioconjug Chem.

      Volume: 25 Issue: 11 Pages: 1921-24

    • DOI

      10.1021/bc500480e

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Conformational studies on peptides having chiral five-membered ring amino acid with two azido or triazole functional groups within the sequence of Aib residues2014

    • Author(s)
      Makoto Oba, Naomi Kawabe, Hiroomi Takazaki, Yosuke Demizu, Mitsunobu Doi, Masaaki Kurihara, Hiroshi Suemune, Masakazu Tanaka
    • Journal Title

      Tetrahedron

      Volume: 70 Issue: 46 Pages: 8900-8907

    • DOI

      10.1016/j.tet.2014.09.086

    • NAID

      120006987171

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Helical Peptide-Foldamers Having a Chiral Five-Membered Ring Amino Acid with Two Azido Functional Groups2014

    • Author(s)
      Makoto Oba, Hiroomi Takazaki, Naomi Kawabe, Mitsunobu Doi, Yosuke Demizu, Masaaki Kurihara, Hiromu Kawakubo, Masanobu Nagano, Hiroshi Suemune, and Masakazu Tanaka
    • Journal Title

      The Journal of Organic Chemistry

      Volume: 79 Issue: 19 Pages: 9125-9140

    • DOI

      10.1021/jo501493x

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] NAD-dependent isocitrate dehydrogenase as a novel target of tributyltin in human embryonic carcinoma cells.2014

    • Author(s)
      Yamada S, Kotake Y, Demizu Y, Kurihara M, Sekino Y, Kanda Y.
    • Journal Title

      Scientific Reports

      Volume: 4 Issue: 1 Pages: 5952-5952

    • DOI

      10.1038/srep05952

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Amphipathic short helix-stabilized peptides with cell-membrane penetrating ability2014

    • Author(s)
      Hiroko Yamashita, Yosuke Demizu, Takuji Shoda, Yukiko Sato, Makoto Oba, Masakazu Tanaka, Masaaki Kurihara
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 22 Issue: 8 Pages: 2403-2408

    • DOI

      10.1016/j.bmc.2014.03.005

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Design and synthesis of tamoxifen derivatives as a selective estrogen receptor down-regulator.2014

    • Author(s)
      Shoda, T., Okuhira, K., Kato, M., Demizu, Y., Inoue, H., Naito, M., and Kurihara, M.
    • Journal Title

      Bioorg Med Chem Lett

      Volume: 24 Issue: 1 Pages: 87-89

    • DOI

      10.1016/j.bmcl.2013.11.078

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Isoheleproline: a new amino acid-sesquiterpene adduct from Inula helenium2014

    • Author(s)
      K. Zaima, D. Wakana, Y. Demizu, Y. Kumeta, H. Kamakura, T. Maruyama, M. Kurihara, Y. Goda*
    • Journal Title

      J. Nat. Med.

      Volume: 68 Issue: 2 Pages: 432-435

    • DOI

      10.1007/s11418-013-0806-8

    • NAID

      40020023355

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] 短鎖ペプチドのヘリカル構造制御と機能化2014

    • Author(s)
      出水庸介*
    • Journal Title

      ペプチドニュースレター

      Volume: 94 Pages: 3-7

    • NAID

      130004749130

    • Related Report
      2014 Research-status Report
    • Acknowledgement Compliant
  • [Presentation] タンパク質の寿命を制御できる分子の開発2018

    • Author(s)
      出水庸介
    • Organizer
      生体分子コバレント修飾の革新的解析拠点形成シンポジウム(招待講演)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 種々の側鎖官能基を有する環状α,α-ジ置換アミノ酸の合成と含有ペプチドの機能評価2018

    • Author(s)
      辻厳一郎,小林寛幸,三澤隆史,木下恵愛,松野研司,出水庸介
    • Organizer
      日本薬学会第138回年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 多様な官能基修飾を志向したヘリカルテンプレートペプチドの開発2018

    • Author(s)
      三澤隆史,諫田泰成,出水庸介
    • Organizer
      日本薬学会第138回年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] LC-CDを用いた危険ドラッグMethylphenidate類似体のキラル分析2018

    • Author(s)
      河村麻衣子,三澤隆史,出水庸介,花尻瑠理,袴塚高志
    • Organizer
      日本薬学会第138回年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] グアニンPNAモノマーの新規カチオン性アナログ2018

    • Author(s)
      杉山亨,小原美咲,桑田啓子,今村保忠,出水庸介,栗原正明,橘高敦史
    • Organizer
      日本薬学会第138回年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 側鎖上にキラルなアセタールを有する4員環状ジ置換アミノ酸よりなるペプチドの二次構造解析2018

    • Author(s)
      江藤諒,大庭誠,上田篤志,土井光暢,出水庸介,栗原正明,宇久翼,田中正一
    • Organizer
      日本薬学会第138回年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] キラルな3員環状アミノ酸の合成と含有ペプチドのコンフォメーション解析2018

    • Author(s)
      古場百合恵,池田光生,上田篤志,大庭誠,出水庸介,土井光暢,田中正一
    • Organizer
      日本薬学会第138回年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Development of helical cell penetrating peptides using non-proteinogenic amino acids2017

    • Author(s)
      Yamashita, H., Misawa, M., Kurihara, M., Demizu, Y.
    • Organizer
      Lindau Nobel Laureate Meetings 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 芳香族炭化水素受容体ユビキチンリガーゼをリクルートする新しいプロテインノックダウン化合物の開発2017

    • Author(s)
      大岡伸通,正田卓司,藤里卓磨,柴田識人,服部隆行,栗原正明,出水庸介,内藤幹彦
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBio2017)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 側鎖に不斉中心を有する三員環状ジ置換アミノ酸とそのペプチドの合成2017

    • Author(s)
      池田光生,古場百合恵,上田篤志,大庭誠,出水庸介,栗原正明,田中正一
    • Organizer
      第34回日本薬学会九州支部大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Development of cationic cell-penetrating peptides focused on their secondary structures2017

    • Author(s)
      小林寛幸,三澤隆史,大庭誠,田中正一,内藤幹彦,松野研司,出水庸介
    • Organizer
      第54回ペプチド討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Development of post functionalizable oligopeptides as helical templates2017

    • Author(s)
      三澤隆史,出水庸介
    • Organizer
      第54回ペプチド討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Peptide foldamers changing their conformations in response to low pH trigger2017

    • Author(s)
      古川かほり,大庭誠,遠山琴美,George Ouma Opiyo,出水庸介,栗原正明,土井光暢,田中正一
    • Organizer
      第54回ペプチド討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Synthesis of chiral three-membered ring α,α-disubstituted α-amino acid and conformational analysis of its peptides2017

    • Author(s)
      古場百合恵,池田光生,上田篤志,大庭誠,出水庸介,土井光暢,田中正一
    • Organizer
      第54回ペプチド討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Peptide nucleic acid possessing PreQ1 as a cationic analogue of guanine2017

    • Author(s)
      杉山亨,小原美咲,桑田啓子,今村保忠,出水庸介,栗原正明,高野真史,橘高敦史
    • Organizer
      第54回ペプチド討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 二次構造制御に基づくペプチド創薬研究2017

    • Author(s)
      出水庸介,三澤隆史,栗原正明
    • Organizer
      第43回反応と合成の進歩シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] Post-modification可能なα,α-ジ置換アミノ酸の合成と含有ペプチドの二次構造解析2017

    • Author(s)
      小林寛幸,三澤隆史,松野研司,出水庸介
    • Organizer
      第43回反応と合成の進歩シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 側鎖上にのみ不斉中心を持つ4員環状アミノ酸よりなるペプチドのヘリックス二次構造2017

    • Author(s)
      江藤諒,大庭誠,上田篤志,土井光暢,出水庸介,栗原正明,宇久翼,田中正一
    • Organizer
      第43回反応と合成の進歩シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 二次構造に着目したカチオン性膜透過ペプチドの創製研究2017

    • Author(s)
      小林寛幸,三澤隆史,大庭誠,田中正一,内藤幹彦,松野研司,出水庸介
    • Organizer
      第34回メディシナルケミストリーシンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 低pHに応答して二次構造を変化させるペプチドフォルダマーの開発2017

    • Author(s)
      大庭誠,古川かほり,遠山琴美,George Ouma Opiyo,出水庸介,栗原正明,土井光暢,田中正一
    • Organizer
      第34回メディシナルケミストリーシンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 小員環状ジ置換アミノ酸を用いたヘリカル二次構造の制御に関する研究2017

    • Author(s)
      古場百合恵,上田篤志,大庭誠,出水庸介,土井光暢,田中正一
    • Organizer
      第34回メディシナルケミストリーシンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 正電荷を帯びたグアニン誘導体をもつPNAの合成2017

    • Author(s)
      杉山亨,小原美咲,桑田啓子,今村保忠,出水庸介,栗原正明,橘高敦史
    • Organizer
      第34回メディシナルケミストリーシンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] カチオン性プロリン誘導体を含む細胞膜高透過性ペプチドの開発2017

    • Author(s)
      小林寛幸,三澤隆史,大庭誠,田中正一,内藤幹彦,松野研司,出水庸介
    • Organizer
      第47回複素環化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 芳香族炭化水素受容体ユビキチンリガーゼをリクルートする新しいプロテインノックダウン化合物の開発2017

    • Author(s)
      大岡伸通,正田卓司,藤里卓磨,柴田識人,服部隆行,栗原正明,出水庸介,内藤幹彦
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] カチオン性プロリン誘導体を導入した細胞膜透過性ペプチドの開発2017

    • Author(s)
      小林寛幸,三澤隆史,内藤幹彦,出水庸介
    • Organizer
      第61回日本薬学会関東支部大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 多様な生理活性付与を志向した安定化ヘリカルテンプレートペプチドの開発2017

    • Author(s)
      三澤隆史,出水庸介
    • Organizer
      第61回日本薬学会関東支部大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] カチオン性プロリン誘導体を含む細胞膜透過性ペプチドの開発2017

    • Author(s)
      小林寛幸,三澤隆史,松野研司,出水庸介
    • Organizer
      第49回若手ペプチド夏の勉強会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ジフェニルメタンを基本骨格とするリガンドの創製2017

    • Author(s)
      栗原正明,三澤隆史,出水庸介
    • Organizer
      第3回Neo Vitamin D Workshop
    • Related Report
      2017 Annual Research Report
  • [Presentation] コンピュータシミュレーションによる違法薬物の活性予測に関する研究2017

    • Author(s)
      出水庸介,田中理恵,袴塚高志,栗原正明,花尻瑠理
    • Organizer
      日本法中毒学会第36回年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 二次構造制御を基盤とした膜透過性ペプチドの開発2017

    • Author(s)
      三澤隆史,小林寛幸,大庭誠,田中正一,栗原正明,出水庸介
    • Organizer
      第33回日本DDS学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] キラルな三員環状ジ置換アミノ酸とそのペプチドの合成2017

    • Author(s)
      古場百合恵,池田光生,上田篤志,大庭誠,出水庸介,栗原正明,田中正一
    • Organizer
      第54回化学関連支部合同九州大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヘリカルペプチドを用いたビタミンD受容体(VDR)―コアクチベータ相互作用阻害剤の創製2017

    • Author(s)
      三澤隆史,出水庸介,栗原正明
    • Organizer
      日本ビタミン学会第69回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Hisタグ融合タンパク質分解誘導分子の設計と合成2017

    • Author(s)
      沖津航陽,服部隆行,三澤隆史,栗原正明,内藤幹彦,出水庸介
    • Organizer
      ケミカルバイオロジー第12回年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 親水性分子の細胞内導入を志向した細胞膜高透過性ペプチドの開発2017

    • Author(s)
      三澤隆史,大岡伸通,大庭誠,田中正一,内藤幹彦,栗原正明,出水庸介
    • Organizer
      第15回次世代を担う有機化学シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 二次構造制御を基軸とした膜透過ペプチドの創製研究2016

    • Author(s)
      出水庸介,三澤隆史,山下博子,大庭誠,田中正一,内藤幹彦,栗原正明
    • Organizer
      第33回メディシナルケミストリーシンポジウム
    • Place of Presentation
      つくば
    • Year and Date
      2016-11-25
    • Related Report
      2016 Research-status Report
  • [Presentation] Hisタグ融合タンパク質分解誘導分子の開発2016

    • Author(s)
      出水庸介,沖津航陽,服部隆行,三澤隆史,内藤幹彦,栗原正明
    • Organizer
      第42回反応と合成の進歩シンポジウム
    • Place of Presentation
      静岡
    • Year and Date
      2016-11-07
    • Related Report
      2016 Research-status Report
  • [Presentation] 側鎖にグアニジノ基を有するプロリン誘導体の合成と細胞膜透過性ペプチドへの応用2016

    • Author(s)
      出水庸介,小林寛幸,山下博子,三澤隆史,大庭誠,田中正一,松野研司,栗原正明
    • Organizer
      第46回複素環化学討論会
    • Place of Presentation
      金沢
    • Year and Date
      2016-09-26
    • Related Report
      2016 Research-status Report
  • [Presentation] Development of helix-stabilized cell-penetrating peptides as an intracellular delivery tool2016

    • Author(s)
      Demizu, Y., Yamashita, H., Misawa, T., Oba, M., Tanaka, M., Kurihara, M.
    • Organizer
      34th European Peptide Symposium & 8th International Peptide Symposium
    • Place of Presentation
      Germany
    • Year and Date
      2016-09-04
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 核内受容体を標的とした転写活性化阻害および分解誘導ペプチドの開2016

    • Author(s)
      出水庸介
    • Organizer
      第48回若手ペプチド夏の勉強会
    • Place of Presentation
      東京
    • Year and Date
      2016-07-31
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] ペプチド二次構造制御に基づく細胞膜高透過性ペプチドの創製2016

    • Author(s)
      出水庸介,山下博子,加藤巧馬,大岡伸通,三澤隆史,服部隆行,田中正一,内藤幹彦,大庭誠,栗原正明
    • Organizer
      ケミカルバイオロジー第11回年会
    • Place of Presentation
      京都
    • Year and Date
      2016-06-15
    • Related Report
      2016 Research-status Report
  • [Presentation] ペプチド二次構造制御に基づく細胞膜高透過性ペプチドの開発2016

    • Author(s)
      出水庸介,山下博子,三澤隆史,大庭誠,田中正一,栗原正明
    • Organizer
      第14回次世代を担う有機化学シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2016-05-27
    • Related Report
      2016 Research-status Report
  • [Presentation] エストロゲン受容体分解誘導ペプチドの創製2016

    • Author(s)
      出水庸介,大岡伸通,三澤隆史,内藤幹彦,栗原正明
    • Organizer
      日本薬学会第136回年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-27
    • Related Report
      2015 Research-status Report
  • [Presentation] ヘリカルプロモーター導入によるオリゴアルギニンの構造制御と膜透過能への効果2016

    • Author(s)
      三澤隆史,山下博子,加藤巧馬,服部隆行,大庭誠,田中正一,内藤幹彦,出水庸介,栗原正明
    • Organizer
      日本薬学会第136回年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-27
    • Related Report
      2015 Research-status Report
  • [Presentation] 環境応答型二次構造変化を利用した細胞膜高透過性ペプチドの開発2016

    • Author(s)
      山下博子,出水庸介,加藤巧馬,大岡伸通,三澤隆史,服部隆行,田中正一,内藤幹彦,大庭誠,栗原正明
    • Organizer
      日本薬学会第136回年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-27
    • Related Report
      2015 Research-status Report
  • [Presentation] Hisタグタンパク質分解誘導分子の開発2016

    • Author(s)
      沖津航陽,服部隆行,出水庸介,三澤隆史,正田卓司,内藤幹彦,栗原正明
    • Organizer
      日本薬学会第136回年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-27
    • Related Report
      2015 Research-status Report
  • [Presentation] 二次構造制御に基づく抗菌ペプチドフォルダマーの開発2016

    • Author(s)
      小澤佑斗,出水庸介,三澤隆史,菊池裕,栗原正明
    • Organizer
      日本薬学会第136回年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-27
    • Related Report
      2015 Research-status Report
  • [Presentation] エストロゲン受容体分解活性を有するラロキシフェン誘導体の開発2016

    • Author(s)
      正田卓司,加藤雅士,藤里卓磨,三澤隆史,出水庸介,井上英史,内藤幹彦,栗原正明
    • Organizer
      日本薬学会第136回年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-27
    • Related Report
      2015 Research-status Report
  • [Presentation] エチレンアセタールを有するキラル5員環アミノ酸を含有するペプチドのヘリカル二次構造2016

    • Author(s)
      古場百合恵,上田篤志,大庭誠,土井光暢,出水庸介,栗原正明,田中正一
    • Organizer
      日本薬学会第136回年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-27
    • Related Report
      2015 Research-status Report
  • [Presentation] デアザグアニン誘導体を持つPNAの合成2016

    • Author(s)
      杉山亨,桑田啓子,今村保忠,出水庸介,栗原正明,高野真史,橘高敦史
    • Organizer
      日本薬学会第136回年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-27
    • Related Report
      2015 Research-status Report
  • [Presentation] Protein knockdown by SNIPER compounds: Application for basic research and cancer therapy2016

    • Author(s)
      Naito, M., Hattori, T., Ohoka, N., Shibata, N., Shoda, T., Demizu, Y., Kurihara, M.
    • Organizer
      The 10th AACR-JCA Joint Conference
    • Place of Presentation
      Hawaii
    • Year and Date
      2016-02-16
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Structural development of stapled short helical peptides as vitamin D receptor (VDR)-coactivator interaction inhibitors2015

    • Author(s)
      Misawa, T., Demizu, Y., Kurihara, M.
    • Organizer
      PACIFICHEM 2015
    • Place of Presentation
      Hawaii
    • Year and Date
      2015-12-15
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Design, synthesis and evaluation of tamoxifen derivatives as new selective estrogen receptor down-regulators2015

    • Author(s)
      Shoda, T., Kato, M., Okuhira, K., Demizu, Y., Inoue, H., Naito, M., Kurihara, M.
    • Organizer
      PACIFICHEM 2015
    • Place of Presentation
      Hawaii
    • Year and Date
      2015-12-15
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] ノンセコステロイド型VDRリガンドによるATRA耐性急性前骨髄球性白血病細胞の分化誘導2015

    • Author(s)
      野尻久雄,村田拓哉,橘高敦史,出水庸介,三澤隆史,栗原正明
    • Organizer
      第36回日本臨床薬理学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2015-12-09
    • Related Report
      2015 Research-status Report
  • [Presentation] エストロゲン受容体を標的とした転写活性化阻害および分解誘導ペプチドの創製2015

    • Author(s)
      出水庸介,三澤隆史,諫田泰成,大岡伸通,関野祐子,内藤幹彦,栗原正明
    • Organizer
      第33回メディシナルケミストリーシンポジウム
    • Place of Presentation
      千葉
    • Year and Date
      2015-11-25
    • Related Report
      2015 Research-status Report
  • [Presentation] ノンセコステロイド型ビタミンD受容体リガンドの創製―官能基変換による活性制御―2015

    • Author(s)
      三澤隆史,依岡桃子,出水庸介,谷内出友美,大岡伸通,木下恵愛,野尻久雄,橘高敦史,槇島誠,内藤幹彦,栗原正明
    • Organizer
      第33回メディシナルケミストリーシンポジウム
    • Place of Presentation
      千葉
    • Year and Date
      2015-11-25
    • Related Report
      2015 Research-status Report
  • [Presentation] エストロゲン受容体転写阻害剤および分解誘導剤の創製2015

    • Author(s)
      依岡桃子,三澤隆史,出水庸介,大岡伸通,諫田泰成,槇島誠,南雲紳史,関野祐子,内藤幹彦,栗原正明
    • Organizer
      第33回メディシナルケミストリーシンポジウム
    • Place of Presentation
      千葉
    • Year and Date
      2015-11-25
    • Related Report
      2015 Research-status Report
  • [Presentation] ラロキシフェン骨格を有する新規エストロゲン受容体分解誘導剤の開発2015

    • Author(s)
      正田卓司,加藤雅士,藤里卓磨,三澤隆史,出水庸介,井上英史,内藤幹彦,栗原正明
    • Organizer
      第33回メディシナルケミストリーシンポジウム
    • Place of Presentation
      千葉
    • Year and Date
      2015-11-25
    • Related Report
      2015 Research-status Report
  • [Presentation] 修飾デアザグアニン含有PNAオリゴマーの合成2015

    • Author(s)
      杉山亨,桑田啓子,今村保忠,出水庸介,栗原正明,高野真史,橘高敦史
    • Organizer
      第33回メディシナルケミストリーシンポジウム
    • Place of Presentation
      千葉
    • Year and Date
      2015-11-25
    • Related Report
      2015 Research-status Report
  • [Presentation] 血管新生促進作用を有する新規2-クロル炭素環オキセタノシンA(COA-Cl)誘導体の創製2015

    • Author(s)
      榊原紀和,五十嵐淳介,高田麻紀,出水庸介,三澤隆史,栗原正明,小西良士,加藤善久,丸山徳見,塚本郁子
    • Organizer
      第33回メディシナルケミストリーシンポジウム
    • Place of Presentation
      千葉
    • Year and Date
      2015-11-25
    • Related Report
      2015 Research-status Report
  • [Presentation] グアニジノ基を有する環状アミノ酸の合成と細胞膜透過性ペプチドへの応用2015

    • Author(s)
      出水庸介,山下博子,三澤隆史,大庭誠,田中正一,栗原正明
    • Organizer
      第45回複素環化学討論会
    • Place of Presentation
      東京
    • Year and Date
      2015-11-19
    • Related Report
      2015 Research-status Report
  • [Presentation] 2-クロル炭素環オキセタノシンA (COA-Cl)の新規誘導体の合成とその血管新生促進作用2015

    • Author(s)
      榊原紀和,五十嵐淳介,高田麻紀,出水庸介,三澤隆史,栗原正明,小西良士,加藤善久,丸山徳見,塚本郁子
    • Organizer
      第45回複素環化学討論会
    • Place of Presentation
      東京
    • Year and Date
      2015-11-19
    • Related Report
      2015 Research-status Report
  • [Presentation] Development of helical peptide as inhibitors of estrogen receptor-mediated transcription2015

    • Author(s)
      出水庸介,三澤隆史,諫田泰成,大岡伸通,関野祐子,内藤幹彦,栗原正明
    • Organizer
      第52回ペプチド討論会
    • Place of Presentation
      神奈川
    • Year and Date
      2015-11-16
    • Related Report
      2015 Research-status Report
  • [Presentation] Design and synthesis of short helical peptides as vitamin D receptor (VDR)-coactivator interaction inhibitors2015

    • Author(s)
      三澤隆史,出水庸介,栗原正明
    • Organizer
      第52回ペプチド討論会
    • Place of Presentation
      神奈川
    • Year and Date
      2015-11-16
    • Related Report
      2015 Research-status Report
  • [Presentation] Development of helix-stabilized cationic peptides with cell-membrane penetrating ability2015

    • Author(s)
      山下博子,出水庸介,三澤隆史,服部隆行,大庭誠,田中正一,内藤幹彦,栗原正明
    • Organizer
      第52回ペプチド討論会
    • Place of Presentation
      神奈川
    • Year and Date
      2015-11-16
    • Related Report
      2015 Research-status Report
  • [Presentation] Development of His-tag fused protein degradation inducer based on protein knockdown strategy2015

    • Author(s)
      沖津航陽,服部隆行,出水庸介,三澤隆史,正田卓司,内藤幹彦,栗原正明
    • Organizer
      第52回ペプチド討論会
    • Place of Presentation
      神奈川
    • Year and Date
      2015-11-16
    • Related Report
      2015 Research-status Report
  • [Presentation] Conformational analysis of peptides composed of chiral cyclic amino acids2015

    • Author(s)
      古場百合恵,上田篤志,大庭誠,土井光暢,出水庸介,栗原正明,田中正一
    • Organizer
      第52回ペプチド討論会
    • Place of Presentation
      神奈川
    • Year and Date
      2015-11-16
    • Related Report
      2015 Research-status Report
  • [Presentation] Synthesis of PNA oligomers containing modified deazaguanines for the development of functional PNA2015

    • Author(s)
      杉山亨,桑田啓子,今村保忠,出水庸介,栗原正明,高野真史,橘高敦史
    • Organizer
      第52回ペプチド討論会
    • Place of Presentation
      神奈川
    • Year and Date
      2015-11-16
    • Related Report
      2015 Research-status Report
  • [Presentation] Development of stabilized helical peptides and their functionalization2015

    • Author(s)
      Demizu, Y., Misawa, T., Kurihara, M.
    • Organizer
      13th International Kyoto Conference on New Aspects of Organic Chemistry
    • Place of Presentation
      京都
    • Year and Date
      2015-11-09
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 血管新生促進剤を指向した2-クロル炭素環オキセタノシンA(COA-Cl)の新規誘導体の創製研究2015

    • Author(s)
      榊原紀和,五十嵐淳介,高田麻紀,出水庸介,三澤隆史,栗原正明,小西良士,加藤善久,丸山徳見,塚本郁子
    • Organizer
      第54回薬学会中国四国支部学術大会
    • Place of Presentation
      高知
    • Year and Date
      2015-10-31
    • Related Report
      2015 Research-status Report
  • [Presentation] 長鎖アルキルを有するノンセコステロイド型VDRリガンドの創製2015

    • Author(s)
      三澤隆史,依岡桃子,出水庸介,大岡伸通,木下恵愛,槇島誠,内藤幹彦,栗原正明
    • Organizer
      第41回反応と合成の進歩シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2015-10-26
    • Related Report
      2015 Research-status Report
  • [Presentation] 細胞膜透過性の向上を指向したカチオン性アミノ酸の合成およびその応用2015

    • Author(s)
      山下博子,出水庸介,三澤隆史,服部隆行,大庭誠,田中正一,内藤幹彦,栗原正明
    • Organizer
      第41回反応と合成の進歩シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2015-10-26
    • Related Report
      2015 Research-status Report
  • [Presentation] Development of cell-penetrating fragment conjugated helical peptides as inhibitors of estrogen receptor-mediated transcription2015

    • Author(s)
      Demizu, Y., Misawa, T., Kanda, Y., Sekino, Y., Kurihara, M.
    • Organizer
      The 11th Australian Peptide Conference 2015
    • Place of Presentation
      Australia
    • Year and Date
      2015-10-25
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Cell-penetrating ability and plasmid DNA delivary using fluorescein-labeled arginine-rich peptides2015

    • Author(s)
      Oba, M., Furukawa, K., Kato, T., Demizu, Y., Yamashita, H., Kurihara, M., Tanaka, M.
    • Organizer
      The 11th Australian Peptide Conference 2015
    • Place of Presentation
      Australia
    • Year and Date
      2015-10-25
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Structure-activity relationship analysis of short helical peptides as VDR-coactivator interaction inhibitors2015

    • Author(s)
      Misawa, T., Demizu, Y., Kurihara, M.
    • Organizer
      第43回構造活性相関シンポジウム,第10回薬物の分子設計と開発に関する日中シンポジウム
    • Place of Presentation
      新潟
    • Year and Date
      2015-09-27
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] コンピュータシミュレーションによる合成カンナビノイドのCB1受容体への結合様式解析2015

    • Author(s)
      出水庸介,三澤隆史,内山奈穂子,花尻瑠理,袴塚高志,栗原正明
    • Organizer
      第59回日本薬学会関東支部大会
    • Place of Presentation
      千葉
    • Year and Date
      2015-09-12
    • Related Report
      2015 Research-status Report
  • [Presentation] ジフェニルメタンを基本骨格とするエストロゲン受容体アンタゴニストの創製2015

    • Author(s)
      田中克哉,三澤隆史,出水庸介,諫田泰成,槇島誠,関野祐子,内藤幹彦,栗原正明
    • Organizer
      第59回日本薬学会関東支部大会
    • Place of Presentation
      千葉
    • Year and Date
      2015-09-12
    • Related Report
      2015 Research-status Report
  • [Presentation] ジフェニルメタンを基本骨格としたエストロゲン受容体転写阻害剤および分解誘導剤の開発2015

    • Author(s)
      依岡桃子,三澤隆史,出水庸介,大岡伸通,槇島誠,南雲紳史,内藤幹彦,栗原正明
    • Organizer
      第59回日本薬学会関東支部大会
    • Place of Presentation
      千葉
    • Year and Date
      2015-09-12
    • Related Report
      2015 Research-status Report
  • [Presentation] 長鎖アルキル基を有するビタミンD受容体リガンドの創製2015

    • Author(s)
      三澤隆史,依岡桃子,出水庸介,大岡伸通,木下恵愛,槇島誠,内藤幹彦,栗原正明
    • Organizer
      第59回日本薬学会関東支部大会
    • Place of Presentation
      千葉
    • Year and Date
      2015-09-12
    • Related Report
      2015 Research-status Report
  • [Presentation] ノンセコステロイド型VDRリガンドの創製2015

    • Author(s)
      三澤隆史,出水庸介,槇島誠,栗原正明
    • Organizer
      第1回Neo Vitamin D Workshop
    • Place of Presentation
      滋賀
    • Year and Date
      2015-08-28
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] エストロゲンによるNOを介した乳癌幹細胞の増殖2015

    • Author(s)
      平田尚也,山田茂,出水庸介,栗原正明,関野祐子,諫田泰成
    • Organizer
      第132回日本薬理学会関東部会
    • Place of Presentation
      千葉
    • Year and Date
      2015-07-04
    • Related Report
      2015 Research-status Report
  • [Presentation] DDSキャリアを指向したカチオン性非天然アミノ酸導入ペプチドの開発2015

    • Author(s)
      山下博子,出水庸介,三澤隆史,大庭誠,田中正一,服部隆行,内藤幹彦,栗原正明
    • Organizer
      第31回日本DDS学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2015-07-02
    • Related Report
      2015 Research-status Report
  • [Presentation] アルギニン含有ペプチドの細胞膜透過性とpDNAデリバリーに関する研究2015

    • Author(s)
      大庭誠,古川かほり,加藤巧馬,山下博子,出水庸介,栗原正明,田中正一
    • Organizer
      第31回日本DDS学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2015-07-02
    • Related Report
      2015 Research-status Report
  • [Presentation] エストロゲン受容体転写活性化阻害能を有するヘリカルペプチドの開発2015

    • Author(s)
      出水庸介,三澤隆史,長久保貴哉,諫田泰成,奥平桂一郎,関野祐子,内藤幹彦,栗原正明
    • Organizer
      ケミカルバイオロジー第10回年会
    • Place of Presentation
      宮城
    • Year and Date
      2015-06-10
    • Related Report
      2015 Research-status Report
  • [Presentation] ヘリカルペプチドを用いたビタミンD受容体(VDR)-コアクチベータ相互作用阻害剤の創製2015

    • Author(s)
      三澤隆史,出水庸介,栗原正明
    • Organizer
      ケミカルバイオロジー第10回年会
    • Place of Presentation
      宮城
    • Year and Date
      2015-06-10
    • Related Report
      2015 Research-status Report
  • [Presentation] Hisタグタンパク質応答性蛍光プローブの開発2015

    • Author(s)
      沖津航陽,出水庸介,三澤隆史,正田卓司,服部隆行,内藤幹彦,栗原正明
    • Organizer
      ケミカルバイオロジー第10回年会
    • Place of Presentation
      宮城
    • Year and Date
      2015-06-10
    • Related Report
      2015 Research-status Report
  • [Presentation] 新規トリアジン誘導体の合成とそれらの抗HIV-1活性評価2015

    • Author(s)
      榊原紀和,Gianfranco Balboni,Cenzo Congiu,Valentina Onnis,出水庸介,三澤隆史,栗原正明,加藤善久,丸山徳見,外山政明,岡本実佳,馬場昌範
    • Organizer
      ケミカルバイオロジー第10回年会
    • Place of Presentation
      宮城
    • Year and Date
      2015-06-10
    • Related Report
      2015 Research-status Report
  • [Presentation] Estrogen induces proliferation of breast cancer stem cells via NO/sGC/cGMP signaling pathway2015

    • Author(s)
      Hirata, N.; Demizu, Y.; Kurihara, M.; Sekino, Y.; Kanda, Y.
    • Organizer
      第13回幹細胞シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2015-05-29
    • Related Report
      2015 Research-status Report
  • [Presentation] エストロゲン受容体転写活性化阻害ペプチドの創製2015

    • Author(s)
      出水庸介,長久保貴哉,三澤隆史,諫田泰成,奥平桂一郎,関野祐子,内藤幹彦,栗原正明
    • Organizer
      日本薬学会第135回年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] カンナビノイド受容体調整薬の設計と合成2015

    • Author(s)
      三澤隆史,出水庸介,船田正彦,栗原正明
    • Organizer
      日本薬学会第135回年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 二次構造制御に基づくカチオン性膜透過ペプチドの開発2015

    • Author(s)
      山下博子, 出水庸介, 三澤隆史, 服部隆行, 大庭誠, 田中正一, 内藤幹彦, 栗原正明
    • Organizer
      日本薬学会第135回年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 細胞内タンパク質に対する蛍光スイッチング機能を持つ小分子プローブの開発2015

    • Author(s)
      沖津航陽,出水庸介,三澤隆史,正田卓司,服部隆行,内藤幹彦,栗原正明
    • Organizer
      日本薬学会第135回年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 非対称ジフェニルメタンを基本骨格とするエストロゲン受容体アンタゴニストの設計と合成2015

    • Author(s)
      田中克哉,依岡桃子,三澤隆史,諫田泰成,関野祐子,出水庸介,栗原正明
    • Organizer
      日本薬学会第135回年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 糖アミノ酸を用いた新規糖質類縁体の合成と抗ウィルス薬への応用2015

    • Author(s)
      岡崎優祐,出水庸介,細谷翼,栗原正明,須原義智
    • Organizer
      日本薬学会第135回年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 三重螺旋構造の安定化を指向したβ-ペプチド導入型コラーゲン模倣物の創製2015

    • Author(s)
      杖本望,出水庸介,百合野翔太郎,中村陽菜,土井麻緒,栗原正明,須原義智
    • Organizer
      日本薬学会第135回年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] アセタールを有するキラル環状ジ置換アミノ酸によるヘリカル二次構造の制御2015

    • Author(s)
      古場百合恵,上田篤志,大庭誠,土井光暢,出水庸介,栗原正明,田中正一
    • Organizer
      日本薬学会第135回年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] D-トレイトール由来のアセタールを有する六員環状ジ置換アミノ酸よりなるペプチドのコンフォメーション解析2015

    • Author(s)
      江藤諒,大庭誠,上田篤志,栗原正明,出水庸介,末宗洋,田中正一
    • Organizer
      日本薬学会第135回年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] リパーゼ触媒を用いた[5]ヘリセン類の速度論的光学分割2015

    • Author(s)
      清水貴士,山本耕介,メイビョウ,出水庸介,栗原正明,末宗洋,臼井一晃
    • Organizer
      日本薬学会第135回年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 3,5-ジメチルベンジル基を有するウラシル誘導体および尿素誘導体の合成とそれらの抗HIV-1活性評価2015

    • Author(s)
      榊原紀和,馬場昌範,岡本実佳,外山政明,出水庸介,三澤隆史,栗原正明,入江晃司,加藤善久,丸山徳見
    • Organizer
      日本薬学会第135回年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] デアザグアニン誘導体を持つPNAモノマーの合成2015

    • Author(s)
      杉山亨,桑田啓子,今村保忠,出水庸介,栗原正明,高野真史,橘高敦史
    • Organizer
      日本薬学会第135回年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] ヘリカルペプチドを用いたエストロゲン受容体転写阻害剤の創製2014

    • Author(s)
      三澤隆史,長久保貴哉,出水庸介,佐藤由紀子,諫田泰成,奥平桂一郎,関野祐子,内藤幹彦,栗原正明
    • Organizer
      第32回メディシナルケミストリーシンポジウム
    • Place of Presentation
      神戸
    • Year and Date
      2014-11-26 – 2014-11-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 生体材料への応用を指向した新規コラーゲン様ペプチドの創製2014

    • Author(s)
      杖本望,出水庸介,百合野翔太郎,小川舞,土井麻緒,中村陽菜,栗原正明,須原義智
    • Organizer
      第32回メディシナルケミストリーシンポジウム
    • Place of Presentation
      神戸
    • Year and Date
      2014-11-26 – 2014-11-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 抗ウィルス薬を目指した新規O-硫酸化多糖類の合成2014

    • Author(s)
      岡崎優祐,出水庸介,細谷翼,川口潤一郎,栗原正明,須原義智
    • Organizer
      第32回メディシナルケミストリーシンポジウム
    • Place of Presentation
      神戸
    • Year and Date
      2014-11-26 – 2014-11-28
    • Related Report
      2014 Research-status Report
  • [Presentation] エストロゲン受容体転写阻害ペプチドの開発2014

    • Author(s)
      出水庸介,長久保貴哉,三澤隆史,佐藤由紀子,諫田泰成,奥平桂一郎,関野祐子,内藤幹彦,栗原正明
    • Organizer
      第40回反応と合成の進歩シンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2014-11-10 – 2014-11-11
    • Related Report
      2014 Research-status Report
  • [Presentation] 二次構造制御に基づく膜透過性ヘリカルペプチドの創製2014

    • Author(s)
      山下博子,出水庸介,三澤隆史,大庭誠,田中正一,栗原正明
    • Organizer
      第40回反応と合成の進歩シンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2014-11-10 – 2014-11-11
    • Related Report
      2014 Research-status Report
  • [Presentation] 環状メチオニンの合成とそのペプチドの二次構造解析2014

    • Author(s)
      小野京,島袋充史,上田篤志,大庭誠,土井光暢,出水庸介,栗原正明,田中正一
    • Organizer
      第40回反応と合成の進歩シンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2014-11-10 – 2014-11-11
    • Related Report
      2014 Research-status Report
  • [Presentation] HIV-1剤を指向した1-置換型ウラシル誘導体および尿素誘導体の創製研究2014

    • Author(s)
      榊原紀和,馬場昌範,岡本実佳,外山政明,出水庸介,三澤隆史,栗原正明,入江晃司,加藤善久,丸山徳見
    • Organizer
      第52回薬学会中国四国支部学術大会
    • Place of Presentation
      愛媛
    • Year and Date
      2014-10-26 – 2014-10-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 短鎖ペプチドのヘリカル構造制御と機能化2014

    • Author(s)
      出水庸介
    • Organizer
      第51回ペプチド討論会
    • Place of Presentation
      徳島
    • Year and Date
      2014-10-22 – 2014-10-24
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Development of stabilized short helical peptides with cell-membrane penetrating ability2014

    • Author(s)
      山下博子,出水庸介,三澤隆史,大庭誠,田中正一,栗原正明
    • Organizer
      第51回ペプチド討論会
    • Place of Presentation
      徳島
    • Year and Date
      2014-10-22 – 2014-10-24
    • Related Report
      2014 Research-status Report
  • [Presentation] Development of cell-permeable peptide for transcriptional inhibitor of estrogen receptor2014

    • Author(s)
      長久保貴哉,出水庸介,三澤隆史,佐藤由紀子,諫田泰成,奥平桂一郎,関野祐子,内藤幹彦,栗原正明
    • Organizer
      第51回ペプチド討論会
    • Place of Presentation
      徳島
    • Year and Date
      2014-10-22 – 2014-10-24
    • Related Report
      2014 Research-status Report
  • [Presentation] Synthesis and conformational analysis of helical oligomers with a changeable chiral acetal moiety2014

    • Author(s)
      江藤諒,大庭誠,上田篤志,石川奈保子,栗原正明,出水庸介,末宗洋,土井光暢,田中正一
    • Organizer
      第51回ペプチド討論会
    • Place of Presentation
      徳島
    • Year and Date
      2014-10-22 – 2014-10-24
    • Related Report
      2014 Research-status Report
  • [Presentation] Modified Deazaguanies for the synthesis of PNA2014

    • Author(s)
      杉山亨,桑田啓子,今村保忠,出水庸介,栗原正明,高野真史,橘高敦史
    • Organizer
      第51回ペプチド討論会
    • Place of Presentation
      徳島
    • Year and Date
      2014-10-22 – 2014-10-24
    • Related Report
      2014 Research-status Report
  • [Presentation] 合成カンナビノイドのCB1受容体に対する結合様式解析に関する研究2014

    • Author(s)
      出水庸介,三澤隆史,内山奈穂子,花尻瑠理,袴塚高志,栗原正明
    • Organizer
      第58回日本薬学会関東支部大会
    • Place of Presentation
      東京
    • Year and Date
      2014-10-04
    • Related Report
      2014 Research-status Report
  • [Presentation] エストロゲン受容体転写阻害能を有するペプチドの創製2014

    • Author(s)
      長久保貴哉,出水庸介,三澤隆史,佐藤由紀子,諫田泰成,奥平桂一郎,関野祐子,内藤幹彦,栗原正明
    • Organizer
      第58回日本薬学会関東支部大会
    • Place of Presentation
      東京
    • Year and Date
      2014-10-04
    • Related Report
      2014 Research-status Report
  • [Presentation] 細胞内Hisタグタンパク質応答性蛍光プローブの開発2014

    • Author(s)
      沖津航陽,出水庸介,三澤隆史,正田卓司,服部隆行,内藤幹彦,栗原正明
    • Organizer
      第58回日本薬学会関東支部大会
    • Place of Presentation
      東京
    • Year and Date
      2014-10-04
    • Related Report
      2014 Research-status Report
  • [Presentation] Conformations of LD-peptides containing equal amounts of L-amino acids, D-amino acids, and achiral α,α-disubstitued amino acids2014

    • Author(s)
      Demizu, Y., Misawa, T., Yamashita, H., Doi, M., Sato, Y., Tanaka, M., Kurihara
    • Organizer
      33rd European Peptide Symposium
    • Place of Presentation
      ブルガリア
    • Year and Date
      2014-08-31 – 2014-09-05
    • Related Report
      2014 Research-status Report
  • [Presentation] Stapled short helical peptides for vitamin D receptor-coactivator interaction inhibitor2014

    • Author(s)
      Kurihara, M., Kawamura, M., Misawa, T., Sato, Y., Demizu, Y.
    • Organizer
      33rd European Peptide Symposium
    • Place of Presentation
      ブルガリア
    • Year and Date
      2014-08-31 – 2014-09-05
    • Related Report
      2014 Research-status Report
  • [Presentation] Helical secondary structures of peptides having chiral cyclic amino acid with two azido functional groups2014

    • Author(s)
      Tanaka, M., Takazaki, H., Kawabe, N., Doi, M., Demizu, Y., Kurihara, M., Suemune, H., Oba, M.
    • Organizer
      33rd European Peptide Symposium
    • Place of Presentation
      ブルガリア
    • Year and Date
      2014-08-31 – 2014-09-05
    • Related Report
      2014 Research-status Report
  • [Presentation] 細胞膜高透過性Tatペプチドミミックの開発2014

    • Author(s)
      出水庸介,三澤隆史,山崎徳和,佐藤由紀子,大庭誠,田中正一,栗原正明
    • Organizer
      第30回日本DDS学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2014-07-30 – 2014-07-31
    • Related Report
      2014 Research-status Report
  • [Presentation] オリゴアルギニンをベースとした細胞膜透過性ヘリカルペプチドの開発2014

    • Author(s)
      山下博子,出水庸介,三澤隆史,大庭誠,田中正一,栗原正明
    • Organizer
      第30回日本DDS学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2014-07-30 – 2014-07-31
    • Related Report
      2014 Research-status Report
  • [Presentation] ヘリカル構造制御に基づく細胞膜高透過性ペプチドの創製2014

    • Author(s)
      出水庸介,三澤隆史,山崎徳和,山下博子,佐藤由紀子,大庭誠,田中正一,栗原正明
    • Organizer
      ケミカルバイオロジー第9回年会
    • Place of Presentation
      大阪
    • Year and Date
      2014-06-12 – 2014-06-13
    • Related Report
      2014 Research-status Report
  • [Presentation] VDR-コアクチベータ結語阻害作用を有するステープルペプチドの創製2014

    • Author(s)
      川村愛,出水庸介,三澤隆史,栗原正明
    • Organizer
      ケミカルバイオロジー第9回年会
    • Place of Presentation
      大阪
    • Year and Date
      2014-06-12 – 2014-06-13
    • Related Report
      2014 Research-status Report
  • [Presentation] 抗HIV-1剤を指向した1-置換型3-(3,5-ジメチルベンジル)ウラシルの創製研究2014

    • Author(s)
      榊原紀和,馬場昌範,岡本実佳,外山政明,出水庸介,栗原正明,入江晃司,加藤善久,丸山徳見
    • Organizer
      ケミカルバイオロジー第9回年会
    • Place of Presentation
      大阪
    • Year and Date
      2014-06-12 – 2014-06-13
    • Related Report
      2014 Research-status Report
  • [Patent(Industrial Property Rights)] 構築物,及び,カーゴ分子を細胞内に輸送する方法2018

    • Inventor(s)
      出水庸介,三澤隆 史,大岡伸通,内藤幹彦
    • Industrial Property Rights Holder
      出水庸介,三澤隆 史,大岡伸通,内藤幹彦
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-000461
    • Filing Date
      2018
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] 細胞膜透過性を有するペプチド,構築物,及び,カーゴ分子を細胞内に輸送する方法2017

    • Inventor(s)
      出水庸介,栗原正明,三澤隆史
    • Industrial Property Rights Holder
      出水庸介,栗原正明,三澤隆史
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017-02-02
    • Related Report
      2016 Research-status Report
    • Overseas
  • [Patent(Industrial Property Rights)] 細胞膜透過性を有するペプチド,構築物,及び,カーゴ分子を細胞内に輸送する方法2016

    • Inventor(s)
      出水庸介,栗原正明,三澤隆史
    • Industrial Property Rights Holder
      出水庸介,栗原正明,三澤隆史
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-018416
    • Filing Date
      2016-02-02
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2019-03-29  

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