Development of stabilized helical peptides as POI degradation inducers

• Project/Area Number: 26460169
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Drug development chemistry
• Research Institution: National Institute of Health Sciences
• Principal Investigator: DEMIZU YOSUKE 国立医薬品食品衛生研究所, 有機化学部, 部長 (90389180)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: アミノ酸 / ペプチド / PPI阻害剤 / 標的タンパク質分解誘導剤 / 細胞膜透過性ペプチド / ヘリカル構造 / ユビキチン-プロテアソームシステム / Hisタグタンパク質 / 膜透過ペプチド / タンパク質分解誘導剤 / プロテインノックダウン / 癌 / 二次構造制御

Outline of Final Research Achievements

Peptide drugs having the advantages of small-molecule medicines and antibodies are attracting attention as new drug discovery seeds. In this study, I developed stabilized helical peptides as POI degradation inducers. Within the period, I succeeded in developing helical peptide-based transcriptional inhibitors and degradation inducers targeting nuclear receptors. I have also developed cell penetrating peptides for efficient delivery of these molecules into cells.

Research Products

• [Journal Article] Rational design and synthesis of post-functionalizable peptide foldamers as helical templates (2017)
  • Author(s): T. Misawa,* Y. Kanda, Y. Demizu*
  • Journal Title: Bioconj. Chem. Volume: 28 Issue: 12 Pages: 3029-3035
  • DOI: 10.1021/acs.bioconjchem.7b00621
  • Peer Reviewed
• [Journal Article] Right-handed and left-handed helical structures with fourteen (R)-chiral centers (2017)
  • Author(s): R. Eto, M. Oba, A. Ueda, T. Uku, M. Doi, Y. Demizu, M. Kurihara, M. Tanaka*
  • Journal Title: Chem. Eur. J. Volume: 23 Issue: 72 Pages: 18120-18124
  • DOI: 10.1002/chem.201705306
  • Peer Reviewed
• [Journal Article] Preorganized cyclic alpha,alpha-disubstituted alpha-amino acids bearing functionalized side chains that act as peptide-helix inducers (2017)
  • Author(s): H. Kobayashi, T. Misawa, K. Matsuno, Y. Demizu*
  • Journal Title: J. Org. Chem. Volume: 82 Issue: 19 Pages: 10722-10726
  • DOI: 10.1021/acs.joc.7b01946
  • Peer Reviewed
• [Journal Article] Development of a peptide-based inducer of protein degradation targeting NOTCH1 (2017)
  • Author(s): Ohoka N, Misawa T, Kurihara M, Demizu Y, Naito M.
  • Journal Title: Bioorg Med Chem Lett. Volume: 27 Issue: 22 Pages: 4985-4988
  • DOI: 10.1016/j.bmcl.2017.10.011
  • Peer Reviewed
• [Journal Article] Simple and efficient knockdown of His-tagged proteins by ternary molecules consist of His-tag ligand, ubiquitin ligase ligand and cell penetrating peptide (2017)
  • Author(s): T. Hattori, K. Okitsu, N. Yamazaki, N. Ohoka, N. Shibata, T. Misawa, M. Kurihara, Y. Demizu,* M. Naito*
  • Journal Title: Bioorg. Med. Chem. Lett. Volume: 27 Issue: 18 Pages: 4478-4481
  • DOI: 10.1016/j.bmcl.2017.08.001
  • Peer Reviewed
• [Journal Article] Development of helix-stabilized antimicrobial peptides composed of lysine and hydrophobic alpha,alpha-disubstituted alpha-amino acid residues (2017)
  • Author(s): T. Misawa, M. Imamura, Y. Ozawa, K. Haishima, M. Kurihara, Y. Kikuchi,* Y. Demizu*
  • Journal Title: Bioorg. Med. Chem. Lett. Volume: 27 Issue: 17 Pages: 3950-3953
  • DOI: 10.1016/j.bmcl.2017.07.074
  • Peer Reviewed
• [Journal Article] PNA monomers fully compatible with standard Fmoc-based solid-phase synthesis of pseudocomplementary PNA (2017)
  • Author(s): Toru Sugiyama, Genki Hasegawa, Chie Niikura, Keiko Kuwata, Yasutada Imamura, Yosuke Demizu, Masaaki Kurihara, and Atsushi Kittaka
  • Journal Title: Bioorg. Med. Chem. Lett. Volume: 27 (15) Issue: 15 Pages: 3337-3341
  • DOI: 10.1016/j.bmcl.2017.06.015
  • Peer Reviewed
• [Journal Article] Low pH-responsive change in side chain structure of an amino acid from cyclic acetal to acyclic diol leads to conformational change in a peptide from a helical to random structure (2017)
  • Author(s): K. Furukawa, M. Oba,* K. Toyama, G. O. Opiyo, Y. Demizu, M. Kurihara, M. Doi, M. Tanaka*
  • Journal Title: Org. Biomol. Chem. Volume: 15 Issue: 30 Pages: 6302-6305
  • DOI: 10.1039/c7ob01374d
  • Peer Reviewed
• [Journal Article] Helical L-Leu-based peptides having chiral five-membered carbocyclic ring amino acids with an ethylene acetal moiety (2017)
  • Author(s): Y. Koba, A. Ueda, M. Oba, M. Doi, Y. Demizu, M. Kurihara, M. Tanaka*
  • Journal Title: ChemistrySelect Volume: 2 Issue: 26 Pages: 8108-8114
  • DOI: 10.1002/slct.201700832
  • NAID: 120006988059
  • Peer Reviewed
• [Journal Article] Development of an ON/OFF switchable fluorescent probe targeting His tag fused proteins in living cells (2017)
  • Author(s): Okitsu K, Misawa T, Shoda T, Kurihara M, Demizu Y.
  • Journal Title: Bioorg Med Chem Lett. Volume: 27 Issue: 15 Pages: 3417-3422
  • DOI: 10.1016/j.bmcl.2017.05.087
  • Peer Reviewed
• [Journal Article] Efficient synthesis of a multi-substituted diphenylmethane skeleton as a steroid mimetic (2017)
  • Author(s): takashi misawa, katsuya tanaka, yosuke demizu, masaaki kurihara
  • Journal Title: bioorganic medicinal chemistry letter Volume: 印刷中 Issue: 11 Pages: 2590-2593
  • DOI: 10.1016/j.bmcl.2017.03.066
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Tamoxifen and fulvestrant hybrid showed potency as a selective estrogen receptor down-regulator (2017)
  • Author(s): Takuji Shoda, Masashi Kato, Takuma Fujisato, Yosuke Demizu, Hideshi Inoue, Mikihiko Naito, Masaaki Kurihara
  • Journal Title: Med. Chem. Volume: 13 Issue: 3 Pages: 206-213
  • DOI: 10.2174/1573406412666160805101408
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Development of helix-stabilized cell-penetrating peptides containing cationic α,α-disubstituted amino acids as helical promoters. (2017)
  • Author(s): Yamashita H, Misawa T, Oba M, Tanaka M, Naito M, Kurihara M, Demizu Y.
  • Journal Title: Bioorg Med Chem. Volume: 25(6) Issue: 6 Pages: 1846-1851
  • DOI: 10.1016/j.bmc.2017.01.044
  • Peer Reviewed
• [Journal Article] Targeted Degradation of Proteins Localized in Subcellular Compartments by Hybrid Small Molecules. (2017)
  • Author(s): Okuhira, K., Shoda, T., Omura, R., Ohoka, N., Hattori, T., Shibata, N., Demizu, Y., Sugihara, R., Ichino, A., Kawahara, H., Itoh, Y., Ishikawa, M., Hashimoto, Y., Kurihara, M., Itoh, S., Saito, H. & Naito, M.
  • Journal Title: Mol pharmacol Volume: 91 Issue: 3 Pages: 159-166
  • DOI: 10.1124/mol.116.105569
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Design and synthesis of novel selective estrogen receptor degradation inducers based on diphenylheptane skeleton (2017)
  • Author(s): T. Misawa, T. Fujisato, Y. Kanda, N. Ohoka, T. Shoda, M. Yorioka, M. Makishima, Y. Sekino, M. Naito, Y. Demizu, Masaaki Kurihara
  • Journal Title: MedChemComm Volume: 8 Issue: 1 Pages: 239-246
  • DOI: 10.1039/c6md00553e
  • Peer Reviewed
• [Journal Article] Influence of L-Leu to D-Leu replacement on the helical secondary structures of L-Leu-Aib-based dodecapeptides (2016)
  • Author(s): Y. Demizu,* K. Okitsu, M. Doi, T. Misawa, M. Oba, M. Tanaka, M. Kurihara*
  • Journal Title: ChemistrySelect Volume: 1 Issue: 18 Pages: 5805-5811
  • DOI: 10.1002/slct.201601493
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Development of BCR-ABL degradation inducers via the conjugation of an imatinib derivative and a cIAP1 ligand. (2016)
  • Author(s): Demizu, Y., Shibata, N., Hattori, T., Ohoka, N., Motoi, H., Misawa, T., Shoda, T., Naito, M. & Kurihara, M.
  • Journal Title: Bioorg Med Chem Lett Volume: 26 Issue: 20 Pages: 4865-4869
  • DOI: 10.1016/j.bmcl.2016.09.041
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Helical structures of homo-chiral isotope-labeled alpha-aminoisobutyric acid peptides (2016)
  • Author(s): A. Ueda, M. Oba, Y. Izumi, Y. Sueyoshi, M. Doi, Y. Demizu, M. Kurihara, M. Tanaka*
  • Journal Title: Tetrahedron Volume: 39 Issue: 39 Pages: 5864-5871
  • DOI: 10.1016/j.tet.2016.08.011
  • Peer Reviewed
• [Journal Article] Development of a Cell-penetrating Peptide that Exhibits Responsive Changes in its Secondary Structure in the Cellular Environment (2016)
  • Author(s): H. Yamashita, T. Kato, M. Oba, T. Misawa, T. Hattori, N. Ohoka, M. Tanaka, M. Naito, M. Kurihara, Y. Demizu
  • Journal Title: Scientific Reports Volume: 6 Issue: 1 Pages: 33003-33003
  • DOI: 10.1038/srep33003
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] The side-chain hydroxy groups of a cyclic alpha,alpha-disubstituted alpha-amino acid promote oligopeptide helix packing in the crystalline state (2016)
  • Author(s): Y. Demizu,* M. Doi, H. Yamashita, T. Misawa, M. Oba, M. Kurihara, H. Suemune, M. Tanaka
  • Journal Title: Biopolymers (Pept. Sci.) Volume: 106 Issue: 5 Pages: 757-768
  • DOI: 10.1002/bip.22881
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Identification of embryonic precursor cells that differentiate into thymic epithelial cells expressing autoimmune regulator. (2016)
  • Author(s): Akiyama N, Takizawa N, Miyauchi M, Yanai H, Tateishi R, Shinzawa M, Yoshinaga R, Kurihara M, Demizu Y, Yasuda H, Yagi S, Wu G, Matsumoto M, Sakamoto R, Yoshida N, Penninger JM, Kobayashi Y, Inoue J, Akiyama T.
  • Journal Title: The Journal of Experimental Medicine Volume: 213 Issue: 8 Pages: 1441-1458
  • DOI: 10.1084/jem.20151780
  • NAID: 120006532434
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Synthesis of chiral five-membered carbocyclic ring amino acids with an acetal moiety and helical conformations of its homo-chiral homopeptide (2016)
  • Author(s): Y. Koba, Y. Hirata, A. Ueda, M. Oba, M. Doi, Y. Demizu, M. Kurihara, M. Tanaka
  • Journal Title: Biopolymers (Pept.Sci.) Volume: 印刷中 Issue: 4 Pages: 555-562
  • DOI: 10.1002/bip.22769
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Peptide Nucleic Acid with a Lysine Side Chain at the β-Position: Synthesis and Application for DNA Cleavage (2016)
  • Author(s): Toru Sugiyama, Keiko Kuwata, Yasutada Imamura, Yosuke Demizu, Masaaki Kurihara, Masashi Takano, and Atsushi Kittaka
  • Journal Title: Chemical and Pharmaceutical Bulletin Volume: 64 Issue: 7 Pages: 817-823
  • DOI: 10.1248/cpb.c16-00191
  • NAID: 130005160035
  • ISSN: 0009-2363, 1347-5223
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Synthesis and evaluation of raloxifene derivatives as a selective estrogen receptor down-regulator (2016)
  • Author(s): Takuji Shoda, Masashi Kato, Takuma Fujisato, Takashi Misawa, Yosuke Demizu, Hideshi Inoue, Mikihiko Naito, Masaaki Kurihara
  • Journal Title: Bioorg. Med. Chem. Volume: 24 Issue: 13 Pages: 2914-2919
  • DOI: 10.1016/j.bmc.2016.04.068
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] alpha-Helical structures of oligopeptides with alternating L-Leu-Aib segment (2016)
  • Author(s): Y. Demizu,* K. Okitsu, H. Yamashita, M. Doi, T. Misawa, M. Oba, M. Tanaka, M. Kurihara*
  • Journal Title: Eur. J. Org. Chem. Volume: XX Issue: 16 Pages: 2815-2820
  • DOI: 10.1002/ejoc.201600327
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Plasmid DNA delivery by arginine-rich cell-penetrating peptides containing unnatural amino acids (2016)
  • Author(s): T. Kato, H. Yamashita, T. Misawa, K. Nishida, M. Kurihara, M. Tanaka, Y. Demizu, M. Oba
  • Journal Title: Bioorganic & Medicinal Chemistry Volume: 24 Issue: 12 Pages: 2681-2687
  • DOI: 10.1016/j.bmc.2016.04.031
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Development of a peptide-based inducer of nuclear receptors degradation. (2016)
  • Author(s): Demizu Y, Ohoka N, Nagakubo T, Yamashita H, Misawa T, Okuhira K, Naito M, Kurihara M.
  • Journal Title: Bioorg Med Chem Lett. Volume: 26 Issue: 11 Pages: 2655-2658
  • DOI: 10.1016/j.bmcl.2016.04.013
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Handedness preferences of heterochiral helical peptides containing homochiral peptide segments (2016)
  • Author(s): Y. Demizu,* H. Yamashita, T. Misawa, M. Doi, M. Oba, M. Tanaka, M. Kurihara*
  • Journal Title: Eur. J. Org. Chem. Volume: 4 Issue: 4 Pages: 840-846
  • DOI: 10.1002/ejoc.201501146
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A Helix-Stabilized Cell-Penetrating Peptide As An Intracellular-Delivery Tool (2016)
  • Author(s): Hiroko Yamashita, Makoto Oba, Takashi Misawa, Masakazu Tanaka, Takayuki Hattori, Mikihiko Naito, Masaaki Kurihara, Yosuke Demizu
  • Journal Title: Chembiochem Volume: 17 Issue: 2 Pages: 137-140
  • DOI: 10.1002/cbic.201500468
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Induction of proteasomal degradation of ERα and subsequent cell death in breast cancer cells (2016)
  • Author(s): K. Okuhira, Y. Demizu, T. Hattori, N. Ohoka, N. Shibata, T. Nishimaki-Mogami, H. Okuda, M. Kurihara, M. Naito*
  • Journal Title: Methods Mol. Biol. Volume: 1366 Pages: 549-560
  • DOI: 10.1007/978-1-4939-3127-9_42
  • ISBN: 9781493931262, 9781493931279
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Effects of alkyl side chains and terminal hydrophilicity on vitamin D receptor (VDR) agonistic activity based on the diphenylpentane skeleton (2015)
  • Author(s): Takashi Misawa, Momoko Yorioka, Yosuke Demizu, Tomomi Noguchi-Yachide, Nobumichi Ohoka, Megumi Kurashima-Kinoshita, Hitomi Motoyoshi, Hisao Nojiri, Atsushi Kittaka, Makoto Makishima, Mikihiko Naito, Masaaki Kurihara
  • Journal Title: Bioorg. Med. Chem. Lett. Volume: 25 Issue: 22 Pages: 5362-5366
  • DOI: 10.1016/j.bmcl.2015.09.030
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Topological study of the structures of heterochiral peptides with equal amounts of L-Leu and D-Leu (2015)
  • Author(s): Y. Demizu,* H. Yamashita, M. Doi, T. Misawa, M. Oba, M. Tanaka, M. Kurihara*
  • Journal Title: J. Org. Chem. Volume: 80 Issue: 17 Pages: 8597-8603
  • DOI: 10.1021/acs.joc.5b01541
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] A synthetic cannabinoid FDU-NNEI, two 2H-indazole isomers of synthetic cannabinoids AB-CHMINACA and NNEI indazole analog (MN-18), a phenethylamine derivative N-OH-EDMA, and a cathinone derivative dimethoxy-α-PHP, newly identified in illegal products (2015)
  • Author(s): N. Uchiyama,* Y. Shimokawa, R. Kikura-Hanajiri, Y. Demizu, Y. Goda, T. Hakamatsuka
  • Journal Title: Forensic Toxicol. Volume: 33 Issue: 2 Pages: 244-259
  • DOI: 10.1007/s11419-015-0268-7
  • Peer Reviewed
• [Journal Article] Synthesis and Evaluation of Novel Carbocyclic Oxetanocin A (COA-Cl) Derivatives as Potential Tube Formation Agents (2015)
  • Author(s): N. Sakakibara,* J. Igarashi, M. Takata, Y. Demizu, T. Misawa, M. Kurihara, R. Konishi, Y. Kato, T. Maruyama, I. Tsukamoto
  • Journal Title: Chemical and Pharmaceutical Bulletin Volume: 63 Issue: 9 Pages: 701-709
  • DOI: 10.1248/cpb.c15-00386
  • NAID: 130005096030
  • ISSN: 0009-2363, 1347-5223
  • Peer Reviewed
• [Journal Article] Design, synthesis, and anti-HIV-1 activity of 1-substituted 3-(3,5-dimethylbenzyl)triazine derivatives (2015)
  • Author(s): N. Sakakibara,* G. Balboni, C. Congiu, V. Onnis, Y. Demizu, T. Misawa, M. Kurihara, Y. Kato, T. Maruyama, M. Toyama, M. Okamoto, M. Baba
  • Journal Title: Antiviral Chem. Chemother. Volume: 24 Issue: 2 Pages: 62-71
  • DOI: 10.1177/2040206615612208
  • Peer Reviewed
• [Journal Article] Plasmid DNA delivery using fluorescein-labeled arginine-rich peptides (2015)
  • Author(s): M. Oba,* Y. Demizu, H. Yamashita, M. Kurihara, M. Tanaka
  • Journal Title: Bioorg. Med. Chem. Volume: 23 Issue: 15 Pages: 4911-4918
  • DOI: 10.1016/j.bmc.2015.05.025
  • NAID: 120006986986
  • Peer Reviewed
• [Journal Article] Structural development of stabilized helical peptides as inhibitors of estrogen receptor (ER)-mediated transcription (2015)
  • Author(s): Y. Demizu*, T. Misawa, T. Nagakubo, Y. Kanda, K. Okuhira, Y. Sekino, M. Naito, M. Kurihara*
  • Journal Title: Bioorg. Med. Chem. Lett. Volume: 23 Issue: 15 Pages: 4132-4138
  • DOI: 10.1016/j.bmc.2015.06.067
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Synthesis and resolution of substituted [5]carbohelicenes (2015)
  • Author(s): K. Usui,* K. Yamamoto, T. Shimizu, M. Biao, M. Okazumi, Y. Demizu, M. Kurihara, H. Suemune*
  • Journal Title: J. Org. Chem. Volume: 80 Issue: 12 Pages: 6502-6508
  • DOI: 10.1021/acs.joc.5b00759
  • Peer Reviewed
• [Journal Article] Synthesis and evaluation of tamoxifen derivatives with a long alkyl side chain as selective estrogen receptor down-regulators (2015)
  • Author(s): T. Shoda,* M. Kato, T. Fujisato, K. Okuhira, Y. Demizu, H. Inoue, M. Naito, M. Kurihara*
  • Journal Title: Bioorg. Med. Chem. Volume: 23 Issue: 13 Pages: 3091-3096
  • DOI: 10.1016/j.bmc.2015.05.002
  • Peer Reviewed
• [Journal Article] A preorganized β-amino acid bearing a guanidinium side chain and its use in cell-penetrating peptides (2015)
  • Author(s): Y. Demizu,* M. Oba, K. Okitsu, H. Yamashita, T. Misawa, M. Doi, M. Tanaka, M. Kurihara, S. H. Gellman
  • Journal Title: Org. Biomol. Chem. Volume: 13 Issue: 20 Pages: 5617-5620
  • DOI: 10.1039/c5ob00389j
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Peptide foldamers composed of six-membered ring α,α-disubstituted α-amino acid with two changeable chiral acetal moieties (2015)
  • Author(s): K. Tanda, R. Eto, K. Kato, M. Oba, A. Ueda, H. Suemune, M. Doi, Y. Demizu, M. Kurihara, M. Tanaka*
  • Journal Title: Tetrahedron Volume: 71 Issue: 23 Pages: 3909-3914
  • DOI: 10.1016/j.tet.2015.04.031
  • NAID: 120006987063
  • Peer Reviewed / Open Access
• [Journal Article] Amino equatorial effect of a six-membered ring amino acid on its peptide 310- and a-helices (2015)
  • Author(s): Takayuki Hirata, Atsushi Ueda, Makoto Oba, Mitsunobu Doi, Yosuke Demizu, Masaaki Kurihara, Masanobu Nagano, Hiroshi Suemune, Masakazu Tanaka
  • Journal Title: Tetrahedron Volume: 71 Issue: 16 Pages: 2409-2420
  • DOI: 10.1016/j.tet.2015.02.075
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Synthesis of a bis-cationic α,α-disubstituted amino acid (9-amino-bispidine-9-carboxylic acid) and its effects on the conformational properties of peptides (2015)
  • Author(s): H. Yamashita, Y. Demizu,* T. Misawa, T. Shoda, M. Kurihara*
  • Journal Title: Tetrahedron Volume: 71 Issue: 15 Pages: 2241-2245
  • DOI: 10.1016/j.tet.2015.02.076
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Structural development of stapled short helical peptides as vitamin D receptor (VDR)-coactivator interaction inhibitors. (2015)
  • Author(s): T. Misawa, Y. Demizu, M. Kawamura, N. Yamagata, M. Kurihara.
  • Journal Title: Bioorganic medicinal chemistry Volume: 23 Issue: 5 Pages: 1055-1061
  • DOI: 10.1016/j.bmc.2015.01.007
  • Peer Reviewed
• [Journal Article] Effects of D-Leu Residues on the Helical Secondary Structures of L-Leu-Based Nonapeptides (2015)
  • Author(s): Y. Demizu,* H. Yamashita, T. Misawa, M. Doi, M. Tanaka, M. Kurihara*
  • Journal Title: Chemical and Pharmaceutical Bulletin Volume: 63 Issue: 3 Pages: 218-224
  • DOI: 10.1248/cpb.c14-00760
  • NAID: 130004803775
  • ISSN: 0009-2363, 1347-5223
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Design, synthesis and anti-HIV-1 activity of 1-aromatic methyl-substituted 3-(3,5-dimethylbenzyl)uracil and N-3,5-dimethylbenzyl-substituted urea derivatives (2015)
  • Author(s): N. Sakakibara,* M. Baba, M. Okamoto, M. Toyama, Y. Demizu, T. Misawa, M. Kurihara, K. Irie, Y. Kato, T. Maruyama
  • Journal Title: Antiviral Chem. Chemother. Volume: 24 Issue: 1 Pages: 3-18
  • DOI: 10.1177/2040206614566584
  • Peer Reviewed
• [Journal Article] 短鎖ペプチドのヘリカル構造制御と機能化 (2015)
  • Author(s): 出水庸介*，三澤隆史，栗原正明*
  • Journal Title: 有機合成化学協会誌 Volume: 72 Pages: 1336-1359
  • NAID: 130004749130
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Development of cell-penetrating R7 fragment-conjugated helical peptides as inhibitors of estrogen receptor-mediated transcription. (2014)
  • Author(s): 2.Nagakubo, T., Demizu, Y., Kanda, Y., Misawa, T., Shoda, T., Okuhira, K., Sekino., Y., Naito, M. and Kurihara, M
  • Journal Title: Bioconjug Chem. Volume: 25 Issue: 11 Pages: 1921-24
  • DOI: 10.1021/bc500480e
  • Peer Reviewed
• [Journal Article] Conformational studies on peptides having chiral five-membered ring amino acid with two azido or triazole functional groups within the sequence of Aib residues (2014)
  • Author(s): Makoto Oba, Naomi Kawabe, Hiroomi Takazaki, Yosuke Demizu, Mitsunobu Doi, Masaaki Kurihara, Hiroshi Suemune, Masakazu Tanaka
  • Journal Title: Tetrahedron Volume: 70 Issue: 46 Pages: 8900-8907
  • DOI: 10.1016/j.tet.2014.09.086
  • NAID: 120006987171
  • Peer Reviewed
• [Journal Article] Helical Peptide-Foldamers Having a Chiral Five-Membered Ring Amino Acid with Two Azido Functional Groups (2014)
  • Author(s): Makoto Oba, Hiroomi Takazaki, Naomi Kawabe, Mitsunobu Doi, Yosuke Demizu, Masaaki Kurihara, Hiromu Kawakubo, Masanobu Nagano, Hiroshi Suemune, and Masakazu Tanaka
  • Journal Title: The Journal of Organic Chemistry Volume: 79 Issue: 19 Pages: 9125-9140
  • DOI: 10.1021/jo501493x
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] NAD-dependent isocitrate dehydrogenase as a novel target of tributyltin in human embryonic carcinoma cells. (2014)
  • Author(s): Yamada S, Kotake Y, Demizu Y, Kurihara M, Sekino Y, Kanda Y.
  • Journal Title: Scientific Reports Volume: 4 Issue: 1 Pages: 5952-5952
  • DOI: 10.1038/srep05952
  • Peer Reviewed / Open Access
• [Journal Article] Amphipathic short helix-stabilized peptides with cell-membrane penetrating ability (2014)
  • Author(s): Hiroko Yamashita, Yosuke Demizu, Takuji Shoda, Yukiko Sato, Makoto Oba, Masakazu Tanaka, Masaaki Kurihara
  • Journal Title: Bioorganic & Medicinal Chemistry Volume: 22 Issue: 8 Pages: 2403-2408
  • DOI: 10.1016/j.bmc.2014.03.005
  • Peer Reviewed
• [Journal Article] Design and synthesis of tamoxifen derivatives as a selective estrogen receptor down-regulator. (2014)
  • Author(s): Shoda, T., Okuhira, K., Kato, M., Demizu, Y., Inoue, H., Naito, M., and Kurihara, M.
  • Journal Title: Bioorg Med Chem Lett Volume: 24 Issue: 1 Pages: 87-89
  • DOI: 10.1016/j.bmcl.2013.11.078
  • Peer Reviewed
• [Journal Article] Isoheleproline: a new amino acid-sesquiterpene adduct from Inula helenium (2014)
  • Author(s): K. Zaima, D. Wakana, Y. Demizu, Y. Kumeta, H. Kamakura, T. Maruyama, M. Kurihara, Y. Goda*
  • Journal Title: J. Nat. Med. Volume: 68 Issue: 2 Pages: 432-435
  • DOI: 10.1007/s11418-013-0806-8
  • NAID: 40020023355
  • Peer Reviewed
• [Journal Article] 短鎖ペプチドのヘリカル構造制御と機能化 (2014)
  • Author(s): 出水庸介*
  • Journal Title: ペプチドニュースレター Volume: 94 Pages: 3-7
  • NAID: 130004749130
  • Acknowledgement Compliant
• [Presentation] タンパク質の寿命を制御できる分子の開発 (2018)
  • Author(s): 出水庸介
  • Organizer: 生体分子コバレント修飾の革新的解析拠点形成シンポジウム(招待講演)
  • Invited
• [Presentation] 種々の側鎖官能基を有する環状α,α-ジ置換アミノ酸の合成と含有ペプチドの機能評価 (2018)
  • Author(s): 辻厳一郎，小林寛幸，三澤隆史，木下恵愛，松野研司，出水庸介
  • Organizer: 日本薬学会第138回年会
• [Presentation] 多様な官能基修飾を志向したヘリカルテンプレートペプチドの開発 (2018)
  • Author(s): 三澤隆史，諫田泰成，出水庸介
  • Organizer: 日本薬学会第138回年会
• [Presentation] LC-CDを用いた危険ドラッグMethylphenidate類似体のキラル分析 (2018)
  • Author(s): 河村麻衣子，三澤隆史，出水庸介，花尻瑠理，袴塚高志
  • Organizer: 日本薬学会第138回年会
• [Presentation] グアニンPNAモノマーの新規カチオン性アナログ (2018)
  • Author(s): 杉山亨，小原美咲，桑田啓子，今村保忠，出水庸介，栗原正明，橘高敦史
  • Organizer: 日本薬学会第138回年会
• [Presentation] 側鎖上にキラルなアセタールを有する4員環状ジ置換アミノ酸よりなるペプチドの二次構造解析 (2018)
  • Author(s): 江藤諒，大庭誠，上田篤志，土井光暢，出水庸介，栗原正明，宇久翼，田中正一
  • Organizer: 日本薬学会第138回年会
• [Presentation] キラルな3員環状アミノ酸の合成と含有ペプチドのコンフォメーション解析 (2018)
  • Author(s): 古場百合恵，池田光生，上田篤志，大庭誠，出水庸介，土井光暢，田中正一
  • Organizer: 日本薬学会第138回年会
• [Presentation] Development of helical cell penetrating peptides using non-proteinogenic amino acids (2017)
  • Author(s): Yamashita, H., Misawa, M., Kurihara, M., Demizu, Y.
  • Organizer: Lindau Nobel Laureate Meetings 2017
  • Int'l Joint Research
• [Presentation] 芳香族炭化水素受容体ユビキチンリガーゼをリクルートする新しいプロテインノックダウン化合物の開発 (2017)
  • Author(s): 大岡伸通，正田卓司，藤里卓磨，柴田識人，服部隆行，栗原正明，出水庸介，内藤幹彦
  • Organizer: 2017年度生命科学系学会合同年次大会(ConBio2017)
• [Presentation] 側鎖に不斉中心を有する三員環状ジ置換アミノ酸とそのペプチドの合成 (2017)
  • Author(s): 池田光生，古場百合恵，上田篤志，大庭誠，出水庸介，栗原正明，田中正一
  • Organizer: 第34回日本薬学会九州支部大会
• [Presentation] Development of cationic cell-penetrating peptides focused on their secondary structures (2017)
  • Author(s): 小林寛幸，三澤隆史，大庭誠，田中正一，内藤幹彦，松野研司，出水庸介
  • Organizer: 第54回ペプチド討論会
• [Presentation] Development of post functionalizable oligopeptides as helical templates (2017)
  • Author(s): 三澤隆史，出水庸介
  • Organizer: 第54回ペプチド討論会
• [Presentation] Peptide foldamers changing their conformations in response to low pH trigger (2017)
  • Author(s): 古川かほり，大庭誠，遠山琴美，George Ouma Opiyo，出水庸介，栗原正明，土井光暢，田中正一
  • Organizer: 第54回ペプチド討論会
• [Presentation] Synthesis of chiral three-membered ring α,α-disubstituted α-amino acid and conformational analysis of its peptides (2017)
  • Author(s): 古場百合恵，池田光生，上田篤志，大庭誠，出水庸介，土井光暢，田中正一
  • Organizer: 第54回ペプチド討論会
• [Presentation] Peptide nucleic acid possessing PreQ1 as a cationic analogue of guanine (2017)
  • Author(s): 杉山亨，小原美咲，桑田啓子，今村保忠，出水庸介，栗原正明，高野真史，橘高敦史
  • Organizer: 第54回ペプチド討論会
• [Presentation] 二次構造制御に基づくペプチド創薬研究 (2017)
  • Author(s): 出水庸介，三澤隆史，栗原正明
  • Organizer: 第43回反応と合成の進歩シンポジウム
• [Presentation] Post-modification可能なα,α-ジ置換アミノ酸の合成と含有ペプチドの二次構造解析 (2017)
  • Author(s): 小林寛幸，三澤隆史，松野研司，出水庸介
  • Organizer: 第43回反応と合成の進歩シンポジウム
• [Presentation] 側鎖上にのみ不斉中心を持つ4員環状アミノ酸よりなるペプチドのヘリックス二次構造 (2017)
  • Author(s): 江藤諒，大庭誠，上田篤志，土井光暢，出水庸介，栗原正明，宇久翼，田中正一
  • Organizer: 第43回反応と合成の進歩シンポジウム
• [Presentation] 二次構造に着目したカチオン性膜透過ペプチドの創製研究 (2017)
  • Author(s): 小林寛幸，三澤隆史，大庭誠，田中正一，内藤幹彦，松野研司，出水庸介
  • Organizer: 第34回メディシナルケミストリーシンポジウム
• [Presentation] 低pHに応答して二次構造を変化させるペプチドフォルダマーの開発 (2017)
  • Author(s): 大庭誠，古川かほり，遠山琴美，George Ouma Opiyo，出水庸介，栗原正明，土井光暢，田中正一
  • Organizer: 第34回メディシナルケミストリーシンポジウム
• [Presentation] 小員環状ジ置換アミノ酸を用いたヘリカル二次構造の制御に関する研究 (2017)
  • Author(s): 古場百合恵，上田篤志，大庭誠，出水庸介，土井光暢，田中正一
  • Organizer: 第34回メディシナルケミストリーシンポジウム
• [Presentation] 正電荷を帯びたグアニン誘導体をもつPNAの合成 (2017)
  • Author(s): 杉山亨，小原美咲，桑田啓子，今村保忠，出水庸介，栗原正明，橘高敦史
  • Organizer: 第34回メディシナルケミストリーシンポジウム
• [Presentation] カチオン性プロリン誘導体を含む細胞膜高透過性ペプチドの開発 (2017)
  • Author(s): 小林寛幸，三澤隆史，大庭誠，田中正一，内藤幹彦，松野研司，出水庸介
  • Organizer: 第47回複素環化学討論会
• [Presentation] 芳香族炭化水素受容体ユビキチンリガーゼをリクルートする新しいプロテインノックダウン化合物の開発 (2017)
  • Author(s): 大岡伸通，正田卓司，藤里卓磨，柴田識人，服部隆行，栗原正明，出水庸介，内藤幹彦
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] カチオン性プロリン誘導体を導入した細胞膜透過性ペプチドの開発 (2017)
  • Author(s): 小林寛幸，三澤隆史，内藤幹彦，出水庸介
  • Organizer: 第61回日本薬学会関東支部大会
• [Presentation] 多様な生理活性付与を志向した安定化ヘリカルテンプレートペプチドの開発 (2017)
  • Author(s): 三澤隆史，出水庸介
  • Organizer: 第61回日本薬学会関東支部大会
• [Presentation] カチオン性プロリン誘導体を含む細胞膜透過性ペプチドの開発 (2017)
  • Author(s): 小林寛幸，三澤隆史，松野研司，出水庸介
  • Organizer: 第49回若手ペプチド夏の勉強会
• [Presentation] ジフェニルメタンを基本骨格とするリガンドの創製 (2017)
  • Author(s): 栗原正明，三澤隆史，出水庸介
  • Organizer: 第3回Neo Vitamin D Workshop
• [Presentation] コンピュータシミュレーションによる違法薬物の活性予測に関する研究 (2017)
  • Author(s): 出水庸介，田中理恵，袴塚高志，栗原正明，花尻瑠理
  • Organizer: 日本法中毒学会第36回年会
• [Presentation] 二次構造制御を基盤とした膜透過性ペプチドの開発 (2017)
  • Author(s): 三澤隆史，小林寛幸，大庭誠，田中正一，栗原正明，出水庸介
  • Organizer: 第33回日本DDS学会学術集会
• [Presentation] キラルな三員環状ジ置換アミノ酸とそのペプチドの合成 (2017)
  • Author(s): 古場百合恵，池田光生，上田篤志，大庭誠，出水庸介，栗原正明，田中正一
  • Organizer: 第54回化学関連支部合同九州大会
• [Presentation] ヘリカルペプチドを用いたビタミンD受容体(VDR)―コアクチベータ相互作用阻害剤の創製 (2017)
  • Author(s): 三澤隆史，出水庸介，栗原正明
  • Organizer: 日本ビタミン学会第69回大会
• [Presentation] Hisタグ融合タンパク質分解誘導分子の設計と合成 (2017)
  • Author(s): 沖津航陽，服部隆行，三澤隆史，栗原正明，内藤幹彦，出水庸介
  • Organizer: ケミカルバイオロジー第12回年会
• [Presentation] 親水性分子の細胞内導入を志向した細胞膜高透過性ペプチドの開発 (2017)
  • Author(s): 三澤隆史，大岡伸通，大庭誠，田中正一，内藤幹彦，栗原正明，出水庸介
  • Organizer: 第15回次世代を担う有機化学シンポジウム
• [Presentation] 二次構造制御を基軸とした膜透過ペプチドの創製研究 (2016)
  • Author(s): 出水庸介，三澤隆史，山下博子，大庭誠，田中正一，内藤幹彦，栗原正明
  • Organizer: 第33回メディシナルケミストリーシンポジウム
  • Place of Presentation: つくば
  • Year and Date: 2016-11-25
• [Presentation] Hisタグ融合タンパク質分解誘導分子の開発 (2016)
  • Author(s): 出水庸介，沖津航陽，服部隆行，三澤隆史，内藤幹彦，栗原正明
  • Organizer: 第42回反応と合成の進歩シンポジウム
  • Place of Presentation: 静岡
  • Year and Date: 2016-11-07
• [Presentation] 側鎖にグアニジノ基を有するプロリン誘導体の合成と細胞膜透過性ペプチドへの応用 (2016)
  • Author(s): 出水庸介，小林寛幸，山下博子，三澤隆史，大庭誠，田中正一，松野研司，栗原正明
  • Organizer: 第46回複素環化学討論会
  • Place of Presentation: 金沢
  • Year and Date: 2016-09-26
• [Presentation] Development of helix-stabilized cell-penetrating peptides as an intracellular delivery tool (2016)
  • Author(s): Demizu, Y., Yamashita, H., Misawa, T., Oba, M., Tanaka, M., Kurihara, M.
  • Organizer: 34th European Peptide Symposium & 8th International Peptide Symposium
  • Place of Presentation: Germany
  • Year and Date: 2016-09-04
  • Int'l Joint Research
• [Presentation] 核内受容体を標的とした転写活性化阻害および分解誘導ペプチドの開 (2016)
  • Author(s): 出水庸介
  • Organizer: 第48回若手ペプチド夏の勉強会
  • Place of Presentation: 東京
  • Year and Date: 2016-07-31
  • Invited
• [Presentation] ペプチド二次構造制御に基づく細胞膜高透過性ペプチドの創製 (2016)
  • Author(s): 出水庸介，山下博子，加藤巧馬，大岡伸通，三澤隆史，服部隆行，田中正一，内藤幹彦，大庭誠，栗原正明
  • Organizer: ケミカルバイオロジー第11回年会
  • Place of Presentation: 京都
  • Year and Date: 2016-06-15
• [Presentation] ペプチド二次構造制御に基づく細胞膜高透過性ペプチドの開発 (2016)
  • Author(s): 出水庸介，山下博子，三澤隆史，大庭誠，田中正一，栗原正明
  • Organizer: 第14回次世代を担う有機化学シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2016-05-27
• [Presentation] エストロゲン受容体分解誘導ペプチドの創製 (2016)
  • Author(s): 出水庸介，大岡伸通，三澤隆史，内藤幹彦，栗原正明
  • Organizer: 日本薬学会第136回年会
  • Place of Presentation: 横浜
  • Year and Date: 2016-03-27
• [Presentation] ヘリカルプロモーター導入によるオリゴアルギニンの構造制御と膜透過能への効果 (2016)
  • Author(s): 三澤隆史，山下博子，加藤巧馬，服部隆行，大庭誠，田中正一，内藤幹彦，出水庸介，栗原正明
  • Organizer: 日本薬学会第136回年会
  • Place of Presentation: 横浜
  • Year and Date: 2016-03-27
• [Presentation] 環境応答型二次構造変化を利用した細胞膜高透過性ペプチドの開発 (2016)
  • Author(s): 山下博子，出水庸介，加藤巧馬，大岡伸通，三澤隆史，服部隆行，田中正一，内藤幹彦，大庭誠，栗原正明
  • Organizer: 日本薬学会第136回年会
  • Place of Presentation: 横浜
  • Year and Date: 2016-03-27
• [Presentation] Hisタグタンパク質分解誘導分子の開発 (2016)
  • Author(s): 沖津航陽，服部隆行，出水庸介，三澤隆史，正田卓司，内藤幹彦，栗原正明
  • Organizer: 日本薬学会第136回年会
  • Place of Presentation: 横浜
  • Year and Date: 2016-03-27
• [Presentation] 二次構造制御に基づく抗菌ペプチドフォルダマーの開発 (2016)
  • Author(s): 小澤佑斗，出水庸介，三澤隆史，菊池裕，栗原正明
  • Organizer: 日本薬学会第136回年会
  • Place of Presentation: 横浜
  • Year and Date: 2016-03-27
• [Presentation] エストロゲン受容体分解活性を有するラロキシフェン誘導体の開発 (2016)
  • Author(s): 正田卓司，加藤雅士，藤里卓磨，三澤隆史，出水庸介，井上英史，内藤幹彦，栗原正明
  • Organizer: 日本薬学会第136回年会
  • Place of Presentation: 横浜
  • Year and Date: 2016-03-27
• [Presentation] エチレンアセタールを有するキラル5員環アミノ酸を含有するペプチドのヘリカル二次構造 (2016)
  • Author(s): 古場百合恵，上田篤志，大庭誠，土井光暢，出水庸介，栗原正明，田中正一
  • Organizer: 日本薬学会第136回年会
  • Place of Presentation: 横浜
  • Year and Date: 2016-03-27
• [Presentation] デアザグアニン誘導体を持つPNAの合成 (2016)
  • Author(s): 杉山亨，桑田啓子，今村保忠，出水庸介，栗原正明，高野真史，橘高敦史
  • Organizer: 日本薬学会第136回年会
  • Place of Presentation: 横浜
  • Year and Date: 2016-03-27
• [Presentation] Protein knockdown by SNIPER compounds: Application for basic research and cancer therapy (2016)
  • Author(s): Naito, M., Hattori, T., Ohoka, N., Shibata, N., Shoda, T., Demizu, Y., Kurihara, M.
  • Organizer: The 10th AACR-JCA Joint Conference
  • Place of Presentation: Hawaii
  • Year and Date: 2016-02-16
  • Int'l Joint Research
• [Presentation] Structural development of stapled short helical peptides as vitamin D receptor (VDR)-coactivator interaction inhibitors (2015)
  • Author(s): Misawa, T., Demizu, Y., Kurihara, M.
  • Organizer: PACIFICHEM 2015
  • Place of Presentation: Hawaii
  • Year and Date: 2015-12-15
  • Int'l Joint Research
• [Presentation] Design, synthesis and evaluation of tamoxifen derivatives as new selective estrogen receptor down-regulators (2015)
  • Author(s): Shoda, T., Kato, M., Okuhira, K., Demizu, Y., Inoue, H., Naito, M., Kurihara, M.
  • Organizer: PACIFICHEM 2015
  • Place of Presentation: Hawaii
  • Year and Date: 2015-12-15
  • Int'l Joint Research
• [Presentation] ノンセコステロイド型VDRリガンドによるATRA耐性急性前骨髄球性白血病細胞の分化誘導 (2015)
  • Author(s): 野尻久雄，村田拓哉，橘高敦史，出水庸介，三澤隆史，栗原正明
  • Organizer: 第36回日本臨床薬理学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2015-12-09
• [Presentation] エストロゲン受容体を標的とした転写活性化阻害および分解誘導ペプチドの創製 (2015)
  • Author(s): 出水庸介，三澤隆史，諫田泰成，大岡伸通，関野祐子，内藤幹彦，栗原正明
  • Organizer: 第33回メディシナルケミストリーシンポジウム
  • Place of Presentation: 千葉
  • Year and Date: 2015-11-25
• [Presentation] ノンセコステロイド型ビタミンD受容体リガンドの創製―官能基変換による活性制御― (2015)
  • Author(s): 三澤隆史，依岡桃子，出水庸介，谷内出友美，大岡伸通，木下恵愛，野尻久雄，橘高敦史，槇島誠，内藤幹彦，栗原正明
  • Organizer: 第33回メディシナルケミストリーシンポジウム
  • Place of Presentation: 千葉
  • Year and Date: 2015-11-25
• [Presentation] エストロゲン受容体転写阻害剤および分解誘導剤の創製 (2015)
  • Author(s): 依岡桃子，三澤隆史，出水庸介，大岡伸通，諫田泰成，槇島誠，南雲紳史，関野祐子，内藤幹彦，栗原正明
  • Organizer: 第33回メディシナルケミストリーシンポジウム
  • Place of Presentation: 千葉
  • Year and Date: 2015-11-25
• [Presentation] ラロキシフェン骨格を有する新規エストロゲン受容体分解誘導剤の開発 (2015)
  • Author(s): 正田卓司，加藤雅士，藤里卓磨，三澤隆史，出水庸介，井上英史，内藤幹彦，栗原正明
  • Organizer: 第33回メディシナルケミストリーシンポジウム
  • Place of Presentation: 千葉
  • Year and Date: 2015-11-25
• [Presentation] 修飾デアザグアニン含有PNAオリゴマーの合成 (2015)
  • Author(s): 杉山亨，桑田啓子，今村保忠，出水庸介，栗原正明，高野真史，橘高敦史
  • Organizer: 第33回メディシナルケミストリーシンポジウム
  • Place of Presentation: 千葉
  • Year and Date: 2015-11-25
• [Presentation] 血管新生促進作用を有する新規2-クロル炭素環オキセタノシンA（COA-Cl）誘導体の創製 (2015)
  • Author(s): 榊原紀和，五十嵐淳介，高田麻紀，出水庸介，三澤隆史，栗原正明，小西良士，加藤善久，丸山徳見，塚本郁子
  • Organizer: 第33回メディシナルケミストリーシンポジウム
  • Place of Presentation: 千葉
  • Year and Date: 2015-11-25
• [Presentation] グアニジノ基を有する環状アミノ酸の合成と細胞膜透過性ペプチドへの応用 (2015)
  • Author(s): 出水庸介，山下博子，三澤隆史，大庭誠，田中正一，栗原正明
  • Organizer: 第45回複素環化学討論会
  • Place of Presentation: 東京
  • Year and Date: 2015-11-19
• [Presentation] 2-クロル炭素環オキセタノシンA (COA-Cl)の新規誘導体の合成とその血管新生促進作用 (2015)
  • Author(s): 榊原紀和，五十嵐淳介，高田麻紀，出水庸介，三澤隆史，栗原正明，小西良士，加藤善久，丸山徳見，塚本郁子
  • Organizer: 第45回複素環化学討論会
  • Place of Presentation: 東京
  • Year and Date: 2015-11-19
• [Presentation] Development of helical peptide as inhibitors of estrogen receptor-mediated transcription (2015)
  • Author(s): 出水庸介，三澤隆史，諫田泰成，大岡伸通，関野祐子，内藤幹彦，栗原正明
  • Organizer: 第52回ペプチド討論会
  • Place of Presentation: 神奈川
  • Year and Date: 2015-11-16
• [Presentation] Design and synthesis of short helical peptides as vitamin D receptor (VDR)-coactivator interaction inhibitors (2015)
  • Author(s): 三澤隆史，出水庸介，栗原正明
  • Organizer: 第52回ペプチド討論会
  • Place of Presentation: 神奈川
  • Year and Date: 2015-11-16
• [Presentation] Development of helix-stabilized cationic peptides with cell-membrane penetrating ability (2015)
  • Author(s): 山下博子，出水庸介，三澤隆史，服部隆行，大庭誠，田中正一，内藤幹彦，栗原正明
  • Organizer: 第52回ペプチド討論会
  • Place of Presentation: 神奈川
  • Year and Date: 2015-11-16
• [Presentation] Development of His-tag fused protein degradation inducer based on protein knockdown strategy (2015)
  • Author(s): 沖津航陽，服部隆行，出水庸介，三澤隆史，正田卓司，内藤幹彦，栗原正明
  • Organizer: 第52回ペプチド討論会
  • Place of Presentation: 神奈川
  • Year and Date: 2015-11-16
• [Presentation] Conformational analysis of peptides composed of chiral cyclic amino acids (2015)
  • Author(s): 古場百合恵，上田篤志，大庭誠，土井光暢，出水庸介，栗原正明，田中正一
  • Organizer: 第52回ペプチド討論会
  • Place of Presentation: 神奈川
  • Year and Date: 2015-11-16
• [Presentation] Synthesis of PNA oligomers containing modified deazaguanines for the development of functional PNA (2015)
  • Author(s): 杉山亨，桑田啓子，今村保忠，出水庸介，栗原正明，高野真史，橘高敦史
  • Organizer: 第52回ペプチド討論会
  • Place of Presentation: 神奈川
  • Year and Date: 2015-11-16
• [Presentation] Development of stabilized helical peptides and their functionalization (2015)
  • Author(s): Demizu, Y., Misawa, T., Kurihara, M.
  • Organizer: 13th International Kyoto Conference on New Aspects of Organic Chemistry
  • Place of Presentation: 京都
  • Year and Date: 2015-11-09
  • Int'l Joint Research
• [Presentation] 血管新生促進剤を指向した2-クロル炭素環オキセタノシンA（COA-Cl）の新規誘導体の創製研究 (2015)
  • Author(s): 榊原紀和，五十嵐淳介，高田麻紀，出水庸介，三澤隆史，栗原正明，小西良士，加藤善久，丸山徳見，塚本郁子
  • Organizer: 第54回薬学会中国四国支部学術大会
  • Place of Presentation: 高知
  • Year and Date: 2015-10-31
• [Presentation] 長鎖アルキルを有するノンセコステロイド型VDRリガンドの創製 (2015)
  • Author(s): 三澤隆史，依岡桃子，出水庸介，大岡伸通，木下恵愛，槇島誠，内藤幹彦，栗原正明
  • Organizer: 第41回反応と合成の進歩シンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 2015-10-26
• [Presentation] 細胞膜透過性の向上を指向したカチオン性アミノ酸の合成およびその応用 (2015)
  • Author(s): 山下博子，出水庸介，三澤隆史，服部隆行，大庭誠，田中正一，内藤幹彦，栗原正明
  • Organizer: 第41回反応と合成の進歩シンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 2015-10-26
• [Presentation] Development of cell-penetrating fragment conjugated helical peptides as inhibitors of estrogen receptor-mediated transcription (2015)
  • Author(s): Demizu, Y., Misawa, T., Kanda, Y., Sekino, Y., Kurihara, M.
  • Organizer: The 11th Australian Peptide Conference 2015
  • Place of Presentation: Australia
  • Year and Date: 2015-10-25
  • Int'l Joint Research
• [Presentation] Cell-penetrating ability and plasmid DNA delivary using fluorescein-labeled arginine-rich peptides (2015)
  • Author(s): Oba, M., Furukawa, K., Kato, T., Demizu, Y., Yamashita, H., Kurihara, M., Tanaka, M.
  • Organizer: The 11th Australian Peptide Conference 2015
  • Place of Presentation: Australia
  • Year and Date: 2015-10-25
  • Int'l Joint Research
• [Presentation] Structure-activity relationship analysis of short helical peptides as VDR-coactivator interaction inhibitors (2015)
  • Author(s): Misawa, T., Demizu, Y., Kurihara, M.
  • Organizer: 第43回構造活性相関シンポジウム，第10回薬物の分子設計と開発に関する日中シンポジウム
  • Place of Presentation: 新潟
  • Year and Date: 2015-09-27
  • Int'l Joint Research
• [Presentation] コンピュータシミュレーションによる合成カンナビノイドのCB1受容体への結合様式解析 (2015)
  • Author(s): 出水庸介，三澤隆史，内山奈穂子，花尻瑠理，袴塚高志，栗原正明
  • Organizer: 第59回日本薬学会関東支部大会
  • Place of Presentation: 千葉
  • Year and Date: 2015-09-12
• [Presentation] ジフェニルメタンを基本骨格とするエストロゲン受容体アンタゴニストの創製 (2015)
  • Author(s): 田中克哉，三澤隆史，出水庸介，諫田泰成，槇島誠，関野祐子，内藤幹彦，栗原正明
  • Organizer: 第59回日本薬学会関東支部大会
  • Place of Presentation: 千葉
  • Year and Date: 2015-09-12
• [Presentation] ジフェニルメタンを基本骨格としたエストロゲン受容体転写阻害剤および分解誘導剤の開発 (2015)
  • Author(s): 依岡桃子，三澤隆史，出水庸介，大岡伸通，槇島誠，南雲紳史，内藤幹彦，栗原正明
  • Organizer: 第59回日本薬学会関東支部大会
  • Place of Presentation: 千葉
  • Year and Date: 2015-09-12
• [Presentation] 長鎖アルキル基を有するビタミンD受容体リガンドの創製 (2015)
  • Author(s): 三澤隆史，依岡桃子，出水庸介，大岡伸通，木下恵愛，槇島誠，内藤幹彦，栗原正明
  • Organizer: 第59回日本薬学会関東支部大会
  • Place of Presentation: 千葉
  • Year and Date: 2015-09-12
• [Presentation] ノンセコステロイド型VDRリガンドの創製 (2015)
  • Author(s): 三澤隆史，出水庸介，槇島誠，栗原正明
  • Organizer: 第1回Neo Vitamin D Workshop
  • Place of Presentation: 滋賀
  • Year and Date: 2015-08-28
  • Invited
• [Presentation] エストロゲンによるNOを介した乳癌幹細胞の増殖 (2015)
  • Author(s): 平田尚也，山田茂，出水庸介，栗原正明，関野祐子，諫田泰成
  • Organizer: 第132回日本薬理学会関東部会
  • Place of Presentation: 千葉
  • Year and Date: 2015-07-04
• [Presentation] DDSキャリアを指向したカチオン性非天然アミノ酸導入ペプチドの開発 (2015)
  • Author(s): 山下博子，出水庸介，三澤隆史，大庭誠，田中正一，服部隆行，内藤幹彦，栗原正明
  • Organizer: 第31回日本DDS学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2015-07-02
• [Presentation] アルギニン含有ペプチドの細胞膜透過性とpDNAデリバリーに関する研究 (2015)
  • Author(s): 大庭誠，古川かほり，加藤巧馬，山下博子，出水庸介，栗原正明，田中正一
  • Organizer: 第31回日本DDS学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2015-07-02
• [Presentation] エストロゲン受容体転写活性化阻害能を有するヘリカルペプチドの開発 (2015)
  • Author(s): 出水庸介，三澤隆史，長久保貴哉，諫田泰成，奥平桂一郎，関野祐子，内藤幹彦，栗原正明
  • Organizer: ケミカルバイオロジー第10回年会
  • Place of Presentation: 宮城
  • Year and Date: 2015-06-10
• [Presentation] ヘリカルペプチドを用いたビタミンD受容体（VDR）-コアクチベータ相互作用阻害剤の創製 (2015)
  • Author(s): 三澤隆史，出水庸介，栗原正明
  • Organizer: ケミカルバイオロジー第10回年会
  • Place of Presentation: 宮城
  • Year and Date: 2015-06-10
• [Presentation] Hisタグタンパク質応答性蛍光プローブの開発 (2015)
  • Author(s): 沖津航陽，出水庸介，三澤隆史，正田卓司，服部隆行，内藤幹彦，栗原正明
  • Organizer: ケミカルバイオロジー第10回年会
  • Place of Presentation: 宮城
  • Year and Date: 2015-06-10
• [Presentation] 新規トリアジン誘導体の合成とそれらの抗HIV-1活性評価 (2015)
  • Author(s): 榊原紀和，Gianfranco Balboni，Cenzo Congiu，Valentina Onnis，出水庸介，三澤隆史，栗原正明，加藤善久，丸山徳見，外山政明，岡本実佳，馬場昌範
  • Organizer: ケミカルバイオロジー第10回年会
  • Place of Presentation: 宮城
  • Year and Date: 2015-06-10
• [Presentation] Estrogen induces proliferation of breast cancer stem cells via NO/sGC/cGMP signaling pathway (2015)
  • Author(s): Hirata, N.; Demizu, Y.; Kurihara, M.; Sekino, Y.; Kanda, Y.
  • Organizer: 第13回幹細胞シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2015-05-29
• [Presentation] エストロゲン受容体転写活性化阻害ペプチドの創製 (2015)
  • Author(s): 出水庸介，長久保貴哉，三澤隆史，諫田泰成，奥平桂一郎，関野祐子，内藤幹彦，栗原正明
  • Organizer: 日本薬学会第135回年会
  • Place of Presentation: 神戸
  • Year and Date: 2015-03-26 – 2015-03-28
• [Presentation] カンナビノイド受容体調整薬の設計と合成 (2015)
  • Author(s): 三澤隆史，出水庸介，船田正彦，栗原正明
  • Organizer: 日本薬学会第135回年会
  • Place of Presentation: 神戸
  • Year and Date: 2015-03-26 – 2015-03-28
• [Presentation] 二次構造制御に基づくカチオン性膜透過ペプチドの開発 (2015)
  • Author(s): 山下博子, 出水庸介, 三澤隆史, 服部隆行, 大庭誠, 田中正一, 内藤幹彦, 栗原正明
  • Organizer: 日本薬学会第135回年会
  • Place of Presentation: 神戸
  • Year and Date: 2015-03-26 – 2015-03-28
• [Presentation] 細胞内タンパク質に対する蛍光スイッチング機能を持つ小分子プローブの開発 (2015)
  • Author(s): 沖津航陽，出水庸介，三澤隆史，正田卓司，服部隆行，内藤幹彦，栗原正明
  • Organizer: 日本薬学会第135回年会
  • Place of Presentation: 神戸
  • Year and Date: 2015-03-26 – 2015-03-28
• [Presentation] 非対称ジフェニルメタンを基本骨格とするエストロゲン受容体アンタゴニストの設計と合成 (2015)
  • Author(s): 田中克哉，依岡桃子，三澤隆史，諫田泰成，関野祐子，出水庸介，栗原正明
  • Organizer: 日本薬学会第135回年会
  • Place of Presentation: 神戸
  • Year and Date: 2015-03-26 – 2015-03-28
• [Presentation] 糖アミノ酸を用いた新規糖質類縁体の合成と抗ウィルス薬への応用 (2015)
  • Author(s): 岡崎優祐，出水庸介，細谷翼，栗原正明，須原義智
  • Organizer: 日本薬学会第135回年会
  • Place of Presentation: 神戸
  • Year and Date: 2015-03-26 – 2015-03-28
• [Presentation] 三重螺旋構造の安定化を指向したβ-ペプチド導入型コラーゲン模倣物の創製 (2015)
  • Author(s): 杖本望，出水庸介，百合野翔太郎，中村陽菜，土井麻緒，栗原正明，須原義智
  • Organizer: 日本薬学会第135回年会
  • Place of Presentation: 神戸
  • Year and Date: 2015-03-26 – 2015-03-28
• [Presentation] アセタールを有するキラル環状ジ置換アミノ酸によるヘリカル二次構造の制御 (2015)
  • Author(s): 古場百合恵，上田篤志，大庭誠，土井光暢，出水庸介，栗原正明，田中正一
  • Organizer: 日本薬学会第135回年会
  • Place of Presentation: 神戸
  • Year and Date: 2015-03-26 – 2015-03-28
• [Presentation] D-トレイトール由来のアセタールを有する六員環状ジ置換アミノ酸よりなるペプチドのコンフォメーション解析 (2015)
  • Author(s): 江藤諒，大庭誠，上田篤志，栗原正明，出水庸介，末宗洋，田中正一
  • Organizer: 日本薬学会第135回年会
  • Place of Presentation: 神戸
  • Year and Date: 2015-03-26 – 2015-03-28
• [Presentation] リパーゼ触媒を用いた[5]ヘリセン類の速度論的光学分割 (2015)
  • Author(s): 清水貴士，山本耕介，メイビョウ，出水庸介，栗原正明，末宗洋，臼井一晃
  • Organizer: 日本薬学会第135回年会
  • Place of Presentation: 神戸
  • Year and Date: 2015-03-26 – 2015-03-28
• [Presentation] 3,5-ジメチルベンジル基を有するウラシル誘導体および尿素誘導体の合成とそれらの抗HIV-1活性評価 (2015)
  • Author(s): 榊原紀和，馬場昌範，岡本実佳，外山政明，出水庸介，三澤隆史，栗原正明，入江晃司，加藤善久，丸山徳見
  • Organizer: 日本薬学会第135回年会
  • Place of Presentation: 神戸
  • Year and Date: 2015-03-26 – 2015-03-28
• [Presentation] デアザグアニン誘導体を持つPNAモノマーの合成 (2015)
  • Author(s): 杉山亨，桑田啓子，今村保忠，出水庸介，栗原正明，高野真史，橘高敦史
  • Organizer: 日本薬学会第135回年会
  • Place of Presentation: 神戸
  • Year and Date: 2015-03-26 – 2015-03-28
• [Presentation] ヘリカルペプチドを用いたエストロゲン受容体転写阻害剤の創製 (2014)
  • Author(s): 三澤隆史，長久保貴哉，出水庸介，佐藤由紀子，諫田泰成，奥平桂一郎，関野祐子，内藤幹彦，栗原正明
  • Organizer: 第32回メディシナルケミストリーシンポジウム
  • Place of Presentation: 神戸
  • Year and Date: 2014-11-26 – 2014-11-28
• [Presentation] 生体材料への応用を指向した新規コラーゲン様ペプチドの創製 (2014)
  • Author(s): 杖本望，出水庸介，百合野翔太郎，小川舞，土井麻緒，中村陽菜，栗原正明，須原義智
  • Organizer: 第32回メディシナルケミストリーシンポジウム
  • Place of Presentation: 神戸
  • Year and Date: 2014-11-26 – 2014-11-28
• [Presentation] 抗ウィルス薬を目指した新規O-硫酸化多糖類の合成 (2014)
  • Author(s): 岡崎優祐，出水庸介，細谷翼，川口潤一郎，栗原正明，須原義智
  • Organizer: 第32回メディシナルケミストリーシンポジウム
  • Place of Presentation: 神戸
  • Year and Date: 2014-11-26 – 2014-11-28
• [Presentation] エストロゲン受容体転写阻害ペプチドの開発 (2014)
  • Author(s): 出水庸介，長久保貴哉，三澤隆史，佐藤由紀子，諫田泰成，奥平桂一郎，関野祐子，内藤幹彦，栗原正明
  • Organizer: 第40回反応と合成の進歩シンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2014-11-10 – 2014-11-11
• [Presentation] 二次構造制御に基づく膜透過性ヘリカルペプチドの創製 (2014)
  • Author(s): 山下博子，出水庸介，三澤隆史，大庭誠，田中正一，栗原正明
  • Organizer: 第40回反応と合成の進歩シンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2014-11-10 – 2014-11-11
• [Presentation] 環状メチオニンの合成とそのペプチドの二次構造解析 (2014)
  • Author(s): 小野京，島袋充史，上田篤志，大庭誠，土井光暢，出水庸介，栗原正明，田中正一
  • Organizer: 第40回反応と合成の進歩シンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2014-11-10 – 2014-11-11
• [Presentation] HIV-1剤を指向した1-置換型ウラシル誘導体および尿素誘導体の創製研究 (2014)
  • Author(s): 榊原紀和，馬場昌範，岡本実佳，外山政明，出水庸介，三澤隆史，栗原正明，入江晃司，加藤善久，丸山徳見
  • Organizer: 第52回薬学会中国四国支部学術大会
  • Place of Presentation: 愛媛
  • Year and Date: 2014-10-26 – 2014-10-27
• [Presentation] 短鎖ペプチドのヘリカル構造制御と機能化 (2014)
  • Author(s): 出水庸介
  • Organizer: 第51回ペプチド討論会
  • Place of Presentation: 徳島
  • Year and Date: 2014-10-22 – 2014-10-24
  • Invited
• [Presentation] Development of stabilized short helical peptides with cell-membrane penetrating ability (2014)
  • Author(s): 山下博子，出水庸介，三澤隆史，大庭誠，田中正一，栗原正明
  • Organizer: 第51回ペプチド討論会
  • Place of Presentation: 徳島
  • Year and Date: 2014-10-22 – 2014-10-24
• [Presentation] Development of cell-permeable peptide for transcriptional inhibitor of estrogen receptor (2014)
  • Author(s): 長久保貴哉，出水庸介，三澤隆史，佐藤由紀子，諫田泰成，奥平桂一郎，関野祐子，内藤幹彦，栗原正明
  • Organizer: 第51回ペプチド討論会
  • Place of Presentation: 徳島
  • Year and Date: 2014-10-22 – 2014-10-24
• [Presentation] Synthesis and conformational analysis of helical oligomers with a changeable chiral acetal moiety (2014)
  • Author(s): 江藤諒，大庭誠，上田篤志，石川奈保子，栗原正明，出水庸介，末宗洋，土井光暢，田中正一
  • Organizer: 第51回ペプチド討論会
  • Place of Presentation: 徳島
  • Year and Date: 2014-10-22 – 2014-10-24
• [Presentation] Modified Deazaguanies for the synthesis of PNA (2014)
  • Author(s): 杉山亨，桑田啓子，今村保忠，出水庸介，栗原正明，高野真史，橘高敦史
  • Organizer: 第51回ペプチド討論会
  • Place of Presentation: 徳島
  • Year and Date: 2014-10-22 – 2014-10-24
• [Presentation] 合成カンナビノイドのCB1受容体に対する結合様式解析に関する研究 (2014)
  • Author(s): 出水庸介，三澤隆史，内山奈穂子，花尻瑠理，袴塚高志，栗原正明
  • Organizer: 第58回日本薬学会関東支部大会
  • Place of Presentation: 東京
  • Year and Date: 2014-10-04
• [Presentation] エストロゲン受容体転写阻害能を有するペプチドの創製 (2014)
  • Author(s): 長久保貴哉，出水庸介，三澤隆史，佐藤由紀子，諫田泰成，奥平桂一郎，関野祐子，内藤幹彦，栗原正明
  • Organizer: 第58回日本薬学会関東支部大会
  • Place of Presentation: 東京
  • Year and Date: 2014-10-04
• [Presentation] 細胞内Hisタグタンパク質応答性蛍光プローブの開発 (2014)
  • Author(s): 沖津航陽，出水庸介，三澤隆史，正田卓司，服部隆行，内藤幹彦，栗原正明
  • Organizer: 第58回日本薬学会関東支部大会
  • Place of Presentation: 東京
  • Year and Date: 2014-10-04
• [Presentation] Conformations of LD-peptides containing equal amounts of L-amino acids, D-amino acids, and achiral α,α-disubstitued amino acids (2014)
  • Author(s): Demizu, Y., Misawa, T., Yamashita, H., Doi, M., Sato, Y., Tanaka, M., Kurihara
  • Organizer: 33rd European Peptide Symposium
  • Place of Presentation: ブルガリア
  • Year and Date: 2014-08-31 – 2014-09-05
• [Presentation] Stapled short helical peptides for vitamin D receptor-coactivator interaction inhibitor (2014)
  • Author(s): Kurihara, M., Kawamura, M., Misawa, T., Sato, Y., Demizu, Y.
  • Organizer: 33rd European Peptide Symposium
  • Place of Presentation: ブルガリア
  • Year and Date: 2014-08-31 – 2014-09-05
• [Presentation] Helical secondary structures of peptides having chiral cyclic amino acid with two azido functional groups (2014)
  • Author(s): Tanaka, M., Takazaki, H., Kawabe, N., Doi, M., Demizu, Y., Kurihara, M., Suemune, H., Oba, M.
  • Organizer: 33rd European Peptide Symposium
  • Place of Presentation: ブルガリア
  • Year and Date: 2014-08-31 – 2014-09-05
• [Presentation] 細胞膜高透過性Tatペプチドミミックの開発 (2014)
  • Author(s): 出水庸介，三澤隆史，山崎徳和，佐藤由紀子，大庭誠，田中正一，栗原正明
  • Organizer: 第30回日本DDS学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2014-07-30 – 2014-07-31
• [Presentation] オリゴアルギニンをベースとした細胞膜透過性ヘリカルペプチドの開発 (2014)
  • Author(s): 山下博子，出水庸介，三澤隆史，大庭誠，田中正一，栗原正明
  • Organizer: 第30回日本DDS学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2014-07-30 – 2014-07-31
• [Presentation] ヘリカル構造制御に基づく細胞膜高透過性ペプチドの創製 (2014)
  • Author(s): 出水庸介，三澤隆史，山崎徳和，山下博子，佐藤由紀子，大庭誠，田中正一，栗原正明
  • Organizer: ケミカルバイオロジー第9回年会
  • Place of Presentation: 大阪
  • Year and Date: 2014-06-12 – 2014-06-13
• [Presentation] VDR-コアクチベータ結語阻害作用を有するステープルペプチドの創製 (2014)
  • Author(s): 川村愛，出水庸介，三澤隆史，栗原正明
  • Organizer: ケミカルバイオロジー第9回年会
  • Place of Presentation: 大阪
  • Year and Date: 2014-06-12 – 2014-06-13
• [Presentation] 抗HIV-1剤を指向した1-置換型3-(3,5-ジメチルベンジル)ウラシルの創製研究 (2014)
  • Author(s): 榊原紀和，馬場昌範，岡本実佳，外山政明，出水庸介，栗原正明，入江晃司，加藤善久，丸山徳見
  • Organizer: ケミカルバイオロジー第9回年会
  • Place of Presentation: 大阪
  • Year and Date: 2014-06-12 – 2014-06-13
• [Patent(Industrial Property Rights)] 構築物，及び，カーゴ分子を細胞内に輸送する方法 (2018)
  • Inventor(s): 出水庸介，三澤隆 史，大岡伸通，内藤幹彦
  • Industrial Property Rights Holder: 出水庸介，三澤隆 史，大岡伸通，内藤幹彦
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2018-000461
  • Filing Date: 2018
• [Patent(Industrial Property Rights)] 細胞膜透過性を有するペプチド，構築物，及び，カーゴ分子を細胞内に輸送する方法 (2017)
  • Inventor(s): 出水庸介，栗原正明，三澤隆史
  • Industrial Property Rights Holder: 出水庸介，栗原正明，三澤隆史
  • Industrial Property Rights Type: 特許
  • Filing Date: 2017-02-02
  • Overseas
• [Patent(Industrial Property Rights)] 細胞膜透過性を有するペプチド，構築物，及び，カーゴ分子を細胞内に輸送する方法 (2016)
  • Inventor(s): 出水庸介，栗原正明，三澤隆史
  • Industrial Property Rights Holder: 出水庸介，栗原正明，三澤隆史
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2016-018416
  • Filing Date: 2016-02-02