Toxicological effects by disposition of chemicals during development of Xenopus tropicalis
| Project/Area Number |
26460171
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental and hygienic pharmacy
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| Research Institution | Hiroshima University |
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Principal Investigator |
Sanoh Seigo 広島大学, 医歯薬保健学研究院(薬), 助教 (00552267)
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| Co-Investigator(Kenkyū-buntansha) |
柏木 昭彦 広島大学, 両生類研究センター, 特任教授 (50106796)
太田 茂 広島大学, 医歯薬保健学研究院(薬), 教授 (60160503)
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| Co-Investigator(Renkei-kenkyūsha) |
KASHIWAGI KEIKO 広島大学, 両生類研究センター, 研究員 (00467763)
HANADA HIDEKI 広島大学, 両生類研究センター, 助教 (50228508)
SUZUKI KEN-ICHI 広島大学, 大学院理学研究科, 特任准教授 (90363043)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ネッタイツメガエル / 甲状腺ホルモン / 薬物代謝酵素 / アミオダロン / ツメガエル / 化学物質 / トランスポーター |
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| Outline of Final Research Achievements |
Several clinical pharmaceuticals detected in the aquatic environment are concerned to result in unexpected effects on aquatic species. We found that amiodarone, anti-arrhythmic drug suppressed the metamorphosis of tadpoles controlled by the endogenous thyroid hormone. The antagonistic activity of amiodarone for thyroid hormone and its high accumulation in tadpoles could induce the toxicity. Furthermore, the levels of several drug-metabolizing enzyme expression changed during development of tadpoles, which could be partly caused by thyroid hormone. These are important findings to evaluate chemical accumulation and its related toxicity.
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Report
(4 results)
Research Products
(8 results)
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[Presentation] ネッタイツメガエルの成長・発達過程における肝臓中薬物代謝酵素の変動とアミオダロンの蓄積2016
Author(s)
佐能正剛, 森淳平, 鈴木賢一, 柏木啓子, 花田秀樹, 重田美津紀, 山本卓, 杉原数美, 北村繁幸, 柏木昭彦, 太田茂
Organizer
平成28年度内外環境応答・代謝酵素研究会
Place of Presentation
静岡県立大学薬学部
Year and Date
2016-09-17
Related Report
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[Presentation] Development Changes of Drug-metabolizing Enzymes Related to Accumulation of Chemicals in Tadpoles and Adult Frogs2016
Author(s)
Seigo Sanoh, Junpei Mori, Ken-ichi T. Suzuki, Keiko Kashiwagi, Hideki Hanada, Mitsuki Shigeta, Takashi Yamamoto, Kazumi Sugihara, Shigeyuki Kitamura, Akihiko Kashiwagi, Shigeru Ohta
Organizer
International Meeting on Aquatic Model Organisms for Human Disease and Toxicology Research
Place of Presentation
Okazaki Conference Center, Okazaki, Japan
Year and Date
2016-03-18
Related Report
Int'l Joint Research / Invited
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