| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
The present study demonstrated that intake of theanine, a major component of amino acids in green tea, enhances hippocampal neurogenesis, which is related to long-term memory, followed by enhancement of hippocampal long-term potentiation (LTP), a cellular mechanism of memory. On the other hand, the present study revealed that intracellular zinc signaling in the glutamatergic synapses in the hippocampus is necesarry for not only memory acquisition but also memory retention via LTP induction and its maintenance. And, the present study indicates that increase in Zn2+ influx into dentate granule cells through AMPA receptors, a subtype of glutamate receptor, loses maintained LTP and memory. Regulation of Zn2+ influx into dentate granule cells is more critical for not only memory acquisition but also memory retention than that of Ca2+ influx.
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