| Project/Area Number |
26460174
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental and hygienic pharmacy
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| Research Institution | Teikyo University |
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Principal Investigator |
Hara Massumi 帝京大学, 医学部, 教授 (70420213)
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| Co-Investigator(Kenkyū-buntansha) |
菊池 健太郎 帝京大学, 医学部, 准教授 (60297158)
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| Research Collaborator |
TSUNEYAMA Koichi 徳島大学, 医学部, 教授
TSUKAMOTO Kazuhisa 帝京大学, 医学部, 教授
KURANO Makoto 東京大学, 医学部, 講師
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | Niacin / NASH / PNPLA3 / apoA-IV / ニコチン酸 / 非アルコール性脂肪肝炎 / monosodium glutamate / 肥満 / 脂肪肝 / アポリポ蛋白 / 食後高血糖 / ビタミンB3 |
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| Outline of Final Research Achievements |
ICR mouse neonatally administered monosodium glutamate (MSG) shows obesity, insulin resistance, and is a murine model of steatohepatitis. In this study, we analysed the effect of nicotinic acid on steatohepatitis of MSG-treated obese mice.
After 12 weeks of treatment of niacin, MSG-treated mice showed less weight of body and liver. Histopathological analyses showed markedly prevention of steatohepatitis. NAFLD activity scores (NAS) of niacin and vehicle groups were 0.0, 5.2, respectively. Niacin also dramatically ameliorated accomplished steatohepatitis. Niacin treatment ameliorated dyslipidemia; atherogenic LDL fraction was disappeared in fasting plasma, and elevations of postprandial NEFA and triglycerides were suppressed. Mircoarray analyses showed that the genes of apolipoprotein A-IV and patatin-like phospholipase domain containing 3 (PNPLA3) were changed in expression with the treatment of niacin.
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