Metallomic analysis to elucidate the metabolism and biological effects of arsenic compounds contained in Seafood
| Project/Area Number |
26460176
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental and hygienic pharmacy
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
畑 明寿 千葉科学大学, 危機管理学部, 講師 (10433690)
圓藤 吟史 公益財団法人大原記念労働科学研究所, 研究部, 客員研究員 (20160393)
加藤 孝一 日本大学, 薬学部, 教授 (60246931)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | ジメチルモノチオアルシン酸 / メタロミクス解析 / アルセノシュガー / 腸内細菌 / 代謝 / ジメチル亜ヒ酸 / グルタチオン / ジメチルメルカプトアルシン / カスパーゼ3/7 / HepaRG細胞 / 硫化水素 / ジメチルアルシン酸 / ジメチルヒ素 / アルセノ脂質 / ジメチルチオアルシン酸 |
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| Outline of Final Research Achievements |
We have reported an analytical methods for arsenic compounds in seafood , among foodstuffs. In addition, we have focused on our attention to dimethylmonothioarsinic acid (DMMTA), which is known as an intermediate metabolite of arsenic compounds in seafood and an high toxic metabolite. Concerning cytotoxicity and toxic mechanism of DMMTA, we found that the toxicity of DMMTA deeply involved GSH and that clarified the possibility that multiple metabolites produced by GSH are involved in the mechanism. The results seem to be very useful for risk assessment of arsenic compounds derived from seafood.
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Report
(4 results)
Research Products
(6 results)
