| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Bacteria contain components that activate the human immune system. The analog can be a pharmaceutical seed. It is effective to create a system in bacteria by modifying the biosynthesis / metabolic system. Achromobacter xylosoxidans has ornithine-containing lipids. Adjuvant activity is known for amino acid-containing lipids including ornithine-containing lipids. Therefore, an analytical method using a matrix-assisted laser desorption ionization time-of-flight mass spectrometer of amino acid-containing lipids was established. Detection and purification of hydroxylated ornithine-containing lipids were carried out using the analytical method. The bioactivity of hydroxylated ornithine-containing lipids and nonhydroxylated ornithine-containing lipids was compared, but there was no difference as far as it was investigated.
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