| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
UbiA prenyltransferase domain containing 1 (UBIAD1) is a novel vitamin K2 biosynthetic enzyme. To investigate the function of UBIAD1 in vascular smooth muscle cells, we attempted to generate vascular specific conditional Ubiad1 knockout mice (Ubiad1-V-KO). Ubiad1-V-KO was generated with conditional deletion of Ubiad1 gene in cells expressing the smooth muscle cell-specific protein SM22α. Ubiad1-V-KO were born according to Mendel's theory of heredity, however all Ubiad1-V-KO were died with pleural effusion at 6-8 weeks-old. Also, we confirmed that abnormality of aortic elastic fiber, ventricular myocardial hypoplasia, hypertension and decrease of heart rate in Ubiad1-V-KO.
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