Analysis for the effects of Streptococcus pneumoniae on the exacerbation of pneumonia in RSV-infected mice compared with a brominated flame retardant
Project/Area Number |
26460183
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Environmental and hygienic pharmacy
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Research Institution | Kyushu University of Health and Welfare |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
明石 敏 九州保健福祉大学, 薬学部, 教授 (10648596)
黒川 昌彦 九州保健福祉大学, 薬学部, 教授 (80186527)
吉田 裕樹 九州保健福祉大学, 薬学部, 講師 (90469411)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | RSウイルス / 肺炎球菌 / RSV / 初期免疫 / 肺炎 |
Outline of Final Research Achievements |
To reveal effects of Streptococcus pneumoniae on the exacerbation of RSV-induced pneumonia, effects of formalin-inactivated the bacteria (SP) on RSV infection in mice were investigated.Single intranasal exposure to SP did not show any exacerbation of pneumonia in RSV-infected mice on day 5 post-infection, compared with a brominated flame retardant TBBPA. By three times exposure to SP, the levels of proinflammatory cytokines, such as TNF-α and IL-6, in bronchoalveolar lavage fluid were strongly suppressed rather than enhancement of inflammation in RSV-infected mice on day 1 post-infection. The tendency to alleviate pneumonia due to the SP-exposure was also found in histopathological analysis. Pulmonary viral titers were significantly decreased due to SP-exposure in RSV-infected mice compare with the control on day 5 post-infection. Analysis for the mechanism of action of our findings should contribute to establish novel approach for reduction of exacerbation of RSV-induced pneumonia.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Titanium dioxide nanoparticles exacerbate pneumonia in respiratory syncytial virus (RSV)-infected mice.2015
Author(s)
Hashiguchi S, Yoshida H, Akashi T, Komemoto K, Ueda T, Ikarashi Y, Miyauchi A, Konno K, Yamanaka S, Hirose A, Kurokowa M, Watanabe W.
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Journal Title
Environ Toxicol Pharmacol
Volume: 39
Issue: 2
Pages: 879-886
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Naringenin suppresses macrophage infiltration into adipose tissue in an early phase of high-fat diet-induced obesity.2014
Author(s)
Yoshida, H., Watanabe, H., Ishida, H., Watanabe, W., Narumi, K., Atsumi, T., Sugita, C., Kurokawa, M.
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Journal Title
Biochem. Biophys. Res. Comm.
Volume: 454
Pages: 95-101
Related Report
Peer Reviewed
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[Journal Article] Anti-allergic activity of probiotics from Mongolian dairy products on type I allergy in mice and mode of anti-allergic action.2014
Author(s)
Takeda, S., Hidaka, M., Yoshida, H., Takeshita, M., Kikuchi, Y., Tsend-Ayush, C., Bumbein, D., Kawahara, S., Muguruma, M., Watanabe, W., Kurokawa, M.
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Journal Title
J. Func. Foods
Volume: 9
Pages: 60-69
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] In vitro and in vivo anti-influenza virus activities of flavonoids and related compounds as components of Brazilian propolis (AF-08).2014
Author(s)
Kai, H., Obuchi, M., Yoshida, H., Watanabe, W., Tsutsumi, S., Park, Y.K., Matsuno, K., Yasukawa K., Kurokawa,
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Journal Title
J Func Foods
Volume: 8
Pages: 214-223
DOI
Related Report
Peer Reviewed / Open Access
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