| Project/Area Number |
26460183
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental and hygienic pharmacy
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| Research Institution | Kyushu University of Health and Welfare |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
明石 敏 九州保健福祉大学, 薬学部, 教授 (10648596)
黒川 昌彦 九州保健福祉大学, 薬学部, 教授 (80186527)
吉田 裕樹 九州保健福祉大学, 薬学部, 講師 (90469411)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | RSウイルス / 肺炎球菌 / RSV / 初期免疫 / 肺炎 |
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| Outline of Final Research Achievements |
To reveal effects of Streptococcus pneumoniae on the exacerbation of RSV-induced pneumonia, effects of formalin-inactivated the bacteria (SP) on RSV infection in mice were investigated.Single intranasal exposure to SP did not show any exacerbation of pneumonia in RSV-infected mice on day 5 post-infection, compared with a brominated flame retardant TBBPA. By three times exposure to SP, the levels of proinflammatory cytokines, such as TNF-α and IL-6, in bronchoalveolar lavage fluid were strongly suppressed rather than enhancement of inflammation in RSV-infected mice on day 1 post-infection. The tendency to alleviate pneumonia due to the SP-exposure was also found in histopathological analysis. Pulmonary viral titers were significantly decreased due to SP-exposure in RSV-infected mice compare with the control on day 5 post-infection.
Analysis for the mechanism of action of our findings should contribute to establish novel approach for reduction of exacerbation of RSV-induced pneumonia.
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