| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
The infection rates were 0.08 to 23.6 % by Giemsa staining. On the other hand, the infection rates were estimated as 0.08 to 2.53 % by cell microarray chip system. Although we could not detect good correlation between two methods above 2.0 % (Fig. 3), good correlation was observed according to simple linear regression analysis (R2=0.9222) below the 1.8 %. This cell microarray chip system was developed for the high sensitive detection of malaria infected erythrocytes (100 times higher sensitivity than that of conventional light microscopy),
Although cell microarray chip system could not detect malaria infected erythrocytes exactly (above 2.0 %), accurate detection could be performed in low infection rate (below 1.8 %). Furthermore, the number of patients was not enough to demonstrate the potential of cell microarray chip system for diagnosis system. We will improve the cell microarray chip system for field setting with more number of malaria patient’s samples.
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