Development of a new treatment strategy using TDM for next generation anticancer drug
| Project/Area Number |
26460188
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Akita University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
Takahashi Naoto 秋田大学, 医学部血液腎臓膠原病内科, 教授 (80344753)
Shibata Hiroyuki 秋田大学, 医学部臨床腫瘍学, 教授 (60393732)
Tsuchiya Norihiko 秋田大学, 医学部泌尿器科学, 准教授 (70282176)
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| Research Collaborator |
Kagaya Hideaki 秋田大学, 医学部附属病院薬剤部
Abumiya Maiko 秋田大学, 医学部附属病院薬剤部
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 分子標的抗がん剤 / 血中濃度 / 精密医療 / 分子標的治療薬 / 個別化治療 / TDM / 抗がん剤 |
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| Outline of Final Research Achievements |
Patients with axitinib C0 more than 5.0 ng/mL showed a tendency toward longer PFS than those with < 5.0 ng/mL. The mean axitinib AUC was significantly higher in patients with the SLCO1B1*15 than without. HPLC-UV method was used to measure the plasma concentrations of regorafenib, active metabolites, M-2 and M-5. Although the therapeutic window of regorafenib cannot yet clarify in the present study, the higher M-5 C0 seems to be related to the side effects of regorafenib. Plasma concentrations of lenalidomide were analyzed by LC-MS/MS. The AUC of lenalidomide can be predicted by the formula using 2 time points, C0h and C4h, in combination with CCr. In Caco-2 cells, the basal-to-apical apparent permeability of lenalidomide was changed, but no change for apical-to-basal, after treatment of the cells with clarithromycin. Clarithromycin inhibited the efflux activity of P-glycoprotein. The lenalidomide C0 was significantly associated with the occurrence of non-hematotoxicity (>21 ng/mL).
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] Clinical effects of single nucleotide polymorphisms on drug-related genes in Japanese metastatic renal cell carcinoma patients treated with sunitinib.2017
Author(s)
Numakura K, Tsuchiya N, Kagaya H, Takahashi M, Tsuruta H, Inoue T, Narita S, Huang M, Satoh S, Niioka T, Miura M, Habuchi T.
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Journal Title
Anticancer Drugs.
Volume: 28(1)
Pages: 97-103
Related Report
Peer Reviewed
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[Journal Article] Low plasma concentration of gefitinib in patients with EGFR exon 21 L858R point mutations shortens progression-free survival.2017
Author(s)
Okuda Y, Sato K, Sudo K, Hasegawa Y, Asano M, Miura H, Takeda M, Sano M, Watanabe H, Kobayashi H, Niioka T, Miura M, Ito H.
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Journal Title
Cancer Chemother Pharmacol.
Volume: in press
Related Report
Peer Reviewed
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[Journal Article] Treatment of multiple myeloma in Akita: features and outcomes in the era of novel agents.2014
Author(s)
Shida S, Takahashi N, Niioka T, Kitabayashi A, Kawabata Y, Kume M, Saitoh H, Hatano Y, Ichikawa Y, Kuroki J, Motegi M, Kobayashi T, Kameoka Y, Tagawa H, Fujishima N, Yoshioka T, Hirokawa M, Miura M, Sawada K.
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Journal Title
J Clin Exp Hematop
Volume: 54
Pages: 89-93
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] A limited sampling model to estimate exposure to lenalidomide in multiple myeloma patients.2014
Author(s)
Shida S, Takahashi N, Miura M, Niioka T, Matsumoto M, Hagihara M, Kobayashi T, Abumiya M, Kameoka Y, Fujishima N, Tagawa H, Hirokawa M, Sawada K.
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Journal Title
Ther Drug Monit
Volume: 36
Issue: 4
Pages: 505-9
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Two-year consolidation by Nilotinib might improve the TFR of STIM trial in CML with DMR2016
Author(s)
Kaichi Nishiwaki, Naoto Takahashi, Chiaki Nakaseko, Hisashi Wakita, Koji Sano, Chikako Ohwada, Nobuyuki Aotsuka, Jun Kuroki, Hideo Kimura, Hideyoshi Noji, Michihide Tokuhira, Kinuko Mitani, Kazuhisa Fujikawa, Osamu Iwase, Kohshi Ohishi, Fumihiko Kimura, Tetsuya Fukuda, Sakae Tanosaki, Masatomo Miura, Kenichi Sawada
Organizer
第78回日本血液学会学術集会
Place of Presentation
横浜
Year and Date
2016-10-13
Related Report
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[Presentation] Association of pharmacokinetics of axitinib with treatment outcome and adverse events in advanced renal cell carcinoma patients.2016
Author(s)
Norihiko Tsuchiya, Ryoma Igarashi, Naoko Suzuki-Honma, Nobuhiro Fujiyama, Shintaro Narita, Takamitsu Inoue, Mitsuru Saito, Susumu Akihama, Hiroshi Tsuruta, Masatomo Miura, Tomonori Habuchi
Organizer
2016 American Society of Clinical Oncology (ASCO) Annual Meeting
Place of Presentation
Chicago
Year and Date
2016-06-03
Related Report
Int'l Joint Research
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[Presentation] The impact of UGT1A1 and SLCO1B1 genetic polymorphisms and pharmacokinetics of axitinib on clinical safety and efficacy in patients with metastatic renal cell carcinoma.2016
Author(s)
Shintaro Narita, Ryoma Igarashi, Norihiko Tsuchiya, Takamitsu Inoue, Nobuhiro Fujiyama, Kazuyuki Numakura, Hiroshi Tsuruta, Hideaki Kagaya, Mitsuru Saito, Takenori Niioka, Masatomo Miura, Shigeru Satoh, Tomonori Habuchi
Organizer
2016 American Society of Clinical Oncology (ASCO) Annual Meeting
Place of Presentation
Chicago
Year and Date
2016-06-03
Related Report
Int'l Joint Research
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[Presentation] Pharmacokinetics of bosutinib and its induced-diarrhea in Ph-positive chronic myeloid leukemia2015
Author(s)
Maiko Abumiya, Naoto Takahashi, Takenori Niioka, Saori Takahashi, Akiko Mita, Takahiro Kobayashi, Yoshihiro Kameoka, Tomoko Yoshioka, Naohito Fujishima, Hiroyuki Tagawa, Kenichi Sawada, Masatomo Miura
Organizer
第77回日本血液学会学術集会
Place of Presentation
金沢
Year and Date
2015-10-16
Related Report
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[Presentation] Pharmacokinetcis of lenalidomide in patients with multiple myeloma on hemodialysis.2014
Author(s)
Takahiro Kobayashi, Naoto Takahashi, Masatomo Miura, Ayano Ohara, Yoshihiro Mitishita, Tekenori Niioka, Maiko Abumiya, Seiji Shida, Kumi Ubukawa, Naohito Fujishima, Yoshihiro Kameoka, Hiroyuki Tagawa, Kenichi Sawada
Organizer
第76回日本血液学会学術集会
Place of Presentation
大阪
Year and Date
2014-10-31
Related Report
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