| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Outline of Final Research Achievements |
This study aimed to construct the quantitative prediction methods of drug removal by hemodialysis (fd), especially focused on the permeation clearance of hemodialyzer (KoA). The predicted fd values, which were calculated by the prediction formula incorporating KoA, are in good concordance with the observed values. This result indicatse that the fd values are quantitatively predictable by evaluating the KoA values of drugs in in vitro study.
In the future studies, we planed to measure the KoA values by in vitro hemodialysis experiment, and determine the in vivo fd values by analyzing the serum specimens obtained from patients receiving hemodialysis to confirm the clinical applicability of our prediction method.
|
