Quantitative prediction of drug removal by hemodialysis based on permeation clearance of hemodialyzer
Project/Area Number |
26460191
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Medical pharmacy
|
Research Institution | The University of Tokyo |
Principal Investigator |
YAMAMOTO Takehito 東京大学, 大学院薬学系研究科(薬学部), 講師 (00376469)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 薬物動態学 / 血液透析 / 投与設計 / クリアランス / 透析性 / 定量的予測 / 透過性 |
Outline of Final Research Achievements |
This study aimed to construct the quantitative prediction methods of drug removal by hemodialysis (fd), especially focused on the permeation clearance of hemodialyzer (KoA). The predicted fd values, which were calculated by the prediction formula incorporating KoA, are in good concordance with the observed values. This result indicatse that the fd values are quantitatively predictable by evaluating the KoA values of drugs in in vitro study. In the future studies, we planed to measure the KoA values by in vitro hemodialysis experiment, and determine the in vivo fd values by analyzing the serum specimens obtained from patients receiving hemodialysis to confirm the clinical applicability of our prediction method.
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Report
(4 results)
Research Products
(5 results)