Role of microRNA on the pharmacokinetics and pharmacodynamics of tacrolimus in inflammatory bowel disease
| Project/Area Number |
26460195
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Mie University |
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Principal Investigator |
IKEMURA Kenji 三重大学, 医学部附属病院, 助教 (70513935)
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| Co-Investigator(Kenkyū-buntansha) |
奥田 真弘 三重大学, 医学部附属病院, 教授 (70252426)
岩本 卓也 三重大学, 医学部附属病院, 准教授 (30447867)
荒木 俊光 三重大学, 医学部附属病院, 講師 (70343217)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | マイクロRNA / 潰瘍性大腸炎 / P-糖タンパク質 / タクロリムス / マイクロＲＮＡ / CYP3A |
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| Outline of Final Research Achievements |
Our study demonstrates that oral absorption of tacrolimus (an immunosuppressant) was increased in dextran sodium sulfate (DSS)-induced ulcerative colitis rats, and this is attributable to decreased intestinal P-glycoprotein. In addition, the altered expression of miRNAs in the small intestine were observed in DSS-induced ulcerative colitis rats. MiRNAs regulate the expression and function of proteins regulating pharmacokinetics in intestinal epithelial cells. Therefore, miRNAs could be significant factors affecting inter- and intra- individual variations in the pharmacokinetics of tacrolimus.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Co-administration of proton pump inhibitors ameliorates nephrotoxicity in patients receiving chemotherapy with cisplatin and fluorouracil: a retrospective cohort study.2017
Author(s)
Ikemura K, Oshima K, Enokiya T, Okamoto A, Oda H, Mizuno T, Ishinaga H, Muraki Y, Iwamoto T, Takeuchi K, Katayama N, Okuda M
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Journal Title
Cancer Chemotherapy and Pharmacology
Volume: 印刷中
Issue: 5
Pages: 943-949
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] Lansoprazole exacerbates pemetrexed-mediated hematological toxicity by competitive inhibition of renal basolateral human organic anion transporter 32016
Author(s)
Ikemura K, Hamada Y, Kaya C, Enokiya T, Muraki Y, Nakahara H, Fujimoto H, Kobayashi T, Iwamoto T, Okuda M
Organizer
2016 AAPS ANNUAL MEETING AND EXPOSITION
Place of Presentation
Colorado Convention Center, Denver (USA)
Year and Date
2016-11-13
Related Report
Int'l Joint Research
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