Establishment of optimization method of antimicrobial agent therapy based on the therapeutic goal achievement probability of target organs

• Project/Area Number: 26460198
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: Hiroshima University
• Principal Investigator: MORIKAWA NORIFUMI 広島大学, 医歯薬保健学研究院(薬), 教授 (30346481)
• Co-Investigator(Kenkyū-buntansha): 池田 佳代 広島大学, 医歯薬保健学研究院(薬), 助教 (30379911) ; 猪川 和朗 広島大学, 医歯薬保健学研究院(薬), 准教授 (40363048)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 臨床 / 感染症 / 抗菌剤 / PK/PD / ＰＫ／ＰＤ

Outline of Final Research Achievements

We reported the therapeutic drug monitoring of voriconazole in Japanese patients used analysis based on clinical practice data. We reported the pharmacokinetic/pharmacodynamic analysis of teicoplanin in patients with MRSA infections. We reported the pharmacokinetics of ampicillin-sulbactam in anuric patients used dosing optimization for prophylaxis during cardiovascular surgery.

Research Products

• [Journal Article] Therapeutic drug monitoring of voriconazole in Japanese patients: analysis based on clinical practice data. (2016)
  • Author(s): Matsumoto K, Abematsu K, Shigemi A, Kanazawa N, Watanabe E, Yokoyama Y, Ikawa K, Morikawa N, Takeda Y.
  • Journal Title: J Chemother. Volume: 28 Issue: 3 Pages: 198-202
  • DOI: 10.1179/1973947815y.0000000057
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Pharmacokinetic/pharmacodynamic analysis of teicoplanin in patients with MRSA infections. (2016)
  • Author(s): Matsumoto K, Watanabe E, Kanazawa N, Fukamizu T, Shigemi A, Yokoyama Y, Ikawa K, Morikawa N, Takeda Y.
  • Journal Title: The Journal of Clinical Pharmacology Volume: 8 Pages: 15-18
  • DOI: 10.2147/cpaa.s96143
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The pharmacokinetics of ampicillin-sulbactam in anuric patients: dosing optimization for prophylaxis during cardiovascular surgery. (2016)
  • Author(s): Yokoyama Y, Matsumoto K, Ikawa K, Watanabe E, Yamamoto H, Imoto Y, Morikawa N, Takeda Y.
  • Journal Title: International Journal of Clinical Pharmacology Volume: 1 Issue: 4 Pages: 1-5
  • DOI: 10.1007/s11096-016-0286-5
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Pharmacokinetics of Prophylactic Ampicillin–Sulbactam and Dosing Optimization in Patients Undergoing Cardiovascular Surgery with Cardiopulmonary Bypass (2015)
  • Author(s): Yokoyama Y, Matsumoto K, Ikawa K, Watanabe E, Yamamoto H, Imoto Y, Morikawa N, Takeda Y.
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 38 Issue: 11 Pages: 1817-1821
  • DOI: 10.1248/bpb.b15-00334
  • NAID: 130005106382
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Penetration of piperacillin-tazobactam into human prostate tissue and dosing considerations for prostatitis based on site-specific pharmacokinetics and pharmacodynamics. (2015)
  • Author(s): Kobayashi I, Ikawa K, Nakamura K, Nishikawa G, Kajikawa K, Yoshizawa T, Watanabe M, Kato Y, Zennami K, Kanao K, Tobiume M, Yamada Y, Mitsui K, Narushima M, Morikawa N, Sumitomo M.
  • Journal Title: J. Infect. Chemother. Volume: 21 Issue: 8 Pages: 575-580
  • DOI: 10.1016/j.jiac.2015.04.015
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Pharmacokinetics and dosing estimation of meropenem in Japanese patients receiving continuous venovenous hemodialysis. (2015)
  • Author(s): Kawano S, Matsumoto K, Hara R, Kuroda Y, Ikawa K, Morikawa N, Horino T, Hori S, Kizu J.
  • Journal Title: J Infect Chemother. Volume: 21(6) Issue: 6 Pages: 476-478
  • DOI: 10.1016/j.jiac.2015.02.011
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Clinical pharmacokinetics of meropenem in pancreatic juice and site-specific pharmacodynamic target attainment against Gram-negative bacteria: dosing considerations. (2014)
  • Author(s): Kondo N, Ikawa K, Murakami Y, Uemura K, Sudo T, Hashimoto Y, Ohge H, Morikawa N, Sueda T.
  • Journal Title: Pancreatology Volume: 14 Pages: 95-99
  • Peer Reviewed / Open Access
• [Journal Article] Pharmacokinetics and pharmacodynamic target attainment of intravenous pazufloxacin in the bile of patients undergoing biliary pancreatic surgery. (2014)
  • Author(s): Uegami S, Ikawa K, Ohge H, Nakashima A, Shigemoto N, Morikawa N, Murakami Y, Sueda T.
  • Journal Title: J. Chemother. Volume: 26 Pages: 287-292
  • Peer Reviewed / Open Access
• [Journal Article] Pharmacokinetic modeling of serum and bronchial concentrations for clarithromycin and telithromycin, and site-specific pharmacodynamic simulation for their dosages. (2014)
  • Author(s): Ikawa K, Kikuchi E, Kikuchi J, Nishimura M, Derendorf H, Morikawa N.
  • Journal Title: J. Clin. Pharm. Ther. Volume: 39 Pages: 411-417
  • Peer Reviewed / Open Access