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Identification of endogenous biomarkers to predict the altered activities of drug transporters by environmental factors

Research Project

Project/Area Number 26460199
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical pharmacy
Research InstitutionKyushu University

Principal Investigator

Hirota Takeshi  九州大学, 薬学研究院, 准教授 (80423573)

Co-Investigator(Kenkyū-buntansha) 家入 一郎  九州大学, 薬学研究院, 教授 (60253473)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords薬剤反応性 / 発現制御 / 薬物トランスポーター / バイオマーカー / クルクミン
Outline of Final Research Achievements

Curcumin, a commonly used spice, is a naturally occurring polyphenol. In this study, we assessed the influence of prior administration of curcumin on the pharmacokinetics of SASP. Orally 4 to 5 days’ time lag between SASP and curcumin intake disappeared the interaction. The disappeared interaction may be responsible for the extremely low bioavailability of curcumin and the disappearance of curcumin in the gastro-intestinal tracts before the administration of SASP. Our findings suggested that 4 to 5 days’ time lag is necessary to avoid the drug interaction between BCRP substrates and curcumin.
In addition to the effects of curcumin, we analyzed the correlation between exosomal miR-328 in plasma, which leaks from the intestines and BCRP activity in human. Exosomal miR-328 levels positively correlated (P < 0.05) with SASP AUC0-48, suggesting that exosomal miR-328 in plasma has potential as a possible biomarker for estimating BCRP function in the human intestines.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (6 results)

All 2016 2015

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 3 results) Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Effect of Curcumin on Sulfasalazine Pharmacokinetics in Healthy Volunteers2016

    • Author(s)
      Tomoko Tokumoto, Takeshi Hirota, Keisuke Gotanda, Miyuki Kimura, Shin Irie, Masato Fukae and Ichiro Ieiri
    • Journal Title

      Journal of Drug Metabolism & Toxicology

      Volume: 7 Pages: 1000206-1000206

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Circulating intestine-derived exosomal miR-328 in plasma, a possible biomarker for estimating BCRP function in the human intestines2016

    • Author(s)
      Gotanda K, Hirota T, Saito J, Fukae M, Egashira Y, Izumi N, Deguchi M, Kimura M, Matsuki S, Irie S, Ieiri I
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 32299-32299

    • DOI

      10.1038/srep32299

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Sulfasalazine disposition in subject with 376C>T (nonsense mutation) and 421C>A variants in ABCG2 gene.2015

    • Author(s)
      Gotanda K, Tokumoto T, Hirota T, Fukae M, Ieiri I.
    • Journal Title

      Br J Clin Pharmacol

      Volume: 未定 Issue: 5 Pages: 1236-1237

    • DOI

      10.1111/bcp.12654

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] ABCG2遺伝子376C>T変異がスルファサラジンの体内動態に与える影響2016

    • Author(s)
      廣田豪、五反田圭介、徳本知子、深江真登、家入一郎
    • Organizer
      日本薬物動態学会 第31回年会
    • Place of Presentation
      長野県松本市
    • Year and Date
      2016-10-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] Sulfasalazine disposition in subject with 376C>T (nonsense mutation) variant in ABCG2 gene2016

    • Author(s)
      Takeshi Hirota, Keisuke Gotanda, Tomoko Tokumoto, Masato Fukae and Ichiro Ieiri
    • Organizer
      International Society for the Study of Xenobiotics
    • Place of Presentation
      Busan, Korea
    • Year and Date
      2016-06-13
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] クルクミンが消化管BCRP発現へ与える影響評価2015

    • Author(s)
      徳本 知子, 廣田 豪, 五反田 圭介, 深江 真登, 家入 一郎
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-26
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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