Development and validation of the cocktail study for the method in detection of drug-drug interactions
| Project/Area Number |
26460202
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | University of Shizuoka |
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Principal Investigator |
UCHIDA shinya 静岡県立大学, 薬学部, 准教授 (80372522)
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| Co-Investigator(Kenkyū-buntansha) |
今井 浩光 大分大学, 医学部, 教授 (30398250)
乾 直輝 浜松医科大学, 医学部, 准教授 (80402254)
小田切 圭一 浜松医科大学, 医学部附属病院, 特任准教授 (70529213)
袴田 晃央 浜松医科大学, 医学部, 助教 (60788280)
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| Co-Investigator(Renkei-kenkyūsha) |
TANAKA Shimako 浜松医科大学, 医学部, 准教授 (10559925)
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| Research Collaborator |
MIURA Tomoyasu
SASANO Tomomi
OZAWA Miki
SHINOHARA Miki
NOGAMI Yuzuki
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | カクテル試験 / 薬物相互作用 / シトクロムP450 / 臨床試験 |
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| Outline of Final Research Achievements |
A “cocktail” approach, which involves simultaneous administration of multiple cytochrome P450 (CYP)-specific probes, concurrently detects the activity of multiple CYP enzymes. We developed and validated the cocktail study by comparing the results of drug-drug interaction from a cocktail study with that from single probe studies. Changes of area under curves of probe drugs in the cocktail study were similar to those in the singe-probe study, suggesting that cocktail approach can evaluate drug interactions. This approach is expected to serve as a convenient method for detecting potential drug-drug interactions.
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Report
(4 results)
Research Products
(14 results)
