| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Outline of Final Research Achievements |
Chronic kidney disease (CKD) and hyperhomocysteinemia are risk factors of cardiovascular disease individually. While the association of CKD and hyperhomocysteinemia is well established in clinical populations, little is known about the role of hyperhomocysteinemia in the development of vascular dysfunction of CKD. This study is conducted to clarify how plasma homocysteine (Hcy) is elevated in CKD and the effects of hyperhomocysteinemia on vascular function in CKD. We determined the turn over rates for Hcy production and disposal of 5/6 nephrectomized rats using a stable isotope technique and showed that decreased remethylation of Hcy to methionine (Met) was associated with hyperhomocysteinemia in CKD. Using 5/6 nephrectomized rats with hyperhomocysteinemia induced by Met-enriched diets, vasodilataions of thoracic aorta were determined. Combination of hyperhomocysteinemia and CKD resulted in impairments of both endothelium-dependent and endothelium-independent vasodilatations.
|
