Biochemical properties of various organic ion transporters in central nervous system
| Project/Area Number |
26460210
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Ritsumeikan University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KATSURA Toshiya 立命館大学, 薬学部, 教授 (10283615)
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| Research Collaborator |
Ganapathy Vadivel Texas Tech University, Health Sciences Center, 教授
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 有機イオントランスポーター / 初代培養神経細胞 / クエン酸回路 / エンケファリン輸送 / 中枢神経系 / アストロサイト / トランスポーター / Na+共役型ジ･トリカルボン酸トランスポーター / TCA回路中間体 / ペプチドトランスポーター / アミノ酸トランスポーター / 電位依存性カルシウムチャネル / gabapentin |
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| Outline of Final Research Achievements |
In this project, we characterized the expression and function of various organic solute transporters, such as amino acid transporter(s), dicarboxylate transporter(s), and opioide peptide transporters, in the central nervous system. After these experiments, functional regulation of these transporters was determined with neurochemical and biochemical techniques. We found that Na+-dependent enkephalin transporter, which is reported to be expressed in cultured neuronal cell line, is expressed functionally in mouse cerebrocortical neurons.
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Report
(4 results)
Research Products
(10 results)
