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Biochemical properties of various organic ion transporters in central nervous system

Research Project

Project/Area Number 26460210
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical pharmacy
Research InstitutionRitsumeikan University

Principal Investigator

FUJITA Takuya  立命館大学, 薬学部, 教授 (00247785)

Co-Investigator(Renkei-kenkyūsha) KATSURA Toshiya  立命館大学, 薬学部, 教授 (10283615)
Research Collaborator Ganapathy Vadivel  Texas Tech University, Health Sciences Center, 教授
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords有機イオントランスポーター / 初代培養神経細胞 / クエン酸回路 / エンケファリン輸送 / 中枢神経系 / アストロサイト / トランスポーター / Na+共役型ジ・トリカルボン酸トランスポーター / TCA回路中間体 / ペプチドトランスポーター / アミノ酸トランスポーター / 電位依存性カルシウムチャネル / gabapentin
Outline of Final Research Achievements

In this project, we characterized the expression and function of various organic solute transporters, such as amino acid transporter(s), dicarboxylate transporter(s), and opioide peptide transporters, in the central nervous system. After these experiments, functional regulation of these transporters was determined with neurochemical and biochemical techniques. We found that Na+-dependent enkephalin transporter, which is reported to be expressed in cultured neuronal cell line, is expressed functionally in mouse cerebrocortical neurons.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (10 results)

All 2017 2016 2015

All Journal Article (3 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (7 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Pharmacokinetic Modeling and Monte Carlo Simulation to Predict Interindividual Variability in Human Exposure to Oseltamivir and Its Active Metabolite, Ro 64-0802.2017

    • Author(s)
      Ito M, Kusuhara K, Ose A, Kondo T, Tanabe K, Nakayama H, Horita S, Fujita T, Sugiyama Y.
    • Journal Title

      AAPS J

      Volume: 19 Issue: 1 Pages: 286-297

    • DOI

      10.1208/s12248-016-9992-0

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Effect of Mechanical Agitation on Cationic Liposome Transport across an Unstirred Water Layer in Caco-2 Cells2016

    • Author(s)
      Kono Y, Iwasaki A, Matsuoka K, Fujita T.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 39 Issue: 8 Pages: 1293-1299

    • DOI

      10.1248/bpb.b16-00050

    • NAID

      130005254677

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] An openable artificial intestinal tract system for the in vitro evaluation of medicines.2015

    • Author(s)
      Satoshi Konishi, Takuya Fujita, Koji Hattori, Yusuke Kono and Yoshifumi Matsushita
    • Journal Title

      Microsystems &Nanoengineering

      Volume: 1 Issue: 1 Pages: 15015-15015

    • DOI

      10.1038/micronano.2015.15

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 神経細胞におけるNa+,Cl- 依存性エンケファリン輸送特性の検討2017

    • Author(s)
      西村春香、松岡芹香、結城綾子、河野裕允、角本幹夫、藤田卓也
    • Organizer
      医療薬学フォーラム2017・第25回クリニカルファーマシーシンポジウム
    • Place of Presentation
      鹿児島市民文化ホール(鹿児島県鹿児島市)
    • Year and Date
      2017-07-01
    • Related Report
      2016 Annual Research Report
  • [Presentation] HepG2 細胞での Na+ 依存性クエン酸輸送における金属イオンの影響2017

    • Author(s)
      結城綾子、西村春香、後藤真耶、船橋理子、河野裕允、藤田卓也
    • Organizer
      医療薬学フォーラム2017・第25回クリニカルファーマシーシンポジウム
    • Place of Presentation
      鹿児島市民文化ホール(鹿児島県鹿児島市)
    • Year and Date
      2017-07-01
    • Related Report
      2016 Annual Research Report
  • [Presentation] アミノ酸枯渇時のヒトアストロサイトにおけるsystem Aアミノ酸トランスポーターの適応調節機構2016

    • Author(s)
      船橋理子、河野裕允、藤田卓也
    • Organizer
      日本薬剤学会第31年会
    • Place of Presentation
      岐阜国際会議場(岐阜県岐阜市)
    • Year and Date
      2016-05-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] Assessment of Intestinal Absorption of New Chemical Entities: In Vitro/In Vivo Correlation.2015

    • Author(s)
      Takua Fujita, Yusuke Kono
    • Organizer
      Association of American Pharamceutical Sciences Annual Meeting and Exposition 2015
    • Place of Presentation
      Orlando, Florida、USA
    • Year and Date
      2015-10-26
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] ヒト乳がん由来細胞 MCF7 におけるカルニチンの輸送機構に関する研究2015

    • Author(s)
      地引麻維子、河野裕允、藤田卓也
    • Organizer
      第23回クリニカルファーマシーシンポジウム:医療薬学フォーラム2015
    • Place of Presentation
      名古屋国際会議場(愛知県、名古屋市)
    • Year and Date
      2015-07-05
    • Related Report
      2015 Research-status Report
  • [Presentation] ヒトアストロサイトにおけるsystem Aアミノ酸トランスポーターの適応調節機構2015

    • Author(s)
      船橋理子、河野裕允、藤田卓也
    • Organizer
      第23回クリニカルファーマシーシンポジウム:医療薬学フォーラム2015
    • Place of Presentation
      名古屋国際会議場(愛知県、名古屋市)
    • Year and Date
      2015-07-05
    • Related Report
      2015 Research-status Report
  • [Presentation] 消化管上皮細胞株 Caco-2 を用いた in vitro 薬物中枢移行評価系の構築2015

    • Author(s)
      青野真実、河野裕允、藤田卓也
    • Organizer
      第23回クリニカルファーマシーシンポジウム:医療薬学フォーラム2015
    • Place of Presentation
      名古屋国際会議場(愛知県、名古屋市)
    • Year and Date
      2015-07-05
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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