| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
A novel method for risk prediction of drug-induced liver injury in human using toxicogenomic analyses and chimeric mice with highly humanized liver has been developed, and was named the Toxicity of Liver Examination method (T-LEX method). In this study, it was established by relating a result of the toxicogenomic experiment in chimeric mice with highly humanized liver after administration of statins to clinical information based on a large-scale drug reactions databese. Various safety information about liver injury induced by generic drugs were possible to indicate as a result of study of T-LEX method.
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