Development and evaluation of drug carrier nanoparticles with liquid crystalline-phase.
| Project/Area Number |
26460224
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Toho University (2016)
University of Shizuoka (2014-2015) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
岩尾 康範 静岡県立大学, 薬学部, 准教授 (30433022)
板井 茂 静岡県立大学, 薬学部, 教授 (80453059)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 立方液晶相 / キューボソーム / 難溶性薬物担体 / 溶解度向上 / ナノ粒子薬物担体 / 難溶性薬物 / 可溶化 |
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| Outline of Final Research Achievements |
Cubosomes are nanoparticles with inverse bicontinuous cubic liquid crystalline phase. We have shown that cubosome can enhance the apparent solubility of insoluble drugs and stabilize the drug that is liable to be hydrolyzed. We have also found that mono-glyceride additives further improved the solubilizing ability of cubosomes. These results suggest that cubosome would be a promising drug carrier especially for highly-insoluble drugs.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Structural investigation of spherical hollow excipient Mannit Q by X-ray microtomography.2015
Author(s)
Kajihara, R., Noguchi, S., Iwao, Y., Yasuda, Y., Segawa, M. & Itai, S.
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Journal Title
International Journal of Pharmaceutics
Volume: 495
Issue: 1
Pages: 204-217
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Suppressed release of clarithromycin from tablets by crystalline phase transition of metastable polymorph form I2015
Author(s)
Fujiki, S., Watanabe, N., Iwao, Y., Noguchi, S., Mizoguchi, M., Iwamura, T., Itai, S.
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Journal Title
Journal of Pharmaceutical Sciences
Volume: 104
Issue: 8
Pages: 2541-2644
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Structural changes of polymer-coated microgranules and excipients on tableting investigated by microtomography using synchrotron X-ray radiation.2015
Author(s)
Kajihara, R., Noguchi, S., Iwao, Y., Suzuki, Y., Terada, Y., Uesugi, K. & Itai, S.
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Journal Title
International Journal of Pharmaceutics
Volume: 481
Issue: 1-2
Pages: 132-139
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] Internal Structures of Polymer-Coated Microgranules Investigated by Microtomography Using Synchrotron X-ray Radiation2014
Author(s)
Noguchi, S., Yamada, N., Mise, R., Ishida, M., Kajihara, R., Iwao, Y. & Itai S.
Organizer
2014 AAPS Annual Meeting and Exposition
Place of Presentation
San Diego, USA
Year and Date
2014-11-05
Related Report
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