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A proposal of treatment of atopic dermatitis targeted at the skin microflora and Langerhans cells

Research Project

Project/Area Number 26460238
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical pharmacy
Research InstitutionMeiji Pharmaceutical University

Principal Investigator

Matsui Katsuhiko  明治薬科大学, 薬学部, 准教授 (20257140)

Research Collaborator HINO Yumi  
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsアトピー性皮膚炎 / 黄色ブドウ球菌 / ランゲルハンス細胞 / IgE / Th1細胞分化 / Th2細胞分化 / ジョサマイシン / アレルギー炎症 / ドキシサイクリン / 抗生物質 / ベタメサゾン
Outline of Final Research Achievements

The present study demonstrated that josamycin, a macrolide antibiotic, inhibited the development of Th1 and Th2 cells mediated by Langerhans cells and topical treatment with josamycin significantly suppressed the increase in the skin severity score in NC/Nga mice. Furthermore, Staphylococcus aureus strains isolated from skin lesions of patients with atopic dermatitis were highly susceptible to josamycin. Therefore, topical application of josamycin to atopic dermatitis lesions colonized by S. aureus would be beneficial for control of dermatitis and preferable to steroids.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (19 results)

All 2017 2016 2015 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Acknowledgement Compliant: 5 results,  Open Access: 2 results) Presentation (11 results) (of which Int'l Joint Research: 1 results) Remarks (1 results)

  • [Journal Article] Topical application of josamycin inhibits development of atopic dermatitis-like skin lesions in NC/Nga mice2017

    • Author(s)
      Matsui K, Tachioka K, Onodera K and Ikeda R.
    • Journal Title

      J. Pharm. Pharm. Sci.

      Volume: 20 Pages: 38-47

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Betamethasone, but Not Tacrolimus, Suppresses the Development of Th2 Cells Mediated by Langerhans Cell-Like Dendritic Cells2016

    • Author(s)
      Matsui K, Tamai S and Ikeda R.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 39 Issue: 7 Pages: 1220-1223

    • DOI

      10.1248/bpb.b16-00075

    • NAID

      130005160764

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Effects of macrolide antibiotics on Th1 cell and Th2 cell development mediated by Langerhans cells2016

    • Author(s)
      Matsui K, Tamai S and Ikeda R.
    • Journal Title

      J. Pharm. Pharm. Sci.

      Volume: 19 Issue: 3 Pages: 357-366

    • DOI

      10.18433/j3z32f

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 皮膚常在菌とランゲルハンス細胞を同時標的にしたアトピー性皮膚炎治療の提案2016

    • Author(s)
      松井勝彦
    • Journal Title

      アレルギーの臨床

      Volume: 36 Pages: 362-366

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] マクロライド系抗生物質を用いたアトピー性皮膚炎治療の提案2016

    • Author(s)
      松井勝彦
    • Journal Title

      アレルギーの臨床

      Volume: 36 Pages: 592-596

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Betamethasone but not tacrolimus suppresses development of Th2 cells mediated by Langerhans cell-like dendritic cells2016

    • Author(s)
      Matsui K, Tamai S, Ikeda R
    • Journal Title

      Biol. Pharm. Bull.

      Volume: 39

    • NAID

      130005160764

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Langerhans cell-like dendritic cells stimulated with an adjuvant direct the development of Th1 and Th2 cells in vivo2015

    • Author(s)
      Matsui K, Mori A, Ikeda R
    • Journal Title

      Clin. Exp. Immunol.

      Volume: 182 Pages: 101-107

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] NC/Ngaマウスのアトピー性皮膚炎様皮膚病変に対するジョサマイシン軟膏の治療効果について2017

    • Author(s)
      松井勝彦、立岡幹太、小野寺けい、池田玲子
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] Topically applied josamycin suppresses development of atopic dermatitis-like skin lesions in NC/Nga mice2017

    • Author(s)
      松井勝彦、池田玲子
    • Organizer
      第90回日本細菌学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] Effects of topical application of josamycin on atopic dermatitis-like skin lersions in NC/Nga mice2016

    • Author(s)
      松井勝彦、池田玲子
    • Organizer
      第45回日本免疫学会学術集会
    • Place of Presentation
      那覇
    • Year and Date
      2016-12-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] ランゲルハンス細胞様樹状細胞を介するTh1/Th2細胞分化に対するマクロライド系抗生物質の影響2016

    • Author(s)
      松井勝彦、玉井咲、池田玲子
    • Organizer
      日本薬学会 第136年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-26
    • Related Report
      2015 Research-status Report
  • [Presentation] 黄色ブドウ球菌の皮膚定着とアトピー性皮膚炎の痒みについて2016

    • Author(s)
      中村翠、尾花典子、池田玲子、松井勝彦
    • Organizer
      日本薬学会 第136年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-26
    • Related Report
      2015 Research-status Report
  • [Presentation] Effects of macrolide antibiotics on Th1 cell and Th2 cell development mediated by Langerhans cell-like dendritic cells2016

    • Author(s)
      松井勝彦、池田玲子
    • Organizer
      第89回 日本細菌学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2016-03-23
    • Related Report
      2015 Research-status Report
  • [Presentation] Effects of 16-membered macrolides against Th1/Th2 cell development induced by Langerhans cell-like dendritic cells2015

    • Author(s)
      松井勝彦、池田玲子
    • Organizer
      第44回 日本免疫学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2015-11-18
    • Related Report
      2015 Research-status Report
  • [Presentation] Betamethasone suppresses Th2 cell development induced by Langerhans cell like dendritic cells.2015

    • Author(s)
      Matsui Katsuhiko, Tamai Saki, Ikeda Reiko
    • Organizer
      World Allergy Congress 2015
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2015-10-14 – 2015-10-17
    • Related Report
      2014 Research-status Report
  • [Presentation] Betamethasone suppresses Th2 cell development induced by Langerhans cell like dendritic cells2015

    • Author(s)
      Matsui K, Tamai S, Ikeda R
    • Organizer
      World Allergy Congress 2015
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2015-10-14
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Langerhans cell-like dendritic cells stimulated with an adjuvant direct Th1/Th2 development2015

    • Author(s)
      松井勝彦、池田玲子
    • Organizer
      第88回 日本細菌学会総会
    • Place of Presentation
      岐阜
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] アジュバント刺激によるランゲルハンス細胞様樹状細胞のTh1/Th2細胞分化誘導について2015

    • Author(s)
      松井勝彦、森晃子、池田玲子
    • Organizer
      日本薬学会 第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-25 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Remarks] 最近のトピックス

    • URL

      https://www.my-pharm.ac.jp/%7Ekansen/type2/matsui.html

    • Related Report
      2016 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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