| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
The blood concentrations of platinum and trace metals including iron, copper, zinc, manganese and lead were determined in esophageal and lung cancer patients receiving cisplatin-based chemotherapy. The data for the patients who received a blood transfusion and iron tablet intake or had blood drawn while in non-fasting state were excluded from the analysis. The patients exhibited the increase in the plasma iron concentration within a week after the CDDP treatment, followed by a subsequent return to baseline level. This transient elevation may have been partly due to the anemia-associated lowering of hemoglobin value. The plasma zinc concentration was also increased on days 1-3 after the cisplatin treatment. The variation in the blood concentrations of iron and zinc showed a certain trend after the start of cisplatin-based chemotherapy, suggesting the usefulness of the analysis of trace metals in the body to understand the physiological responses to platinum-based cancer chemotherapy.
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