Usefulness of the analysis of trace metals to predict adverse effects and understand their underlying mechanisms during platinum-based cancer chemotherapy
| Project/Area Number |
26460245
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Osaka University of Pharmaceutical Sciences (2016)
Himeji Dokkyo University (2014-2015) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
高橋 稔 姫路獨協大学, 薬学部, 助教 (80620872)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | プラチナ / 癌 / バイオメタル / プラチナ系抗癌剤 |
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| Outline of Final Research Achievements |
The blood concentrations of platinum and trace metals including iron, copper, zinc, manganese and lead were determined in esophageal and lung cancer patients receiving cisplatin-based chemotherapy. The data for the patients who received a blood transfusion and iron tablet intake or had blood drawn while in non-fasting state were excluded from the analysis. The patients exhibited the increase in the plasma iron concentration within a week after the CDDP treatment, followed by a subsequent return to baseline level. This transient elevation may have been partly due to the anemia-associated lowering of hemoglobin value. The plasma zinc concentration was also increased on days 1-3 after the cisplatin treatment. The variation in the blood concentrations of iron and zinc showed a certain trend after the start of cisplatin-based chemotherapy, suggesting the usefulness of the analysis of trace metals in the body to understand the physiological responses to platinum-based cancer chemotherapy.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Genetic polymorphisms in SLC23A2 as predictive biomarkers of severe acute toxicities after treatment with a definitive 5-fluorouracil/cisplatin-based chemoradiotherapy in Japanese patients with esophageal squamous cell carcinoma.2014
Author(s)
T. Minegaki, A. Kuwahara, M. Yamamori, T. Nakamura, T. Okuno, I. Miki, H. Omatsu, T. Tamura, M. Hirai, T. Azuma, T. Sakaeda, K. Nishiguchi.
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Journal Title
Int J Med Sci.
Volume: 11
Issue: 4
Pages: 321-326
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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