| Project/Area Number |
26460246
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Himeji Dokkyo University |
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Principal Investigator |
Takara Kohji 姫路獨協大学, 薬学部, 教授 (00329939)
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| Co-Investigator(Kenkyū-buntansha) |
峯垣 哲也 京都薬科大学, 薬学部, 助教 (10549306)
木下 淳 姫路獨協大学, 薬学部, 講師 (60454766)
中山 優子 姫路獨協大学, 薬学部, 助手 (50708419)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | エピジェネティクス / 癌 / 抗癌剤耐性 |
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| Outline of Final Research Achievements |
The various types of mechanism are participated in the phenomena which shows the resistance to anticancer drugs in cancer cells. Herein, from the viewpoints of epigenetics causing the change in the gene function, the relation with the drug resistance and epigenetics were examined. As results, the differences in the global DNA methylation were not found in HeLa and its resistant cells. However, the expressions of mRNA involving in the epigenetics were different among the cells. Treatment with drugs having the activity of demethylation increased sensitivity to cisplatin in either cells. Consequently, the novel possibility of reversal of resistance may be demonstrated, although the relation with the drug resistance and epigenetics has not reached the sufficient evidence.
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