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Study of neurodevelopment using viral infection model during pregnancy

Research Project

Project/Area Number 26460252
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General anatomy (including histology/embryology)
Research InstitutionMie University

Principal Investigator

Ohkawara Takeshi  三重大学, 医学系研究科, 講師 (20469034)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords自閉症 / 妊娠中のウイルス感染 / セロトニン神経 / サイトカイン
Outline of Final Research Achievements

Recently, the prevalence of autism spectrum disorder (ASD) is increased. It is reported that viral infection during pregnancy is one of the risk factors of ASD. However, little is known about critical period to viral infection during pregnancy that cause ASD. To examine the critical period to viral infection during pregnancy that cause ASD, I made viral infection model during pregnancy and examined the critical period. I revealed that there are at least two critical periods to viral infection during pregnancy that induce abnormality to serotonergic system of offspring.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (5 results)

All 2017 2016 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (4 results)

  • [Journal Article] Analysis of brain serotonin content following viral infection in timed-pregnant and developing rat - Implications for maternal viral infection in the cause of SIDS-2016

    • Author(s)
      Ohkawara T, Ida-Eto M, Narita M.
    • Journal Title

      Journal of Japan SIDS Research Society

      Volume: 16 Pages: 3-7

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Presentation] 妊娠中のウイルス感染は児の呼吸動態に影響を与える ―ウイルス感染モデルラットを用いた実験より2017

    • Author(s)
      大河原剛
    • Organizer
      日本解剖学会
    • Place of Presentation
      長崎大学(長崎県・長崎市)
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] Viral infection during pregnancy causes long term effects on the gene expression in the rat brain2016

    • Author(s)
      大河原剛
    • Organizer
      日本神経科学会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] 妊娠中のウイルス感染は産まれてきた仔の脳セロトニン神経関連遺伝子の発現に影響を及ぼす2016

    • Author(s)
      大河原剛
    • Organizer
      日本解剖学会
    • Place of Presentation
      ビックパレット福島(福島県・郡山市)
    • Year and Date
      2016-03-28
    • Related Report
      2015 Research-status Report
  • [Presentation] 妊娠中のウイルス感染は、生後の脳セロトニン含量に影響する -ウイルス感染モデル動物を用いた臨界期の検討-2015

    • Author(s)
      大河原 剛
    • Organizer
      日本解剖学会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2015-03-23
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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