| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Outline of Final Research Achievements |
In this study, we analyzed the developmental mechanism and functional significance of physiological lymphovenous anastomosis, and whether lymphovenous anastomosis in peripheral tissues improves severe embryonic edema caused by the loss of physiological lymphovenous anastomosis. We found that the formation of physiological lymphovenous anastomosis is regulated by Aspp1, that it is essential for fetal development and survival, and that the abnormality caused by its loss is not improved by lymphovenous anastomosis in peripheral tissues. Although the novel guidance molecule Semaphorin 3G is dispensable for formation of physiological lymphovenous anastomosis, we found that it regulates lymphatic vascular distribution by providing repulsion signals to lymphatic endothelial cells via Nrp2/PlexinD1 receptor complex.
|
