| Project/Area Number |
26460254
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General anatomy (including histology/embryology)
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| Research Institution | Hiroshima University |
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Principal Investigator |
Aoyama Hirohiko 広島大学, 医歯薬保健学研究院(医), 教授 (70143948)
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| Co-Investigator(Renkei-kenkyūsha) |
KAGAYA MIYUKI 広島大学, 大学院医歯薬保健学研究院, 助教 (50623790)
SAKAMOTO NOBUYUKI 広島大学, 大学院医歯薬保健学研究院, 助教 (90346487)
MATSUI KOUJI 広島大学, 大学院医歯薬保健学研究院, 助教 (80183945)
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| Research Collaborator |
MATSUTANI KAORU 広島大学, 大学院医歯薬保健学研究科, 大学院生
MATSUMORI DAISUKE 広島大学, 大学院医歯薬保健学研究科, 大学院生
KATSURA-GOU YUKARI 広島大学, 大学院医歯薬保健学研究科, 大学院生
CHAOUKE JILE 広島大学, 大学院医歯薬保健学研究科, 大学院生
FAN HAIMING 広島大学, 大学院医歯薬保健学研究科, 大学院生
MASUDA TASUKU 広島大学, 大学院医歯薬保健学研究科, 大学院生
NAITOU MICHIKO 広島大学, 大学院医歯薬保健学研究科, 大学院生
YAMAAI MAKOTO 広島大学, 大学院医歯薬保健学研究科, 大学院生
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 体節 / 側板中胚葉 / 細胞間相互作用 / in vitroモデル / 接触阻害 / 軸骨格 / 部域化 / 肋骨 / 形態形成 / 細胞接触 / in vitro |
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| Outline of Final Research Achievements |
In the course of the phylogenesis of vertebrates, the ribs has been localized in the thoracic region in their axial skeleton, which allow mammals and birds to acquire flexibility in their body and more active lung breathing.
In a developing embryo, the ribs are derived from the somites. The rib-genesis begins with migration of somite cells into the lateral plate that is adjacent to the somites. When we transplanted the thoracic somite into the lumbo-sacral region, the somite cells did not migrate into the lumbo-sacral lateral plate. In vitro, when the thoracic somite cells contact thoracic lateral plate cells, the somite cells tended to migrate forwardly as before. On the contrary when the thoracic somite cells contact lumbo-sacral lateral plate, the somite cells start to migrate in the opposite direction. These findings suggest that the behavior of somite cells in vitro represents the phenomenon seen in vivo. This in vitro system would be available for further molecular study.
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