Developmental modularities behind evolution of the jaw and middle ear in mammals
Project/Area Number |
26460256
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General anatomy (including histology/embryology)
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Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
TAKECHI Masaki 東京医科歯科大学, 大学院医歯学総合研究科, テニュアトラック助教 (10455355)
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Research Collaborator |
FURUTERA Toshiko
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Project Period (FY) |
2014-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 中耳 / 鼓膜 / 外耳道 / 咽頭弓 / 進化発生 / マウス / ニワトリ / 下顎 / 形態進化 / 発生進化 / Hoxa2 / Otx2 |
Outline of Final Research Achievements |
We have focused on morphological evolution of the mammalian middle ear and have reported that the tympanic membrane (TM), consisting of the external auditory meatus (EAM) and first pharyngeal pouch, evolved independently in mammalian and diapsid (modern reptiles and birds) lineages. In this study, we compare TM formation along the anterior-posterior axis of pharyngeal arches in mouse and chick embryos. In mouse, TM is formed in the first pharyngeal arch (PA1) and this arch plays a crucial role in TM formation. By contrast, the EAM begins to invaginate at the surface ectoderm of the second pharyngeal arch (PA2) in chick, and the entire TM is formed in PA2. These results indicate that the classical idea of TM formation is not correct in either animal and further strengthen the idea of independent origin of the TM during amniote evolution.
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Report
(5 results)
Research Products
(18 results)
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[Journal Article] Developmental mechanisms of the tympanic membrane in mammals and non-mammalian amniotes2016
Author(s)
Takechi, M., Kitazawa, T., Hirasawa, T., Hirai, T., Iseki, S., Kurihara, H., Kuratani, S.
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Journal Title
Congenital Anomalies
Volume: 56
Issue: 1
Pages: 12-17
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Differing contributions of the first and second pharyngeal arches to tympanic membrane formation in the mouse and chick.2018
Author(s)
Takechi. M., Furutera, T., Kitazawa, T., Rijli, F., Kurihara. H., Kuratani, S., Iseki, S.
Organizer
Gordon Research Conference, Craniofacial Morphogenesis and Tissue Regeneration
Related Report
Int'l Joint Research
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[Presentation] Differing contributions of the first and second pharyngeal arches to tympanic membrane formation in the mouse and chick2017
Author(s)
Takechi, M., Furutera, T., Kitazawa, T., Takei, J., Yamada, T., Rijli, F. M., Kurihara, H., Kuratani, S., Iseki. S.
Organizer
50th Annual meeting for Japanese Society of Developmental Biologists
Related Report
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