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Search of novel cardiogenesis signal pathway using large scale chemical library

Research Project

Project/Area Number 26460261
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General anatomy (including histology/embryology)
Research InstitutionNational Institute of Advanced Industrial Science and Technology

Principal Investigator

ITO Yuzuru  国立研究開発法人産業技術総合研究所, 創薬基盤研究部門, 研究グル-プ長 (30500079)

Co-Investigator(Renkei-kenkyūsha) HARAMOTO Yoshikazu  国立研究開発法人産業技術総合研究所, 創薬基盤研究部門, 主任研究員 (30540869)
Research Collaborator YAMADA Shiori  
KANO Eriko  
KAJIYAMA Kouhei  
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsツメガエル / 心筋 / 化合物 / 発生
Outline of Final Research Achievements

Using pluripotent stem cells and mesenchymal stem cells, many researchers study to produce various organ cells and to provide them aiming to the drug discovery and regenerative medicine. In order to realize efficient screening of new drugs and regenerative medicine with high therapeutic effect, it is necessary to supply high-performance cells, but it is still difficult to produce fully functioning organ cells. Therefore, in this study, I used a compound library to screen novel compounds that affect myocardial induction using Xenopus laevis embryos that can use a large number of early embryos. Expression analysis and functional analysis of genes specifically expressed in late cardiomyocytes by the compound were advanced.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (24 results)

All 2017 2016 2015 2014

All Journal Article (14 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 11 results,  Open Access: 7 results,  Acknowledgement Compliant: 3 results) Presentation (10 results)

  • [Journal Article] Identification and comparative analyses of Siamois cluster genes in the Xenopus laevis and tropicalis.2017

    • Author(s)
      Yoshikazu Haramoto, Tomohito Saijyo, Toshiaki Tanaka, Nobuaki Furuno, Atsushi Suzuki, Yuzuru Ito, Mariko Kondo, Masanori Taira, and Shuji Takahashi.
    • Journal Title

      Developmental Biology

      Volume: 印刷中 Issue: 2 Pages: 374-383

    • DOI

      10.1016/j.ydbio.2016.07.015

    • NAID

      120006605592

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Genome evolution in the allotetraploid frog Xenopus laevis2016

    • Author(s)
      Session AM, Uno Y, Kwon T, Chapman JA, Toyoda A et al.
    • Journal Title

      Nature

      Volume: 538 Issue: 7625 Pages: 336

    • DOI

      10.1038/nature19840

    • NAID

      120006240046

    • URL

      https://pure.teikyo.jp/en/publications/7cb1b606-b88e-4144-9b58-280a85c3c635

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Complete mitochondrial genome of “xenopus tropicalis” Asashima line (Anura: Pipidae), a possible undescribed species2015

    • Author(s)
      Haramoto Y, Oshima T, Takahashi S, Asashima M, Ito Y, Kurabayashi A.
    • Journal Title

      Mitochondrial DNA.

      Volume: 27 Issue: 5 Pages: 3341

    • DOI

      10.3109/19401736.2015.1018213

    • Related Report
      2016 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A stable chimeric Fibroblast Growth Factor (FGF) can successfully replace basic FGF in human pluripotent stem cell culture2015

    • Author(s)
      Onuma Y, Higuchi K, Aiki Y, Shu Y, Asada M, Asashima M, Suzuki M, Imamura T, Ito Y
    • Journal Title

      PLoS One

      Volume: 10 Issue: 4 Pages: e0118931-e0118931

    • DOI

      10.1371/journal.pone.0118931

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Elimination of tumorigenic human pluripotent stem cells by a recombinant lectin-toxin fusion protein2015

    • Author(s)
      Tateno H, Onuma Y, Ito Y, Minoshima F, Saito S, Shimizu M, Aiki Y, Asashima M, Hirabayashi J
    • Journal Title

      Stem Cell Reports

      Volume: 4 Issue: 5 Pages: 811

    • DOI

      10.1016/j.stemcr.2015.02.016

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Insulin-like factor regulates neural induction through an IGF1 receptor-independent mechanism2015

    • Author(s)
      Haramoto Y, Takahashi S, Oshima T, Onuma Y, Ito Y, Asashima M.
    • Journal Title

      Scientific Reports

      Volume: 5 Issue: 1 Pages: 11603-11603

    • DOI

      10.1038/srep11603

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Physicochemical and biological characterizations of Pxt peptides from amphibian (Xenopus tropicalis) skin.2015

    • Author(s)
      Shigeri Y, Horie M, Yoshida T, Hagihara Y, Imura T, Inagaki H, Haramoto Y, Ito Y, Asashima M
    • Journal Title

      J Biochem

      Volume: なし

    • NAID

      40020869436

    • Related Report
      2015 Research-status Report
  • [Journal Article] A Novel Probe as Surface Glycan Marker of Pluripotent Stem Cells: Research Outcomes and Application to Regenerative Medicine.2015

    • Author(s)
      Hirabayashi J, Tateno H, Onuma Y, Ito Y
    • Journal Title

      Adv Healthc Mater.

      Volume: なし Issue: 16 Pages: 2520-2529

    • DOI

      10.1002/adhm.201400837

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] 幹細胞の品質評価指標の開発2015

    • Author(s)
      小沼泰子、伊藤弓弦
    • Journal Title

      三次元ティッシュエンジニアリング

      Volume: なし Pages: 53-56

    • Related Report
      2015 Research-status Report
  • [Journal Article] 安定型キメラFGF(FGFC)はヒト多能性幹細胞の培養においてbFGFを代替する。2015

    • Author(s)
      小沼泰子、伊藤弓弦
    • Journal Title

      BioMedサーカス.com

      Volume: なし

    • Related Report
      2015 Research-status Report
    • Open Access
  • [Journal Article] Aminolevulinate synthase 2 mediates erythrocyte differentiation by regulating larval globin expression during Xenopus primary hematopoiesis.2015

    • Author(s)
      Ogawa-Otomo A, Kurisaki A, Ito Y.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 456 Issue: 1 Pages: 476-481

    • DOI

      10.1016/j.bbrc.2014.11.110

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Improved Transport of the Model Amphibian, <i>Xenopus tropicalis</i>, and Its Viable Temperature for Transport2014

    • Author(s)
      Kurabayashi, A., R. Kakehashi, I. Tazawa, Y. Haramoto, T. Oshima, Y. Ito and M. Sumida
    • Journal Title

      Current Herpetology

      Volume: 33 Issue: 1 Pages: 75-87

    • DOI

      10.5358/hsj.33.75

    • NAID

      130003393156

    • ISSN
      1345-5834, 1881-1019
    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cell-Mass Structures Expressing the Aromatase Gene Cyp19a1 Lead to Ovarian Cavities in Xenopus laevis2014

    • Author(s)
      Shuuji Mawaribuchi, Nozomi Ikeda, Kazuko Fujitani, Yuzuru Ito, Yasuko Onuma, Tohru Komiya, Nobuhiko Takamatsu, Michihiko Ito
    • Journal Title

      Endocrinology

      Volume: 155 Issue: 10 Pages: 3996-4005

    • DOI

      10.1210/en.2014-1096

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Characterization of the insulin-like growth factor binding protein family in Xenopus tropicalis2014

    • Author(s)
      Haramoto Y, Oshima T, Takahashi S, Yuzuru Ito.
    • Journal Title

      Int. J. Dev. Biol.

      Volume: 58 Issue: 9 Pages: 705-711

    • DOI

      10.1387/ijdb.150032yi

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 再生医療への適用に向けた、自動培養装置によるiPS細胞等の培養評価2016

    • Author(s)
      伊藤弓弦、清水真都香、道上達男、小沼泰子
    • Organizer
      第15回 産総研・産技連 LS-BT合同研究発表会
    • Place of Presentation
      産業技術総合研究所(つくば)
    • Year and Date
      2016-02-02
    • Related Report
      2015 Research-status Report
  • [Presentation] 多能性幹細胞を用いた細胞治療における残存未分化細胞の除去研究2016

    • Author(s)
      小沼泰子,相木泰彦,樋口久美子,清水真都香,舘野浩章,平林淳,伊藤弓弦
    • Organizer
      第15回 産総研・産技連 LS-BT合同研究発表会
    • Place of Presentation
      産業技術総合研究所(つくば)
    • Year and Date
      2016-02-02
    • Related Report
      2015 Research-status Report
  • [Presentation] 両生類における有核血球の役割について2016

    • Author(s)
      梶山康平、原本悦和、小沼泰子、王碧昭、伊藤弓弦
    • Organizer
      第15回 産総研・産技連 LS-BT合同研究発表会
    • Place of Presentation
      産業技術総合研究所(つくば)
    • Year and Date
      2016-02-02
    • Related Report
      2015 Research-status Report
  • [Presentation] 山田しおり、原本悦和、小沼泰子、鈴木理、伊藤弓弦2016

    • Author(s)
      ツメガエルを用いた幼若型心筋細胞から成体型心筋細胞への変換メカニズムの解析
    • Organizer
      第15回 産総研・産技連 LS-BT合同研究発表会
    • Place of Presentation
      産業技術総合研究所(つくば)
    • Year and Date
      2016-02-02
    • Related Report
      2015 Research-status Report
  • [Presentation] 中胚葉誘導因子に対する応答能の両生類間の比較2016

    • Author(s)
      狩野絵吏子、原本悦和、二宮裕将、有泉高史、王碧昭、伊藤弓弦
    • Organizer
      第15回 産総研・産技連 LS-BT合同研究発表会
    • Place of Presentation
      産業技術総合研究所(つくば)
    • Year and Date
      2016-02-02
    • Related Report
      2015 Research-status Report
  • [Presentation] 間葉系幹細胞の骨形成関連遺伝子の解析2016

    • Author(s)
      長真優子、原本悦和、清水真都香、相木泰彦、樋口久美子、小沼泰子、青柳秀紀、豊田雅士、阿久津英憲、伊藤弓弦
    • Organizer
      第15回 産総研・産技連 LS-BT合同研究発表会
    • Place of Presentation
      産業技術総合研究所(つくば)
    • Year and Date
      2016-02-02
    • Related Report
      2015 Research-status Report
  • [Presentation] アフリカツメガエルを用いた初期心臓形成に関わる遺伝子の解析2015

    • Author(s)
      梶山 康平、王 碧昭、伊藤 弓弦
    • Organizer
      平成26 年度つくば学生研究交流会
    • Place of Presentation
      つくば
    • Year and Date
      2015-03-03
    • Related Report
      2014 Research-status Report
  • [Presentation] アフリカツメガエル胚を用いた二分脊椎症病態モデルの作成と発症メカニズムの解明2014

    • Author(s)
      狩野絵吏子、伊藤弓弦、王碧昭
    • Organizer
      第66回日本生物工学会大会
    • Place of Presentation
      札幌
    • Year and Date
      2014-09-09 – 2014-09-11
    • Related Report
      2014 Research-status Report
  • [Presentation] Comparative analysis of insulin-like growth factor binding proteins.2014

    • Author(s)
      Yoshikazu Haramoto, Tomomi Oshima, Shuji Takahashi, Makoto Asashima, Yuzuru Ito
    • Organizer
      15th International Xenopus Conference
    • Place of Presentation
      California City, USA
    • Year and Date
      2014-08-24 – 2014-08-28
    • Related Report
      2014 Research-status Report
  • [Presentation] Functional analyses of a novel insulin-like factor2014

    • Author(s)
      原本 悦和、高橋秀治、小沼 泰子、伊藤 弓弦、浅島 誠
    • Organizer
      第47回日本発生生物学会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-05-28
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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